Abstract:
PURPOSE OF REVIEW:Asthma is a chronic inflammatory disease in which changes in macrophage polarization have been shown to contribute to the pathogenesis. The present review discusses the contribution of changes in macrophage function to asthma related to polarization changes and elaborates on possible therapeutic strategies targeting macrophage function and polarization. RECENT FINDINGS:Macrophage function alterations were shown to contribute to asthma pathology in several ways. One is by impaired phagocytosis and efferocytosis. Another is by changing inflammation, by altered (anti)inflammatory cytokine production and induction of the inflammasome. Finally, macrophages can contribute to remodeling in asthma, although little evidence is present in humans yet.Novel therapeutic strategies targeting macrophages include dampening inflammation by changing polarization or by inhibiting the NLRP3 inflammasome, and by targeting efferocytosis. However, many of these studies were performed in animal models leaving their translation to the clinic for future research. SUMMARY:The present review emphasizes the contribution of altered macrophage function to asthma, gives insight in possible new therapeutic strategies targeting macrophages, and indicates which knowledge gaps remain open.
journal_name
Curr Opin Pulm Medjournal_title
Current opinion in pulmonary medicineauthors
van der Veen TA,de Groot LES,Melgert BNdoi
10.1097/MCP.0000000000000647subject
Has Abstractpub_date
2020-01-01 00:00:00pages
62-68issue
1eissn
1070-5287issn
1531-6971journal_volume
26pub_type
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200401000-00003
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
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abstract:PURPOSE OF REVIEW:Need for intensive care in the patient with pulmonary arterial hypertension is associated with high mortality. This review will provide an overview of causes of ICU admission for patients with pulmonary hypertension and provide guidance on management. RECENT FINDINGS:There is a paucity of evidence-ba...
journal_title:Current opinion in pulmonary medicine
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abstract::It is usually assumed that upper airway pressure receptors mediate the reflexes involved in sleep apneas, but many other receptors may be involved, including those responding to chemical stimuli. The reflexes to upper airway negative pressure have been further studied, and the timing of their inputs shown to be import...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-199811000-00013
更新日期:1998-11-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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doi:10.1097/00063198-199903000-00005
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32833eec92
更新日期:2010-11-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:1998-05-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32835ceefc
更新日期:2013-03-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200007000-00012
更新日期:2000-07-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e3283218318
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to examine the evidence for the effectiveness of systemic corticosteroids in managing acute asthma in children as it relates to the timing of its administration. RECENT FINDINGS:Three themes relevant to the timing of systemic corticosteroid administration as it relates to m...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e32835b590a
更新日期:2013-01-01 00:00:00
abstract::The progressive breakdown of the cell-mediated immunity, which characterizes the natural history of HIV infection, invariably leads to the development of miscellaneous opportunistic infections or neoplasms involving a number of tissues, including the respiratory tract. In particular, given the extent and the severity ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:
更新日期:1995-09-01 00:00:00
abstract::There have been a large number of randomized trials comparing standard unfractionated intravenous heparin with low-molecular-weight heparin for the treatment of deep-vein thrombosis, but only two of these have looked at outpatient therapy. There have been only two randomized trials including patients with symptomatic ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200109000-00019
更新日期:2001-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e328344db65
更新日期:2011-05-01 00:00:00
abstract::Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma. This ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-200301000-00004
更新日期:2003-01-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/MCP.0b013e3283560840
更新日期:2012-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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journal_title:Current opinion in pulmonary medicine
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更新日期:2011-11-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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更新日期:2009-11-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1097/00063198-199901000-00009
更新日期:1999-01-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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更新日期:2002-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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更新日期:2003-11-01 00:00:00
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更新日期:2007-05-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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更新日期:2007-09-01 00:00:00
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journal_title:Current opinion in pulmonary medicine
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更新日期:2006-09-01 00:00:00