The small airways in chronic obstructive pulmonary disease: pathology and effects on disease progression and survival.

abstract：PURPOSE OF REVIEW:The immunopathogenesis of sarcoidosis is considered to involve contributions from both adaptive and innate immune responses. Although the identification of adaptive responses to candidate pathogenic antigens will elucidate mechanisms that regulate inflammation in sarcoidosis, innate mechanisms likely ...

journal_title：Current opinion in pulmonary medicine

authors： Chen ES

更新日期：2016-09-01 00:00:00

abstract：:The majority of men with cystic fibrosis (CF) have associated congenital bilateral absence of the vas deferens (CBVAD). This congenital defect results in the absence of the anatomic ducts through which spermatozoa pass from the testes to the urethra. No spermatozoa are found in the semen, a condition referred to as ob...

journal_title：Current opinion in pulmonary medicine

authors： Sokol RZ

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Exacerbations of asthma in children are most frequently precipitated by respiratory infections with a seasonal pattern. However, management takes little account of the underlying infective or other precipitant abnormality. RECENT FINDINGS:Interactions between environmental triggers, the airway microb...

journal_title：Current opinion in pulmonary medicine

authors： Cook J,Saglani S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, there have been exciting developments in bronchoscopic efforts at attaining lung volume reduction (LVR), given real and perceived risks of surgical LVR. The purpose of this review is to discuss these techniques, with special emphasis on what we have learnt in the past 1-2 years....

journal_title：Current opinion in pulmonary medicine

authors： Taneja A

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work demonstrates that patients with refractory asthma are likely to be sensitized to environmental fungi and that specific antifungal treatments may be of benefit to this group. RECENT FINDINGS:The relationships among fungal sensitization, exposure and asthma severity are imperfectly understo...

journal_title：Current opinion in pulmonary medicine

authors： Gore RB

更新日期：2010-01-01 00:00:00

abstract：:The occurrence of lung cancer in patients with diffuse interstitial pulmonary disease is well-known. The incidence, however, varies and ranges from 9.8 to 38%. The pathogenesis of lung cancer in pulmonary fibrosis is unclear, but genetic as well as environmental factors seem to be involved. ...

journal_title：Current opinion in pulmonary medicine

authors： Sharma OP,Lamb C

更新日期：2003-09-01 00:00:00

abstract：:Prognosis for patients with cystic fibrosis has improved dramatically over the past three decades. In the United States, median survival age is now 28.9 years. Although genotype predicts exocrine pancreatic function, it does not correlate with pulmonary status or overall clinical outcome. However, there are a number o...

journal_title：Current opinion in pulmonary medicine

authors： Rosenstein BJ,Zeitlin PL

更新日期：1995-11-01 00:00:00

abstract：:As the number of inhaled drugs available for cystic fibrosis grows, there is increasing awareness of delivery device issues. Current jet and ultrasonic nebulizers are inefficient at delivering drugs to the lower respiratory tract. There are large differences in output characteristics between nebulizers and high inters...

journal_title：Current opinion in pulmonary medicine

authors： Geller DE

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Heparin-induced thrombocytopenia is a severe side effect of treatment with unfractionated heparin. The relation of low-molecular-weight heparin to heparin-induced thrombocytopenia is less well understood. This review will summarize what is known about the similarities and differences between thrombocy...

journal_title：Current opinion in pulmonary medicine

authors： Walenga JM,Prechel M,Jeske WP,Bakhos M

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is one of the most prevalent and increasing health problems in the elderly on a worldwide scale. The management of COPD in older patients presents practical diagnostic and treatment issues, which are reviewed with reference to the stable stage of the diseas...

journal_title：Current opinion in pulmonary medicine

authors： Pistelli R,Ferrara L,Misuraca C,Bustacchini S

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis of sleep apnoea was performed in sleep laboratories with polysomnography. This requires a room with supervision and presence of technologists and trained sleep experts. Today, clinical guidelines in most countries recommend home sleep apnoea testing with simple systems using six signals only...

journal_title：Current opinion in pulmonary medicine

authors： Penzel T,Fietze I,Glos M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:It has been an ongoing challenge to translate knowledge pertaining to the molecular basis of cystic fibrosis (CF) into a clear understanding of the development of CF lung disease. Various hypotheses have attempted to explain the apparent breach of innate defenses in CF, although a definitive explanati...

journal_title：Current opinion in pulmonary medicine

authors： Donaldson SH,Boucher RC

更新日期：2003-11-01 00:00:00

abstract：:Wheezing in infants and children presents a difficult differential diagnosis contingent on the presenting symptoms and age of the child. A determination of the anatomy of the lower airway, combined with allergic, infectious, and noninfectious irritants, is requisite to a complete evaluation. The intervention strategie...

journal_title：Current opinion in pulmonary medicine

authors： Chipps BE,Chipps DR

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis. RECENT FINDINGS:Available data are responsible for a lack of consensus regarding treatment of distal deep vein thrombosis. SUMMARY:One standard diagnostic approach of suspected deep vein t...

journal_title：Current opinion in pulmonary medicine

authors： Righini M,Bounameaux H

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The catastrophic collapse of the World Trade Center (WTC) towers on September 11, 2001 created a large-scale disaster site in a densely populated urban environment. Over the ensuing months, tens of thousands of rescue, recovery and cleanup workers, volunteers, and residents of the adjacent community w...

journal_title：Current opinion in pulmonary medicine

authors： Banauch GI,Dhala A,Prezant DJ

更新日期：2005-03-01 00:00:00

abstract：:Although it had been appreciated that high levels of antituberculous drug resistance existed in some regions of the world, the full extent of the problem was not known. A combined initiative by the World Health Organization and the International Union Against Tuberculosis and Lung Disease was launched in 1994 to addre...

journal_title：Current opinion in pulmonary medicine

authors： Willcox PA

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) and lung cancer are the leading causes of morbidity and mortality worldwide. The current research is focused on identifying the common and disparate events involved in epigenetic modifications that concurrently occur during the pathogenesis of COPD and lung...

journal_title：Current opinion in pulmonary medicine

authors： Sundar IK,Mullapudi N,Yao H,Spivack SD,Rahman I

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis of idiopathic interstitial pneumonias (IIPs) requires the exclusion of, among others, concomitant connective tissue diseases (CTDs), which may present as interstitial lung disease (ILD). This review focuses on the evaluation required to separate these entities through serology, although not ...

journal_title：Current opinion in pulmonary medicine

authors： Papiris SA,Kagouridis K,Bouros D

更新日期：2012-09-01 00:00:00

abstract：:Small cell lung cancer (SCLC) accounts for 20% to 25% of bronchogenic carcinoma cases. Combination chemotherapy offers the best chance for improved survival. Cisplatin plus etoposide appears to be the most reasonable choice for first line therapy. Increasing dose intensity, although sometimes associated with higher re...

journal_title：Current opinion in pulmonary medicine

authors： Adjei AA

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Ever since sarcoidosis was first described, its relationship with tuberculosis has been debated. Whereas some consider sarcoidosis and tuberculosis as two extremes of the same disease process, other researchers have negated the role of mycobacteria in causation of sarcoidosis. Whether or not linked ca...

journal_title：Current opinion in pulmonary medicine

authors： Gupta D,Agarwal R,Aggarwal AN,Jindal SK

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of inhaled corticosteroids is one of the most controversial issues in COPD pharmacotherapy. Experts disagree about the benefits and harms of ICS for patients with COPD, yet a majority of patients with COPD are being treated with inhaled corticosteroids. This is a review of the most recent lite...

journal_title：Current opinion in pulmonary medicine

authors： Highland KB

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcoidosis is a granulomatous systemic disease of unknown cause where the lung is the most frequently affected organ. Therapeutic management of the disease is challenging as clinical presentation and prognosis are very heterogeneous. In the present review, we will summarize the main advances in sarco...

journal_title：Current opinion in pulmonary medicine

authors： Sellarés J,Francesqui J,Llabres M,Hernandez-Gonzalez F,Baughman RP

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Bronchial and bronchiolar abnormalities in interstitial lung diseases (ILDs) are an issue often underestimated. However, new interstitial patterns with bronchiolar involvement are being described and the concept is still evolving. The scope of this review is to introduce a comprehensive approach to ai...

journal_title：Current opinion in pulmonary medicine

authors： Pappas K

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic pulmonary fibrosis (IPF) is a progressive, invariably fatal condition with a median survival from diagnosis of only 3 years. Despite improvements in disease understanding, challenges remain in establishing a diagnosis and predicting prognosis in individual patients. Furthermore, limited und...

journal_title：Current opinion in pulmonary medicine

authors： Maher TM

更新日期：2013-09-01 00:00:00

abstract：:The bronchiolitides can be categorized broadly as constrictive or proliferative, each with characteristic CT features. The cardinal CT signs of constrictive bronchiolitis are mosaic perfusion, enhanced on expiratory CT scan and variably associated with bronchiectasis and, less frequently, centrilobular branching struc...

journal_title：Current opinion in pulmonary medicine

authors： Wells AU

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the current understanding and clinical applicability of severity scoring systems in pneumonia management. RECENT FINDINGS:Severity scores in community-acquired pneumonia are strong markers of mortality, but are not necessarily clinical decision-aid tools. The use of severity scores to sup...

journal_title：Current opinion in pulmonary medicine

authors： Ranzani OT,Taniguchi LU,Torres A

更新日期：2018-05-01 00:00:00

abstract：:Disorders of sleep in children are distinctly different from sleep disorders in adults. Since children are forced to constantly learn and adapt, the effects of disordered sleep may be more profound. This paper reviews the disorders of sleep that are most significant in each of the stages of development from infancy to...

journal_title：Current opinion in pulmonary medicine

authors： Anstead M

更新日期：2000-11-01 00:00:00

abstract：:Uvulopalatopharyngoplasty has limited efficacy in treating obstructive sleep apnea, with excellent results achieved in fewer than half of patients who undergo this procedure. Attempting to select patients who have only retropalatal collapse of the pharynx increases the likelihood of a successful outcome. Although this...

journal_title：Current opinion in pulmonary medicine

authors： Sher AE

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Respiratory tract infections are a common reason for prescribing antibiotics, although not all of these infections require such therapy. Rapid diagnosis of etiology using point-of-care tests is a potentially useful way of reducing prescriptions of both unnecessary and unnecessarily broad-spectrum anti...

journal_title：Current opinion in pulmonary medicine

authors： Charles PG

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review highlights the clinical findings and the management of community-acquired, health-care associated and nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:Although previously considered as a purely nosocomial event, community-acquired MRSA pneumon...

journal_title：Current opinion in pulmonary medicine

authors： Tacconelli E,De Angelis G

更新日期：2009-05-01 00:00:00