Innate immunity in sarcoidosis pathobiology.

abstract：PURPOSE OF REVIEW:Cystic fibrosis (CF) is a complex genetic disease affecting many organs, although 85% of the mortality is a result of lung disease. The natural history of the lung disease consists of early and persistent infection, an exaggerated inflammatory response, structural airway changes (i.e. bronchiectasis),...

journal_title：Current opinion in pulmonary medicine

authors： Flume PA

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the associations between chronic obstructive pulmonary disease (COPD) and renal and hepatobiliary diseases, with emphasis on the epidemiology and clinical outcomes, along with current information on pathophysiologic mechanisms and risk factors. RECENT FINDINGS:Glomerular filtrati...

journal_title：Current opinion in pulmonary medicine

authors： Mapel D

更新日期：2014-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is the fourth leading cause of death in the United States, affecting approximately 10% of all adults. Several articles published during the past year contributed significantly to our understanding of the complicated management of this disease. New information concerning bronchodil...

journal_title：Current opinion in pulmonary medicine

authors： Navin DM,Gross NJ

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Microscopic polyangiitis is a systemic necrotizing vasculitis that affects small vessels, resulting in a wide spectrum of organ involvement including the kidneys and the lungs. This paper reviews recent insights and observations into the pathogenesis, clinical manifestations, and treatment of pulmonar...

journal_title：Current opinion in pulmonary medicine

authors： Collins CE,Quismorio FP Jr

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of noninvasive ventilatory support in patients with cystic fibrosis (CF) has increased exponentially over the past 2 decades. This review examines the current knowledge and considers potential future directions for use of noninvasive ventilation in CF patients. RECENT FINDINGS:Noninvasive ven...

journal_title：Current opinion in pulmonary medicine

authors： Bright-Thomas RJ,Johnson SC

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) imposes a large burden on the global population and even more so for the elderly who face significant obstacles in the diagnosis, management, and psychosocial effects of the disease. This review describes the current challenges and key points in the managem...

journal_title：Current opinion in pulmonary medicine

authors： Allen B,Aboussouan LS

更新日期：2021-03-01 00:00:00

abstract：:Bronchial carcinoids and hamartomas are, respectively, the most common malignant and benign unusual primary lung neoplasms. These tumors are often asymptomatic but can cause central airway obstruction. Helical computed tomographic and radionuclide scintigraphic advances in their detection and evolution, together with ...

journal_title：Current opinion in pulmonary medicine

authors： Chan AL,Shelton DK,Yoneda KY

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Disorders of glucose metabolism, including insulin resistance, prediabetes, and diabetes, have been identified as risk factors for worsened asthma. This review summarizes emerging evidence for their role as modifiable risk factors in asthma, including the potential benefit of diabetes medications on a...

journal_title：Current opinion in pulmonary medicine

authors： Wu TD

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Nuclear medicine techniques have the capacity to investigate neuronal dysfunction at the synapse level. For instance, metaiodobenzylguanidine (MIBG) shows a similar uptake, storage and release as norepinephrine. Intravenously injected radiolabeled MIBG is able to reflect neuronal damage induced by inf...

journal_title：Current opinion in pulmonary medicine

authors： van Kroonenburgh M,Mostard R,Vöö S

更新日期：2010-09-01 00:00:00

abstract：:Thoracoscopy has received increasing attention over the past decade as a result of the considerable advances that have been made in the development of endoscopic instruments. In contrast to the newly established video-assisted thoracoscopic surgery, the classic way to perform thoracoscopy is using only local anesthesi...

journal_title：Current opinion in pulmonary medicine

authors： Loddenkemper R,Schönfeld N

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is caused by a mixture of small airway disease (obstructive bronchitis) and parenchymal lung tissue destruction (emphysema). The relative contributions of these two pathologic states vary from person to person. Having the ability to phenotype patients into ...

journal_title：Current opinion in pulmonary medicine

authors： Stewart JI,Criner GJ

更新日期：2013-03-01 00:00:00

abstract：:Parapneumonic effusions are frequent complications of bacterial pneumonia. Depending on the severity of the underlying pneumonia, the promptness of antibiotic therapy, and the virulence of the infecting organism, 5% to 50% of patients will require pleural fluid drainage to prevent progression to an empyema. The decisi...

journal_title：Current opinion in pulmonary medicine

authors： Heffner JE

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Accurate diagnosis of interstitial lung diseases (ILDs) can be challenging, and a substantial percentage of ILD patients remain unclassifiable even after thorough assessment by an experienced multidisciplinary team. In this review, we summarize the recent literature on the definition, prevalence, diag...

journal_title：Current opinion in pulmonary medicine

authors： Guler SA,Ryerson CJ

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to summarize the evidence base for tuberculosis (TB) diagnostics, review recent policies on TB diagnostics, and discuss issues such as how evidence is translated into policy, limitations of the existing evidence base, and challenges involved in translating policies into impact. RECENT FIND...

journal_title：Current opinion in pulmonary medicine

authors： Pai M,Minion J,Steingart K,Ramsay A

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work demonstrates that patients with refractory asthma are likely to be sensitized to environmental fungi and that specific antifungal treatments may be of benefit to this group. RECENT FINDINGS:The relationships among fungal sensitization, exposure and asthma severity are imperfectly understo...

journal_title：Current opinion in pulmonary medicine

authors： Gore RB

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Obstructive sleep apnea (OSA) is heterogeneous in terms of contributing pathophysiological mechanisms, clinical presentation, and consequences. Different study models from animal models of intermittent hypoxia over case-control, cohort, and population-based observational studies to uncontrolled interv...

journal_title：Current opinion in pulmonary medicine

authors： Schwarz EI

更新日期：2019-11-01 00:00:00

abstract：:Pulmonary embolism occurs in more than 175,000 patients each year in the United States. The objectives of treatment are to prevent death from the existing embolus, to prevent death and morbidity from recurrent pulmonary embolism, and to prevent morbidity from recurrent deep-vein thrombosis. For patients with adequate ...

journal_title：Current opinion in pulmonary medicine

authors： Raskob GE

更新日期：1999-07-01 00:00:00

abstract：:Although it had been appreciated that high levels of antituberculous drug resistance existed in some regions of the world, the full extent of the problem was not known. A combined initiative by the World Health Organization and the International Union Against Tuberculosis and Lung Disease was launched in 1994 to addre...

journal_title：Current opinion in pulmonary medicine

authors： Willcox PA

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review highlights the clinical findings and the management of community-acquired, health-care associated and nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:Although previously considered as a purely nosocomial event, community-acquired MRSA pneumon...

journal_title：Current opinion in pulmonary medicine

authors： Tacconelli E,De Angelis G

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Telomere attrition has been proposed as one of the aging hallmarks in pulmonary fibrosis. Telomere shortening and telomerase gene mutations have been widely evaluated in recent years. Reduced telomere length may be identified in a quarter of patients with sporadic idiopathic pulmonary fibrosis (IPF) a...

journal_title：Current opinion in pulmonary medicine

authors： Molina-Molina M,Borie R

更新日期：2018-09-01 00:00:00

abstract：:Interstitial lung diseases are characterized by disruption of the distal pulmonary parenchyma. The clinical history manifestations, cough and dyspnea, and physical exam manifestations, inspiratory crackles, are nonspecific. Pulmonary function testing aids in the evaluation and management of patients with interstitial ...

journal_title：Current opinion in pulmonary medicine

authors： Flaherty KR,Martinez FJ

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been much recent interest in the use of macrolide antibiotics as chronic suppressive therapy in patients with cystic fibrosis. Three recent randomized, placebo-controlled trials have been conducted. RECENT FINDINGS:All three trials used similar regimens of azithromycin, and lung function im...

journal_title：Current opinion in pulmonary medicine

authors： Saiman L

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In previous years, there was limited research related to the role of sleep in interstitial lung diseases (ILDs). Physicians treating ILD patients tended to focus mainly on the daily disabling symptoms overlooking the possible significant role of coexisting sleep disorders, such as obstructive sleep ap...

journal_title：Current opinion in pulmonary medicine

authors： Schiza SE,Bouloukaki I,Bolaki M,Antoniou KM

更新日期：2020-09-01 00:00:00

abstract：:The author describes a current status of nuclear imaging in interstitial lung disease. A number of tests have been proposed for the evaluation of disease activity. The only one that is used in many centers, however, is 67Ga scan. If the goal is the evaluation of functional impairment, 99mTc-penta-acetic acid aerosol m...

journal_title：Current opinion in pulmonary medicine

authors： Rizzato G

更新日期：1997-09-01 00:00:00

abstract：:Many individuals are now surviving their injuries to face the consequences of an activated immunoinflammatory system and the complications of supportive therapy. The pulmonary system bears the force of this insult. An understanding of the epidemiology of acute respiratory failure, as well as a greater knowledge of the...

journal_title：Current opinion in pulmonary medicine

authors： O'Keefe GE,Maier RV

更新日期：1997-05-01 00:00:00

abstract：:Antibiotic resistance in respiratory pathogens has dramatically increased during recent years. Resistance to penicillin and multiple antimicrobial agents in pneumococci and resistance to ampicillin in Moraxella catarrhalis and Haemophilus influenzae, as a result of betalactamase production, have become highly prevalen...

journal_title：Current opinion in pulmonary medicine

authors： Dominguez MA,Pallares R

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the implementation of precision medicine, based on treatable traits and mechanisms, in the daily clinical management of chronic airways diseases. RECENT FINDINGS:Recent insights into the complex and heterogeneous nature of chronic airway diseases including chronic obstructive ...

journal_title：Current opinion in pulmonary medicine

authors： Ulrik CS,Vijverberg S,Hanania NA,Diamant Z

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Pleural infection remains an important pulmonary disease, causing significant morbidity and mortality. There is a resurgence of disease burden despite introduction of antibiotics and pneumococcal vaccines. A revisit of the pathogenesis and update on intervention may improve the care of pleural infecti...

journal_title：Current opinion in pulmonary medicine

authors： Chan KP,Fitzgerald DB,Lee YCG

更新日期：2018-07-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide. For patients diagnosed with early-stage lung cancer, complete surgical resection remains the best hope for cure. Limited resections are avoided when possible because of higher recurrence rates and potentially worse long-term survival. Traditionally, a...

journal_title：Current opinion in pulmonary medicine

authors： Moffatt SD,Mitchell JD,Whyte RI

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. RECENT ...

journal_title：Current opinion in pulmonary medicine

authors： Sivapalan P,Diamant Z,Ulrik CS

更新日期：2015-01-01 00:00:00