当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > Foxj1 transcription factors are master regulators of the motile ciliogenic program.

Foxj1 transcription factors are master regulators of the motile ciliogenic program.

Abstract：

:Motile cilia induce fluid movement through their rhythmic beating activity. In mammals, the transcription factor Foxj1 has been implicated in motile cilia formation. Here we show that a zebrafish Foxj1 homolog, foxj1a, is a target of Hedgehog signaling in the floor plate. Loss of Foxj1a compromises the assembly of motile cilia that decorate floor plate cells. Besides the floor plate, foxj1a is expressed in Kupffer's vesicle and pronephric ducts, where it also promotes ciliary differentiation. We show that Foxj1a activates a constellation of genes essential for motile cilia formation and function, and that its activity is sufficient for ectopic development of cilia that resemble motile cilia. We also document that a paralogous gene, foxj1b, is expressed in the otic vesicle and seems to regulate motile cilia formation in this tissue. Our findings identify a dedicated master regulatory role for Foxj1 in the transcriptional program that controls the production of motile cilia.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Yu X,Ng CP,Habacher H,Roy S

doi

10.1038/ng.263

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1445-53

issue

12

eissn

1061-4036

issn

1546-1718

pii

ng.263

journal_volume

40

pub_type

杂志文章

相关文献

NATURE GENETICS文献大全
  • A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice.

    abstract：:Plant cytoplasmic male sterility (CMS) results from incompatibilities between the organellar and nuclear genomes and prevents self pollination, enabling hybrid crop breeding to increase yields. The Wild Abortive CMS (CMS-WA) has been exploited in the majority of 'three-line' hybrid rice production since the 1970s, but...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2570

    authors： Luo D,Xu H,Liu Z,Guo J,Li H,Chen L,Fang C,Zhang Q,Bai M,Yao N,Wu H,Wu H,Ji C,Zheng H,Chen Y,Ye S,Li X,Zhao X,Li R,Liu YG

    更新日期：2013-05-01 00:00:00

  • X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo.

    abstract：:During mammalian development, one of the two X chromosomes in female embryos is randomly inactivated in the somatic cell in order to achieve gene dosage compensation. But is X inactivation established simultaneously or is it accomplished over time in a lineage-dependent fashion? We have examined this question in mouse...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0293-170

    authors： Tan SS,Williams EA,Tam PP

    更新日期：1993-02-01 00:00:00

  • Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.

    abstract：:High rates of APOBEC-signature mutations are found in many tumors, but factors affecting this mutation pattern are not well understood. Here we explored the contribution of two common germline variants in the APOBEC3 region. SNP rs1014971 was associated with bladder cancer risk, increased APOBEC3B expression, and enri...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3670

    authors： Middlebrooks CD,Banday AR,Matsuda K,Udquim KI,Onabajo OO,Paquin A,Figueroa JD,Zhu B,Koutros S,Kubo M,Shuin T,Freedman ND,Kogevinas M,Malats N,Chanock SJ,Garcia-Closas M,Silverman DT,Rothman N,Prokunina-Olsson L

    更新日期：2016-11-01 00:00:00

  • Bioinformatics in the post-sequence era.

    abstract：:In the past decade, bioinformatics has become an integral part of research and development in the biomedical sciences. Bioinformatics now has an essential role both in deciphering genomic, transcriptomic and proteomic data generated by high-throughput experimental technologies and in organizing information gathered fr...

    journal_title：Nature genetics

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/ng1109

    authors： Kanehisa M,Bork P

    更新日期：2003-03-01 00:00:00

  • Convergent evolution of the genomes of marine mammals.

    abstract：:Marine mammals from different mammalian orders share several phenotypic traits adapted to the aquatic environment and therefore represent a classic example of convergent evolution. To investigate convergent evolution at the genomic level, we sequenced and performed de novo assembly of the genomes of three species of m...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3198

    authors： Foote AD,Liu Y,Thomas GW,Vinař T,Alföldi J,Deng J,Dugan S,van Elk CE,Hunter ME,Joshi V,Khan Z,Kovar C,Lee SL,Lindblad-Toh K,Mancia A,Nielsen R,Qin X,Qu J,Raney BJ,Vijay N,Wolf JB,Hahn MW,Muzny DM,Worley KC,

    更新日期：2015-03-01 00:00:00

  • Requirement for Wnt3 in vertebrate axis formation.

    abstract：:Several studies have implicated Wnt signalling in primary axis formation during vertebrate embryogenesis, yet no Wnt protein has been shown to be essential for this process. In the mouse, primitive streak formation is the first overt morphological sign of the anterior-posterior axis. Here we show that Wnt3 is expresse...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/11932

    authors： Liu P,Wakamiya M,Shea MJ,Albrecht U,Behringer RR,Bradley A

    更新日期：1999-08-01 00:00:00

  • The genomic landscape of schwannoma.

    abstract：:Schwannomas are common peripheral nerve sheath tumors that can cause debilitating morbidities. We performed an integrative analysis to determine genomic aberrations common to sporadic schwannomas. Exome sequence analysis with validation by targeted DNA sequencing of 125 samples uncovered, in addition to expected NF2 d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3688

    authors： Agnihotri S,Jalali S,Wilson MR,Danesh A,Li M,Klironomos G,Krieger JR,Mansouri A,Khan O,Mamatjan Y,Landon-Brace N,Tung T,Dowar M,Li T,Bruce JP,Burrell KE,Tonge PD,Alamsahebpour A,Krischek B,Agarwalla PK,Bi WL,Dun

    更新日期：2016-11-01 00:00:00

  • Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33.

    abstract：:Three hundred million individuals are at risk of infection by schistosomes and around 200,000 die each year of this disease. Severe clinical disease in schistosomiasis is often the consequence of heavy infection which, in several endemic areas, are determined largely by the susceptibility/resistance of individuals. Pr...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1096-181

    authors： Marquet S,Abel L,Hillaire D,Dessein H,Kalil J,Feingold J,Weissenbach J,Dessein AJ

    更新日期：1996-10-01 00:00:00

  • ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome.

    abstract：:Walker-Warburg syndrome (WWS) is clinically defined as congenital muscular dystrophy that is accompanied by a variety of brain and eye malformations. It represents the most severe clinical phenotype in a spectrum of diseases associated with abnormal post-translational processing of a-dystroglycan that share a defect i...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2252

    authors： Willer T,Lee H,Lommel M,Yoshida-Moriguchi T,de Bernabe DB,Venzke D,Cirak S,Schachter H,Vajsar J,Voit T,Muntoni F,Loder AS,Dobyns WB,Winder TL,Strahl S,Mathews KD,Nelson SF,Moore SA,Campbell KP

    更新日期：2012-05-01 00:00:00

  • A reference genome for pea provides insight into legume genome evolution.

    abstract：:We report the first annotated chromosome-level reference genome assembly for pea, Gregor Mendel's original genetic model. Phylogenetics and paleogenomics show genomic rearrangements across legumes and suggest a major role for repetitive elements in pea genome evolution. Compared to other sequenced Leguminosae genomes,...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-019-0480-1

    authors： Kreplak J,Madoui MA,Cápal P,Novák P,Labadie K,Aubert G,Bayer PE,Gali KK,Syme RA,Main D,Klein A,Bérard A,Vrbová I,Fournier C,d'Agata L,Belser C,Berrabah W,Toegelová H,Milec Z,Vrána J,Lee H,Kougbeadjo A,Térézol

    更新日期：2019-09-01 00:00:00

  • Rapid amplification of a retrotransposon subfamily is evolving the mouse genome.

    abstract：:Retrotransposition affects genome structure by increasing repetition and producing insertional mutations. Dispersion of the retrotransposon L1 throughout mammalian genomes suggests that L1 activity might be an important evolutionary force. Here we report that L1 retrotransposition contributes to rapid genome evolution...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/3104

    authors： DeBerardinis RJ,Goodier JL,Ostertag EM,Kazazian HH Jr

    更新日期：1998-11-01 00:00:00

  • A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase.

    abstract：:The development of a quantitative understanding of viral evolution and the fitness landscape in HIV-1 drug resistance is a formidable challenge given the large number of available drugs and drug resistance mutations. We analyzed a dataset measuring the in vitro fitness of 70,081 virus samples isolated from HIV-1 subty...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.795

    authors： Hinkley T,Martins J,Chappey C,Haddad M,Stawiski E,Whitcomb JM,Petropoulos CJ,Bonhoeffer S

    更新日期：2011-05-01 00:00:00

  • Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

    abstract：:Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR-Cas9-mediated forward genetic screen, we identified MORC2 as an essential gene required for epigenetic silencing b...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3878

    authors： Tchasovnikarova IA,Timms RT,Douse CH,Roberts RC,Dougan G,Kingston RE,Modis Y,Lehner PJ

    更新日期：2017-07-01 00:00:00

  • Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome.

    abstract：:Beare-Stevenson cutis gyrata syndrome (MIM 123790) is an autosomal dominant condition characterized by the furrowed skin disorder of cutis gyrata, acanthosis nigricans, craniosynostosis, craniofacial dysmorphism, digital anomalies, umbilical and anogenital abnormalities and early death. Many of these features are char...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0896-492

    authors： Przylepa KA,Paznekas W,Zhang M,Golabi M,Bias W,Bamshad MJ,Carey JC,Hall BD,Stevenson R,Orlow S,Cohen MM Jr,Jabs EW

    更新日期：1996-08-01 00:00:00

  • Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families.

    abstract：:The hereditary breast cancer gene BRCA2 was recently cloned and is believed to account for almost half of site-specific breast cancer families and the majority of male breast cancer families. We screened 49 site-specific breast cancer families for mutations in the BRCA2 gene using single strand conformation analysis (...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0596-120

    authors： Phelan CM,Lancaster JM,Tonin P,Gumbs C,Cochran C,Carter R,Ghadirian P,Perret C,Moslehi R,Dion F,Faucher MC,Dole K,Karimi S,Foulkes W,Lounis H,Warner E,Goss P,Anderson D,Larsson C,Narod SA,Futreal PA

    更新日期：1996-05-01 00:00:00

  • Mouse segmental duplication and copy number variation.

    abstract：:Detailed analyses of the clone-based genome assembly reveal that the recent duplication content of mouse (4.94%) is now comparable to that of human (5.5%), in contrast to previous estimates from the whole-genome shotgun sequence assembly. However, the architecture of mouse and human genomes differs markedly: most mous...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.172

    authors： She X,Cheng Z,Zöllner S,Church DM,Eichler EE

    更新日期：2008-07-01 00:00:00

  • Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster.

    abstract：:The abundance of transposable elements and DNA repeat sequences in mammalian genomes raises the question of whether such insertions represent passive evolutionary baggage or may influence the expression of complex traits. We addressed this question in Drosophila melanogaster, in which the effects of single transposabl...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1823

    authors： Rollmann SM,Magwire MM,Morgan TJ,Ozsoy ED,Yamamoto A,Mackay TF,Anholt RR

    更新日期：2006-07-01 00:00:00

  • PHF6 mutations in T-cell acute lymphoblastic leukemia.

    abstract：:Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with an increased incidence in males. In this study, we report the identification of inactivating mutations and deletions in the...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.542

    authors： Van Vlierberghe P,Palomero T,Khiabanian H,Van der Meulen J,Castillo M,Van Roy N,De Moerloose B,Philippé J,González-García S,Toribio ML,Taghon T,Zuurbier L,Cauwelier B,Harrison CJ,Schwab C,Pisecker M,Strehl S,Langerak AW

    更新日期：2010-04-01 00:00:00

  • Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures.

    abstract：:Advances in sequencing technologies have enabled the identification of mutations acquired by bacterial pathogens during infection. However, it remains unclear whether adaptive mutations fix in the population or lead to pathogen diversification within the patient. Here we study the genotypic diversity of Burkholderia d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2848

    authors： Lieberman TD,Flett KB,Yelin I,Martin TR,McAdam AJ,Priebe GP,Kishony R

    更新日期：2014-01-01 00:00:00

  • Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.

    abstract：:It is now feasible to map disease genes by screening the genome for linkage disequilibrium between the disease and marker alleles. This report presents the first application of this approach for a previously unmapped locus. A gene for benign recurrent intrahepatic cholestasis (BRIC) was mapped to chromosome 18 by sear...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1294-380

    authors： Houwen RH,Baharloo S,Blankenship K,Raeymaekers P,Juyn J,Sandkuijl LA,Freimer NB

    更新日期：1994-12-01 00:00:00

  • Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation.

    abstract：:Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL) has recently been defined based on a highly characteristic constellation of abnormalities observed by magnetic resonance imaging and spectroscopy. LBSL is an autosomal recessive disease, most often manifesting in early childho...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng2013

    authors： Scheper GC,van der Klok T,van Andel RJ,van Berkel CG,Sissler M,Smet J,Muravina TI,Serkov SV,Uziel G,Bugiani M,Schiffmann R,Krägeloh-Mann I,Smeitink JA,Florentz C,Van Coster R,Pronk JC,van der Knaap MS

    更新日期：2007-04-01 00:00:00

  • A genome-wide association study identifies two new risk loci for Graves' disease.

    abstract：:Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls....

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.898

    authors： Chu X,Pan CM,Zhao SX,Liang J,Gao GQ,Zhang XM,Yuan GY,Li CG,Xue LQ,Shen M,Liu W,Xie F,Yang SY,Wang HF,Shi JY,Sun WW,Du WH,Zuo CL,Shi JX,Liu BL,Guo CC,Zhan M,Gu ZH,Zhang XN,Sun F,Wang ZQ,Song ZY,Zou CY

    更新日期：2011-08-14 00:00:00

  • Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development.

    abstract：:We identified homozygous truncating mutations in HOXA1 in three genetically isolated human populations. The resulting phenotype includes horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation and a...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1636

    authors： Tischfield MA,Bosley TM,Salih MA,Alorainy IA,Sener EC,Nester MJ,Oystreck DT,Chan WM,Andrews C,Erickson RP,Engle EC

    更新日期：2005-10-01 00:00:00

  • A functional genomics predictive network model identifies regulators of inflammatory bowel disease.

    abstract：:A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) usin...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3947

    authors： Peters LA,Perrigoue J,Mortha A,Iuga A,Song WM,Neiman EM,Llewellyn SR,Di Narzo A,Kidd BA,Telesco SE,Zhao Y,Stojmirovic A,Sendecki J,Shameer K,Miotto R,Losic B,Shah H,Lee E,Wang M,Faith JJ,Kasarskis A,Brodmerkel C

    更新日期：2017-10-01 00:00:00

  • Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.

    abstract：:We present here a Sleeping Beauty-based transposition system that offers a simple and efficient way to investigate the regulatory architecture of mammalian chromosomes in vivo. With this system, we generated several hundred mice and embryos, each with a regulatory sensor inserted at a random genomic position. This lar...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.790

    authors： Ruf S,Symmons O,Uslu VV,Dolle D,Hot C,Ettwiller L,Spitz F

    更新日期：2011-03-20 00:00:00

  • The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta.

    abstract：:Trophoblast cells of the placenta are established at the blastocyst stage and differentiate into specialized subtypes after implantation. In mice, the outer layer of the placenta consists of trophoblast giant cells that invade the uterus and promote maternal blood flow to the implantation site by producing cytokines w...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/77076

    authors： Anson-Cartwright L,Dawson K,Holmyard D,Fisher SJ,Lazzarini RA,Cross JC

    更新日期：2000-07-01 00:00:00

  • Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

    abstract：:Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide association studies (GWAS) for six erythrocyte traits, including hemoglobin concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemo...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.466

    authors： Ganesh SK,Zakai NA,van Rooij FJ,Soranzo N,Smith AV,Nalls MA,Chen MH,Kottgen A,Glazer NL,Dehghan A,Kuhnel B,Aspelund T,Yang Q,Tanaka T,Jaffe A,Bis JC,Verwoert GC,Teumer A,Fox CS,Guralnik JM,Ehret GB,Rice K,Feli

    更新日期：2009-11-01 00:00:00

  • New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

    abstract：:Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in indepe...

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41588-018-0321-7

    authors： Shrine N,Guyatt AL,Erzurumluoglu AM,Jackson VE,Hobbs BD,Melbourne CA,Batini C,Fawcett KA,Song K,Sakornsakolpat P,Li X,Boxall R,Reeve NF,Obeidat M,Zhao JH,Wielscher M,Weiss S,Kentistou KA,Cook JP,Sun BB,Zhou J,Hu

    更新日期：2019-03-01 00:00:00

  • An inducible long noncoding RNA amplifies DNA damage signaling.

    abstract：:Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA damage response. DNA damage activated transcription of the DINO (Damage Induced Noncoding) lncRNA via p53. DINO was required for p53-dependent gen...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3673

    authors： Schmitt AM,Garcia JT,Hung T,Flynn RA,Shen Y,Qu K,Payumo AY,Peres-da-Silva A,Broz DK,Baum R,Guo S,Chen JK,Attardi LD,Chang HY

    更新日期：2016-11-01 00:00:00

  • A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2.

    abstract：:Obesity is a major predisposing factor for the development of several chronic diseases including non-insulin dependent diabetes mellitus (NIDDM) and coronary heart disease (CHD). Leptin is a serum protein which is secreted by adipocytes and thought to play a role in the regulation of body fat. Leptin levels in humans ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0397-273

    authors： Comuzzie AG,Hixson JE,Almasy L,Mitchell BD,Mahaney MC,Dyer TD,Stern MP,MacCluer JW,Blangero J

    更新日期：1997-03-01 00:00:00