Airway inflammation and remodeling in asthma.

abstract：PURPOSE OF REVIEW:There is growing evidence that genetics plays a role in the development of chronic obstructive pulmonary disease. This review deals with the most recent findings, new methods to detect genetic susceptibility that may be helpful in this field, and how the environment may act on the genetic code of susc...

journal_title：Current opinion in pulmonary medicine

authors： Molfino NA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Symptoms of anxiety and depression are prevalent in at least 20-40% of patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) and are known to affect prognosis and worsen quality of life. This review examines whether pulmonary rehabilitation can effectively improve psychological...

journal_title：Current opinion in pulmonary medicine

authors： Coventry PA

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize recent advances in our understanding of the impact sleep disturbances have on our health, with particular focus on the brain. The present review considers the influence of sleep disturbance on the neurovascular unit; the role of sleep disturbance in neurodege...

journal_title：Current opinion in pulmonary medicine

authors： Aguirre CC

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Time to clinical worsening (TTCW) can be used to assess disease progression associated with pulmonary arterial hypertension (PAH). As a consequence, it is highly relevant to patients, clinicians, and regulatory agencies. The majority of clinical trials of PAH-specific drug therapies have included TTCW...

journal_title：Current opinion in pulmonary medicine

authors： Galiè N,Simonneau G,Barst RJ,Badesch D,Rubin L

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Survival for patients with cystic fibrosis (CF) continues to improve. The proportion of CF patients over the age of 18 years is nearly 50%, and care providers will need to better understand this patient population. Despite these improvements, young females continue to have a worse prognosis and lower ...

journal_title：Current opinion in pulmonary medicine

authors： McIntyre K

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant central airway obstruction heavily impacts patients' quality of life and its management continues to be a challenge. The current article will review the use of airway stents in this population. RECENT FINDINGS:Airway stenting is highly effective in palliating symptoms of airway obstruction....

journal_title：Current opinion in pulmonary medicine

authors： Casal RF

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the fact that primary pulmonary lymphoma (PPL) is a rare lung tumour, significant advances addressing clinical features, histological diagnosis, prognostic criteria and therapeutic management of this disease have been made within the past decade. RECENT FINDINGS:Monoclonality and phenotyping ...

journal_title：Current opinion in pulmonary medicine

authors： Cardenas-Garcia J,Talwar A,Shah R,Fein A

更新日期：2015-07-01 00:00:00

abstract：:Lung volume reduction surgery and lung transplantation have been shown to improve lung function, exercise capacity, and quality of life in patients with advanced emphysema. Because the indications for both surgical procedures overlap, lung volume reduction surgery may be used as an alternative treatment or as a "bridg...

journal_title：Current opinion in pulmonary medicine

authors： Cordova FC,Criner GJ

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is one of the most prevalent and increasing health problems in the elderly on a worldwide scale. The management of COPD in older patients presents practical diagnostic and treatment issues, which are reviewed with reference to the stable stage of the diseas...

journal_title：Current opinion in pulmonary medicine

authors： Pistelli R,Ferrara L,Misuraca C,Bustacchini S

更新日期：2011-12-01 00:00:00

abstract：:Many individuals are now surviving their injuries to face the consequences of an activated immunoinflammatory system and the complications of supportive therapy. The pulmonary system bears the force of this insult. An understanding of the epidemiology of acute respiratory failure, as well as a greater knowledge of the...

journal_title：Current opinion in pulmonary medicine

authors： O'Keefe GE,Maier RV

更新日期：1997-05-01 00:00:00

abstract：:Pulmonary disease remains a major problem for the 33 million individuals who are thought to be infected with human immunodeficiency virus (HIV) worldwide. Respiratory infections are responsible for a large number of the 2 million deaths that occur each year in association with HIV disease. In countries where the major...

journal_title：Current opinion in pulmonary medicine

authors： Ashley EA,Johnson MA,Lipman MC

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of inhaled corticosteroids is one of the most controversial issues in COPD pharmacotherapy. Experts disagree about the benefits and harms of ICS for patients with COPD, yet a majority of patients with COPD are being treated with inhaled corticosteroids. This is a review of the most recent lite...

journal_title：Current opinion in pulmonary medicine

authors： Highland KB

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In previous years, there was limited research related to the role of sleep in interstitial lung diseases (ILDs). Physicians treating ILD patients tended to focus mainly on the daily disabling symptoms overlooking the possible significant role of coexisting sleep disorders, such as obstructive sleep ap...

journal_title：Current opinion in pulmonary medicine

authors： Schiza SE,Bouloukaki I,Bolaki M,Antoniou KM

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The article aims to provide an updated and evidence-based review of the innovative electronic health interventions to monitor and improve inhaler technique and adherence to recommended therapy in asthma. RECENT FINDINGS:Out of the 290 articles identified by the search strategy, 23 manuscripts fulfill...

journal_title：Current opinion in pulmonary medicine

authors： Bonini M,Usmani OS

更新日期：2018-01-01 00:00:00

abstract：:Tuberculosis is currently an enormous global health problem. In industrialized countries in Western Europe and North America, tuberculosis case rates are low and an increasing proportion of cases now occur in foreign-born individuals and in marginalized populations, including the homeless, prisoners, drug users, and p...

journal_title：Current opinion in pulmonary medicine

authors： Johnson JL,Ellner JJ

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review highlights the clinical findings and the management of community-acquired, health-care associated and nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:Although previously considered as a purely nosocomial event, community-acquired MRSA pneumon...

journal_title：Current opinion in pulmonary medicine

authors： Tacconelli E,De Angelis G

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Historically, pleural effusions have been attributed to a single cause. There is growing recognition that a substantial proportion of pleural effusions may have more than one underlying cause. The purpose of this review is to summarise recent findings regarding the diagnosis and treatment of effusions...

journal_title：Current opinion in pulmonary medicine

authors： Walker S,Maskell N

更新日期：2017-07-01 00:00:00

abstract：:Apoptosis, also known as activation-induced cell death or programmed cell death, is an active suicide mechanism that is involved in normal tissue turnover during embryogenesis and adult life. There are many examples of apoptosis in the immune system, including programmed cell death of T cells during negative intrathym...

journal_title：Current opinion in pulmonary medicine

authors： Agostini C,Perin A,Semenzato G

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:A relatively new class of CD4 expressing T cells that also express and release interleukin-17 (Th17 cells) is gaining attention based on their capacity to regulate inflammatory responses in a spectrum of chronic autoimmune diseases. The purpose of this review is to consider recent studies relating to ...

journal_title：Current opinion in pulmonary medicine

authors： Crouser ED

更新日期：2018-09-01 00:00:00

abstract：:Wheezing in infants and children presents a difficult differential diagnosis contingent on the presenting symptoms and age of the child. A determination of the anatomy of the lower airway, combined with allergic, infectious, and noninfectious irritants, is requisite to a complete evaluation. The intervention strategie...

journal_title：Current opinion in pulmonary medicine

authors： Chipps BE,Chipps DR

更新日期：1999-01-01 00:00:00

abstract：:Lung volume reduction surgery (LVRS) is a palliative surgical procedure for patients with severe emphysema. Resection of nonfunctional emphysematous lung tissue has been reported to relieve breathlessness and to improve quality of life for many patients by improving lung elastic recoil, respiratory muscle function, an...

journal_title：Current opinion in pulmonary medicine

authors： Meyer KC,Cornwell RD,Love RB

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Although currently available drugs to treat asthma are effective in most patients, a proportion of patients do not respond or experience side-effects; which is partly genetically determined. Pharmacogenetics is the study of how genetic variations influence drug response. In this review, we summarize p...

journal_title：Current opinion in pulmonary medicine

authors： Kersten ET,Koppelman GH

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis of sleep apnoea was performed in sleep laboratories with polysomnography. This requires a room with supervision and presence of technologists and trained sleep experts. Today, clinical guidelines in most countries recommend home sleep apnoea testing with simple systems using six signals only...

journal_title：Current opinion in pulmonary medicine

authors： Penzel T,Fietze I,Glos M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Classic descriptions of chronic obstructive pulmonary disease (COPD) centered on its impact on respiratory function. It is currently recognized that comorbidities contribute to the severity of symptoms and COPD progression. Understanding COPD-comorbidities associations could provide innovative treatme...

journal_title：Current opinion in pulmonary medicine

authors： Brown JP,Martinez CH

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent studies that have quantified the incidence of death due to late thromboembolic disease among patients initially diagnosed with acute unprovoked pulmonary embolism. These findings will aid clinicians who must weigh the risk versus the benefits of long-term anticoagulant therapy. RE...

journal_title：Current opinion in pulmonary medicine

authors： White RH,Murin S

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Coal mine workers are at risk for a range of chronic respiratory diseases including coal workers' pneumoconiosis, diffuse dust-related fibrosis, and chronic obstructive pulmonary disease. The purpose of this review is to describe coal mining processes and associated exposures to inform the diagnostic ...

journal_title：Current opinion in pulmonary medicine

authors： Go LH,Krefft SD,Cohen RA,Rose CS

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The chronic lung diseases, asthma and chronic obstructive pulmonary disease, are pulmonary disorders in which persistent inflammation and alterations in lung structure contribute to a progressive loss of lung function. Although the exact type of inflammation and damage in each disease is distinct, the...

journal_title：Current opinion in pulmonary medicine

authors： Mohsenin A,Blackburn MR

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Pleural infection remains an important pulmonary disease, causing significant morbidity and mortality. There is a resurgence of disease burden despite introduction of antibiotics and pneumococcal vaccines. A revisit of the pathogenesis and update on intervention may improve the care of pleural infecti...

journal_title：Current opinion in pulmonary medicine

authors： Chan KP,Fitzgerald DB,Lee YCG

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Severe asthma is a heterogeneous syndrome, encompassing several distinct clinical phenotypes. Different molecular and cellular pathways or endotypes determine the type of underlying airway inflammation in patients with severe asthma, which can be categorized as eosinophilic asthma (allergic and nonall...

journal_title：Current opinion in pulmonary medicine

authors： Brusselle GG,Joos G

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Pleural effusions are frequent in the context of acute idiopathic pericarditis and following pericardiotomy, but they have seldom been characterized. This review summarizes their most relevant clinical features. RECENT FINDINGS:In acute idiopathic pericarditis, pleural effusions tend to be left-sided...

journal_title：Current opinion in pulmonary medicine

authors： Porcel JM

更新日期：2017-07-01 00:00:00