Overcoming ecologic bias using the two-phase study design.

Abstract:

:Ecologic (aggregate) data are widely available and widely utilized in epidemiologic studies. However, ecologic bias, which arises because aggregate data cannot characterize within-group variability in exposure and confounder variables, can only be removed by supplementing ecologic data with individual-level data. Here the authors describe the two-phase study design as a framework for achieving this objective. In phase 1, outcomes are stratified by any combination of area, confounders, and error-prone (or discretized) versions of exposures of interest. Phase 2 data, sampled within each phase 1 stratum, provide accurate measures of exposure and possibly of additional confounders. The phase 1 aggregate-level data provide a high level of statistical power and a cross-classification by which individuals may be efficiently sampled in phase 2. The phase 2 individual-level data then provide a control for ecologic bias by characterizing the within-area variability in exposures and confounders. In this paper, the authors illustrate the two-phase study design by estimating the association between infant mortality and birth weight in several regions of North Carolina for 2000-2004, controlling for gender and race. This example shows that the two-phase design removes ecologic bias and produces gains in efficiency over the use of case-control data alone. The authors discuss the advantages and disadvantages of the approach.

journal_name

Am J Epidemiol

authors

Wakefield J,Haneuse SJ

doi

10.1093/aje/kwm386

subject

Has Abstract

pub_date

2008-04-15 00:00:00

pages

908-16

issue

8

eissn

0002-9262

issn

1476-6256

pii

kwm386

journal_volume

167

pub_type

杂志文章
  • Lung cancer risk among hairdressers: a pooled analysis of case-control studies conducted between 1985 and 2010.

    abstract::Increased lung cancer risks among hairdressers were observed in large registry-based cohort studies from Scandinavia, but these studies could not adjust for smoking. Our objective was to evaluate the lung cancer risk among hairdressers while adjusting for smoking and other confounders in a pooled database of 16 case-c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt119

    authors: Olsson AC,Xu Y,Schüz J,Vlaanderen J,Kromhout H,Vermeulen R,Peters S,Stücker I,Guida F,Brüske I,Wichmann HE,Consonni D,Landi MT,Caporaso N,Tse LA,Yu IT,Siemiatycki J,Richardson L,Mirabelli D,Richiardi L,Simonato L

    更新日期:2013-11-01 00:00:00

  • Detection of hepatitis B virus DNA in asymptomatic hepatitis B surface antigen carriers: relation to sexual transmission.

    abstract::The authors tested, by molecular hybridization, for hepatitis B virus DNA in serum specimens of 182 asymptomatic hepatitis B surface antigen (HBsAg) Greek carriers who were heterosexual partners of patients with acute hepatitis B (group A: 96 cases) or healthy subjects who were susceptible to hepatitis B (group B: 86 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114698

    authors: Tassopoulos NC,Papaevangelou GJ,Roumeliotou-Karayannis A,Ticehurst JR,Feinstone SM,Purcell RH

    更新日期:1987-10-01 00:00:00

  • Neighborhood psychosocial hazards and the association of cumulative lead dose with cognitive function in older adults.

    abstract::Before the 1970s, today's older Americans were exposed to high levels of lead in the environment. The authors previously reported that lifetime cumulative lead dose was associated with lower cognitive test performance in older adults. Experiments suggest that environmental stress may intensify the detrimental influenc...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwn390

    authors: Glass TA,Bandeen-Roche K,McAtee M,Bolla K,Todd AC,Schwartz BS

    更新日期:2009-03-15 00:00:00

  • Dietary Quality and Ovarian Cancer Risk in African-American Women.

    abstract::This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American d...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/aje/kwx022

    authors: Qin B,Moorman PG,Kelemen LE,Alberg AJ,Barnholtz-Sloan JS,Bondy M,Cote ML,Funkhouser E,Peters ES,Schwartz AG,Terry P,Schildkraut JM,Bandera EV

    更新日期:2017-06-15 00:00:00

  • A comparison of frequency and quantitative dietary methods for epidemiologic studies of diet and disease.

    abstract::Agreement between frequency and quantitative dietary methods was assessed for the ability of frequency intake data to substitute for quantitative intake data in diet-disease investigations. Frequency and quantitative intakes of 342 male subjects participating in an ongoing case-control study in Hawaii during 1981-1982...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113751

    authors: Chu SY,Kolonel LN,Hankin JH,Lee J

    更新日期:1984-03-01 00:00:00

  • Sample size requirements for association studies of gene-gene interaction.

    abstract::In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.5.478

    authors: Gauderman WJ

    更新日期:2002-03-01 00:00:00

  • Leukemia among New Zealand agricultural workers. A cancer registry-based study.

    abstract::Mortality studies have indicated that workers in agriculture and forestry may be at increased risk of leukemia. Findings are reported from a New Zealand Cancer Registry-based case-control study involving 546 male leukemia patients registered during 1979-1983 and aged 20 years or more at time of registration. Controls ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114410

    authors: Pearce NE,Sheppard RA,Howard JK,Fraser J,Lilley BM

    更新日期:1986-09-01 00:00:00

  • Birth weight and smoking during pregnancy--effect modification by maternal age.

    abstract::Cigarette smoking during pregnancy is an important, avoidable factor associated with low birth weight. Maternal age is also associated with variations in birth weight. Using birth certificate data from all 347,650 singleton births for which maternal age and birth weight were recorded during 1984-1988 in Washington Sta...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116940

    authors: Fox SH,Koepsell TD,Daling JR

    更新日期:1994-05-15 00:00:00

  • The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): reliability and validity against doubly labeled water and 7-day activity diaries.

    abstract::We determined measurement properties of the Sedentary Time and Activity Reporting Questionnaire (STAR-Q), which was designed to estimate past-month activity energy expenditure (AEE). STAR-Q validity and reliability were assessed in 102 adults in Alberta, Canada (2009-2011), who completed 14-day doubly labeled water (D...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwu150

    authors: Csizmadi I,Neilson HK,Kopciuk KA,Khandwala F,Liu A,Friedenreich CM,Yasui Y,Rabasa-Lhoret R,Bryant HE,Lau DC,Robson PJ

    更新日期:2014-08-15 00:00:00

  • Alcohol intake and sickness absence: a curvilinear relation.

    abstract::Little is known about the U-shaped relation between alcohol intake and health beyond findings related to cardiovascular disease. Medically certified sickness absence is a health indicator in which coronary heart disease is only a minor factor. To investigate the relation between alcohol intake and sickness absence, re...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf138

    authors: Vahtera J,Poikolainen K,Kivimäki M,Ala-Mursula L,Pentti J

    更新日期:2002-11-15 00:00:00

  • Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men.

    abstract::Obesity, android fat distribution, and other anthropometric measures have been associated with coronary heart disease in long-term prospective studies. However, fluctuations in weight due to age-related hormonal changes and changes in lifestyle practices may bias relative risk estimates over a long follow-up period. T...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117385

    authors: Rimm EB,Stampfer MJ,Giovannucci E,Ascherio A,Spiegelman D,Colditz GA,Willett WC

    更新日期:1995-06-15 00:00:00

  • Early-Pregnancy Plasma Concentrations of Perfluoroalkyl Substances and Birth Outcomes in Project Viva: Confounded by Pregnancy Hemodynamics?

    abstract::Associations of prenatal exposure to perfluoroalkyl substances (PFAS), ubiquitous chemicals used in stain- and water-resistant products, with adverse birth outcomes may be confounded by pregnancy hemodynamics. We measured plasma concentrations of 4 PFAS in early pregnancy (median length of gestation, 9 weeks) among 1,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx332

    authors: Sagiv SK,Rifas-Shiman SL,Fleisch AF,Webster TF,Calafat AM,Ye X,Gillman MW,Oken E

    更新日期:2018-04-01 00:00:00

  • Evaluating the Effectiveness of New York City Health Policy Initiatives in Reducing Cardiovascular Disease Mortality, 1990-2011.

    abstract::Beginning in 2002, New York City (NYC) implemented numerous policies and programs targeting cardiovascular disease (CVD) risk factors. Using death certificates, we analyzed trends in NYC-specific and US mortality rates from 1990 to 2011 for all causes, any CVD, atherosclerotic CVD (ACVD), coronary artery disease (CAD)...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx134

    authors: Ong P,Lovasi GS,Madsen A,Van Wye G,Demmer RT

    更新日期:2017-09-01 00:00:00

  • Genital chlamydial infections.

    abstract::The isolation of chlamydial trachomatis in sera of patients with gon ococcal urethritis (GU), non-gonococcal urethritis (NGU), post-gonococca l urethritis (PGU) and trachomainclusion conjunctivitis (TRIC) is discussed. Chlamydiae were isolated in 40% of men with NGU, 20-30% with GU and 0-7% of men with symptomatic or...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.aje.a112243

    authors: Richmond SJ,Sparling PF

    更新日期:1976-05-01 00:00:00

  • A study of the birth weight-obesity relation using a longitudinal cohort and sibling and twin pairs.

    abstract::Sibling and twin study designs provide control for confounding factors that are typically unmeasured in traditional cohort studies. Using nationally representative data from the National Longitudinal Study of Adolescent Health collected at 3 visits during 1994-2002, the authors evaluated the longitudinal association b...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq169

    authors: The NS,Adair LS,Gordon-Larsen P

    更新日期:2010-09-01 00:00:00

  • Diarrheal disease in Cambodian children at a camp in Thailand.

    abstract::The etiology of acute diarrhea (less than or equal to 3 days duration) and persistent diarrhea (greater than or equal to 14 days duration) was determined in Cambodian children under age 5 years in a refugee camp on the Thai-Cambodian border between May and October 1989; potential risk factors associated with persisten...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116321

    authors: Arthur JD,Bodhidatta L,Echeverria P,Phuphaisan S,Paul S

    更新日期:1992-03-01 00:00:00

  • Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study.

    abstract::Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19-55 years participated in both the second and third surveys of t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr456

    authors: Mai XM,Chen Y,Camargo CA Jr,Langhammer A

    更新日期:2012-05-15 00:00:00

  • Do good health and material circumstances protect older people from the increased risk of death after bereavement?

    abstract::An increased risk of death in persons who have suffered spousal bereavement has been described in many populations. The impact of modifying factors, such as chronic disease and material circumstances, is less well understood. The authors followed 171,720 [corrected] couples 60 years of age or older in a United Kingdom...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws162

    authors: Shah SM,Carey IM,Harris T,DeWilde S,Victor CR,Cook DG

    更新日期:2012-10-15 00:00:00

  • Seroimmunity to poliomyelitis in an American community.

    abstract::In an effort to determine the immune status of individuals in a natural community, neutralizing antibody titers for the three types of poliovirus were examined in 301 randomly sampled sera collected in 1966 and 308 specimens from 1971. The specimens were part of a larger collection obtained from residents of Tecumseh,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112101

    authors: Oberhofer TR,Brown GC,Monto AS

    更新日期:1975-04-01 00:00:00

  • Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes.

    abstract::We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses' Health Study (1984-2016), Nurses' ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz251

    authors: Ding M,Ahmad S,Qi L,Hu Y,Bhupathiraju SN,Guasch-Ferré M,Jensen MK,Chavarro JE,Ridker PM,Willett WC,Chasman DI,Hu FB,Kraft P

    更新日期:2020-05-05 00:00:00

  • US childhood asthma prevalence estimates: the Impact of the 1997 National Health Interview Survey redesign.

    abstract::The 1997 redesign of the National Health Interview Survey (NHIS) affected US childhood asthma prevalence estimates. The 1997 asthma attack prevalence estimate for children 0-17 years was 5.4%. Pre-redesign NHIS childhood asthma period prevalence estimates peaked in 1995 at 7.5%. It is unclear whether the difference re...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwg109

    authors: Akinbami LJ,Schoendorf KC,Parker J

    更新日期:2003-07-15 00:00:00

  • Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors.

    abstract::Hyperinsulinemia is associated with multiple metabolic disorders including high triglyceride level, low high density lipoprotein (HDL) cholesterol level, hypertension, and impaired glucose tolerance (IGT). This metabolic constellation is also called the insulin resistance syndrome. All previous data on clustering of t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009272

    authors: Mykkänen L,Haffner SM,Rönnemaa T,Bergman RN,Laakso M

    更新日期:1997-08-15 00:00:00

  • Diet and cancer mortality in the counties of Sweden.

    abstract::The association between standardized cancer mortality rate ratios from 1969-1978 and dietary practices was examined in an ecologic study of the 24 counties of Sweden by means of several independent data sources. The study supports the hypothesis that a high intake of cereal fiber protects against colorectal cancer (r ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.aje.a114789

    authors: Rosén M,Nyström L,Wall S

    更新日期:1988-01-01 00:00:00

  • Racial differences in serum selenium concentration: analysis of US population data from the Third National Health and Nutrition Examination Survey.

    abstract::Lower intake of the essential trace element selenium may be a risk factor for prostate cancer and other cancers. In the United States, many racial disparities in cancer incidence, such as the 61% higher incidence of prostate cancer among Blacks relative to Whites, remain unexplained. Using data from a large, nationall...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm075

    authors: Vogt TM,Ziegler RG,Patterson BH,Graubard BI

    更新日期:2007-08-01 00:00:00

  • Causal Effect of Parental Schooling on Early Childhood Undernutrition: Quasi-Experimental Evidence From Zimbabwe.

    abstract::An estimated 3.1 million children die each year because of undernutrition. Although cross-sectional and longitudinal studies have found a protective association between greater parental education and undernutrition in their children, no randomized trial has identified a causal effect, to our knowledge. Using the 1980 ...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章

    doi:10.1093/aje/kwx195

    authors: De Neve JW,Subramanian SV

    更新日期:2018-01-01 00:00:00

  • Prevalence of erectile dysfunction and active depression: an analytic cross-sectional study of general medical patients.

    abstract::Erectile dysfunction is a common problem, affecting more than half of all men between the ages of 40 and 70 years. The authors' goal was to quantify the prevalence of concomitant erectile dysfunction and active depression among patients seen in a general medical setting between September 1998 and September 1999. Simpl...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf142

    authors: Kantor J,Bilker WB,Glasser DB,Margolis DJ

    更新日期:2002-12-01 00:00:00

  • Associations between inflammatory and immune response genes and adverse respiratory outcomes following exposure to outdoor air pollution: a HuGE systematic review.

    abstract::Variants of inflammatory and immune response genes have been associated with adverse respiratory outcomes following exposure to air pollution. However, the genes involved and their associations are not well characterized, and there has been no systematic review. Thus, we conducted a review following the guidelines of ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/aje/kwt269

    authors: Vawda S,Mansour R,Takeda A,Funnell P,Kerry S,Mudway I,Jamaludin J,Shaheen S,Griffiths C,Walton R

    更新日期:2014-02-15 00:00:00

  • Invited commentary: Physical activity over the life course--whose behavior changes, when, and why?

    abstract::Physical activity tends to decline from childhood into adulthood. Maintaining high levels of physical activity throughout life is therefore an important public health objective. Relatively little is known about changes in physical activity behavior over the life course, the domains of physical activity in which they o...

    journal_title:American journal of epidemiology

    pub_type: 评论,杂志文章

    doi:10.1093/aje/kwp273

    authors: Corder K,Ogilvie D,van Sluijs EM

    更新日期:2009-11-01 00:00:00

  • No long-term excess mortality after measles infection: a community study from Senegal.

    abstract::Because measles immunization has been found in all studies to reduce mortality with more than the share of deaths attributed to acute measles, the authors examined mortality after measles infection in a study in a rural area of Senegal that included 6,924 unimmunized children, whom 1,118 developed measles. Age-adjuste...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008667

    authors: Aaby P,Samb B,Andersen M,Simondon F

    更新日期:1996-05-15 00:00:00

  • Selection of controls in case-control studies. III. Design options.

    abstract::Several design options available in the planning stage of case-control studies are examined. Topics covered include matching, control/case ratio, choice of nested case-control or case-cohort design, two-stage sampling, and other methods that can be used for control selection. The effect of potential problems in obtain...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116398

    authors: Wacholder S,Silverman DT,McLaughlin JK,Mandel JS

    更新日期:1992-05-01 00:00:00