Abstract:
BACKGROUND:In order to assess relationships between thyroid hormone status and findings on brain MRI, a subset of babies was recruited to a multi-centre randomised, placebo-controlled trial of levothyroxine (LT4) supplementation for babies born before 28 weeks' gestation (known as the TIPIT study, for Thyroxine supplementation In Preterm InfanTs). These infants were imaged at term-equivalence. MATERIALS AND METHODS:Forty-five TIPIT participants had brain MRI using diffusion tensor imaging (DTI) to estimate white matter development by apparent diffusion coefficient (ADC), fractional anisotropy (FA) and tractography metrics of number and length of streamlines. We made comparisons between babies with the lowest and highest plasma FT4 concentrations during the initial 4 weeks after birth. RESULTS:There were no differences in DTI metrics between babies who had received LT4 supplementation and those who had received a placebo. Among recipients of a placebo, babies in the lowest quartile of plasma-free thyroxine (FT4) concentrations had significantly higher apparent diffusion coefficient measurements in the posterior corpus callosum and streamlines that were shorter and less numerous in the right internal capsule. Among LT4-supplemented babies, those who had plasma FT4 concentrations in the highest quartile had significantly lower apparent diffusion coefficient values in the left occipital lobe, higher fractional anisotropy in the anterior corpus callosum and longer and more numerous streamlines in the anterior corpus callosum. CONCLUSION:DTI variables were not associated with allocation of placebo or thyroid supplementation. Markers of poorly organised brain microstructure were associated with low plasma FT4 concentrations after birth. The findings suggest that plasma FT4 concentrations affect brain development in very immature infants and that the effect of LT4 supplementation for immature babies with low FT4 plasma concentrations warrants further study.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Ng SM,Turner MA,Gamble C,Didi M,Victor S,Atkinson J,Sluming V,Parkes LM,Tietze A,Abernethy LJ,Weindling AMdoi
10.1007/s00247-014-2911-6subject
Has Abstractpub_date
2014-08-01 00:00:00pages
987-96issue
8eissn
0301-0449issn
1432-1998journal_volume
44pub_type
杂志文章,多中心研究,随机对照试验abstract::Uterine didelphys with obstructed hemivagina and ipsilateral renal anomalies is a rare congenital malformation of the female urogenital tract. While the urinary anomalies almost always involve renal agenesis, we report a rare case of a 17-year-old girl with the malformation associated with ectopic ureteral insertion i...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-009-1454-8
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The natural history of focal splenic lesions in paediatric Gaucher disease (GD) is unknown and these lesions are thought to persist despite enzyme replacement therapy (ERT). OBJECTIVE:To assess the prevalence, evolution and resolution of splenic nodules in a cohort of paediatric Gaucher patients treated wit...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-008-0811-3
更新日期:2008-06-01 00:00:00
abstract::We review the physiological basis of diffusion-weighted imaging and discuss the implementation of diffusion-weighted imaging pulse sequences and the subsequent postprocessing to yield quantitative estimations of diffusion parameters. We also introduce the concept of directionality of "apparent" diffusion in vivo and t...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-007-0516-z
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Magnetic resonance imaging (MRI) usage has anecdotally increased due to the principles of ALARA and the desire to Image Gently. Aside from a single abstract in the emergency medicine literature, pediatric emergency department MRI usage has not been described. OBJECIVE:Our objective was to determine whether ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-016-3764-y
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Currently, there is only limited and contradictory evidence of the role of diffusion-weighted MRI (DW-MRI) in the management of children with cholesteatoma. OBJECTIVE:To provide surgically controlled data that may allow to replace second-look surgery by non-echoplanar DW-MRI in children. MATERIALS AND METH...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-015-3287-y
更新日期:2015-07-01 00:00:00
abstract::Anomalous origin of the left pulmonary artery in tetralogy of Fallot was diagnosed in a 4-year-old boy be cardiac catheterization. Corrective surgery was performed. The child died immediately following the surgical procedure. Postmortem examination revealed obstructive pulmonary vascular disease of the left lung and n...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388368
更新日期:1985-01-01 00:00:00
abstract::Venous drainage to the portal vein in pulmonary sequestration is rare. A 7-month-old girl was referred to our hospital following surgery for ventricular septal defect because of a left upper abdominal mass with a large feeding artery from the abdominal aorta and venous drainage to the portal vein. She had had frequent...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000251
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:A pull-back tube esophagogram (PBTE) is widely accepted in the literature as the radiological investigation of choice for the diagnosis of tracheoesophageal fistula without esophageal atresia. However, PBTE is rarely performed in our institution, as we have been successful in confirming the presence of such ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-006-0269-0
更新日期:2006-11-01 00:00:00
abstract::Abnormalities of the fetal urinary tract, most commonly hydronephrosis of differing causes, can be detected by ultrasound (US). Prenatal measurements of the kidney can help to predict the postnatal outcome of hydronephrosis. About 20% of abnormalities evident in utero are not present after birth. After delivery, vario...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s002470050434
更新日期:1998-08-01 00:00:00
abstract::We review our experience with unusual ocular pathologies, some mimicking retinoblastoma, that were referred to our institution during the past two decades. After presenting the imaging anatomy of the normal eye, we discuss pertinent clinical and pathological features, and illustrate the US and MRI appearance of retino...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-012-2374-6
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Paediatric non-accidental injury is a considerable health problem, and imaging plays a fundamental role in its assessment. Since the introduction of joint guidelines published by the Royal College of Radiologists (RCR) and Royal College of Paediatrics and Child Health (RCPCH) in 2008, there has been a concer...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-014-3063-4
更新日期:2014-12-01 00:00:00
abstract::Fetal MRI is the modality of choice to study supratentorial brain malformations. To accurately interpret the MRI, the radiologist needs to understand the normal sequence of events that occurs during prenatal brain development; this includes familiarity with the processes of hemispheric cleavage, formation of interhemi...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-020-04696-z
更新日期:2020-12-01 00:00:00
abstract::The presence of fungus balls within the collecting system is an important clue to the radiological diagnosis of genitourinary candidiasis. In this report, an 8-month-old infant with this opportunistic infection is described. Emphasis is placed on the radiological findings of renal candidiasis, including previously unr...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000351
更新日期:2000-12-01 00:00:00
abstract::This article is the first of a two-part series on intracranial calcification in childhood. Intracranial calcification can be either physiological or pathological. Physiological intracranial calcification is not an expected neuroimaging finding in the neonatal or infantile period but occurs, as children grow older, in ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-020-04721-1
更新日期:2020-09-01 00:00:00
abstract::A peanut is a commonly inhaled foreign body during childhood. Some cases are difficult to diagnose especially in cases without a clear history of inhalation. We describe a 16-month-old boy presenting with stridor and fever. The chest x-ray suggested inhalation of a foreign body but there was no history of this. A high...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02019867
更新日期:1992-01-01 00:00:00
abstract::Peutz-Jeghers syndrome (PJS) is a rare, though well-described, hereditary polyposis syndrome associated with mucocutaneous pigmentation that typically presents in the second decade of life with complications related to intestinal polyps. We present two cases of teenaged girls presenting with small-bowel intussusceptio...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-002-0695-6
更新日期:2002-09-01 00:00:00
abstract::We present a 10-week-old girl with myositis ossificans circumscripta (MO) of the neck secondary to nonaccidental trauma. This condition is rarely seen in infants; furthermore, the majority of MO lesions develop in the extremities rather than the head and neck region. We will detail the US-guided biopsy technique used ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-011-2270-5
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The volume of CT examinations has increased with resultant increases in collective dose values over the last decade. OBJECTIVE:To analyze the impact of the tube current and voltage modulation for dose values and image quality of pediatric head CT examinations. MATERIALS AND METHODS:Head CT examinations wer...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-015-3398-5
更新日期:2015-11-01 00:00:00
abstract::We report a 6-month-old infant with a fibroblastic ring obstructing her hypopharynx. Surgical myotomy gave relief of symptoms. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02386642
更新日期:1986-01-01 00:00:00
abstract::A case of spontaneous disappearance of an intrathoracic meningocele following insertion of a ventriculo-venous shunt is reported. The shunt was performed for treatment of hydrocephalus secondary to Arnold-Chiari malformation. The intrathoracic meningocele reappeared when the shunt obstructed and decreased in size when...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00973987
更新日期:1977-03-17 00:00:00
abstract::Ureteral valves are an uncommon cause of upper urinary tract obstruction. The majority of cases are discovered only at surgery or autopsy. We report a case diagnosed by antegrade pyelography under sonographic guidance and we review the literature. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388420
更新日期:1988-01-01 00:00:00
abstract::Retrograde radiologic gastrostomy is one of several techniques used for placing a gastrostomy and is a common technique used in children. The use of a retention anchor suture (RAS) is an important component of this procedure. This pictorial essay explores the normal course and passage of the RAS, as well as abnormal m...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-013-2627-z
更新日期:2013-08-01 00:00:00
abstract::The aim of this review is to emphasize the role of fetal MR in the evaluation of the supratentorial space. The advantages of MRI compared to US are stressed in three fields of application: cerebral biometry, sulcation and cerebral parenchyma. In each field, normal data are displayed and MR applications with patterns o...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-004-1249-x
更新日期:2004-09-01 00:00:00
abstract::Abdominal aortic injury after blunt trauma is rare in the pediatric population. There have been fewer than 20 reported cases in the literature since 1960, and most were the result of motor vehicle collisions. We report the case of a 16-month-old boy who is the youngest reported patient to sustain this type of injury. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-009-1224-7
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Infantile myofibromatosis is the most common fibrous tumor of infancy. It can involve the skin, muscle, bone, and viscera. This uncommon entity is subdivided into solitary and multicentric forms, with or without visceral involvement. OBJECTIVE:To describe the imaging characteristics of extracranial myofibro...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1357-7
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Stress fractures of many etiologies are found not infrequently in various tarsal bones but are less commonly recognized in carpal bones. OBJECTIVE:To assess the distribution of tarsal and carpal stress fractures. MATERIALS AND METHODS:During the last three decades, the senior author collected locations of ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1577-y
更新日期:2010-08-01 00:00:00
abstract::Diffusion-weighted MRI of the brain is becoming clinically available as a tool to investigate cerebral ischaemia. We report a newborn girl presenting with seizures in whom diffusion-weighted MRI showed a large hyperintensity in the area perfused by the left middle cerebral artery. Short-term neurological follow-up bef...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470100442
更新日期:2001-05-01 00:00:00
abstract::In this article, the fourth author's name is misspelled. The correct spelling, as shown above, should be "Nadia F. Mahmood." ...
journal_title:Pediatric radiology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00247-019-04343-2
更新日期:2019-03-01 00:00:00
abstract::An evaluation of the Siemens Digiscan has been undertaken to determine whether digital luminescence radiography (DLR) could replace conventional radiography in the examination of the neonate and young infant. Whilst the overall image quality of the digital radiograph was consistently higher than for conventional radio...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011600
更新日期:1992-01-01 00:00:00
abstract::We present a case of Kniest dysplasia, a rare form of the type II collagenopathies, with prenatal MRI. Sonography revealed only short limbs in the fetus. Fetal MRI findings included enlarged hyaline cartilaginous structures with abnormally high T2 signal intensity, delayed ossification of the pubic and ischial bones, ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-009-1444-x
更新日期:2010-03-01 00:00:00