Does gender matter: sex-specific aspects of symptoms, outcome, and therapy of obstructive sleep apnea.

abstract：PURPOSE OF REVIEW:Severe asthma is a heterogeneous syndrome, encompassing several distinct clinical phenotypes. Different molecular and cellular pathways or endotypes determine the type of underlying airway inflammation in patients with severe asthma, which can be categorized as eosinophilic asthma (allergic and nonall...

journal_title：Current opinion in pulmonary medicine

authors： Brusselle GG,Joos G

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The article aims to provide an updated and evidence-based review of the innovative electronic health interventions to monitor and improve inhaler technique and adherence to recommended therapy in asthma. RECENT FINDINGS:Out of the 290 articles identified by the search strategy, 23 manuscripts fulfill...

journal_title：Current opinion in pulmonary medicine

authors： Bonini M,Usmani OS

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Telomere attrition has been proposed as one of the aging hallmarks in pulmonary fibrosis. Telomere shortening and telomerase gene mutations have been widely evaluated in recent years. Reduced telomere length may be identified in a quarter of patients with sporadic idiopathic pulmonary fibrosis (IPF) a...

journal_title：Current opinion in pulmonary medicine

authors： Molina-Molina M,Borie R

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic pulmonary fibrosis (IPF) is a progressive, invariably fatal condition with a median survival from diagnosis of only 3 years. Despite improvements in disease understanding, challenges remain in establishing a diagnosis and predicting prognosis in individual patients. Furthermore, limited und...

journal_title：Current opinion in pulmonary medicine

authors： Maher TM

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Dornase alfa (Pulmozyme) is one of the most commonly used medications to treat the lung disease of cystic fibrosis (CF). As other respiratory medications have entered the clinical market, understanding the proper use and indication for dornase alfa is increasingly important. In addition, dornase alfa ...

journal_title：Current opinion in pulmonary medicine

authors： Wagener JS,Kupfer O

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Although currently available drugs to treat asthma are effective in most patients, a proportion of patients do not respond or experience side-effects; which is partly genetically determined. Pharmacogenetics is the study of how genetic variations influence drug response. In this review, we summarize p...

journal_title：Current opinion in pulmonary medicine

authors： Kersten ET,Koppelman GH

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Regions of the neocortex most strongly activated during waking exhibit increased sleep intensity during subsequent sleep. The novel concept that aspects of sleep homeostasis are determined locally in the cortex contrasts with the established views that global changes in neocortical activity during sle...

journal_title：Current opinion in pulmonary medicine

authors： Szymusiak R

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review and compare the constellations of causes and consequences of the two current pandemics, Covid-19 and climate change. RECENT FINDINGS:There has been a transient counterbalancing, in which the response to Covid-19 has briefly mitigated pollution and greenhouse gasses. This divergence belies m...

journal_title：Current opinion in pulmonary medicine

authors： Joshi M,Caceres J,Ko S,Epps SM,Bartter T

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Asthma is a heterogeneous disorder presenting with many phenotypes. Precise phenotypic definition has eluded the medical research community for years, despite recognition of different disease subtypes. Improved phenotypic characterization and knowledge of underlying pathobiology is necessary for linka...

journal_title：Current opinion in pulmonary medicine

authors： Kiley J,Smith R,Noel P

更新日期：2007-01-01 00:00:00

abstract：:Although asthma is considered to be an inflammatory disease of the airways, neural mechanisms remain very important. Neural control of airways is far more complex than has been previously recognized. In addition to the classic neural pathways, the nonadrenergic, noncholinergic pathway has been described in the airways...

journal_title：Current opinion in pulmonary medicine

authors： Choi DC,Kwon OJ

更新日期：1998-01-01 00:00:00

abstract：:The nontuberculous mycobacteria (NTM), especially Mycobacterium avium complex, are being recognized with increasing frequency as clinical pathogens, not only as a cause of disseminated disease in patients with AIDS but also as a cause of chronic lung disease in patients without AIDS. These infections have traditionall...

journal_title：Current opinion in pulmonary medicine

authors： Griffith DE

更新日期：1997-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis. RECENT FINDINGS:Available data are responsible for a lack of consensus regarding treatment of distal deep vein thrombosis. SUMMARY:One standard diagnostic approach of suspected deep vein t...

journal_title：Current opinion in pulmonary medicine

authors： Righini M,Bounameaux H

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:although long-acting beta-agonists (LABAs) have been used for two decades, with many studies showing benefit versus increasing inhaled corticosteroid (ICS), controversy regarding safety has resulted in the United States Food and Drug Administration (FDA) recently mandating label changes restricting LA...

journal_title：Current opinion in pulmonary medicine

authors： Sears MR

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In previous years, there was limited research related to the role of sleep in interstitial lung diseases (ILDs). Physicians treating ILD patients tended to focus mainly on the daily disabling symptoms overlooking the possible significant role of coexisting sleep disorders, such as obstructive sleep ap...

journal_title：Current opinion in pulmonary medicine

authors： Schiza SE,Bouloukaki I,Bolaki M,Antoniou KM

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Community-acquired pneumonia (CAP) is the most common infectious disease cause of death. We summarize recent findings regarding the epidemiology of CAP in adults, efficacy of vaccines against Streptococcus pneumoniae, diagnostics, and discuss the current controversy between CAP and healthcare-associat...

journal_title：Current opinion in pulmonary medicine

authors： José RJ,Periselneris JN,Brown JS

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Microscopic polyangiitis is a systemic necrotizing vasculitis that affects small vessels, resulting in a wide spectrum of organ involvement including the kidneys and the lungs. This paper reviews recent insights and observations into the pathogenesis, clinical manifestations, and treatment of pulmonar...

journal_title：Current opinion in pulmonary medicine

authors： Collins CE,Quismorio FP Jr

更新日期：2005-09-01 00:00:00

abstract：:Pulmonary function changes in interstitial lung disease are characterized by loss of lung volume, increase in ratio of forced expiratory volume in 1 second to forced vital capacity, and decrease in carbon monoxide diffusion capacity. Recent developments in the assessment of respiratory mechanics in infiltrative lung d...

journal_title：Current opinion in pulmonary medicine

authors： Baydur A

更新日期：1996-09-01 00:00:00

abstract：:Considerable progress has been made over the past 2 decades in defining and measuring health-related quality of life (QOL), and there is a growing recognition that these measures provide unique information about the impact of a chronic illness and its treatment. For patients with cystic fibrosis (CF), health-related Q...

journal_title：Current opinion in pulmonary medicine

authors： Quittner AL

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Secondary spontaneous pneumothorax (SSP) can occur in patients who are suffering from diffuse lung disease. The main cause of SSP is chronic obstructive pulmonary disease (COPD). In contrast to primary spontaneous pneumothorax, SSP is a potentially life-threatening condition because patients with SSP ...

journal_title：Current opinion in pulmonary medicine

authors： Nakajima J

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Obstructive sleep apnea (OSA) is heterogeneous in terms of contributing pathophysiological mechanisms, clinical presentation, and consequences. Different study models from animal models of intermittent hypoxia over case-control, cohort, and population-based observational studies to uncontrolled interv...

journal_title：Current opinion in pulmonary medicine

authors： Schwarz EI

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is one of the most prevalent and increasing health problems in the elderly on a worldwide scale. The management of COPD in older patients presents practical diagnostic and treatment issues, which are reviewed with reference to the stable stage of the diseas...

journal_title：Current opinion in pulmonary medicine

authors： Pistelli R,Ferrara L,Misuraca C,Bustacchini S

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In many cases, the specific pathogen responsible for a respiratory infection is not identified and can lead to improper medical treatment, increased duration of illness, and possibly contributes to the development of antibiotic resistance. Molecular-based diagnostic methodologies have significantly im...

journal_title：Current opinion in pulmonary medicine

authors： Lednicky JA,Rayner JO

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There is growing evidence that genetics plays a role in the development of chronic obstructive pulmonary disease. This review deals with the most recent findings, new methods to detect genetic susceptibility that may be helpful in this field, and how the environment may act on the genetic code of susc...

journal_title：Current opinion in pulmonary medicine

authors： Molfino NA

更新日期：2007-03-01 00:00:00

abstract：:An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes se...

journal_title：Current opinion in pulmonary medicine

authors： Fahy JV,Corry DB,Boushey HA

更新日期：2000-01-01 00:00:00

abstract：:Wheezing in infants and children presents a difficult differential diagnosis contingent on the presenting symptoms and age of the child. A determination of the anatomy of the lower airway, combined with allergic, infectious, and noninfectious irritants, is requisite to a complete evaluation. The intervention strategie...

journal_title：Current opinion in pulmonary medicine

authors： Chipps BE,Chipps DR

更新日期：1999-01-01 00:00:00

abstract：:Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma. This ...

journal_title：Current opinion in pulmonary medicine

authors： Wills-Karp M,Chiaramonte M

更新日期：2003-01-01 00:00:00

abstract：:Bronchial carcinoids and hamartomas are, respectively, the most common malignant and benign unusual primary lung neoplasms. These tumors are often asymptomatic but can cause central airway obstruction. Helical computed tomographic and radionuclide scintigraphic advances in their detection and evolution, together with ...

journal_title：Current opinion in pulmonary medicine

authors： Chan AL,Shelton DK,Yoneda KY

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Minimally invasive diagnostic strategies for pulmonary embolism are in constant evolution, integrating new diagnostic tools along with the better use of clinical information. RECENT FINDINGS:In the past year, several reports have provided more data on the value of clinical signs and symptoms for diag...

journal_title：Current opinion in pulmonary medicine

authors： Le Gal G,Perrier A

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Asthma outcomes constitute the cornerstone of asthma clinical research. Despite their known importance, it has been difficult for researchers to standardize these outcomes in large part because of the heterogeneity of the disease. This review seeks to provide an overview of recent recommendations for ...

journal_title：Current opinion in pulmonary medicine

authors： Parulekar AD,Alobaidy A,Hanania NA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Cancer patients with venous thromboembolism (VTE) are at increased risk of mortality. Estimating the risks for specific causes of death may help to weigh the risks and benefits of different therapeutic strategies in an individual patient. RECENT FINDINGS:In the Registro Informatizado de la Enfermedad...

journal_title：Current opinion in pulmonary medicine

authors： Trujillo-Santos J,Monreal M

更新日期：2012-09-01 00:00:00