Abstract:
:Many individuals are now surviving their injuries to face the consequences of an activated immunoinflammatory system and the complications of supportive therapy. The pulmonary system bears the force of this insult. An understanding of the epidemiology of acute respiratory failure, as well as a greater knowledge of the cellular and subcellular mechanisms by which pulmonary dysfunction occurs, has led to novel approaches to the management of acute respiratory failure. It also appears that lung injury is caused, or at least exacerbated, by iatrogenic insults, such as positive-pressure ventilation. The purpose of this review is to discuss the etiology and pathophysiology of acute respiratory failure following severe injury and the novel therapeutic approaches. A combination of immunomodulating and mechanical ventilation strategies will likely provide the most successful approach to reducing the morbidity and mortality associated with acute respiratory failure following injury.
journal_name
Curr Opin Pulm Medjournal_title
Current opinion in pulmonary medicineauthors
O'Keefe GE,Maier RVdoi
10.1097/00063198-199705000-00008subject
Has Abstractpub_date
1997-05-01 00:00:00pages
227-33issue
3eissn
1070-5287issn
1531-6971journal_volume
3pub_type
杂志文章,评审abstract::Recently, with radiology some advances have been made in the care of patients with interstitial lung disease, predominately through the use of high-resolution computed tomography. This technique is helpful not only in the diagnosis of interstitial lung disease, but also in patient follow-up and management. Other techn...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
doi:10.1097/00063198-199909000-00002
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Pleural effusions are a common finding in the nearly six million Americans diagnosed with heart failure. This review focuses on the historical, present and potential future trends in the management of such benign pleural effusions. RECENT FINDINGS:The management of symptomatic pleural effusions, in g...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0000000000000176
更新日期:2015-07-01 00:00:00
abstract::This review summarizes the recent literature published on the microbiology, diagnosis, and medical and surgical management of acute and chronic frontal sinus disease. Two retrospective studies investigated the microbiology of frontal sinusitis in patients that underwent sinus surgery. Streptococcus pneumoniae, Haemoph...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200305000-00003
更新日期:2003-05-01 00:00:00
abstract::Antibiotic resistance in respiratory pathogens has dramatically increased during recent years. Resistance to penicillin and multiple antimicrobial agents in pneumococci and resistance to ampicillin in Moraxella catarrhalis and Haemophilus influenzae, as a result of betalactamase production, have become highly prevalen...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma is a chronic inflammatory disease in which changes in macrophage polarization have been shown to contribute to the pathogenesis. The present review discusses the contribution of changes in macrophage function to asthma related to polarization changes and elaborates on possible therapeutic strat...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0000000000000647
更新日期:2020-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent work demonstrates that patients with refractory asthma are likely to be sensitized to environmental fungi and that specific antifungal treatments may be of benefit to this group. RECENT FINDINGS:The relationships among fungal sensitization, exposure and asthma severity are imperfectly understo...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328333900a
更新日期:2010-01-01 00:00:00
abstract::Corticosteroids were the mainstay of therapy for idiopathic pulmonary fibrosis (IPF) for more than four decades, but their efficacy is unproven and toxicities are substantial. The course of IPF is characterized by progressive respiratory insufficiency, leading to death within 3 to 8 years from the onset of symptoms. A...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200109000-00009
更新日期:2001-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The immunopathogenesis of sarcoidosis is considered to involve contributions from both adaptive and innate immune responses. Although the identification of adaptive responses to candidate pathogenic antigens will elucidate mechanisms that regulate inflammation in sarcoidosis, innate mechanisms likely ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0000000000000305
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines the associations between chronic obstructive pulmonary disease (COPD) and renal and hepatobiliary diseases, with emphasis on the epidemiology and clinical outcomes, along with current information on pathophysiologic mechanisms and risk factors. RECENT FINDINGS:Glomerular filtrati...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0000000000000024
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Obstructive sleep apnea (OSA) has historically been considered as a male disease. As a result, female individuals with OSA were often under-diagnosed and under-treated compared with male individuals. However, recent data suggest that several OSA-associated adverse cardiovascular outcomes are more pron...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
doi:10.1097/MCP.0000000000000728
更新日期:2020-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Nuclear medicine techniques have the capacity to investigate neuronal dysfunction at the synapse level. For instance, metaiodobenzylguanidine (MIBG) shows a similar uptake, storage and release as norepinephrine. Intravenously injected radiolabeled MIBG is able to reflect neuronal damage induced by inf...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32833b1e1f
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Dornase alfa (Pulmozyme) is one of the most commonly used medications to treat the lung disease of cystic fibrosis (CF). As other respiratory medications have entered the clinical market, understanding the proper use and indication for dornase alfa is increasingly important. In addition, dornase alfa ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328358d51f
更新日期:2012-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The review highlights the clinical findings and the management of community-acquired, health-care associated and nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:Although previously considered as a purely nosocomial event, community-acquired MRSA pneumon...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e3283292666
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:There has been much recent interest in the use of macrolide antibiotics as chronic suppressive therapy in patients with cystic fibrosis. Three recent randomized, placebo-controlled trials have been conducted. RECENT FINDINGS:All three trials used similar regimens of azithromycin, and lung function im...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/01.mcp.0000142101.53084.f0
更新日期:2004-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Isolated distal deep-vein thrombosis (iDDVT) is a distal deep-vein thrombosis (DVT) without proximal DVT or pulmonary embolism. Although its clinical significance is uncertain, its prevalence is increasing with the use of whole leg compression ultrasonography. Epidemiological data giving reported rate...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328349a9e3
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Respiratory tract infections are a common reason for prescribing antibiotics, although not all of these infections require such therapy. Rapid diagnosis of etiology using point-of-care tests is a potentially useful way of reducing prescriptions of both unnecessary and unnecessarily broad-spectrum anti...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e3282f7642f
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The chronic lung diseases, asthma and chronic obstructive pulmonary disease, are pulmonary disorders in which persistent inflammation and alterations in lung structure contribute to a progressive loss of lung function. Although the exact type of inflammation and damage in each disease is distinct, the...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/01.mcp.0000199002.46038.cb
更新日期:2006-01-01 00:00:00
abstract::Lung volume reduction surgery and lung transplantation have been shown to improve lung function, exercise capacity, and quality of life in patients with advanced emphysema. Because the indications for both surgical procedures overlap, lung volume reduction surgery may be used as an alternative treatment or as a "bridg...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200103000-00007
更新日期:2001-03-01 00:00:00
abstract:PURPOSE OF REVIEW:In cystic fibrosis (CF) patients with end-stage pulmonary disease, lung transplantation (LTx) remains a life-extending therapy with good outcome in most patients. Despite early concern about chronic pretransplantation infections in the context of posttransplantation immunosuppression, typical CF-assoc...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0000000000000431
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Although known for several decades, catamenial pneumothorax has been considered until recently as an extremely rare entity. The condition is now more easily recognized and several studies have been published, with somewhat relevant discrepancies with respect to etiologic, epidemiologic, and management...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32833a9fc2
更新日期:2010-07-01 00:00:00
abstract::The author describes a current status of nuclear imaging in interstitial lung disease. A number of tests have been proposed for the evaluation of disease activity. The only one that is used in many centers, however, is 67Ga scan. If the goal is the evaluation of functional impairment, 99mTc-penta-acetic acid aerosol m...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-199709000-00010
更新日期:1997-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the principles of staging cancer as applied to nonsmall cell lung cancer. RECENT FINDINGS:The current staging system is under review for update. It is timely to review the principles of staging cancer to see how the nonsmall cell lung cancer staging system can be improved. Staging systems s...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328302406f
更新日期:2008-07-01 00:00:00
abstract::While the most recent trend in secondary prophylaxis after venous thromboembolism has been toward a prolonged duration, it has become obvious that individualization according to risk factors is crucial. Subgroup analyses in a long-term follow-up of a previous trial, as well as new trials on patients with idiopathic th...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200007000-00012
更新日期:2000-07-01 00:00:00
abstract::We review recently published literature on behavioral aspects of asthma, including program descriptions, reviews, and original research reports. Most of the literature on behavioral aspects of asthma has been in the area of self-management, including education, medication use, and peak flow monitoring. Recent studies ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The Sleep Heart Health Study began in 1994 as a prospective cohort study of cardiovascular disease. The results of longitudinal analysis are not yet available, but numerous analyses of cross-sectional data have been published. This review provides an overview of study results so far. RECENT FINDINGS:...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328312ed61
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the recent advancements of the epidemiology, pathophysiology, clinical characteristics, radiographic studies, diagnostic modalities, treatment, and prognosis of pulmonary hypertension in sarcoidosis. RECENT FINDINGS:A large retrospective study found 73.8% of patients with sarcoidosis liste...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328273bc5c
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights the prevalence of pulmonary hypertension as a chronic complication of sickle cell disease (SCD) and its importance in the prognosis. RECENT FINDINGS:In recent years, the limitations of echocardiogram for the appropriate diagnosis of SCD-associated pulmonary hypertension have be...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0000000000000200
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Disorders of glucose metabolism, including insulin resistance, prediabetes, and diabetes, have been identified as risk factors for worsened asthma. This review summarizes emerging evidence for their role as modifiable risk factors in asthma, including the potential benefit of diabetes medications on a...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
doi:10.1097/MCP.0000000000000738
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the recent findings of the last 2 years on the epidemiology and phenotypes of occupational asthma, as well as new developments in its diagnosis and management. RECENT FINDINGS:Data from nine longitudinal studies showed a population attributable fraction for the occupational contribution t...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
doi:10.1097/MCP.0000000000000737
更新日期:2021-01-01 00:00:00
abstract::There have been a large number of randomized trials comparing standard unfractionated intravenous heparin with low-molecular-weight heparin for the treatment of deep-vein thrombosis, but only two of these have looked at outpatient therapy. There have been only two randomized trials including patients with symptomatic ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200109000-00019
更新日期:2001-09-01 00:00:00