Abstract:
:Growing teratoma is still an often unsolved problem especially in male with mixed malignant GCTs of the testis or the mediastinum. This specific situation with progressive tumor growth and simultaneous normalization of tumor markers during or after treatment of malignant GCTs with teratomatous elements is judged as a fatal situation if this situation can not be controlled by extensive surgery, as teratoma are not sensible to chemotherapy or irradiation. Here, we report the case history of a 17-year old male patient with a testicular malignant GCT and wide spread lymph node metastases, who developed a rapidly progressive growing teratoma within the lymph node metastases. Within the molecular profile of the tumor we could find a cytogenetic picture typically found in malignant adult GCTs. In view of the bulky abdominal, thoracic and cervical metastases and the uncontrolled tumor progression, the situation was considered incurable. However, following an individual treatment attempt, this patient was treated with a four-agent combination of drugs with antiangiogenetic potential as well as low-dose cyclic chemotherapy. This approach resulted in a sustained disease stabilization followed by extensive surgical resection of the metastases. We therefore would like to highlight this treatment approach in unresectable growing teratoma and would like to stimulate further research and collaboration to come to an optimized treatment suggestion for this group of poor prognostic patients.
journal_name
Klin Padiatrjournal_title
Klinische Padiatrieauthors
Calaminus G,Schneider DT,Weissbach L,Schönberger S,Okpanyi V,Leuschner I,Poremba C,Göbel Udoi
10.1055/s-0029-1220738subject
Has Abstractpub_date
2009-05-01 00:00:00pages
136-40issue
3eissn
0300-8630issn
1439-3824journal_volume
221pub_type
杂志文章abstract::Transfusion-induced hemochromatosis remains a major therapeutic complication in the management of patients with chronic hemolytic anemias. Red cell units harvested with blood cell separators have an average estimated mean cell age of 30 days, compared to 60 days for unfractionated blood. Our initial experience with tr...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1033936
更新日期:1985-03-01 00:00:00
abstract::The Thorax-Tube according to Matthys and its successful application in 18 premature and mature newborns and older children is described. The advantages of this new device are discussed. ...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::Since 1980, a growing number of pediatric patients with mutism following posterior fossa surgery have been recognized. This syndrome typically affects children and in rare cases young adults who become mute one or two days after tumor operation but do not show disturbances of consciousness or language comprehension. T...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1043886
更新日期:1998-07-01 00:00:00
abstract::Initially a right sided pulmonary hypoplasia was diagnosed in our patient at the age of 9 years. The previous years were characterized by recurrent pneumonia, bronchitis and daily coughing fits. Findings of the chest radiograph suggested the diagnosis of right sided hypoplasia. The right hemithorax was small with medi...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2007-1025500
更新日期:1990-03-01 00:00:00
abstract::Corticosteroids for treatment or prevention of pulmonary disease are milestones in the management of preterm infants nowadays. Prenatal maternal administration as well as postnatal treatment of the mechanically ventilated preterm infant with bronchopulmonary dysplasia (BPD) are considered to be established concepts. H...
journal_title:Klinische Padiatrie
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1043969
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Currently there are 3 pneumococcal vaccines available in Germany. The aim of this study is to evaluate the potential of the three currently available pneumococcal vaccines to reduce the burden of invasive pneumococcal disease in children. SUBJECTS:Children younger than 16 years who have been hospitalized be...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-0030-1268465
更新日期:2011-03-01 00:00:00
abstract::We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cy...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1046547
更新日期:1995-07-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2008-1046460
更新日期:1996-05-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-0042-115300
更新日期:2017-01-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2001-18460
更新日期:2001-11-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:First-line treatment in AML commonly included high cumulative doses of anthracyclines with an increasing risk of cardiotoxicity. Liposomal daunorubicin (L-DNR) is thought to be less cardiotoxic without impairment of efficacy. METHODS:The AML-BFM REZ 97 study included two reinduction blocks with L-DNR (2 x 6...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2002-33185
更新日期:2002-07-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/a-0637-9653
更新日期:2018-10-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2004-832356
更新日期:2004-11-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章,评审
doi:10.1055/s-2005-872499
更新日期:2005-11-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2007-1025334
更新日期:1992-03-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2000-9667
更新日期:2000-07-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1034383
更新日期:1983-07-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章,评审
doi:10.1055/s-2007-1025390
更新日期:1991-01-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1035594
更新日期:1980-05-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1043941
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journal_title:Klinische Padiatrie
pub_type: 杂志文章,多中心研究
doi:10.1055/s-2008-1043788
更新日期:1999-07-01 00:00:00
abstract::Report about cyclic agranulocytosis in a 10 1/2 years old girls, having stomatitis, sore throat and fever up to 39 degrees C in the interval of approximately 3 weeks since the age of 6 months. By the prophylactic treatment with pulverized tetracyclin, which is already given 2 days prior to the expected decrease of the...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 共识发展会议,杂志文章
doi:10.1055/s-0032-1306277
更新日期:2012-04-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章,评审
doi:10.1055/s-2001-16857
更新日期:2001-07-01 00:00:00
abstract::Short presentation of the common procedures to avoid transmission of human-immunodeficiency-virus (HIV) by hemoderivates especially clotting-factor-preparations. The stepwise seroconversion (ELISA, IFT, Western-blot) of HIV is shown in a 7 5/12 ys old boy with hemophilia A after administration of a dry-heated factor V...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-2008-1033736
更新日期:1988-09-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
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journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::Purpose To determine the population prevalence and risk factors of myopia in children and adolescents in Germany. Methods The prevalence of myopia in Germany was computed using data from the 2003-2006 German Health Interview and Examination Survey for Children and Adolescents (N=17 640, 49% girls). Status of myopia wa...
journal_title:Klinische Padiatrie
pub_type: 杂志文章
doi:10.1055/s-0043-102938
更新日期:2017-07-01 00:00:00