Abstract:
PURPOSE OF REVIEW:The chronic lung diseases, asthma and chronic obstructive pulmonary disease, are pulmonary disorders in which persistent inflammation and alterations in lung structure contribute to a progressive loss of lung function. Although the exact type of inflammation and damage in each disease is distinct, they share the common feature that they are chronic in nature. Despite efforts, little is known about the cellular and molecular mechanisms that drive the chronicity of these two diseases. This review will summarize important findings regarding the role of adenosine, a signaling nucleoside implicated in the pathogenesis of these two disorders. RECENT FINDINGS:Aerosolized adenosine induces bronchoconstriction in patients with asthma and chronic obstructive pulmonary disease primarily through the release of mast cell mediators. In this setting it can not only be used to aid in diagnosis but also to monitor patient responses to steroid therapy. Adenosine levels are elevated in the lungs of asthma patients, indicating greater flux through adenosine receptor signaling pathways. In-vitro studies have shown adenosine to access pathways leading to the genesis of chronic inflammation via the release of proinflammatory cytokines and chemokines. Animal studies demonstrate that merely elevating adenosine levels in the mouse is sufficient to induce a pulmonary phenotype with features of asthma and chronic obstructive pulmonary disease. SUMMARY:Identifying mediators regulating the chronic nature of asthma and chronic obstructive pulmonary disease is critical towards advancements in treatment options. Adenosine has been implicated in promoting the inflammation and airway remodeling seen in chronic lung disease and thus makes an attractive therapeutic target.
journal_name
Curr Opin Pulm Medjournal_title
Current opinion in pulmonary medicineauthors
Mohsenin A,Blackburn MRdoi
10.1097/01.mcp.0000199002.46038.cbkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
54-9issue
1eissn
1070-5287issn
1531-6971pii
00063198-200601000-00011journal_volume
12pub_type
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32835cfd59
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journal_title:Current opinion in pulmonary medicine
pub_type: 社论,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
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更新日期:2021-03-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32831de235
更新日期:2009-01-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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更新日期:2009-07-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200305000-00003
更新日期:2003-05-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-199807000-00010
更新日期:1998-07-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200003000-00006
更新日期:2000-03-01 00:00:00
abstract::Chronic obstructive pulmonary disease is the fourth leading cause of death in the United States, affecting approximately 10% of all adults. Several articles published during the past year contributed significantly to our understanding of the complicated management of this disease. New information concerning bronchodil...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-199603000-00011
更新日期:1996-03-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200205000-00010
更新日期:2002-05-01 00:00:00
abstract::Lung volume reduction surgery and lung transplantation have been shown to improve lung function, exercise capacity, and quality of life in patients with advanced emphysema. Because the indications for both surgical procedures overlap, lung volume reduction surgery may be used as an alternative treatment or as a "bridg...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200103000-00007
更新日期:2001-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Malignant pleural effusion is a common cause of breathlessness and signifies advanced disease. Common options for definitive pleural intervention include insertion of an indwelling pleural catheter (IPC) or talc pleurodesis. RECENT FINDINGS:Administration of graded talc through an IPC offers an incre...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章
doi:10.1097/MCP.0000000000000587
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328363f48d
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This manuscript reviews the recent literature related to new developments in the understanding of existing and novel virulence factors of the pneumococcus that are of potential importance in the development of novel preventive and therapeutic strategies. RECENT FINDINGS:The pneumococcal capsule and p...
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pub_type: 杂志文章
doi:10.1097/MCP.0000000000000674
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights recent data detailing the prevalence and characteristics of pleural effusions occurring in patients with superior vena cava syndrome. RECENT FINDINGS:Numerous case reports have described pleural effusions in conjunction with the superior vena cava syndrome. Recent data suggest ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32812144aa
更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
abstract::Wheezing in infants and children presents a difficult differential diagnosis contingent on the presenting symptoms and age of the child. A determination of the anatomy of the lower airway, combined with allergic, infectious, and noninfectious irritants, is requisite to a complete evaluation. The intervention strategie...
journal_title:Current opinion in pulmonary medicine
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更新日期:2016-03-01 00:00:00
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更新日期:2016-11-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2001-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2007-05-01 00:00:00
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更新日期:2013-01-01 00:00:00