当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > Molecular landmarks of tumor hypoxia across cancer types.

Molecular landmarks of tumor hypoxia across cancer types.

Abstract：

:Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia. Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular hallmarks of tumor hypoxia remain poorly defined. To fill this gap, we quantified hypoxia in 8,006 tumors across 19 tumor types. In ten tumor types, hypoxia was associated with elevated genomic instability. In all 19 tumor types, hypoxic tumors exhibited characteristic driver-mutation signatures. We observed widespread hypoxia-associated dysregulation of microRNAs (miRNAs) across cancers and functionally validated miR-133a-3p as a hypoxia-modulated miRNA. In localized prostate cancer, hypoxia was associated with elevated rates of chromothripsis, allelic loss of PTEN and shorter telomeres. These associations are particularly enriched in polyclonal tumors, representing a constellation of features resembling tumor nimbosus, an aggressive cellular phenotype. Overall, this work establishes that tumor hypoxia may drive aggressive molecular features across cancers and shape the clinical trajectory of individual tumors.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Bhandari V,Hoey C,Liu LY,Lalonde E,Ray J,Livingstone J,Lesurf R,Shiah YJ,Vujcic T,Huang X,Espiritu SMG,Heisler LE,Yousif F,Huang V,Yamaguchi TN,Yao CQ,Sabelnykova VY,Fraser M,Chua MLK,van der Kwast T,Liu SK,Bout

doi

10.1038/s41588-018-0318-2

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

308-318

issue

2

eissn

1061-4036

issn

1546-1718

pii

10.1038/s41588-018-0318-2

journal_volume

51

pub_type

杂志文章

相关文献

NATURE GENETICS文献大全
  • Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187.

    abstract：:Dominantly inherited familial amyloidosis, Finnish type (FAF) is caused by the accumulation of a 71-amino acid amyloidogenic fragment of mutant gelsolin (GSN). FAF is common in Finland but is very rare elsewhere. In Finland and in two American families, the mutation is a G654A transition leading to an Asp to Asn subst...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1092-157

    authors： de la Chapelle A,Tolvanen R,Boysen G,Santavy J,Bleeker-Wagemakers L,Maury CP,Kere J

    更新日期：1992-10-01 00:00:00

  • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

    abstract：:To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant ex...

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/ng.2897

    authors： DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.,Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium.,South Asian Type 2 Diabetes (SAT2D) Consortium.,Mexican American Type 2 Diabetes (MAT2D) Consortium.,

    更新日期：2014-03-01 00:00:00

  • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

    abstract：:A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.627

    authors： Liu X,Invernizzi P,Lu Y,Kosoy R,Lu Y,Bianchi I,Podda M,Xu C,Xie G,Macciardi F,Selmi C,Lupoli S,Shigeta R,Ransom M,Lleo A,Lee AT,Mason AL,Myers RP,Peltekian KM,Ghent CN,Bernuzzi F,Zuin M,Rosina F,Borghesio E

    更新日期：2010-08-01 00:00:00

  • Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome.

    abstract：:Beare-Stevenson cutis gyrata syndrome (MIM 123790) is an autosomal dominant condition characterized by the furrowed skin disorder of cutis gyrata, acanthosis nigricans, craniosynostosis, craniofacial dysmorphism, digital anomalies, umbilical and anogenital abnormalities and early death. Many of these features are char...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0896-492

    authors： Przylepa KA,Paznekas W,Zhang M,Golabi M,Bias W,Bamshad MJ,Carey JC,Hall BD,Stevenson R,Orlow S,Cohen MM Jr,Jabs EW

    更新日期：1996-08-01 00:00:00

  • Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE. By fine mapping and genomic re-sequencing in ethni...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.766

    authors： Adrianto I,Wen F,Templeton A,Wiley G,King JB,Lessard CJ,Bates JS,Hu Y,Kelly JA,Kaufman KM,Guthridge JM,Alarcón-Riquelme ME,BIOLUPUS and GENLES Networks.,Anaya JM,Bae SC,Bang SY,Boackle SA,Brown EE,Petri MA,Gallant C

    更新日期：2011-03-01 00:00:00

  • MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome.

    abstract：:The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include transcriptional clusters whose dynamic establishment and functioning depend on multivalent interactions occurring among transcription factors, cofactors and basal transcrip...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-020-00724-8

    authors： Fasciani A,D'Annunzio S,Poli V,Fagnocchi L,Beyes S,Michelatti D,Corazza F,Antonelli L,Gregoretti F,Oliva G,Belli R,Peroni D,Domenici E,Zambrano S,Intartaglia D,Settembre C,Conte I,Testi C,Vergyris P,Ruocco G,Zippo

    更新日期：2020-12-01 00:00:00

  • X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo.

    abstract：:During mammalian development, one of the two X chromosomes in female embryos is randomly inactivated in the somatic cell in order to achieve gene dosage compensation. But is X inactivation established simultaneously or is it accomplished over time in a lineage-dependent fashion? We have examined this question in mouse...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0293-170

    authors： Tan SS,Williams EA,Tam PP

    更新日期：1993-02-01 00:00:00

  • Lung cancer susceptibility locus at 5p15.33.

    abstract：:We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.254

    authors： McKay JD,Hung RJ,Gaborieau V,Boffetta P,Chabrier A,Byrnes G,Zaridze D,Mukeria A,Szeszenia-Dabrowska N,Lissowska J,Rudnai P,Fabianova E,Mates D,Bencko V,Foretova L,Janout V,McLaughlin J,Shepherd F,Montpetit A,Narod S

    更新日期：2008-12-01 00:00:00

  • Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is a complex autoimmune disease that causes substantial morbidity. As is typical for many other multifactorial disorders, much of the heritability of SLE remains unknown. We identified a rare autosomal recessive form of SLE, in which autozygome analysis revealed a null mutation in th...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.975

    authors： Al-Mayouf SM,Sunker A,Abdwani R,Abrawi SA,Almurshedi F,Alhashmi N,Al Sonbul A,Sewairi W,Qari A,Abdallah E,Al-Owain M,Al Motywee S,Al-Rayes H,Hashem M,Khalak H,Al-Jebali L,Alkuraya FS

    更新日期：2011-10-23 00:00:00

  • Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.

    abstract：:Overgrowth disorders are a heterogeneous group of conditions characterized by increased growth parameters and other variable clinical features such as intellectual disability and facial dysmorphism. To identify new causes of human overgrowth, we performed exome sequencing in ten proband-parent trios and detected two d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2917

    authors： Tatton-Brown K,Seal S,Ruark E,Harmer J,Ramsay E,Del Vecchio Duarte S,Zachariou A,Hanks S,O'Brien E,Aksglaede L,Baralle D,Dabir T,Gener B,Goudie D,Homfray T,Kumar A,Pilz DT,Selicorni A,Temple IK,Van Maldergem L,Yac

    更新日期：2014-04-01 00:00:00

  • Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate.

    abstract：:Pioneer transcription factors establish new cell-fate competence by triggering chromatin remodeling. However, many features of pioneer action, such as their kinetics and stability, remain poorly defined. Here, we show that Pax7, by opening a unique repertoire of enhancers, is necessary and sufficient for specification...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-017-0035-2

    authors： Mayran A,Khetchoumian K,Hariri F,Pastinen T,Gauthier Y,Balsalobre A,Drouin J

    更新日期：2018-02-01 00:00:00

  • Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia.

    abstract：:The amnionless gene, Amn, on mouse chromosome 12 encodes a type I transmembrane protein that is expressed in the extraembryonic visceral layer during gastrulation. Mice homozygous with respect to the amn mutation generated by a transgene insertion have no amnion. The embryos are severely compromised, surviving to the ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1098

    authors： Tanner SM,Aminoff M,Wright FA,Liyanarachchi S,Kuronen M,Saarinen A,Massika O,Mandel H,Broch H,de la Chapelle A

    更新日期：2003-03-01 00:00:00

  • A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

    abstract：:To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1,...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.694

    authors： Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2.,Strange A,Capon F,Spencer CC,Knight J,Weale ME,Allen MH,Barton A,Band G,Bellenguez C,Bergboer JG,Blackwell JM,Bramon E,Bumpstead SJ,Casa

    更新日期：2010-11-01 00:00:00

  • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice.

    abstract：:The mammalian homeobox transcription factor CDX2 has key roles in intestinal development and differentiation. Heterozygous Cdx2 mice develop one or two benign hamartomas in the proximal colon, whereas heterozygous Apc(Delta716) mice develop numerous adenomatous polyps, mostly in the small intestine. Here we show that ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1265

    authors： Aoki K,Tamai Y,Horiike S,Oshima M,Taketo MM

    更新日期：2003-12-01 00:00:00

  • A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

    abstract：:We conducted a three-stage genome-wide association study (GWAS) of breast cancer in 9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. In stage 1, we genotyped 528,173 SNPs in 1,145 cases of invasive breast cancer and 1,142 controls. In stage 2, we analyzed 24,909 top S...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.353

    authors： Thomas G,Jacobs KB,Kraft P,Yeager M,Wacholder S,Cox DG,Hankinson SE,Hutchinson A,Wang Z,Yu K,Chatterjee N,Garcia-Closas M,Gonzalez-Bosquet J,Prokunina-Olsson L,Orr N,Willett WC,Colditz GA,Ziegler RG,Berg CD,Buys SS

    更新日期：2009-05-01 00:00:00

  • The genomic landscape of schwannoma.

    abstract：:Schwannomas are common peripheral nerve sheath tumors that can cause debilitating morbidities. We performed an integrative analysis to determine genomic aberrations common to sporadic schwannomas. Exome sequence analysis with validation by targeted DNA sequencing of 125 samples uncovered, in addition to expected NF2 d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3688

    authors： Agnihotri S,Jalali S,Wilson MR,Danesh A,Li M,Klironomos G,Krieger JR,Mansouri A,Khan O,Mamatjan Y,Landon-Brace N,Tung T,Dowar M,Li T,Bruce JP,Burrell KE,Tonge PD,Alamsahebpour A,Krischek B,Agarwalla PK,Bi WL,Dun

    更新日期：2016-11-01 00:00:00

  • Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.

    abstract：:Notch and the m9/10 gene (groucho) of the Enhancer of split (E(spI)) complex are members of the "Notch group" of genes, which is required for a variety of cell fate choices in Drosophila. We have characterized human cDNA clones encoding a family of proteins, designated TLE, that are homologous to the E(spI) m9/10 gene...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1092-119

    authors： Stifani S,Blaumueller CM,Redhead NJ,Hill RE,Artavanis-Tsakonas S

    更新日期：1992-10-01 00:00:00

  • Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures.

    abstract：:Advances in sequencing technologies have enabled the identification of mutations acquired by bacterial pathogens during infection. However, it remains unclear whether adaptive mutations fix in the population or lead to pathogen diversification within the patient. Here we study the genotypic diversity of Burkholderia d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2848

    authors： Lieberman TD,Flett KB,Yelin I,Martin TR,McAdam AJ,Priebe GP,Kishony R

    更新日期：2014-01-01 00:00:00

  • Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni.

    abstract：:Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags (ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampli...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1237

    authors： Verjovski-Almeida S,DeMarco R,Martins EA,Guimarães PE,Ojopi EP,Paquola AC,Piazza JP,Nishiyama MY Jr,Kitajima JP,Adamson RE,Ashton PD,Bonaldo MF,Coulson PS,Dillon GP,Farias LP,Gregorio SP,Ho PL,Leite RA,Malaquias LC,

    更新日期：2003-10-01 00:00:00

  • Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias.

    abstract：:The diaphragm is an essential mammalian skeletal muscle, and defects in diaphragm development are the cause of congenital diaphragmatic hernias (CDHs), a common and often lethal birth defect. The diaphragm is derived from multiple embryonic sources, but how these give rise to the diaphragm is unknown, and, despite the...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3250

    authors： Merrell AJ,Ellis BJ,Fox ZD,Lawson JA,Weiss JA,Kardon G

    更新日期：2015-05-01 00:00:00

  • Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.

    abstract：:Deletions on human chromosome 8p22-23 in prostate cancer cells and linkage studies in families affected with hereditary prostate cancer (HPC) have implicated this region in the development of prostate cancer. The macrophage scavenger receptor 1 gene (MSR1, also known as SR-A) is located at 8p22 and functions in severa...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng994

    authors： Xu J,Zheng SL,Komiya A,Mychaleckyj JC,Isaacs SD,Hu JJ,Sterling D,Lange EM,Hawkins GA,Turner A,Ewing CM,Faith DA,Johnson JR,Suzuki H,Bujnovszky P,Wiley KE,DeMarzo AM,Bova GS,Chang B,Hall MC,McCullough DL,Partin A

    更新日期：2002-10-01 00:00:00

  • Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome.

    abstract：:The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes. Emerging evidence suggests that Polycomb complexes act through controlling spatial genome organization. We show that PRC1 functions as a master regulator of mou...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3393

    authors： Schoenfelder S,Sugar R,Dimond A,Javierre BM,Armstrong H,Mifsud B,Dimitrova E,Matheson L,Tavares-Cadete F,Furlan-Magaril M,Segonds-Pichon A,Jurkowski W,Wingett SW,Tabbada K,Andrews S,Herman B,LeProust E,Osborne CS,Kose

    更新日期：2015-10-01 00:00:00

  • Common variants in FOXP1 are associated with generalized vitiligo.

    abstract：:In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with ...

    journal_title：Nature genetics

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ng.602

    authors： Jin Y,Birlea SA,Fain PR,Mailloux CM,Riccardi SL,Gowan K,Holland PJ,Bennett DC,Wallace MR,McCormack WT,Kemp EH,Gawkrodger DJ,Weetman AP,Picardo M,Leone G,Taïeb A,Jouary T,Ezzedine K,van Geel N,Lambert J,Overbeck A

    更新日期：2010-07-01 00:00:00

  • Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.

    abstract：:Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associat...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3268

    authors： Gutierrez-Achury J,Zhernakova A,Pulit SL,Trynka G,Hunt KA,Romanos J,Raychaudhuri S,van Heel DA,Wijmenga C,de Bakker PI

    更新日期：2015-06-01 00:00:00

  • Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.

    abstract：:Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale. Although many significant results have been derived from microarray studies, one limitation has been the lack of standards for presenting and exchanging such data. Here we present a proposal, the Minimum In...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1201-365

    authors： Brazma A,Hingamp P,Quackenbush J,Sherlock G,Spellman P,Stoeckert C,Aach J,Ansorge W,Ball CA,Causton HC,Gaasterland T,Glenisson P,Holstege FC,Kim IF,Markowitz V,Matese JC,Parkinson H,Robinson A,Sarkans U,Schulze-Krem

    更新日期：2001-12-01 00:00:00

  • A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.

    abstract：:Extremes of the electrocardiographic QT interval, a measure of cardiac repolarization, are associated with increased cardiovascular mortality. We identified a common genetic variant influencing this quantitative trait through a genome-wide association study on 200 subjects at the extremes of a population-based QT inte...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1790

    authors： Arking DE,Pfeufer A,Post W,Kao WH,Newton-Cheh C,Ikeda M,West K,Kashuk C,Akyol M,Perz S,Jalilzadeh S,Illig T,Gieger C,Guo CY,Larson MG,Wichmann HE,Marbán E,O'Donnell CJ,Hirschhorn JN,Kääb S,Spooner PM,Meitinger T

    更新日期：2006-06-01 00:00:00

  • Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

    abstract：:To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population controls across 73.5 million variants. We then imputed from these sequences ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3761

    authors： Luo Y,de Lange KM,Jostins L,Moutsianas L,Randall J,Kennedy NA,Lamb CA,McCarthy S,Ahmad T,Edwards C,Serra EG,Hart A,Hawkey C,Mansfield JC,Mowat C,Newman WG,Nichols S,Pollard M,Satsangi J,Simmons A,Tremelling M,Uh

    更新日期：2017-02-01 00:00:00

  • Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk.

    abstract：:Key challenges for human genetics, precision medicine and evolutionary biology include deciphering the regulatory code of gene expression and understanding the transcriptional effects of genome variation. However, this is extremely difficult because of the enormous scale of the noncoding mutation space. We developed a...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-018-0160-6

    authors： Zhou J,Theesfeld CL,Yao K,Chen KM,Wong AK,Troyanskaya OG

    更新日期：2018-08-01 00:00:00

  • Genome-wide association study of PR interval.

    abstract：:The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AG...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.517

    authors： Pfeufer A,van Noord C,Marciante KD,Arking DE,Larson MG,Smith AV,Tarasov KV,Müller M,Sotoodehnia N,Sinner MF,Verwoert GC,Li M,Kao WH,Köttgen A,Coresh J,Bis JC,Psaty BM,Rice K,Rotter JI,Rivadeneira F,Hofman A,Kors

    更新日期：2010-02-01 00:00:00

  • Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.

    abstract：:Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15-40 in Western European populations. The incidence of TGCT has risen dramatically over the last century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/72877

    authors： Rapley EA,Crockford GP,Teare D,Biggs P,Seal S,Barfoot R,Edwards S,Hamoudi R,Heimdal K,Fossâ SD,Tucker K,Donald J,Collins F,Friedlander M,Hogg D,Goss P,Heidenreich A,Ormiston W,Daly PA,Forman D,Oliver TD,Leahy M

    更新日期：2000-02-01 00:00:00