Abstract：
:The recovery pattern of threshold shift (TS) and 'dynamic' changes in the stereocilia after exposure to high-level impulse noise in guinea pigs were investigated. 33 albino guinea pigs were exposed to 10 impulse noises at the rate of 1/min. The noise had peak level of 166 dB SPL and a duration of 0.1 ms. Thirteen of the exposed animals were used to systematically measure threshold shifts at regular intervals from 0.5 h to 30 days post-exposure by click auditory cortex evoked response (AC-ER). Twelve of the animals who had typical TS at the same intervals were killed for scanning electron microscopic examination. The recovery pattern of threshold shifts was non-monotonic, which was different from that seen with continuous noise. There was an increase in TS after the exposure and the maximum level of TS was found at 8 h post-exposure. Morphological analysis also showed delayed changes in the stereocilia after exposure. The severity of changes in the stereocilia reached a peak at 8 h, at which time complete fusion of hair bundles took place. The tectorial material found on the tips of the stereocilia may be responsible for the sequence of the changes.
journal_name
Hear Resjournal_title
Hearing researchauthors
Gao WY,Ding DL,Zheng XY,Ruan FMdoi
10.1016/0378-5955(91)90123-qsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
296-304issue
2eissn
0378-5955issn
1878-5891pii
0378-5955(91)90123-Qjournal_volume
54pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:In the cochlea, outer hair cells (OHCs) generate the active cochlear mechanics whereas the supporting cells, such as Deiters' cells and Hensen's cells, may play a role in both the active and passive cochlear mechanics. The presence of receptors for adenosine triphosphate (ATP) on OHCs, Deiters' cells and Hensen's cell...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00019-7
更新日期：1998-04-01 00:00:00
abstract：:The cytosolic pH (pHi) of transitional cells from the ampulla of the gerbil was measured micro-fluorometrically with the pH-sensitive dye 2',7'-bicarboxyethyl-5(6)-carboxyfluorescein (BCECF) to assess the possible contribution of a Na+/H+ exchanger to the regulation of pHi. All experiments were conducted in virtually ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90098-l
更新日期：1993-09-01 00:00:00
abstract：:Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.09.005
更新日期：2007-12-01 00:00:00
abstract：:When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.02.013
更新日期：2010-05-01 00:00:00
abstract：:The directionality of the cat's pinna was studied by using the amplitude of the cochlear microphonic (CM) as a quantitative indicator of tympanic sound pressure level (SPL). It was found that tympanic SPL varied with the location of a free field stimulator in anechoic space. For high (tonal) frequencies, there was a c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90031-4
更新日期：1982-09-01 00:00:00
abstract：:The voice is a rich source of information, which the human brain has evolved to decode and interpret. Empirical observations have shown that the human auditory system is especially sensitive to the human voice, and that activity within the voice-sensitive regions of the primary and secondary auditory cortex is modulat...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2015.07.003
更新日期：2015-10-01 00:00:00
abstract：:Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.02.017
更新日期：2017-05-01 00:00:00
abstract：:In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.006
更新日期：2006-02-01 00:00:00
abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.01.007
更新日期：2019-05-01 00:00:00
abstract：:This report describes the effects of L-glutamate (Glu) introduced into the perilymph of scala tympani on the spontaneous and tone-evoked activity of guinea pig single primary auditory afferents. Concentrations below 2 mmol/l were in general ineffective, while a concentration of 5 mmol/l caused a marked decrease of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90128-c
更新日期：1990-05-01 00:00:00
abstract：:Previous investigations have shown that a subset of inferior colliculus neurons, which have been designated type O units, respond selectively to isolated features of the cat's head-related transfer functions (HRTFs: the directional transformation of a free-field sound as it propagates from the head to the eardrum). Ba...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.01.008
更新日期：2008-04-01 00:00:00
abstract：:Superposition of point processes has often been suggested as an abstract model for the generation of neural discharge patterns due to its simplicity (input spike trains are simply merged and then retransmitted by the model neuron). The properties of the superposition of two renewal processes are examined in relation t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90015-8
更新日期：1986-01-01 00:00:00
abstract：:The purpose of this study is to investigate whether repeated noise exposure aggravates the level of permanent noise-induced hearing loss (NIHL) in diabetic rats and whether N-acetylcysteine (NAC), a precursor of glutathione, attenuates the level of noise-induced permanent hearing loss in diabetic rats. Fifty male Wist...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.03.082
更新日期：2010-08-01 00:00:00
abstract：:In cases of sudden, reversible hearing loss where perilymphatic fistulas are thought to be the cause, a multitude of causes have been postulated. These include perilymphatic pressure changes, Simmons' double-break theory, perilymphatic hemorrhage, pneumolabyrinth, and others. This study was proposed to explore the rol...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00389-1
更新日期：2002-05-01 00:00:00
abstract：:The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examine...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00142-6
更新日期：1996-11-01 00:00:00
abstract：:Projections from the posterior thalamus and medial geniculate body were labeled retrogradely with wheat germ agglutinin conjugated to horseradish peroxidase injected into the rat, cat, and squirrel monkey inferior colliculus. Neurons were found ipsilaterally in the (1) medial division of the medial geniculate body, (2...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00489-6
更新日期：2002-06-01 00:00:00
abstract：:Primary afferent activity was recorded from the cochlear ganglion in chicken embryos (Gallus domesticus) at 19 days of incubation (E19). The ganglion was accessed via the recessus scala tympani and impaled with glass micropipettes. Frequency tuning curves were obtained using a computerized threshold tracking procedure...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)00172-m
更新日期：1995-02-01 00:00:00
abstract：:High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2012.11.016
更新日期：2013-01-01 00:00:00
abstract：:Although pulmonary infections caused by Pseudomonas aeruginosa can hardly be eradicated in patients with cystic fibrosis (CF, the most common genetic disease among Caucasians), these patients are mainly treated with intravenous and nebulized tobramycin. Long-term treatment with tobramycin, however, may induce ototoxic...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00191-3
更新日期：1998-01-01 00:00:00
abstract：:A linear (frequency-domain) model of the cat cochlea (implemented in both 1- and 2-dimensional versions) has been developed which uses outer hair cell (OHC) forces in a geometry which includes the longitudinal (base-to-apex) tilt of the outer hair cells (OHCs). When positive (contractile) real OHC force-constants are ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00064-b
更新日期：1995-06-01 00:00:00
abstract：:We determined velocity discrimination thresholds and Weber fractions for sounds revolving around the listener at very high velocities. Sounds used were a broadband white noise and two harmonic sounds with fundamental frequencies of 330 Hz and 1760 Hz. Experiment 1 used velocities ranging between 288°/s and 720°/s in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：:Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/s0378-5955(00)00127-1
更新日期：2000-09-01 00:00:00
abstract：:Cochlear Implant (CI) sound coding strategies based on simultaneous stimulation lead to an increased loudness percept when compared to sequential stimulation using the same current levels. This is due to loudness summation as a result of channel interactions. Studying the loudness perception evoked by dual-channels co...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108091
更新日期：2020-12-01 00:00:00
abstract：:A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.12.013
更新日期：2005-08-01 00:00:00
abstract：:Congenital hearing loss (HL) affects about 1 in every 500 infants. Among those affected more than half are caused by genetic mutations. According to the cellular sites affected by mutations in the cochlea, deafness genes could be classified into three major groups: those affecting the function of hair cells and synaps...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.107858
更新日期：2020-09-01 00:00:00
abstract：:Intracellular recordings were made from both inner and outer hair cells (IHC, OHC) in the basal coil of the guinea pig cochlea before, during and after the animal was exposed to loud, pure tones. Following multiple loud tones both types of sensory cells demonstrate a culmulative decrease in their voltage responses to ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90040-8
更新日期：1988-09-01 00:00:00
abstract：:We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence stud...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00040-6
更新日期：2003-04-01 00:00:00
abstract：:The standard procedure to study temporal encoding of sound waveforms in the auditory system has been Fourier analysis of responses to periodic stimuli. We introduce a new metric--correlation index (CI)--which is based on a simple counting of spike coincidences. It can be used for responses to aperiodic stimuli and doe...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.03.010
更新日期：2006-06-01 00:00:00
abstract：:The cochlear influence of otitis media was investigated in order to identify damaged regions causing cochlear malfunction. BALB/c mice were challenged with viable Streptococcus pneumoniae into the middle ear cavity and were killed 1 day to 1 month later for immunohistochemical analysis. Otitis media was induced in all...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00025-8
更新日期：1999-05-01 00:00:00
abstract：:Using transgenic fluorescent reporter mice in combination with an established tissue clearing method, we detail heretofore optically opaque regions of the spiral lamina and spiral limbus where the auditory peripheral nervous system is located and provide insight into changes in cochlear vascular density with ageing. W...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.012
更新日期：2019-01-01 00:00:00
