Diaphyseal medullary stenosis (sclerosis) with bone malignancy (malignant fibrous histiocytoma): Hardcastle syndrome.

Abstract:

:Hardcastle syndrome is a rare, autosomally dominant inherited skeletal dysplasia, characterized by diaphyseal sclerosis, medullary stenosis, pathological fractures, bony infarction, and malignant transformation. A 19-year-old proband is presented and discussed, adding a fourth family to the world literature. Radiographic screening of family members is suggested from puberty onward. Thallium scanning is proposed as a more tumor-sensitive screening agent in affected individuals.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Norton KI,Wagreich JM,Granowetter L,Martignetti JA

doi

10.1007/BF01356833

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

675-7

issue

9

eissn

0301-0449

issn

1432-1998

journal_volume

26

pub_type

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