Abstract:
:With the advent of chemotherapy, mortality rates in acute lymphoblastic leukaemia (ALL) have decreased, but complications in the central nervous system have appeared. These include direct involvement of the brain itself and the development of chemotherapy-related encephalopathy as a delayed reaction. In most reported cases, this encephalopathy is believed to be due to necrotising angiitis arising from the combination of chemotherapy with adjuvant radiotherapy. We report the cases of four children with ALL who had been treated with high-dose intravenous and intrathecal chemotherapy but no radiation therapy, and who were admitted to hospital because of seizures. CT of the brain revealed the presence of diffuse periventricular white matter hypodensities in all cases and subcortical hyperdense foci in three cases. MRI showed diffuse hyperintense white matter lesions on T2-weighted images in all four patients; hypointense changes were observed on susceptibility-sensitive FLASH sequences in the hyperdense foci seen on CT as well as changes that were hyperintense on T1-weighted images. It was, therefore, concluded that the lesions corresponded to a leukoencephalopathy with calcific deposits. These findings are of a pure form of methotrexate encephalopathy causing seizures.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Lövblad K,Kelkar P,Ozdoba C,Ramelli G,Remonda L,Schroth Gdoi
10.1007/s002470050299subject
Has Abstractpub_date
1998-02-01 00:00:00pages
86-91issue
2eissn
0301-0449issn
1432-1998journal_volume
28pub_type
杂志文章abstract::Parameters of linear measurement were compared with actual brain volume to assess the significance of linear measurements as indices of atrophy in 31 neurologically normal children and 22 neurologically abnormal children. Brain volume was established by means of an image-analyzing system using contiguous CT scans. The...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02013822
更新日期:1993-01-01 00:00:00
abstract::Alagille syndrome, or arteriohepatic dysplasia, is a disorder characterized by paucity of intrahepatic bile ducts, peculiar facies and skeletal anomalies. We report a typical case of this syndrome in an 18-year-old girl, in whom abdominal CT showed bilateral renal cysts and aortic wall calcification, findings unreport...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011114
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Preterm and low-birth-weight infants have an increased risk of sensorineural hearing loss. Brainstem auditory-evoked potentials (BAEP) are an effective method to detect subtle deficits in impulse conduction in the auditory pathway. Abnormalities on diffusion tensor imaging (DTI) have been shown to be associa...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-009-1278-6
更新日期:2009-08-01 00:00:00
abstract::This is the first clinical and angiographic description of congenital subclavian steal in a patient with left aortic arch, isolation of the right subclavian artery, and an aortic diverticulum. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01092954
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND:Fetal MRI at 3 T is associated with increased acoustic noise relative to 1.5 T. OBJECTIVE:The goal of this study is to determine if there is an increased prevalence of congenital hearing loss in neonates who had a 3-T prenatal MR vs. those who had it at 1.5 T. MATERIALS AND METHODS:We retrospectively ident...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4261-2
更新日期:2019-01-01 00:00:00
abstract::Ultrasound is an excellent tool to evaluate many pediatric musculoskeletal conditions. It may be used for both diagnosis and for guidance for therapeutic procedures. With US, the radiologist can readily evaluate the contralateral side for comparison. No sedation is typically required and ionizing radiation is avoided....
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-012-2599-4
更新日期:2013-03-01 00:00:00
abstract::The use of the technique of wax-plate serial section-reconstruction, based on contiguous axial plane CT images of the upper thorax, to prepare a replica of the central air-way (trachea and major bronchi) of an infant with sling left pulmonary artery type 2B, with bridging bronchus, abortive right main bronchus, and tr...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02075204
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:A new children's hospital provided the impetus to investigate radiation dose and image quality in a fluoroscope that was specially engineered for pediatric fluoroscopy. Radiation protection management recommends radiation exposures that are as low as reasonably achievable, while still maintaining diagnostic ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050728
更新日期:2000-04-01 00:00:00
abstract::Primary idiopathic chylopericardium is rare and represents a fraction of all pericardial effusions in the pediatric population. Most cases of chylopericardium occur as a complication of cardiac surgery or after trauma. They may also be caused by tuberculosis, neoplasm, or congenital lymphangiomatosis. Primary idiopath...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-003-0885-x
更新日期:2003-05-01 00:00:00
abstract::Paternal uniparental disomy for chromosome 14 (patUPD14) is a rare condition, this being the eighth report. A male infant, born prematurely, was noted to have extremely lax skin and bilateral inguinal hernias. Skin biopsy confirmed the clinical diagnosis of congenital cutis laxa, but this did not explain the limb abno...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-003-0931-8
更新日期:2003-07-01 00:00:00
abstract::We performed 25 percutaneous fine needle biopsies (PFNB) on pediatric patients during a 3-year period. Of 17 patients with proven malignancies, PFNB was true positive in 16 and false negative in one. In nine patients with benign or inflammatory disorders, there were three true positives and six false negatives. There ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388363
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:It has been suggested that increased hepatic and intramuscular fat is associated with insulin resistance, and that increased pancreatic fat is related to impaired insulin secretion. OBJECTIVE:We postulated that in obese nondiabetic teenagers insulin levels would be directly related to increases in intramusc...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-005-1413-y
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:The unicameral bone cyst (UBC) is a common cystic bone lesion seen in children. We review and summarize its MR findings, focusing on their appearance following contrast enhancement, and correlating them to known histologic features of UBC. SUBJECTS AND METHODS:A retrospective review of 20 cases (13 boys, 7 g...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000258
更新日期:2000-08-01 00:00:00
abstract::Hardcastle syndrome is a rare, autosomally dominant inherited skeletal dysplasia, characterized by diaphyseal sclerosis, medullary stenosis, pathological fractures, bony infarction, and malignant transformation. A 19-year-old proband is presented and discussed, adding a fourth family to the world literature. Radiograp...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01356833
更新日期:1996-09-01 00:00:00
abstract::Fetal MRI is the modality of choice to study supratentorial brain malformations. To accurately interpret the MRI, the radiologist needs to understand the normal sequence of events that occurs during prenatal brain development; this includes familiarity with the processes of hemispheric cleavage, formation of interhemi...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-020-04696-z
更新日期:2020-12-01 00:00:00
abstract::Hemangiomas are common vascular tumors occurring in children. Though most of the lesions present in infants and young children with a typical appearance, it is important to understand that they all do not behave in the same way. Rather, they are a group of vascular lesions with different clinico-pathological subtypes,...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-011-2076-5
更新日期:2011-07-01 00:00:00
abstract::Abdominal aortic injury after blunt trauma is rare in the pediatric population. There have been fewer than 20 reported cases in the literature since 1960, and most were the result of motor vehicle collisions. We report the case of a 16-month-old boy who is the youngest reported patient to sustain this type of injury. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-009-1224-7
更新日期:2009-07-01 00:00:00
abstract::A patient with Down syndrome is presented who had hypospadias, a large low implanted prostatic utricle, and refluxing ejaculatory ducts entering the utricle. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02021709
更新日期:1995-01-01 00:00:00
abstract::We present two patients with airway obstruction due to supraglottic swelling; one was caused by a brown spider bite on an ear (loxoscelism) and the other from eating buffalo fish. In the latter patient it was likely due to scrombroid poisoning, a histamine-like reaction, but may have been an anaphylaxic reaction. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02015631
更新日期:1991-01-01 00:00:00
abstract::A case of thanatophoric dwarfism living for 10 weeks with minimal supportive care is presented. Although early death is usual, survival for months is compatible with the diagnosis. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00975319
更新日期:1976-12-15 00:00:00
abstract::Trichorhinophalangeal syndrome type II is a rare genetic disorder with the few published case reports mainly reporting the radiographic skeletal manifestations. There are no published imaging reports of long bone cysts involving multiple bones in this condition. We report a unique case of bone cysts involving multiple...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-017-3839-4
更新日期:2017-07-01 00:00:00
abstract::Post-traumatic subperiosteal hematoma of the iliac bone may present insidiously without external evidence of bleeding or go undetected in the acute setting. In some cases, the patient may come to medical attention due to femoral nerve palsy rather than hip or groin pain. In this report, we describe a case of femoral n...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-016-3581-3
更新日期:2016-08-01 00:00:00
abstract::We present the MRI findings in a case of subcutaneous fat necrosis of the newborn. To our knowledge, the MRI findings of this entity have not been reported. Subcutaneous fat necrosis of the newborn is an uncommon, benign process in full-term infants. Hypercalcemia may be a potentially life-threatening complication of ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050696
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:The natural history of focal splenic lesions in paediatric Gaucher disease (GD) is unknown and these lesions are thought to persist despite enzyme replacement therapy (ERT). OBJECTIVE:To assess the prevalence, evolution and resolution of splenic nodules in a cohort of paediatric Gaucher patients treated wit...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-008-0811-3
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Abnormalities of the placenta affect 5-7% of pregnancies. Because disturbances in fetal growth are often preceded by dysfunction of the placenta or attenuation of its normal expansion, placental health warrants careful surveillance. There are limited normative data available for placental volume by MRI. OBJ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4213-x
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Unstable posterior pelvic ring fractures and dislocations are uncommon but potentially life-threatening injuries in children. Early definitive management reduces risk of immediate complications as well as chronic pain and gait dysfunction. Conventional operative therapy carries substantial risk of extensive ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1291-8
更新日期:2004-12-01 00:00:00
abstract::To evaluate cystourethrography in the era of fetal screening, we evaluated retrospectively the clinical and imaging findings of all children up to the age of 1 year who underwent a cystourethrogram in a 5-year period (1987-1992). There were 292 children, 64 neonates (< 1 month, 51 boys, 13 girls) and 228 infants (1 mo...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02015017
更新日期:1994-01-01 00:00:00
abstract::A newborn suffered immediate neonatal respiratory distress because of an obstructive, soft-tissue nasal mass. Clinical examination revealed a cleft palate with a protruding polypoid mass. CT and MRI showed a heterogeneous nasopharyngeal mass and associated intracranial abnormalities - duplication of the hypophysis and...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050354
更新日期:1998-05-01 00:00:00
abstract::The authors present a case of cervical chordoma which manifested in a 5-year-old boy as a dumbbell-shaped epidural tumor without bone destruction. Both CT and MRI demonstrated tumor features suggesting this diagnosis, which was confirmed by histology. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01403709
更新日期:1996-01-01 00:00:00
abstract::Airway compression is a common problem in children with certain forms of congenital heart disease. Although various surgical approaches are available to overcome this form of airway obstruction, internal stenting is necessary in a minority of patients. It can be difficult to assess the success of stenting at the time ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-006-0174-6
更新日期:2006-08-01 00:00:00