Allelic variation in srtAs of Streptococcus suis strains.

Abstract:

:Streptococcus suis NCTC10234 possesses five srtA homologs: srtA encodes sortase, which anchors surface proteins with an LPXTG motif to the cell wall, while the functions of the other four homologs (the srtBCD cluster and srtE) remain unknown. The genetic organization of the srtA region was found to be conserved in the 59 S. suis strains examined in this study. Although the srtAs in three of these strains showed strong sequence divergence, their functions were verified to be overlapping by genetic complementation, indicating the functional conservation of srtAs during the evolution of these strains. These results indicate the importance of an srtA-mediated cell wall sorting system for displaying proteins on the surface of S. suis.

journal_name

FEMS Microbiol Lett

authors

Osaki M,Takamatsu D,Shimoji Y,Sekizaki T

doi

10.1016/S0378-1097(03)00058-2

keywords:

subject

Has Abstract

pub_date

2003-02-28 00:00:00

pages

195-201

issue

2

eissn

0378-1097

issn

1574-6968

pii

S0378109703000582

journal_volume

219

pub_type

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