Abstract:
:Follicle stimulating hormone (FSH) is a member of the glycoprotein hormone family that includes luteinzing hormone (LH), thyroid stimulating hormone, and chorionic gonadotropin. These heterodimeric hormones share a common alpha subunit and differ in their hormone-specific beta subunit. The biological activity is conferred only by the heterodimers. FSH and LH are synthesized in the same cells of the pituitary, the gonadotrophs. FSH receptors are localized to Sertoli cells of the testes and granulosa cells of the ovary. Minimal data has been accumulated so far involving human mutations in the FSH beta, LH beta, or the gonadotropin receptor genes. There are no known mouse strains with mutations in the FSH beta gene. To generate animal models for human diseases involving the gonadotropin signal transduction pathway, we produced mice deficient in the FSH beta subunit and therefore in FSH using ES cell technology. FSH-deficient females are infertile due to a block in folliculogenesis prior to antral follicle formation. Although FSH was predicted to be necessary for spermatogenesis and Sertoli cell growth in males, FSH-deficient males are fertile despite having small testes. Our findings have important implications for male contraceptive development in humans.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Kumar TR,Wang Y,Lu N,Matzuk MMdoi
10.1038/ng0297-201subject
Has Abstractpub_date
1997-02-01 00:00:00pages
201-4issue
2eissn
1061-4036issn
1546-1718journal_volume
15pub_type
杂志文章相关文献
NATURE GENETICS文献大全abstract::Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found acr...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3145
更新日期:2014-12-01 00:00:00
abstract::To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined the exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC tumor-normal pairs. Recurrent alterations in lung SqCCs were more similar to those of other squamou...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3564
更新日期:2016-06-01 00:00:00
abstract::Gastric cancer is classified into intestinal and diffuse types, the latter including a highly malignant form, linitis plastica. A two-stage genome-wide association study (stage 1: 85,576 SNPs on 188 cases and 752 references; stage 2: 2,753 SNPs on 749 cases and 750 controls) in Japan identified a significant associati...
journal_title:Nature genetics
pub_type: 杂志文章,多中心研究
doi:10.1038/ng.152
更新日期:2008-06-01 00:00:00
abstract::Exome sequencing has become a powerful and effective strategy for the discovery of genes underlying Mendelian disorders. However, use of exome sequencing to identify variants associated with complex traits has been more challenging, partly because the sample sizes needed for adequate power may be very large. One strat...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.2344
更新日期:2012-07-08 00:00:00
abstract::To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CH...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3943
更新日期:2017-10-01 00:00:00
abstract::Pediatric midline high-grade astrocytomas (mHGAs) are incurable with few treatment targets identified. Most tumors harbor mutations encoding p.Lys27Met in histone H3 variants. In 40 treatment-naive mHGAs, 39 analyzed by whole-exome sequencing, we find additional somatic mutations specific to tumor location. Gain-of-fu...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.2950
更新日期:2014-05-01 00:00:00
abstract::Retrotransposition affects genome structure by increasing repetition and producing insertional mutations. Dispersion of the retrotransposon L1 throughout mammalian genomes suggests that L1 activity might be an important evolutionary force. Here we report that L1 retrotransposition contributes to rapid genome evolution...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/3104
更新日期:1998-11-01 00:00:00
abstract::Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor alpha gene (RARA) and the PML gene, is sensitive to retinoic acid (RA) treatment, while APL patients harbouring translocations between RARA and the PLZF gene do not respond to RA. We have generated PML-...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0298-126
更新日期:1998-02-01 00:00:00
abstract::Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Iceland...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.323
更新日期:2009-03-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) participate in the most common signal transduction system at the plasma membrane. The wide distribution of heterotrimeric G proteins in the internal membranes suggests that a similar signalling mechanism might also be used at intracellular locations. We provide here structural evide...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/12715
更新日期:1999-09-01 00:00:00
abstract::The Ras signal transduction pathway is often deregulated in human myeloid leukaemia. For example, activating point mutations in RAS genes are found in some patients with juvenile chronic myelogenous leukaemia (JCML), while other patients with JCML show loss of the neurofibromatosis type 1 (NF1) gene, a Ras GTPase acti...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0296-137
更新日期:1996-02-01 00:00:00
abstract::New genetic data has enabled scientists to re-examine the relationship between human genetic variation and 'race'. We review the results of genetic analyses that show that human genetic variation is geographically structured, in accord with historical patterns of gene flow and genetic drift. Analysis of many loci now ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1435
更新日期:2004-11-01 00:00:00
abstract::Hundreds of genes reside in structurally complex, poorly understood regions of the human genome. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) responsible for digesting starch into sugar. Copy number of AMY1 is reported to be the largest genomic influence on obesity, although genome-wide ass...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3340
更新日期:2015-08-01 00:00:00
abstract::We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have further shown that 53BP2, which corresponds to a C-terminal fragment of ASPP2, acts as a dominant negative inhibitor of p5...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1070
更新日期:2003-02-01 00:00:00
abstract::Cretinism is marked by irreversible mental and growth retardation. We describe here an entirely new case of cretinism showing combined pituitary hormone deficiencies of thyrotropin, growth hormone and prolactin that appears to be caused by homozygosity for a nonsense mutation in the gene for the pituitary specific tra...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0492-56
更新日期:1992-04-01 00:00:00
abstract::Studies in experimental systems have identified a multitude of mutational mechanisms including DNA replication infidelity and DNA damage followed by inefficient repair or replicative bypass. However, the relative contributions of these mechanisms to human germline mutation remain unknown. Here, we show that error-pron...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/s41588-018-0285-7
更新日期:2019-01-01 00:00:00
abstract::The progressive familial intrahepatic cholestases (PFIC) are a group of inherited disorders with severe cholestatic liver disease from early infancy. A subgroup characterized by normal serum cholesterol and gamma-glutamyltranspeptidase (gammaGT) levels is genetically heterogeneous with loci on chromosomes 2q (PFIC2) a...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/3034
更新日期:1998-11-01 00:00:00
abstract::Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associat...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3268
更新日期:2015-06-01 00:00:00
abstract::Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia. Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular hallmarks of tumor hypoxia remain poorly defined. To fill this gap, we quantified hypoxia in 8,006 tumors across 19 tumor types. In ten tumo...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/s41588-018-0318-2
更新日期:2019-02-01 00:00:00
abstract::The combination of inhibition of RNA degradation and comparative genomic scanning is a powerful new method for detecting gene disruptions. The utility of the method is well-illustrated by a series of observations linking the ephrin receptor EPHB2 to prostate cancer. ...
journal_title:Nature genetics
pub_type: 评论,新闻
doi:10.1038/ng0904-937
更新日期:2004-09-01 00:00:00
abstract::Linkage disequilibrium mapping in isolated populations provides a powerful tool for fine structure localization of disease genes. Here, Luria and Delbrück's classical methods for analysing bacterial cultures are adapted to the study of human isolated founder populations in order to estimate (i) the recombination fract...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1192-204
更新日期:1992-11-01 00:00:00
abstract::Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. Mutations in SMO (encoding Smoothened, SMO) are common in ameloblastomas o...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.2986
更新日期:2014-07-01 00:00:00
abstract::Through whole-genome sequencing of 2,630 Icelanders and imputation into 11,114 Icelandic cases and 267,140 controls followed by testing in Danish and Iranian samples, we discovered 4 previously unreported variants affecting risk of type 2 diabetes (T2D). A low-frequency (1.47%) variant in intron 1 of CCND2, rs76895963...
journal_title:Nature genetics
pub_type: 信件
doi:10.1038/ng.2882
更新日期:2014-03-01 00:00:00
abstract::Three new studies have identified new genes and sequence variants implicated in blood lipids, inflammatory markers, hemoglobin levels and adult height variation in Sardinia. These reports highlight the usefulness of large-scale genotype imputation based on whole-genome sequencing, particularly in isolated populations,...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3426
更新日期:2015-11-01 00:00:00
abstract::Motile cilia induce fluid movement through their rhythmic beating activity. In mammals, the transcription factor Foxj1 has been implicated in motile cilia formation. Here we show that a zebrafish Foxj1 homolog, foxj1a, is a target of Hedgehog signaling in the floor plate. Loss of Foxj1a compromises the assembly of mot...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.263
更新日期:2008-12-01 00:00:00
abstract::Haematopoietic development is regulated by nuclear protein complexes that coordinate lineage-specific patterns of gene expression. Targeted mutagenesis in embryonic stem cells and mice has revealed roles for the X-linked gene Gata1 in erythrocyte and megakaryocyte differentiation. GATA-1 is the founding member of a fa...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/73480
更新日期:2000-03-01 00:00:00
abstract::The DiGeorge/velocardiofacial syndrome (DGS/VCFS) is a relatively common human disorder, usually associated with deletions of chromosome 22q11. The genetic basis for the wide range of developmental anomalies in the heart, glands and facial structures has been elusive. We have investigated the potential role of one can...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/85845
更新日期:2001-03-01 00:00:00
abstract::The rate at which allelic diversity at the HLA loci evolves has been the subject of considerable controversy. The patchwork pattern of sequence polymorphism within the second exon of the HLA class II loci, particularly in the DPB1 locus, may have been generated by segmental exchange (gene conversion). We have analysed...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0895-407
更新日期:1995-08-01 00:00:00
abstract::The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sou...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0598-60
更新日期:1998-05-01 00:00:00
abstract::We have carried out automated extraction of explicit and implicit biomedical knowledge from publicly available gene and text databases to create a gene-to-gene co-citation network for 13,712 named human genes by automated analysis of titles and abstracts in over 10 million MEDLINE records. The associations between gen...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0501-21
更新日期:2001-05-01 00:00:00