Description of an albumin binding activity for Streptococcus suis serotype 2.

Abstract:

:This study was undertaken to investigate the binding activity of Streptococcus suis serotype 2 to albumin. Using flow cytometry we observed a binding activity of S. suis to albumin for virulent as well as for avirulent isolates. Western immunoblots analysis revealed that a 39-kDa S. suis protein was responsible, at least in part, for this binding activity. This protein showed high N-terminal homology (95.6% for the first 23 residues) with a group A Streptococcus glyceraldehyde-3-phosphate dehydrogenase. Furthermore, the addition of albumin to the culture broth resulted in an increase in the virulence of S. suis strains in mice. These results suggest that an interaction with albumin could play a role in the pathogenesis of S. suis serotype 2 infections.

journal_name

FEMS Microbiol Lett

authors

Quessy S,Busque P,Higgins R,Jacques M,Dubreuil JD

doi

10.1111/j.1574-6968.1997.tb10249.x

subject

Has Abstract

pub_date

1997-02-15 00:00:00

pages

245-50

issue

2

eissn

0378-1097

issn

1574-6968

pii

S0378-1097(96)00534-4

journal_volume

147

pub_type

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