[Antacids for postoperative prevention of stress ulcer in infants: a dose finding study].

Abstract:

UNLABELLED:In the prophylaxis of stress ulcers with antacids in young infants there are no recommendations of dosages that consider the physiologic maturation of gastric acid secretion. During the first six month of life the amount of gastric acid secretion in relation to body weight and body surface area increases exponentially. Therefore adult dosages of antacids cannot be transferred to infants. METHODS:In a cross over study 12 infants aged between 4 and 174 days, who had been undergoing a cardiosurgical intervention with the heart lung machine, were treated during 48 hours with 2 different antacid regimens over a period of 24 hours each, monitoring the gastric pH continuously. The used antacid consisted of an aluminium-magnesium complex (Al(OH)3, 90 mg/ml and Mg(OH)2, 60 mg/ml): Regimen A: 6 x 0.5 ml per kg body weight. Regimen B: 0.25 ml per kg body weight at a gastric pH less than 3, with the pH read every 30 minutes. RESULTS:Compared to 28 applications under regimen B, 72 single doses were given under regimen A, 58 of them at a gastric pH of higher than 3. Thus, the mean administered dose was significant lower under regimen B (2.2 ml) than under regimen A (12.0 ml). Consequently, the mean level of gastric pH was higher under regimen A (median: 5.96 +/- 1.31 versus 4.94 +/- 1.16). pH-values lower than 3 were more often measured under regimen B, whereas the phases at this pH-level were longer under regimen A. CONCLUSION:The usual body weight related dosage of antacids seems to be to high for early infancy. In the face of the discrepancy of the administered antacid quantity comparing regimen A with regimen B, it seems to be reasonable for the studied age group to reduce the single antacid dose to 0.25 ml/kg body weight while adhering to a high application frequency of 6 times a day.

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Kentrup H,Skopnik H,Wolter L,Engelhart W,Nauert C,Heimann G

doi

10.1055/s-2008-1043985

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

14-6

issue

1

eissn

0300-8630

issn

1439-3824

journal_volume

208

pub_type

临床试验,杂志文章,随机对照试验
  • [Diagnostic and differential-diagnostic considerations regarding the assessment of children's reactions within the scope of psychosocial care in paediatric oncology and haematology].

    abstract::Oncological diseases in children and adolescents represent a considerable burden for the children themselves and for their families. In order to position such concomitants of a life-threatening disease appropriately among the diagnostic options of psychosocial cancer care one is repeatedly confronted with the issue of...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-985872

    authors: Schreiber-Gollwitzer B,Gollwitzer K

    更新日期:2007-11-01 00:00:00

  • [Familial chromosome translocation (1;5;15) as a cause of partial trisomy 1p].

    abstract::An unbalanced structural chromosome aberration was found in a 6-year-old girl. Mother and maternal grandmother were shown to be carriers of a complex balanced translocation involving chromosomes 1, 5 and 15 and are of normal phenotype. The unbalanced status in the proband was defined as a partial trisomy 1p21-1p31. Pa...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026754

    authors: Schürmann M,Wethling H,Niemeyer ML,Schwinger E

    更新日期:1987-01-01 00:00:00

  • Assessment of Needs for Counseling After Prenatal Diagnosis of Congenital Heart Disease - A Multidisciplinary Approach.

    abstract:BACKGROUND:Congenital heart disease is the most common cause of major congenital anomalies. After prenatal diagnosis effective counseling is crucial. However, little research has been undertaken in determining the most effective techniques. OBJECTIVES:To develop a questionnaire suitable to assess parental needs for co...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/a-0633-3331

    authors: Kovacevic A,Simmelbauer A,Starystach S,Elsässer M,Sohn C,Müller A,Bär S,Gorenflo M

    更新日期:2018-09-01 00:00:00

  • [Acute leukemia in a 13-year old boy with a synchronous occurrence of lympho- and monoblasts (author's transl)].

    abstract::The synchronous occurrence of blasts of the lymphatic and myelogenous lineage in acute leukemia has been rarely observed. Reviewing individual case reports it is suggested that malignant transformation already starts at the level of the stem cell. We are reporting a case of a 13-year old boy who initially showed morph...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034453

    authors: Creutzig U,Eschenbach C,Ritter J,Schellong G

    更新日期:1981-05-01 00:00:00

  • [Experiences with enteral nutrition of patients with cystic fibrosis (CF) via a percutaneous endoscopic gastrostomy (PEG)].

    abstract:BACKGROUND:We wanted improve the nutritional status of patients with cystic fibrosis with enteral feeding via a percutaneous endoscopic gastrostomy (PEG). PATIENTS AND METHODS:In a period of 8 years 11 patients underwent a percutaneous endoscopic gastrostomy (PEG), 4 males and 7 females, in the median 14,9 years of ag...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2001-18460

    authors: Richter T,Meier C,Steppberger K,Knorrek G,Lietz T

    更新日期:2001-11-01 00:00:00

  • [Integration of psychosocial services into the management of the child with cancer].

    abstract::The integration of colleagues from psychosocial occupations into the traditional team of doctors and nurses demands a holistic treatment concept, the general desire for interdisciplinary action, and readiness for patience in the process of mutual learning. The acceptance of the psychosocial services by the patient and...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026726

    authors: Janssen F

    更新日期:1989-07-01 00:00:00

  • [Trans-Sectoral Patient Care in Pediatric Oncology: Quality Assurance by Novel Reimbursement Models for Outpatient Services].

    abstract:BACKGROUND:The medical care of pediatric cancer patients in the German health care system relies on special structures. All children and adolescents with a diagnosis of cancer receive uniform treatment within clinical studies or registers and exclusively at centers which can ensure interdisciplinary care by a multiprof...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/a-1158-9341

    authors: Reinke E,Jürgens H,Haier J,Froehlich B,Kontny U,Rossig C

    更新日期:2020-11-01 00:00:00

  • [Hyperammonemia due to ornithine transcarbamylase deficiency--a cause of lethal metabolic crisis during the newborn period and infancy (author's transl)].

    abstract::A severe hyperammonemia is the characteristic finding in patients with enzyme defects in urea cycle and one of the main causes of the acute metabolic crisis dsuring the newborn period and infancy. A case report is given about two male infants, who died in the age of one and of seven months respectively. In the second ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035594

    authors: Schuchmann L,Colombo JP,Fischer H

    更新日期:1980-05-01 00:00:00

  • [Pneumatocele after hydrocarbon aspiration].

    abstract::Report of accidental ingestion and aspiration of lamp oil of a boy aged 16 months. He develops in a few hours a severe pneumonitis with tachycardia. Echocardiography shows diminished contractability. After losing his symptoms, the chest x-rays on the 13th day show bilateral pneumatoceles. The course remains asymptomat...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1043916

    authors: Leuchter D,Stübecke W,Oberschulte-Beckmann D

    更新日期:1998-11-01 00:00:00

  • Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor.

    abstract::Growing teratoma is still an often unsolved problem especially in male with mixed malignant GCTs of the testis or the mediastinum. This specific situation with progressive tumor growth and simultaneous normalization of tumor markers during or after treatment of malignant GCTs with teratomatous elements is judged as a ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0029-1220738

    authors: Calaminus G,Schneider DT,Weissbach L,Schönberger S,Okpanyi V,Leuschner I,Poremba C,Göbel U

    更新日期:2009-05-01 00:00:00

  • Lichen sclerosus Mistaken for Sexual Abuse--Prevention of Victimization.

    abstract::This case report describes the forensic examination of 7 girls aged between 4-11 years with suspected sexual abuse. The children had been reported by local pediatricians, hospital physicians or authorities such as the youth welfare office and police due to mucosal changes in the anogenital area. All children presented...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0034-1395616

    authors: Navarro-Crummenauer B,Pickhardt CP,Urban R

    更新日期:2015-07-01 00:00:00

  • [Peritonitis and infection in children with idiopathic nephrotic syndrome].

    abstract::We analyzed episodes of peritonitis and/or sepsis associated with the idiopathic nephrotic syndrome (ns) in 23 children treated between 1975 and 1985 at our clinic. 37.5% of the children with infantile ns, 16% of those with steroidsensible ns, and 13.6% of those with steroidresistant ns developed peritonitis. Children...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033683

    authors: Feldhoff C,Kleine L,Bachmann H

    更新日期:1988-01-01 00:00:00

  • [Supplementary intravenous nutrition in term and preterm neonates (author's transl)].

    abstract::16 term and preterm neonates received intravenous nutriton for at least three days. The dosage was 1--2 g amino acids, 1 g of fat, and 8--10 g glucose per kg body weight and day. Compatibility was investigated by daily determinations of the amino acid pattern in the serum and measurement of free fatty acids and trigly...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Petrich C,Stephan U,Remy R,von Voss H,Göbel U,Herpertz LM

    更新日期:1979-07-01 00:00:00

  • The impact of an inpatient family-oriented rehabilitation program on parent-reported psychological symptoms of chronically ill children.

    abstract:OBJECTIVE:To investigate the change of psychological symptoms and quality of life in children and adolescents with congenital heart disease, cancer, or cystic fibrosis after a family-oriented inpatient rehabilitation program. METHODS:302 participants in the intervention (aged 4-17 years, mean=8.7) were assessed using ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0030-1262831

    authors: Goldbeck L,Hölling I,Schlack R,West C,Besier T

    更新日期:2011-03-01 00:00:00

  • [Achalasia, alacrimia and cortisol deficiency--Allgrove syndrome].

    abstract::Review of a rare multisystem disorder with the main symptoms achalasia of the esophagus, alacrimia and glucocorticoid deficiency as well as multiple other symptoms especially of the nervous system. Report of one case diagnosed in the age of 11.5 years with a case history of about 7 years. Description of the danger to ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1046527

    authors: Hübschmann K

    更新日期:1995-05-01 00:00:00

  • [The infantile chronic-visceral form of niemann-Pick diseases (author's transl)].

    abstract::A report was made of three patients who exhibited pronounced heptosplenomegaly at the time of hospital admission: a six-year-old girl and two brothers, 1 year 4 months and 4 years 4 months of age. As is typical for Niemann-Pick disease, foam cells were found in the bone marrow and the liver biopsy specimens for the th...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Priscu R,Pancu L,Balan A,Petrescu TC,Iacob C

    更新日期:1977-11-01 00:00:00

  • [NHL-BFM 90 therapy study in treatment of malignant non-Hodgkin's lymphoma in children and adolescents. Part 3: An intermediate term analysis of the B-NHL/B-ALL].

    abstract::The aims of trial NHL-BFM 90 for patients (pts) suffering from B-cell neoplasms are to prove whether: 1. Treatment for pts with complete resection can be reduced from 3 to 2 therapy courses; 2. Results for pts of stage III with large abdominal tumors can be improved by high dose (HD) chemotherapy; 3. Survival for pts ...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-2008-1046610

    authors: Reiter A,Schrappe M,Yakisan E,Sauter S,Ebell W,Zimmermann M,Hartmann W,Kremens B,Kuhn N,Claviez A

    更新日期:1994-07-01 00:00:00

  • Protein supplementation of human milk for the nutrition of VLBW-infants: human milk protein vs. meat protein hydrolysate.

    abstract::In 25 very low birth weight infants appropriate for gestational age the influences of different human milk (HM) preparations on weight gain, gross indices of nitrogen metabolism and energy balance were studied during the second month of postnatal life. HM was fortified either by HM-protein (HMP) or by an enzymatic mea...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-1025538

    authors: Boehm G,Senger H,Friedrich M,Müller DM,Beyreiss K

    更新日期:1990-09-01 00:00:00

  • [The meconium ileus equivalent in mucoviscidosis].

    abstract::Meconium ileus equivalent (MIE) complicating cystic fibrosis of the pancreas (CF) increases in frequently with increasing age of patients. In the present paper the course of 11 children and adolescents with MIE diagnosed and treated at the University Dept. of Paediatrics in Zürich during the last 15 years, i.e. 9% of ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034390

    authors: Rosenberg E,Shmerling DH

    更新日期:1983-09-01 00:00:00

  • Hematopoietic stem cell transplantation for severe combined immunodeficiency.

    abstract::Severe combined immunodeficiency (SCID) is a heterogeneous group of congenital diseases characterized by their presentation with life threatening infections in the first months of life. The clinical presentation and the therapeutic outcome is influenced by multiple factors: the genetic defect, infectious complications...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1287826

    authors: Hönig M,Schulz A,Friedrich W

    更新日期:2011-11-01 00:00:00

  • [Social deprivation in early childhood: endangered development and prevention].

    abstract::In view of present-day knowledge and findings relating to the development of young children, the stimulating interaction between the child and its social and material surroundings must be considered of supreme importance. Any disturbance or radical restriction of the structure of social relationships can thus seriousl...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034076

    authors: Jungmann J

    更新日期:1984-09-01 00:00:00

  • [Progressive combined immunity defect with ectomesodermal dysplasia (author's transl)].

    abstract::A boy with dysplastic features had to be treated for recurrent diarrhoea and bronchitis since his tenth month of life. Defects in humoral and cellular immunity were found. The ecto-mesodermal abnormalities are so characteristic that in connection with the immunological changes it seems to be justified to assume a yet ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Tympner KD,Belohradsky B,Eife R,Klose PK

    更新日期:1978-11-01 00:00:00

  • Pathology and molecular biology of teratomas in childhood and adolescence.

    abstract::The biologic behaviour of teratomas depends on various interdependent clinical and epidemiologic variables such as the age at diagnosis, sex, tumor site, histology which all correlate to different cytogenetic and molecular biologic aberrations. Thus, testicular teratomas of infancy are generally benign. Accordingly, p...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2006-942271

    authors: Harms D,Zahn S,Göbel U,Schneider DT

    更新日期:2006-11-01 00:00:00

  • [Arteriovenous intracranial and extracranial angiomas in infants and children (author's transl)].

    abstract::Five patients with arteriovenous angiomas in the head (2 galea angiomas, 1 mixed form with extracranial and intracranial localization of the arteriovenous fistulas and 2 intracranial arteriovenous fistulas) were described. Four patients were examined as newborns or infants. Oximetric data, intracardial pressure and ci...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Pohl V

    更新日期:1976-05-01 00:00:00

  • What are Palliative Care Physicians for Adults Taught on Palliative Care for Children? Paediatric Aspects in Palliative Care Curricula for Adults.

    abstract:BACKGROUND:Children suffering from life limiting diseases are frequently cared for by adult palliative care teams due to missing paediatric structures in that field. However it is questionable whether palliative care curricula for physicians comprehensively cover issues of paediatric palliative care (PaedPC). AIM:To i...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0035-1569266

    authors: Schiessl C,Gottschling S,Gronwald BM

    更新日期:2016-01-01 00:00:00

  • [Wiedemann-Beckwith syndrome: clinical characteristics, constitutional chromosome abnormalities and tumor incidence].

    abstract::The observation of constitutional chromosome abnormalities in a one and half year old boy with Wiedemann-Beckwith syndrome (WBS) and hepatoblastoma prompted us to review the currently available literature dealing with this subject. In approximately 500 published cases with complete and incomplete forms of WBS, 42 mali...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026804

    authors: Haas OA,Zoubek A,Grümayer ER,Ferstl G,Gadner H

    更新日期:1987-07-01 00:00:00

  • Cognitive function in patients with epidermolysis bullosa: social adjustment and emotional problems.

    abstract:BACKGROUND:Children with Epidermolysis bullosa (EB) suffer from an intractable, burdensome skin disease that may result in cognitive as well as social and emotional problems. PATIENTS:To assess cognitive problems in patients with EB, we investigated 20 affected children and adolescents, 6-17 years of age (mean: 10.8 y...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0031-1295437

    authors: Feldmann R,Weglage J,Frosch M

    更新日期:2012-01-01 00:00:00

  • [Glutaric acidemia/glutaric aciduria I as differential chorea minor diagnosis].

    abstract::Glutaracidemia/glutaraciduria type I is an acute or subacute neuropathic disorder of infancy or early childhood. The following symptoms characterize the clinical course: macrocephalus present at birth, cerebral atrophy revealed by CT or MRI scans, most striking in the frontal and temporal lobes, choreoathetosis and dy...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025211

    authors: Voll R,Hoffmann GF,Lipinski CG,Trefz FK,Weisser J

    更新日期:1993-03-01 00:00:00

  • [The Value of Conventional Radiographs of the Pelvis in Detection of Perthes Disease 3 Months After an Episode of Acute Transient Synovitis].

    abstract::Background: Transient synovitis is the most common hip joint disorder in children. Perthes disease occurs around the same age and may not be distinguishable to an episode of transient synovitis in the early stage. Therefore all children in our clinic with transient synovitis underwent a follow-up X-ray 3 months later ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0042-116150

    authors: Lenoir U,Slongo T,Aghayev E,Joeris A

    更新日期:2017-03-01 00:00:00

  • A massive intestinal vaso-occlusive crisis or "girdle syndrome" in a 6-year-old boy observed as a first manifestation of sickle cell disease.

    abstract:UNLABELLED:Sickle cell disease is a chronic hematologic disease with variable but often severe systemic symptoms. In this report, we describe a 6-year-old boy presenting with acute bowel pseudo-obstruction. During this episode, previously undiagnosed sickle cell disease was discovered upon peripheral blood smear analys...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0034-1389907

    authors: Knorr M,Bienemann K,Walde G,Kaufhold A,Schündeln MM

    更新日期:2014-11-01 00:00:00