Abstract:
:Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Gudbjartsson DF,Bjornsdottir US,Halapi E,Helgadottir A,Sulem P,Jonsdottir GM,Thorleifsson G,Helgadottir H,Steinthorsdottir V,Stefansson H,Williams C,Hui J,Beilby J,Warrington NM,James A,Palmer LJ,Koppelman GH,Heinzmanndoi
10.1038/ng.323subject
Has Abstractpub_date
2009-03-01 00:00:00pages
342-7issue
3eissn
1061-4036issn
1546-1718pii
ng.323journal_volume
41pub_type
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