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PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.

Abstract：

:We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, P(nominal/lambda corrected) = 5.91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Schormair B,Kemlink D,Roeske D,Eckstein G,Xiong L,Lichtner P,Ripke S,Trenkwalder C,Zimprich A,Stiasny-Kolster K,Oertel W,Bachmann CG,Paulus W,Högl B,Frauscher B,Gschliesser V,Poewe W,Peglau I,Vodicka P,Vávrová J,S

doi

10.1038/ng.190

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

946-8

issue

8

eissn

1061-4036

issn

1546-1718

pii

ng.190

journal_volume

40

pub_type

杂志文章

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