Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study.


:Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19-55 years participated in both the second and third surveys of the Nord-Trøndelag Health Study (HUNT 2 (1995-1997) and HUNT 3 (2006-2008)). Serum 25(OH)D levels measured at baseline and anthropometric measurements taken at both baseline and follow-up were available for a random sample of 2,460 subjects. Overall, 40% of the 2,460 subjects had a serum 25(OH)D level less than 50.0 nmol/L, and 37% had a level of 50.0-74.9 nmol/L. The prevalence and cumulative incidence of obesity, defined as body mass index (weight (kg)/height (m)(2)) ≥30, were 12% and 15%, respectively. Lower serum 25(OH)D level was associated with a higher prevalence of obesity. In the 2,165 subjects with baseline BMI less than 30, a serum 25(OH)D level less than 50.0 nmol/L was associated with a significantly increased odds ratio for incident obesity during follow-up (adjusted odds ratio = 1.73, 95% confidence interval: 1.24, 2.41). When prevalent and incident obesity were classified according to waist circumference (≥88 cm for women, ≥102 cm for men), similar results were obtained. In addition to prevalent obesity, a serum 25(OH)D level less than 50.0 nmol/L was significantly associated with new-onset obesity in adults.


Am J Epidemiol


Mai XM,Chen Y,Camargo CA Jr,Langhammer A




Has Abstract


2012-05-15 00:00:00














  • Racial discrimination and breast cancer incidence in US Black women: the Black Women's Health Study.

    abstract::Perceived discrimination may contribute to somatic disease. The association between perceived discrimination and breast cancer incidence was assessed in the Black Women's Health Study. In 1997, participants completed questions on perceived discrimination in two domains: "everyday" discrimination (e.g., being treated a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Taylor TR,Williams CD,Makambi KH,Mouton C,Harrell JP,Cozier Y,Palmer JR,Rosenberg L,Adams-Campbell LL

    更新日期:2007-07-01 00:00:00

  • Blood pressure and risk of death from external causes among men screened for the Multiple Risk Factor Intervention Trial.

    abstract::A few epidemiologic studies have shown an increased risk of death from external causes among men with hypertension. Previous studies were limited by small numbers of events, however, and none assessed the association of blood pressure with specific types of "accidental" death. The authors examined data obtained from b...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Terry PD,Abramson JL,Neaton JD,MRFIT Research Group.

    更新日期:2007-02-01 00:00:00

  • Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women.

    abstract::High-fiber diets are associated with improved lipid profiles. However, pre- and postmenopausal women respond differently to fiber intake, suggesting that endogenous estradiol mediates the effect. The authors' objective was to determine the direct effect of fiber intake on lipoprotein cholesterol levels independent of ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Mumford SL,Schisterman EF,Siega-Riz AM,Gaskins AJ,Wactawski-Wende J,VanderWeele TJ

    更新日期:2011-01-15 00:00:00

  • Two randomized controlled trials of virucidal nasal tissues in the prevention of natural upper respiratory infections.

    abstract::Two six-month randomized, controlled double-blind trials of the efficacy of virucidal nasal tissues in the prevention of natural colds were conducted in Charlottesville, Virginia, between 1983 and 1986. Tissues impregnated with malic and citric acids and sodium lauryl sulfate were used in both trials. Placebo tissues ...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Farr BM,Hendley JO,Kaiser DL,Gwaltney JM

    更新日期:1988-11-01 00:00:00

  • Allergy and cancer: organ site-specific results from the Adventist Health Study.

    abstract::The relation between allergy and risk of cancer was evaluated in a cohort study of 34,198 Seventh-day Adventists in California. Information on prevalence of asthma, hay fever, and reactions to chemicals, medications, bee stings, and poison oak (or ivy) was obtained by questionnaire in 1976. The reported allergies must...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Mills PK,Beeson WL,Fraser GE,Phillips RL

    更新日期:1992-08-01 00:00:00

  • Self-reported life satisfaction and 20-year mortality in healthy Finnish adults.

    abstract::The authors investigated the role of self-reported life satisfaction in mortality with a prospective cohort study (1976-1995). A nationwide sample of healthy adults (18-64 years, n = 22,461) from the Finnish Twin Cohort responded to a questionnaire about life satisfaction and known predictors of mortality in 1975. A s...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Koivumaa-Honkanen H,Honkanen R,Viinamäki H,Heikkilä K,Kaprio J,Koskenvuo M

    更新日期:2000-11-15 00:00:00

  • Correcting for Measurement Error in Time-Varying Covariates in Marginal Structural Models.

    abstract::Unbiased estimation of causal parameters from marginal structural models (MSMs) requires a fundamental assumption of no unmeasured confounding. Unfortunately, the time-varying covariates used to obtain inverse probability weights are often error-prone. Although substantial measurement error in important confounders is...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Kyle RP,Moodie EE,Klein MB,Abrahamowicz M

    更新日期:2016-08-01 00:00:00

  • Are Gulf War veterans experiencing illness due to exposure to smoke from Kuwaiti oil well fires? Examination of Department of Defense hospitalization data.

    abstract::There has been much concern among the public and veterans that specific environmental exposures incurred during the Gulf War were the cause of subsequent illness among Gulf War veterans. In this historical cohort study, the authors compared the postwar morbidity of US military personnel exposed to smoke from the 1991 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Smith TC,Heller JM,Hooper TI,Gackstetter GD,Gray GC

    更新日期:2002-05-15 00:00:00

  • Personal sampling of particles in adults: relation among personal, indoor, and outdoor air concentrations.

    abstract::To investigate the validity of outdoor particulate matter with a 50% cutoff diameter of 10-microm (PM10) concentrations as a measure of exposure in time series studies, the association between personal and outdoor concentrations, within subjects, over time was investigated. Repeated measurements of personal, indoor, a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Janssen NA,Hoek G,Brunekreef B,Harssema H,Mensink I,Zuidhof A

    更新日期:1998-03-15 00:00:00

  • Transmission of hepatitis B virus among siblings.

    abstract::The authors investigated families with at least one hepatitis B surface antigen (HBsAg) carried in Okinawa, Japan, to determine possible routes of hepatitis B virus transmission within family units. A total of 175 members of 37 families on the western part of Iriomote Island, Okinawa, were followed up for 2-13 years; ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Kashiwagi S,Hayashi J,Ikematsu H,Nomura H,Kajiyama W,Shingu T,Hayashida K,Kaji M

    更新日期:1984-10-01 00:00:00

  • Predictors of the risk of development of acquired immunodeficiency syndrome within 24 months among gay men seropositive for human immunodeficiency virus type 1: a report from the Multicenter AIDS Cohort Study.

    abstract::The natural history of infection with human immunodeficiency virus type 1 (HIV-1) is characterized by a relentless decline in CD4-positive lymphocytes and the ultimate development of acquired immunodeficiency syndrome (AIDS). However, variables other than the CD4-positive lymphocyte level contribute to the measurement...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Saah AJ,Muñoz A,Kuo V,Fox R,Kaslow RA,Phair JP,Rinaldo CR Jr,Detels R,Polk BF

    更新日期:1992-05-15 00:00:00

  • Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program.

    abstract::Recent studies suggest that no distinct glycemic threshold consistently differentiates individuals with or without retinopathy. The authors sought to determine whether the same was true for other microvascular complications. They studied 5,094 participants with fasting plasma glucose values and concurrent microvascula...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Nang EE,Khoo CM,Tai ES,Lim SC,Tavintharan S,Wong TY,Heng D,Lee J

    更新日期:2009-06-15 00:00:00

  • Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) and its determinants: a cohort study in Kigali, Rwanda.

    abstract::The authors report the results of the first 2 years of follow-up of a prospective cohort study on the mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) and its determinants which started in November 1988 in Kigali, Rwanda. The study sample consists of 218 newborns of 215 HIV-1 seropositive wo...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Lepage P,Van de Perre P,Msellati P,Hitimana DG,Simonon A,Van Goethem C,Mukamabano B,Karita E,Stevens AM,Mathieu G

    更新日期:1993-03-15 00:00:00

  • What Level of Risk Compensation Would Offset the Preventive Effect of Early Antiretroviral Therapy? Simulations From the TEMPRANO Trial.

    abstract::Whether risk compensation could offset the preventive effect of early initiation of antiretroviral therapy (ART) on human immunodeficiency virus (HIV) transmission remains unknown. Using virological and behavioral data collected 12 months after inclusion in the TEMPRANO randomized trial of early ART (Abidjan, Côte d'I...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Jean K,Boily MC,Danel C,Moh R,Badjé A,Desgrées-du-Loû A,Eholié S,Lert F,Dray-Spira R,Anglaret X,Ouattara E

    更新日期:2016-11-15 00:00:00

  • Lung cancer risk among hairdressers: a pooled analysis of case-control studies conducted between 1985 and 2010.

    abstract::Increased lung cancer risks among hairdressers were observed in large registry-based cohort studies from Scandinavia, but these studies could not adjust for smoking. Our objective was to evaluate the lung cancer risk among hairdressers while adjusting for smoking and other confounders in a pooled database of 16 case-c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Olsson AC,Xu Y,Schüz J,Vlaanderen J,Kromhout H,Vermeulen R,Peters S,Stücker I,Guida F,Brüske I,Wichmann HE,Consonni D,Landi MT,Caporaso N,Tse LA,Yu IT,Siemiatycki J,Richardson L,Mirabelli D,Richiardi L,Simonato L

    更新日期:2013-11-01 00:00:00

  • Epidemiology of invasive Streptococcus pneumoniae among Navajo children in the era before use of conjugate pneumococcal vaccines, 1989-1996.

    abstract::Streptococcus pneumoniae is the most common cause of invasive bacterial disease among children worldwide. The authors aimed to determine the incidence, clinical characteristics, and serotype distribution of invasive pneumococcal disease (IPD) among Navajo children in the southwestern United States. Active population-b...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: O'Brien KL,Shaw J,Weatherholtz R,Reid R,Watt J,Croll J,Dagan R,Parkinson AJ,Santosham M

    更新日期:2004-08-01 00:00:00

  • Risk factors for nosocomial urinary tract infection.

    abstract::In a prospective study carried out in June 1979-April 1981, 134 of 1,458 adult inpatients at New England Deaconess Hospital, Boston, Massachusetts, acquired 136 urinary tract infections during 1,474 indwelling bladder catheterizations. Multiple logistic regression analysis identified nine factors that were significant...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Platt R,Polk BF,Murdock B,Rosner B

    更新日期:1986-12-01 00:00:00

  • Duration of breastfeeding and risk of overweight: a meta-analysis.

    abstract::Observational studies suggest a longer duration of breastfeeding to be associated dose dependently with a decrease in risk of overweight in later life. The authors performed a comprehensive meta-analysis of the existing studies on duration of breastfeeding and risk of overweight. Studies were included that reported th...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析


    authors: Harder T,Bergmann R,Kallischnigg G,Plagemann A

    更新日期:2005-09-01 00:00:00

  • Prevalence survey of cytomegalovirus infection in children in Chengdu.

    abstract::Cytomegalovirus (CMV) is a common worldwide perinatal infection. Although usually asymptomatic, it may cause deafness in up to 15% of these infants. A cross-sectional study was performed to determine the age-specific prevalence of CMV seropositivity in Chinese children and to determine if any risk factors for infectio...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Liu Z,Wang E,Taylor W,Yu H,Wu T,Wan Z,Huang Y,Ni Z,Sackett D

    更新日期:1990-01-01 00:00:00

  • An outbreak of salmonellosis propagated by person-to-person transmission on an Indian reservation.

    abstract::Between December 21, 1969, and April 14, 1970, 44 symptomatic cases of Salmonella typhimurium gastroenteritis occurred among the approximately 2500 Sioux Indians of the Lake Traverse Reservation in South Dakota. Twenty-five cases were confirmed by positive stool culture. All 19 cases not confirmed by culture had diarr...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Loewenstein MS

    更新日期:1975-09-01 00:00:00

  • Sexually transmitted disease core theory: roles of person, place, and time.

    abstract::The authors' purpose was to expand sexually transmitted disease core theory by examining the roles of person, place, and time in differentiating geographic core areas from outbreak areas. The authors mapped yearly census-tract-level syphilis rates for San Francisco, California, based on new primary and secondary syphi...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Gesink DC,Sullivan AB,Miller WC,Bernstein KT

    更新日期:2011-07-01 00:00:00

  • Occupations with exposure to electromagnetic fields: a possible risk factor for Alzheimer's disease.

    abstract::The authors present analyses of data from three independent clinical series and controls indicating an association between working in occupations with probable medium to high exposure to extremely low frequency (< 300 Hz) electromagnetic fields and sporadic Alzheimer's disease. Case-control analyses were carried out u...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Sobel E,Davanipour Z,Sulkava R,Erkinjuntti T,Wikstrom J,Henderson VW,Buckwalter G,Bowman JD,Lee PJ

    更新日期:1995-09-01 00:00:00

  • Epidemiology of rabies virus variants. Differentiation using monoclonal antibodies and discriminant analysis.

    abstract::Rabies virus was isolated by cell culture from the brains of 104 confirmed rabies cases diagnosed by the fluorescent-antibody staining technique in the United States during 1974-1984. Eighty-seven isolates were obtained from wild-life species, 10 from humans, and seven from domestic animals. These isolates were tested...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Rupprecht CE,Glickman LT,Spencer PA,Wiktor TJ

    更新日期:1987-08-01 00:00:00

  • Use of surveillance, epidemiology, and end results-medicare data to conduct case-control studies of cancer among the US elderly.

    abstract::Cancer is an important cause of morbidity in the elderly, and many medical conditions and treatments influence cancer risk. The Surveillance, Epidemiology, and End Results (SEER)-Medicare database can be used to conduct population-based case-control studies that elucidate the etiology of cancer among the US elderly. S...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Engels EA,Pfeiffer RM,Ricker W,Wheeler W,Parsons R,Warren JL

    更新日期:2011-10-01 00:00:00

  • Heterogeneous Exposure Associations in Observational Cohort Studies: The Example of Blood Pressure in Older Adults.

    abstract::Heterogeneous exposure associations (HEAs) can be defined as differences in the association of an exposure with an outcome among subgroups that differ by a set of characteristics. In this article, we intend to foster discussion of HEAs in the epidemiologic literature and present a variant of the random forest algorith...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Odden MC,Rawlings AM,Khodadadi A,Fern X,Shlipak MG,Bibbins-Domingo K,Covinsky K,Kanaya AM,Lee A,Haan MN,Newman AB,Psaty BM,Peralta CA

    更新日期:2020-01-31 00:00:00

  • Childhood diabetes, epidemics, and epidemiology: an approach for controlling diabetes. World Health Organization DIAMOND Project Group on Epidemics.

    abstract::The identification of the environmental factors causing insulin-dependent diabetes in children has remained elusive. However, evidence is rapidly accumulating that childhood diabetes exhibits epidemic patterns, much like that seen with an infectious disease. It is likely that within these epidemics the environmental d...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章



    更新日期:1992-04-01 00:00:00

  • The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels.

    abstract::The relation of diet and nutritional supplements, cigarette use, alcohol consumption, and blood lipids to plasma levels of beta-carotene and alpha-tocopherol was studied among 330 men and women aged 18-79 years. Dietary carotene, preformed vitamin A, and vitamin E intake were estimated by a self-administered semiquant...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Stryker WS,Kaplan LA,Stein EA,Stampfer MJ,Sober A,Willett WC

    更新日期:1988-02-01 00:00:00

  • Possible relation of Tunisian pemphigus with traditional cosmetics: a multicenter case-control study.

    abstract::Pemphigus is a severe, autoimmune, blistering disorder with a high incidence among young women in rural Tunisia. The authors investigated explanatory environmental factors. A multicenter case-control study was conducted prospectively from 1992 to 1996 in Tunisia. Sixty-eight incident female cases of pemphigus and 166 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Bastuji-Garin S,Turki H,Mokhtar I,Nouira R,Fazaa B,Jomaa B,Zahaf A,Osman AB,Souissi R,Hémon D,Roujeau JC,Kamoun MR

    更新日期:2002-02-01 00:00:00

  • Invited commentary: identifying women with hypertension during pregnancy--is high specificity sufficient?

    abstract::Hypertensive complications of pregnancy contribute to the burden of maternal morbidity and subsequently have an impact on neonatal morbidity and mortality. Although codes from the International Classification of Diseases should delineate the specific subtypes of pregnancy-related hypertension, how diagnoses are applie...

    journal_title:American journal of epidemiology

    pub_type: 评论,杂志文章


    authors: Callaghan WM

    更新日期:2007-07-15 00:00:00

  • Breast feeding and the risk of severe cholera in rural Bangladeshi children.

    abstract::The association between breast feeding and the risk of severe cholera was examined in a case-control study of rural Bangladeshi children under 36 months of age who were studied in 1985-1986 during a field trial of killed oral cholera vaccines. A total of 116 cases who were treated for severe cholera were compared with...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Clemens JD,Sack DA,Harris JR,Khan MR,Chakraborty J,Chowdhury S,Rao MR,van Loon FP,Stanton BF,Yunus M

    更新日期:1990-03-01 00:00:00