Abstract:
:Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19-55 years participated in both the second and third surveys of the Nord-Trøndelag Health Study (HUNT 2 (1995-1997) and HUNT 3 (2006-2008)). Serum 25(OH)D levels measured at baseline and anthropometric measurements taken at both baseline and follow-up were available for a random sample of 2,460 subjects. Overall, 40% of the 2,460 subjects had a serum 25(OH)D level less than 50.0 nmol/L, and 37% had a level of 50.0-74.9 nmol/L. The prevalence and cumulative incidence of obesity, defined as body mass index (weight (kg)/height (m)(2)) ≥30, were 12% and 15%, respectively. Lower serum 25(OH)D level was associated with a higher prevalence of obesity. In the 2,165 subjects with baseline BMI less than 30, a serum 25(OH)D level less than 50.0 nmol/L was associated with a significantly increased odds ratio for incident obesity during follow-up (adjusted odds ratio = 1.73, 95% confidence interval: 1.24, 2.41). When prevalent and incident obesity were classified according to waist circumference (≥88 cm for women, ≥102 cm for men), similar results were obtained. In addition to prevalent obesity, a serum 25(OH)D level less than 50.0 nmol/L was significantly associated with new-onset obesity in adults.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Mai XM,Chen Y,Camargo CA Jr,Langhammer Adoi
10.1093/aje/kwr456subject
Has Abstractpub_date
2012-05-15 00:00:00pages
1029-36issue
10eissn
0002-9262issn
1476-6256pii
kwr456journal_volume
175pub_type
杂志文章abstract::Influenza epidemics exhibit a strongly seasonal pattern, with winter peaks that occur with similar timing across temperate areas of the Northern Hemisphere. This synchrony could be influenced by population movements, environmental factors, host immunity, and viral characteristics. The historical isolation of Iceland a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws140
更新日期:2012-10-01 00:00:00
abstract::Maternal angiogenic factors (placental growth factor, soluble fms-like tyrosine kinase 1 (Flt-1), and soluble endoglin) may be associated with fetal growth restriction, and the associations may differ according to stage of pregnancy. Among children born to pregnant women without preeclampsia in Norway between 1992 and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq373
更新日期:2011-03-15 00:00:00
abstract::A community sample made in the fall of 1972 in Durham County, North Carolina, and that consisted of 331 persons 65 years of age and older was assessed for adequacy of social support along three parameters: roles and available attachments, perceived social support, and frequency of social interaction. This approach to ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113351
更新日期:1982-05-01 00:00:00
abstract::This paper introduces the projection methods for describing and testing the differences between pairs of continuous distributions. These methods include the projection plot, the projection spline, and the iter-1 test. The projection plot displays the difference between corresponding quantiles against the average of th...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009234
更新日期:1997-12-15 00:00:00
abstract::Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation, endothelial function, and adiposity and cancer risk, but results from prospective studies have been limited. The authors' objective was to prospectively examine the relations between these biomarkers and cancer r...
journal_title:American journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/aje/kws359
更新日期:2013-01-01 00:00:00
abstract::Breast cancer is diagnosed at a younger age and a more advanced stage in African-American women than in White women. The authors investigated the effects of several factors, including race, on stage of breast cancer in women aged 20-54 years living in Atlanta, Georgia, and diagnosed between 1990 and 1992. A total of 2...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm177
更新日期:2007-11-01 00:00:00
abstract::The Air Pollution and Health: a European Approach (APHEA) project is a coordinated study of the short-term effects of air pollution on mortality and hospital admissions using data from 15 European cities, with a wide range of geographic, sociodemographic, climatic, and air quality patterns. The objective of this paper...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009249
更新日期:1997-07-15 00:00:00
abstract::Ninety-four strains of Venezuelan encephalitis (VE) virus isolated from sentinel hamsters exposed in the Middle American countries of Mexico, Guatemala, Belize, and Honduras were examined for the presence of virions with marker characteristics of strains that cause large epidemics and equine epizootics. Thirty-four st...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113531
更新日期:1983-02-01 00:00:00
abstract::Pemphigus is a severe, autoimmune, blistering disorder with a high incidence among young women in rural Tunisia. The authors investigated explanatory environmental factors. A multicenter case-control study was conducted prospectively from 1992 to 1996 in Tunisia. Sixty-eight incident female cases of pemphigus and 166 ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/155.3.249
更新日期:2002-02-01 00:00:00
abstract::Heterogeneous exposure associations (HEAs) can be defined as differences in the association of an exposure with an outcome among subgroups that differ by a set of characteristics. In this article, we intend to foster discussion of HEAs in the epidemiologic literature and present a variant of the random forest algorith...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz218
更新日期:2020-01-31 00:00:00
abstract::Cytomegalovirus (CMV) is a common worldwide perinatal infection. Although usually asymptomatic, it may cause deafness in up to 15% of these infants. A cross-sectional study was performed to determine the age-specific prevalence of CMV seropositivity in Chinese children and to determine if any risk factors for infectio...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115467
更新日期:1990-01-01 00:00:00
abstract::A repeatability study of dietary intake has been carried out using 94 control subjects from a previously reported case-control study of diet and colorectal cancer. Dietary histories readministered on average seven years after an initial interview were used to estimate intake of various macro- and microdietary componen...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115146
更新日期:1989-02-01 00:00:00
abstract::The survival duration for pancreatic cancer is short. Given its low lifetime risk (1.5%), established factors for the disease have insufficient specificity to identify individuals at high risk of nonfamilial cancer, and prediagnostic signs and symptoms are vague and not limited to pancreatic causes. We considered whet...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv026
更新日期:2015-07-01 00:00:00
abstract::A total of 348 cases of meningitis caused by Streptococcus pneumoniae were reported to and investigated by the New York City Department of Health during the six years 1973-1978. The descriptive epidemiology and completeness of reporting of this disease entity are presented. The total crude incidence was estimated at 1...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113566
更新日期:1983-04-01 00:00:00
abstract::After diagnosis with prostate cancer, Black men in the United States have poorer survival than White men, even after controlling for differences in cancer stage. The extent to which these racial survival differences are due to biologic versus non-biologic factors is unclear, and it has been hypothesized that differenc...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a010221
更新日期:2000-02-15 00:00:00
abstract::Differences in hygienic habits and base-line secretory immunoglobulin (Ig) A which might have contributed to the prevalence of skin infections and/or absence of increased serum IgA values were sought in patients with poststreptococcal acute glomerulonephritis (nephritis) in contrast to patients with acute rheumatic fe...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113382
更新日期:1982-06-01 00:00:00
abstract::Ecologic (aggregate) data are widely available and widely utilized in epidemiologic studies. However, ecologic bias, which arises because aggregate data cannot characterize within-group variability in exposure and confounder variables, can only be removed by supplementing ecologic data with individual-level data. Here...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm386
更新日期:2008-04-15 00:00:00
abstract::The role of dietary carbohydrates in weight loss has received considerable attention in light of the current obesity epidemic. The authors investigated the association of body mass index (weight (kg)/height (m)(2)) with dietary intake of carbohydrates and with measures of the induced glycemic response, using data from...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi051
更新日期:2005-02-15 00:00:00
abstract::Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a m...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwy083
更新日期:2018-09-01 00:00:00
abstract::The relation between body size and breast cancer remains uncertain, particularly with regard to differences between pre- and postmenopausal women. The authors examined whether height, weight, body mass index, and weight change were associated with breast cancer risk among pre- and postmenopausal women. This population...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009057
更新日期:1997-06-01 00:00:00
abstract::This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American d...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwx022
更新日期:2017-06-15 00:00:00
abstract::Blood pressure later in life has been inversely associated with birth weight. However, concerns have been raised about whether this association merely reflects common environmental risk factors for both fetal growth restriction and high blood pressure or whether there is a genetic tendency to give birth to small babie...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/153.8.779
更新日期:2001-04-15 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant. Although experimental evidence suggests that TCDD alters thyroid hormone levels in rodents, human data are inconsistent. In 1976, a trichlorophenol plant exploded in Seveso, Italy. Women living in highly exposed areas were followed t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwu160
更新日期:2014-09-01 00:00:00
abstract::A multicenter prospective study has been designed to determine whether participation in an exercise program which produces a significant training effect will affect the recurrence rate in men who have survived an initial myocardial infarction. The control group consists of subjects who participate in a program involvi...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.aje.a112174
更新日期:1975-11-01 00:00:00
abstract::Several design options available in the planning stage of case-control studies are examined. Topics covered include matching, control/case ratio, choice of nested case-control or case-cohort design, two-stage sampling, and other methods that can be used for control selection. The effect of potential problems in obtain...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116398
更新日期:1992-05-01 00:00:00
abstract::The analysis of exposure misclassification has received considerable attention in the epidemiologic literature, with the result that methods for correcting many summary risk estimates for such misclassification are well known. However, the application of such methods typically requires more data than are usually publi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117653
更新日期:1995-08-15 00:00:00
abstract::The etiology of insulin-dependent diabetes mellitus remains obscure. In an attempt to clarify some aspects of the epidemiology, including its compatibility with an acute infectious process, the authors undertook in-depth analyses of childhood cases accumulated in a population-based register in Montreal during the peri...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114427
更新日期:1986-10-01 00:00:00
abstract::In a population-based case-control study of the association between use of diuretics and renal cell cancer, 120 white men whose cancer was diagnosed during the years 1980-1991 and 86 white women diagnosed in 1960-1991 were identified among members of the Kaiser Permanente Northwest health plan. Controls were plan memb...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117328
更新日期:1994-11-01 00:00:00
abstract::The age-specific prevalence of hepatitis A antibodies has been analyzed using a catalytic epidemic model for populations in seven European countries: West Germany, Norway, Greece, Switzerland, Holland, France and Sweden. The results indicate a significant decline in the force of infection in recent decades. However, t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112790
更新日期:1979-07-01 00:00:00
abstract::The authors conducted descriptive and case-control studies to find factors associated with earthquake deaths due to the Great Hanshin-Awaji earthquake on January 17, 1995, in Nishinomiya, Japan. In the case-control study, cases included all 1,104 deaths. Controls were randomly selected from survivors. Earthquake morta...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/153.2.153
更新日期:2001-01-15 00:00:00