Genetics of age-related hearing loss in mice. II. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds.


:The effects of genotype and diet on age-related hearing loss were evaluated using auditory brainstem response (ABR) thresholds and post-mortem cochlear histopathology in 5 inbred mouse strains, CBA/H-T6J (CH), DBA/2J (D2), C57BL/6J (B6), BALB/cByJ (BY) and WB/ReJ (WB), and their 10 F1 hybrid strains. The mice had been maintained since weaning on either a high-energy (HE) control diet or low-energy (LE) calorically restricted diet. ABR thresholds were obtained when the mice were 23 months old; the mice were allowed to age until they died from natural causes prior to obtaining the histological material. The severity of post-mortem cochlear pathology in mice maintained with the HE diet supports our earlier genetic model which postulated that B6, BY, and WB strains each possessed a different recessive allele causing age-related hearing loss, D2 mice possessed all 3 genes, and CH mice possessed none. The histopathology indicates that the genes act at the cochlear level. Dietary restriction resulted in increased longevity in a number of strains, but age-related changes in cochlear pathology were not ameliorated in any of these; indeed, in some strains long-lived LE mice exhibited severe cochlear degeneration. In strains for which longevity was not extended by caloric restriction, only B6 mice exhibited an ameliorative effect of the LE diet on cochlear pathology. ABRs in 23-month-olds indicated a slowing of age-related hearing loss in LE mice of 3 F1 hybrid strains.


Hear Res


Hearing research


Willott JF,Erway LC,Archer JR,Harrison DE




Has Abstract


1995-08-01 00:00:00














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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Prigioni I,Russo G,Valli P,Masetto S

    更新日期:1990-07-01 00:00:00

  • Maturation of middle ear transmission in children.

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    journal_title:Hearing research

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    authors: Mishra SK,Dinger Z,Renken L

    更新日期:2017-02-01 00:00:00

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    journal_title:Hearing research

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    authors: Lechner TP

    更新日期:1993-04-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Berg A,Watson GM

    更新日期:2002-12-01 00:00:00

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    journal_title:Hearing research

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    authors: Barnes-Davies M,Owens S,Forsythe ID

    更新日期:2001-12-01 00:00:00

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    abstract::Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with ...

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    pub_type: 杂志文章,评审


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    更新日期:2017-06-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


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    更新日期:1997-04-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Rutkowski RG,Miasnikov AA,Weinberger NM

    更新日期:2003-07-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Glass I

    更新日期:1983-11-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


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    更新日期:1984-07-01 00:00:00

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    journal_title:Hearing research

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    journal_title:Hearing research

    pub_type: 杂志文章


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    更新日期:2011-12-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


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    更新日期:1984-09-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1987-01-01 00:00:00

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    更新日期:2003-04-01 00:00:00

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    journal_title:Hearing research

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    pub_type: 杂志文章


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    journal_title:Hearing research

    pub_type: 杂志文章


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    journal_title:Hearing research

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Hearing research

    pub_type: 杂志文章


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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Zrull MC,Coleman JR

    更新日期:1990-05-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Summers RJ,Bailey PJ,Roberts B

    更新日期:2017-02-01 00:00:00

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Lefebvre PP,Weber T,Rigo JM,Staecker H,Moonen G,Van De Water TR

    更新日期:1992-03-01 00:00:00