Collagen-induced STAT family members activation in Entamoeba histolytica trophozoites.

Abstract:

:The interaction of Entamoeba histolytica trophozoites with collagen type I and calcium induces a membrane to nuclei signaling. The transduction pathways involved in such phenomena are still poorly understood. Using a combination of immunoprecipitation assays, Western immunoblot analysis, electrophoretic mobility shift assays and immunocytochemistry we demonstrate here the expression, tyrosine phosphorylation, nuclear translocation and DNA binding of two members of the signal transducers and activators of transcription family of inducible transcription factors in the protozoan parasite E. histolytica. These results support the notion that the interaction of the extracellular matrix components with the parasite turns on a genetic program that facilitates the invasion of the host.

journal_name

FEMS Microbiol Lett

authors

Cruz-Vera J,Clara L,Hernández-Kelly R,Alfredo Méndez J,Pérez-Salazar E,Ortega A

doi

10.1016/S0378-1097(03)00822-X

keywords:

subject

Has Abstract

pub_date

2003-12-12 00:00:00

pages

203-9

issue

2

eissn

0378-1097

issn

1574-6968

pii

S037810970300822X

journal_volume

229

pub_type

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