Pharmacogenetics of asthma: toward precision medicine.

abstract：:Interstitial lung diseases are characterized by disruption of the distal pulmonary parenchyma. The clinical history manifestations, cough and dyspnea, and physical exam manifestations, inspiratory crackles, are nonspecific. Pulmonary function testing aids in the evaluation and management of patients with interstitial ...

journal_title：Current opinion in pulmonary medicine

authors： Flaherty KR,Martinez FJ

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent data detailing the prevalence and characteristics of pleural effusions occurring in patients with superior vena cava syndrome. RECENT FINDINGS:Numerous case reports have described pleural effusions in conjunction with the superior vena cava syndrome. Recent data suggest ...

journal_title：Current opinion in pulmonary medicine

authors： Rice TW

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we describe the 'state-of-the-art' in our knowledge of asthma and what gaps exist, which can be exploited in the future for effective translation of our knowledge from the bench or population studies to diagnosis and therapy. RECENT FINDINGS:The advent of microbiome research has expan...

journal_title：Current opinion in pulmonary medicine

authors： Brar T,Nagaraj S,Mohapatra S

更新日期：2012-01-01 00:00:00

abstract：:The 24-hour properties of sleepiness affect behavior by reducing performance and increasing the likelihood of accidents. This is important to pulmonary physicians who diagnose and treat sleep apnea, because diagnoses of sleep apnea and narcolepsy are associated with as much as a sevenfold increase in the risk of havin...

journal_title：Current opinion in pulmonary medicine

authors： Mitler MM

更新日期：1996-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis of idiopathic interstitial pneumonias (IIPs) requires the exclusion of, among others, concomitant connective tissue diseases (CTDs), which may present as interstitial lung disease (ILD). This review focuses on the evaluation required to separate these entities through serology, although not ...

journal_title：Current opinion in pulmonary medicine

authors： Papiris SA,Kagouridis K,Bouros D

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an update on the diagnosis and classification of interstitial lung disease (ILD), with a specific focus on newly described ILD subtypes and phenotypes. In addition, the strengths and limitations of the current approach to ILD diagnosis and management are discus...

journal_title：Current opinion in pulmonary medicine

authors： Ryerson CJ,Collard HR

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Glucocorticosteroids (GCSs) remain the cornerstone of therapy for treating the inflammatory component of asthma. Clinical response to GCS is heterogeneous, varying both within asthma 'endotypes', as well as the same individual. Different factors and micro-environment can alter the canonical GCS-induce...

journal_title：Current opinion in pulmonary medicine

authors： Mukherjee M,Svenningsen S,Nair P

更新日期：2017-01-01 00:00:00

abstract：:This review summarizes the recent literature published on the microbiology, diagnosis, and medical and surgical management of acute and chronic frontal sinus disease. Two retrospective studies investigated the microbiology of frontal sinusitis in patients that underwent sinus surgery. Streptococcus pneumoniae, Haemoph...

journal_title：Current opinion in pulmonary medicine

authors： Brook I

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) imposes a large burden on the global population and even more so for the elderly who face significant obstacles in the diagnosis, management, and psychosocial effects of the disease. This review describes the current challenges and key points in the managem...

journal_title：Current opinion in pulmonary medicine

authors： Allen B,Aboussouan LS

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The immunopathogenesis of sarcoidosis is considered to involve contributions from both adaptive and innate immune responses. Although the identification of adaptive responses to candidate pathogenic antigens will elucidate mechanisms that regulate inflammation in sarcoidosis, innate mechanisms likely ...

journal_title：Current opinion in pulmonary medicine

authors： Chen ES

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Lung cancer is the leading cause of cancer mortality in men and women. Most patients present with advanced disease and face significant morbidity, with many reporting distressing symptoms throughout the course of their illness. The purpose of this review is to highlight the recent studies that support...

journal_title：Current opinion in pulmonary medicine

authors： Shin J,Temel J

更新日期：2013-07-01 00:00:00

abstract：:In reviewing recent advances in upper respiratory tract infections, we focus on five key topics. First, the use of ribavirin in the treatment of respiratory syncytial virus infection has been limited to the immunosuppressed. Prophylaxis in high-risk patients with specific immunoglobulin is effective and a new monoclon...

journal_title：Current opinion in pulmonary medicine

authors： Moore DA,Sharland M,Friedland JS

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant pleural effusion is a common cause of breathlessness and signifies advanced disease. Common options for definitive pleural intervention include insertion of an indwelling pleural catheter (IPC) or talc pleurodesis. RECENT FINDINGS:Administration of graded talc through an IPC offers an incre...

journal_title：Current opinion in pulmonary medicine

authors： Dipper A,Bhatnagar R,Maskell N

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of inhaled corticosteroids is one of the most controversial issues in COPD pharmacotherapy. Experts disagree about the benefits and harms of ICS for patients with COPD, yet a majority of patients with COPD are being treated with inhaled corticosteroids. This is a review of the most recent lite...

journal_title：Current opinion in pulmonary medicine

authors： Highland KB

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis of sleep apnoea was performed in sleep laboratories with polysomnography. This requires a room with supervision and presence of technologists and trained sleep experts. Today, clinical guidelines in most countries recommend home sleep apnoea testing with simple systems using six signals only...

journal_title：Current opinion in pulmonary medicine

authors： Penzel T,Fietze I,Glos M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective is to discuss recent progress in our understanding of the role of the indoor environment in asthma, focusing on the special role of cat allergens. RECENT FINDINGS:Sensitization to Fel d 1 is the dominant event in inhalant responses to cat; however, there are also IgE responses to the li...

journal_title：Current opinion in pulmonary medicine

authors： Kelly LA,Erwin EA,Platts-Mills TA

更新日期：2012-01-01 00:00:00

abstract：:Wheezing in infants and children presents a difficult differential diagnosis contingent on the presenting symptoms and age of the child. A determination of the anatomy of the lower airway, combined with allergic, infectious, and noninfectious irritants, is requisite to a complete evaluation. The intervention strategie...

journal_title：Current opinion in pulmonary medicine

authors： Chipps BE,Chipps DR

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the principles of staging cancer as applied to nonsmall cell lung cancer. RECENT FINDINGS:The current staging system is under review for update. It is timely to review the principles of staging cancer to see how the nonsmall cell lung cancer staging system can be improved. Staging systems s...

journal_title：Current opinion in pulmonary medicine

authors： Filner JJ,Ost D

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Minimally invasive diagnostic strategies for pulmonary embolism are in constant evolution, integrating new diagnostic tools along with the better use of clinical information. RECENT FINDINGS:In the past year, several reports have provided more data on the value of clinical signs and symptoms for diag...

journal_title：Current opinion in pulmonary medicine

authors： Le Gal G,Perrier A

更新日期：2006-09-01 00:00:00

abstract：:A gamma-scintigraphic study was carried out in 13 healthy individuals to compare the lung deposition of budesonide from a novel multidose dry powder inhaler (MDPI; Novolizer) with that from the Pulmicort Turbuhaler, and to assess the degree of flow rate dependence of the Novolizer. Median whole lung depositions for th...

journal_title：Current opinion in pulmonary medicine

authors： Newman SP,Hirst PH,Pitcairn GR

更新日期：2001-04-01 00:00:00

abstract：:Lung volume reduction surgery and lung transplantation have been shown to improve lung function, exercise capacity, and quality of life in patients with advanced emphysema. Because the indications for both surgical procedures overlap, lung volume reduction surgery may be used as an alternative treatment or as a "bridg...

journal_title：Current opinion in pulmonary medicine

authors： Cordova FC,Criner GJ

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Cancer patients with venous thromboembolism (VTE) are at increased risk of mortality. Estimating the risks for specific causes of death may help to weigh the risks and benefits of different therapeutic strategies in an individual patient. RECENT FINDINGS:In the Registro Informatizado de la Enfermedad...

journal_title：Current opinion in pulmonary medicine

authors： Trujillo-Santos J,Monreal M

更新日期：2012-09-01 00:00:00

abstract：:The bronchiolitides can be categorized broadly as constrictive or proliferative, each with characteristic CT features. The cardinal CT signs of constrictive bronchiolitis are mosaic perfusion, enhanced on expiratory CT scan and variably associated with bronchiectasis and, less frequently, centrilobular branching struc...

journal_title：Current opinion in pulmonary medicine

authors： Wells AU

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis. RECENT FINDINGS:Available data are responsible for a lack of consensus regarding treatment of distal deep vein thrombosis. SUMMARY:One standard diagnostic approach of suspected deep vein t...

journal_title：Current opinion in pulmonary medicine

authors： Righini M,Bounameaux H

更新日期：2008-09-01 00:00:00

abstract：:The majority of men with cystic fibrosis (CF) have associated congenital bilateral absence of the vas deferens (CBVAD). This congenital defect results in the absence of the anatomic ducts through which spermatozoa pass from the testes to the urethra. No spermatozoa are found in the semen, a condition referred to as ob...

journal_title：Current opinion in pulmonary medicine

authors： Sokol RZ

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Cystic fibrosis (CF) is a complex genetic disease affecting many organs, although 85% of the mortality is a result of lung disease. The natural history of the lung disease consists of early and persistent infection, an exaggerated inflammatory response, structural airway changes (i.e. bronchiectasis),...

journal_title：Current opinion in pulmonary medicine

authors： Flume PA

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Respiratory infection is a major contributor to morbidity and mortality in cystic fibrosis (CF). One infection the CF community is particularly concerned about is methicillin-resistant Staphylococcus aureus (MRSA). Worldwide, the prevalence of MRSA has been rising and the impact on clinical outcomes a...

journal_title：Current opinion in pulmonary medicine

authors： Dasenbrook EC

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent observations in the area of infectious lung complications in individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Since the immunodeficiency was first characterized, it has been associated with enhanced susceptibilit...

journal_title：Current opinion in pulmonary medicine

authors： Boyton RJ

更新日期：2005-05-01 00:00:00

abstract：:There has been increased recognition of the importance of inflammatory cells and their products in the pathogenesis of asthma. From this recognition has evolved a number of new approaches to treat the various components of the asthmatic inflammatory response. Nonselective anti-inflammatory agents such as cyclosporine ...

journal_title：Current opinion in pulmonary medicine

authors： Floreani AA,Rennard SI

更新日期：1997-01-01 00:00:00

abstract：:Staging of sarcoidosis needs a synthesis of clinical features, histology, radiology, biochemical changes, and immunologic aberrations to distinguish this disease from nonspecific sarcoid-tissue reactions. The main aim of this report is to offer readers an overview on immunologic markers that have been evaluated in the...

journal_title：Current opinion in pulmonary medicine

authors： Semenzato G,Bortoli M,Agostini C

更新日期：2002-09-01 00:00:00