Bleeding and thrombosis in children with acute lymphoblastic leukaemia, treated according to the ALL-BFM-90 protocol.

abstract：:To evaluate the impact of megatherapy on the outcome of high risk neuroblastoma, 39 patients with stage IV neuroblastoma, who underwent megatherapy, were analyzed retrospectively and compared to 49 patients, who continued chemotherapy according to the German cooperative trial NB85. The groups were comparable concernin...

journal_title：Klinische Padiatrie

authors： Hero B,Kremens B,Klingebiel T,Bender-Götze C,Burdach S,Schrappe M,Berthold F

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:The prognosis of children with multisystem Langerhans cell histiocytosis (LCH) has improved with the application of chemotherapy. However, treatment strategies used varied from conservative approach with treatment only during disease exacerbation to intensive chemotherapy starting immediately after diagnosis...

journal_title：Klinische Padiatrie

authors： Minkov M,Grois N,Heitger A,Pötschger U,Westermeier T,Gadner H

更新日期：2000-07-01 00:00:00

abstract：:The diagnosis of HFI is easily missed during childhood. It should be suspected in children presenting with hepatomegaly and an isolated increase in GGT. A carefully taken nutritional history forms the basis of the diagnosis of HFI which can be confirmed by molecular analysis with a sensitivity of > 95%. I.v. fructose ...

journal_title：Klinische Padiatrie

authors： Wössmann W,Wiemann J,Körber F,Gortner L

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain tumors (PNET). These common childhood brain tumors are composed of...

journal_title：Klinische Padiatrie

authors： Grotzer MA,Janss AJ,Phillips PC,Trojanowski JQ

更新日期：2000-07-01 00:00:00

abstract：:An increasing number of children with acute leukemia show cerebral complications. 10 out of 78 children treated in our hospital for acute lymphoblastic leukemia or non-Hodgkin's lymphoma who underwent remission induction therapy or were in continuous complete remission developed central nervous system complications. D...

journal_title：Klinische Padiatrie

authors： Ludwig R,Meyer E,Brandeis WE

更新日期：1980-07-01 00:00:00

abstract：:Background For the new cystic fibrosis (CF) newborn screening program in Germany the Federal Joint Committee (G-BA) implemented a new screening protocol using immunoreactive trypsinogen (IRT) as first and pancreatitis associated protein (PAP) as second tier. Gene analysis with a panel of 31 CFTR-mutations is used as t...

journal_title：Klinische Padiatrie

authors： Sommerburg O,Stahl M,Hammermann J,Okun JG,Kulozik A,Hoffmann G,Mall M

更新日期：2017-03-01 00:00:00

abstract：:Prolactin levels were measured immediately after the seizure in some, and 15 to 20 minutes later in all of 67 children aged between 6 months and 17 years. Values were determined after grand mal, complex partial and petit mal seizures and psychogen seizures. A more than 2 to 3 fold prolactin increase over the baseline ...

journal_title：Klinische Padiatrie

authors： Kurlemann G,Heyen P,Menges EM,Palm DG

更新日期：1992-05-01 00:00:00

abstract：:Between 1981 and 2000, 6 609 children (<18 years of age) were treated in 5 consecutive trials of the Berlin-Frankfurt-Münster (BFM) study group for childhood acute lymphoblastic leukemia (ALL). Patients were treated in up to 82 centers in Germany, Austria, and Switzerland. Probability of 10-year event-free survival (s...

journal_title：Klinische Padiatrie

authors： Schrappe M,Möricke A,Reiter A,Henze G,Welte K,Gadner H,Ludwig WD,Ritter J,Harbott J,Mann G,Klingebiel T,Gruhn B,Niemeyer C,Kremens B,Niggli F,Debatin KM,Ratei R,Stanulla M,Beier R,Cario G,Schrauder A,Zimmermann

更新日期：2013-05-01 00:00:00

abstract：UNLABELLED:We present an unusual case of neonatal liver failure. Isolated ascites was diagnosed in a female fetus at week 34 gestational age upon routine ultrasound. In the 35th week of gestation a cesarean section was carried out after puncture of fetal ascites. After birth the patient showed symptoms and complication...

journal_title：Klinische Padiatrie

authors： Keller M,Scholl-Buergi S,Sergi C,Theurl I,Weiss G,Unsinn KM,Trawöger R

更新日期：2008-01-01 00:00:00

abstract：:In 24 patients at risk for SIDS (12 infants with a near miss event and 12 infants with apnea and perioral cyanosis during sleep) respiratory and esophageal function were investigated by impedance pneumography (IP) and esophageal manometry combined with simultaneous pH-monitoring (EMPH). Both groups had ad early pathol...

journal_title：Klinische Padiatrie

authors： Landler U,Höllwarth ME,Uray E,Schober PH,Reiterer F,Schenkeli R

更新日期：1990-01-01 00:00:00

abstract：:An increasing number of children suffering from cancer has been treated successfully during the last 25 years using therapy protocols of the Gesellschaft für Pädiatrische Onkologie und Hämatologie. The patients had to undergo an interdisciplinary treatment modality and a mostly intensive chemotherapy. Late effects cou...

journal_title：Klinische Padiatrie

authors： Beck JD,Winkler K,Niethammer D,Brandis M,Hertzberg H,von der Hardt K,Greil J,Uberall MA,Rossi R,Lamprecht-Dinnesen A

更新日期：1995-07-01 00:00:00

abstract：:More than 40 years ago, Toxocara ssp. was identified as the cause of larva migrans visceralis and ocular larva migrans, which mainly affect infants and children. Although widespread in most parts of the world, the parasitic disease is rarely diagnosed in Germany. Focusing on clinical and pathophysiological similaritie...

journal_title：Klinische Padiatrie

authors： Hohenschild S

更新日期：1998-05-01 00:00:00

abstract：:630 neonates with risk factors of perinatal hearing impairment were screened of hearing loss by means of registration of transient otoacoustic emissions before discharge from the newborn nursery. Neonates were screened additionally by means of brainstem evoked response audiometry, if they had bilateral negative emissi...

journal_title：Klinische Padiatrie

authors： Sitka U,Rehm K,Rasinski C

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Anticonvulsants require special consideration particularly at the interface from hospital to ambulatory care. PATIENTS AND METHOD:Observational study for 6 months with prospectively enrolled consecutive patients in a neuropediatric ward of a university hospital (age 0-<18 years) with long-term therapy of at...

journal_title：Klinische Padiatrie

authors： Bertsche A,Dahse AJ,Neininger MP,Bernhard MK,Syrbe S,Frontini R,Kiess W,Merkenschlager A,Bertsche T

更新日期：2013-09-01 00:00:00

abstract：:In our experience the prognosis of hematological relapse in patients with acute lymphatic leukemia treated according to the Pinkel programme is very bad. It may be a little better for patients in whom relapse occurred after the end of therapy and who were submitted to intensified cytostatic treatment. The chances for ...

journal_title：Klinische Padiatrie

authors： Gröbe H,Schellong G

更新日期：1977-01-01 00:00:00

abstract：:340 consecutive patients with neuroblastoma stage IV were analyzed for the possible impact of chemotherapy on general condition, remission status, event free survival and survival. The children entered the trials NB 79, NB 82 and NB 85 of the German Pediatric Oncology Society (GPO). The patients did benefit from chemo...

journal_title：Klinische Padiatrie

authors： Berthold F,Burdach S,Kremens B,Lampert F,Niethammer D,Riehm H,Ritter J,Treuner J,Utsch S,Zieschang J

更新日期：1990-07-01 00:00:00

abstract：:Pre- and retrorenal growing neuroblastomas did not produce any displacement of the kidney or any obstruction in the intravenous pyelogram. The diagnosis was done by ultrasound-scanning as well as biochemically before surgery. The reported cases show that sonography and determination of the catecholamine metabolites ar...

journal_title：Klinische Padiatrie

authors： Burdach SE,Bliesener JA,Evers KG,Gharib M

更新日期：1983-01-01 00:00:00

abstract：:A case of arteriovenous aneurysm of the great vein of Galen with congestive heart failure in a newborn infant is presented. Efficiancy of medical management and stop of growth of the head circumference point towards a good prognosis. Patients with this malformation have been divided into four clinical groups presentin...

journal_title：Klinische Padiatrie

authors： Beitzke A,Zach M,Gypser G,Schreyer H

更新日期：1977-09-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of infancy and young childhood. The clinical presentation includes recurrent unexplained fever with hepatosplenomegaly. Cytopenia, hypofibrinogenemia and/or hypertriglyceridemia and hemophagocytosis in bone marrow, spleen and lymphnode confirm the diagnosis. H...

journal_title：Klinische Padiatrie

authors： Dürken M,Schneider EM,Blütters-Sawatzki R,Stollmann-Gibbels B,Nessler G,Bretz R,Körholz D,Probst EN,Holsten-Griffin H,Harps E,Zander AR,Janka GE

更新日期：1998-07-01 00:00:00

abstract：:Purpose To determine the population prevalence and risk factors of myopia in children and adolescents in Germany. Methods The prevalence of myopia in Germany was computed using data from the 2003-2006 German Health Interview and Examination Survey for Children and Adolescents (N=17 640, 49% girls). Status of myopia wa...

journal_title：Klinische Padiatrie

authors： Schuster AK,Elflein HM,Pokora R,Urschitz MS

更新日期：2017-07-01 00:00:00

abstract：:Several randomized controlled trials (RCTs) have investigated the prophylactic use of probiotics in preterm infants aimed at reducing the rate of necrotising enterocolitis (NEC). There are 4 meta-analyses on this subject. 2 more RCTs have been published since these meta-analyses were completed. Each meta-analysis, as ...

journal_title：Klinische Padiatrie

authors： Guthmann F,Kluthe C,Bührer C

更新日期：2010-09-01 00:00:00

abstract：:The death of a child after an oncologic disease gives rise to feelings of mourning, loss and anger in family members and often also in oncology team members. All people involved need to find ways of coping with these emotions and thought. Therefore, the oncology team of the Children's Hospital Tuebingen has, for many ...

journal_title：Klinische Padiatrie

authors： Kochendörfer S

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The association between Hepatitis B virus infection and membranous nephropathy has been confirmed by sources in several countries. Most commonly, the illness is seen as a nephrotic syndrome. Optimal treatment remains undefined. Antiviral therapies observed with recombinant human interferon alpha may be the b...

journal_title：Klinische Padiatrie

authors： Steiss JO,Piske-Keyser K,Gröne HJ,Gortner L

更新日期：2000-09-01 00:00:00

abstract：:Problems of terminology, differential diagnosis, etiology and therapy of language development disorders are demonstrated by a casuistic example. Besides the importance of clinical date special attention was laid on neuropsychological diagnostic procedures and their therapeutic implications. Therapeutic interventions c...

journal_title：Klinische Padiatrie

authors： Niebergall G,Wiesse J

更新日期：1978-09-01 00:00:00

abstract：:We report about two patients with compression of the spinal cord caused by lymphosarcomas. In the first patient the tumour was localized in the lumbal region and destroyed two vertebrae. In the second patient the lymphosarcoma also infiltrated the meninx, the cord, and some internal organs. Both children died. ...

journal_title：Klinische Padiatrie

authors： Kaufmann U

更新日期：1979-03-01 00:00:00

abstract：:This report describes the case of a 10 days old newborn of a diabetic mother with gestosis, who developed erythema and swelling of the right cheek. A diagnosis of acute suppurative parotitis due to S. aureus was made. Following this case report the most important facts of epidemiology, pathogenesis, clinical manifesta...

journal_title：Klinische Padiatrie

authors： Möckel A,Nissler K,Wilhelm T,Handrick W

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:Despite about 3 decades of clinical experience with the therapy of inherited thrombocytopathies (HTP) with desmopressin (DDAVP) the mechanisms of haemostatic effects of DDAVP in these diseases remain unclear. Therefore platelet function diagnostics was carried out in whole blood (WB) from children with aspir...

journal_title：Klinische Padiatrie

authors： Tauer JT,Gneuss A,Lohse JE,Jürgens T,Knöfler R

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Gender differences in overall neonatal survival and in short term pulmonary outcome have been reported. Furthermore gender differences in childhood chronic lung disorders have been described all in favor of females. METHODS:A typical survey on published data regarding gender differences in lung development ...

journal_title：Klinische Padiatrie

authors： Gortner L,Shen J,Tutdibi E

更新日期：2013-03-01 00:00:00

abstract：:48 patients between one and seventeen years of age were stimulated with GRF (1-29) NH2. Seventeen of them showed a constitutional delay in growth and puberty, twenty-three suffered from growth-hormone deficiency (GHD) and eight had a suspected GHD as a result of pharmacological tests. Although the results demonstrate ...

journal_title：Klinische Padiatrie

authors： Andler W,Eiden S

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:One of the strongest predictive factors for therapy outcome in childhood acute lymphoblastic leukaemia (ALL), treated according to ALL-BFM protocols, is the response to initial prednisone treatment. Prednisone response is characterized by the peripheral leukaemic blast count. The threshold value for the char...

journal_title：Klinische Padiatrie

authors： Lauten M,Stanulla M,Zimmermann M,Welte K,Riehm H,Schrappe M

更新日期：2001-07-01 00:00:00