BCGitis and BCGosis in children with primary immunodeficiency - imaging characteristics.

Abstract:

BACKGROUND:When administered to an immune-compromised patient, BCG (Bacille Calmette-Guérin) can cause disseminated and life-threatening infections. OBJECTIVE:To describe the imaging findings in children with primary immunodeficiency and BCG-related infections. MATERIALS AND METHODS:We reviewed the imaging findings of children with primary immunodeficiency treated at a children's hospital during 2012-2014 with localized or disseminated BCG infection. Imaging modalities included US, CT and radiography. RESULTS:Nine children with primary immunodeficiency had clinical signs of post-vaccination BCGitis; seven of these children showed disseminated disease and two showed only regional lesions with characteristic ipsilateral lymphadenopathy. Overall, lymphadenopathy was the most prevalent feature (n = 8) and characteristically appeared as a ring-enhancing hypodense (CT) or hypoechoic (US) lesion. Visceral involvement with multiple abscesses appeared in the spleen (n = 2), liver (n = 1) and bones (n = 1). All lesions regressed following appropriate anti-tuberculosis treatment. CONCLUSION:BCG infection needs to be considered in children with typical findings and with suspected primary immunodeficiency.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Shrot S,Barkai G,Ben-Shlush A,Soudack M

doi

10.1007/s00247-015-3464-z

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

237-45

issue

2

eissn

0301-0449

issn

1432-1998

pii

10.1007/s00247-015-3464-z

journal_volume

46

pub_type

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