Abstract:
:An EBV type 1 variant strain was detected in two Turkish siblings (boy and girl), who both suffered and died from similar progressive Epstein-Barr virus (EBV)-associated lymphoproliferative disease. Molecular characterisation of this EBV isolate revealed a 51bp-deletion and six nucleotide changes within the Epstein-Barr nuclear antigen 2 (EBNA2). Both isolates contained EBV type 2 sequences in the Epstein-Barr virus-encoded small RNAs (EBER), which are 40 kb proximal to EBNA2. Sequencing of the EBV isolates in a region of Epstein-Barr nuclear antigen 3 (EBNA3a), which is 40 kb distal to EBNA2, revealed the normal EBV type 1 sequence of laboratory strain B95-8. This EBV isolate may represent a distinct wild type EBV strain with altered biological properties. It is suggested that this EBNA2-variant strain may be responsible at least in part for the severe clinical course in both affected children.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Schuster V,Seidenspinner S,Kreth HWdoi
10.1002/(SICI)1096-9071(199601)48:1<114::AID-JMV18subject
Has Abstractpub_date
1996-01-01 00:00:00pages
114-20issue
1eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(199601)48:1<114::AID-JMV18journal_volume
48pub_type
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