Genetics of age-related hearing loss in mice. II. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds.


:The effects of genotype and diet on age-related hearing loss were evaluated using auditory brainstem response (ABR) thresholds and post-mortem cochlear histopathology in 5 inbred mouse strains, CBA/H-T6J (CH), DBA/2J (D2), C57BL/6J (B6), BALB/cByJ (BY) and WB/ReJ (WB), and their 10 F1 hybrid strains. The mice had been maintained since weaning on either a high-energy (HE) control diet or low-energy (LE) calorically restricted diet. ABR thresholds were obtained when the mice were 23 months old; the mice were allowed to age until they died from natural causes prior to obtaining the histological material. The severity of post-mortem cochlear pathology in mice maintained with the HE diet supports our earlier genetic model which postulated that B6, BY, and WB strains each possessed a different recessive allele causing age-related hearing loss, D2 mice possessed all 3 genes, and CH mice possessed none. The histopathology indicates that the genes act at the cochlear level. Dietary restriction resulted in increased longevity in a number of strains, but age-related changes in cochlear pathology were not ameliorated in any of these; indeed, in some strains long-lived LE mice exhibited severe cochlear degeneration. In strains for which longevity was not extended by caloric restriction, only B6 mice exhibited an ameliorative effect of the LE diet on cochlear pathology. ABRs in 23-month-olds indicated a slowing of age-related hearing loss in LE mice of 3 F1 hybrid strains.


Hear Res


Hearing research


Willott JF,Erway LC,Archer JR,Harrison DE




Has Abstract


1995-08-01 00:00:00














  • Plasticity in the auditory system.

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    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Irvine DRF

    更新日期:2018-05-01 00:00:00

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  • The sensitive period and optimum dosage for induction of audiogenic seizure susceptibility by kanamycin in the Wistar rat.

    abstract::The incidence and severity of audiogenic seizures in kanamycin (KM)-treated rat pups, from a Wistar strain which is inherently seizure-resistant, was analyzed as a function of (a) postnatal age at the time of KM injection (i.p.) and (b) KM dosage. The vigor of the pinna reflex response on postnatal day (PND) 28 was co...

    journal_title:Hearing research

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    authors: Pierson MG,Swann JW

    更新日期:1988-01-01 00:00:00

  • Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex.

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    authors: Basta D,Goetze R,Ernst A

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    authors: Ruan RS,Leong SK,Yeoh KH

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    authors: Jiang H,Wang X,Zhang J,Kachelmeier A,Lopez IA,Shi X

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    authors: Xu L,Jen PH

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    authors: Yamamoto H,Tominaga M,Sone M,Nakashima T

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  • Temporal response properties of the auditory nerve: data from human cochlear-implant recipients.

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    authors: Hughes ML,Castioni EE,Goehring JL,Baudhuin JL

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    journal_title:Hearing research

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    更新日期:1990-06-01 00:00:00

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    journal_title:Hearing research

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    journal_title:Hearing research

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    更新日期:2008-08-01 00:00:00

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    journal_title:Hearing research

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    authors: Dobrev I,Sim JH,Pfiffner F,Huber AM,Röösli C

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  • Cellular targets of estrogen signaling in regeneration of inner ear sensory epithelia.

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    journal_title:Hearing research

    pub_type: 杂志文章,评审


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    更新日期:2009-06-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Minami SB,Sha SH,Schacht J

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Formby C,Rutledge JC,Sherlock LP

    更新日期:2002-02-01 00:00:00

  • Ensemble spontaneous activity in the guinea-pig cochlear nerve.

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Searchfield GD,Muñoz DJ,Thorne PR

    更新日期:2004-06-01 00:00:00