Abstract:
:The interaction of Entamoeba histolytica trophozoites with collagen type I and calcium induces a membrane to nuclei signaling. The transduction pathways involved in such phenomena are still poorly understood. Using a combination of immunoprecipitation assays, Western immunoblot analysis, electrophoretic mobility shift assays and immunocytochemistry we demonstrate here the expression, tyrosine phosphorylation, nuclear translocation and DNA binding of two members of the signal transducers and activators of transcription family of inducible transcription factors in the protozoan parasite E. histolytica. These results support the notion that the interaction of the extracellular matrix components with the parasite turns on a genetic program that facilitates the invasion of the host.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Cruz-Vera J,Clara L,Hernández-Kelly R,Alfredo Méndez J,Pérez-Salazar E,Ortega Adoi
10.1016/S0378-1097(03)00822-Xkeywords:
subject
Has Abstractpub_date
2003-12-12 00:00:00pages
203-9issue
2eissn
0378-1097issn
1574-6968pii
S037810970300822Xjournal_volume
229pub_type
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journal_title:FEMS microbiology letters
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