Abstract:
:Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associations that account for 18% of the genetic risk. Taking these new loci together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Gutierrez-Achury J,Zhernakova A,Pulit SL,Trynka G,Hunt KA,Romanos J,Raychaudhuri S,van Heel DA,Wijmenga C,de Bakker PIdoi
10.1038/ng.3268subject
Has Abstractpub_date
2015-06-01 00:00:00pages
577-8issue
6eissn
1061-4036issn
1546-1718pii
ng.3268journal_volume
47pub_type
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