Structure of the barn owl's (Tyto alba) inner ear.

abstract：:Mortality is a major complication in animal models of cisplatin-induced hearing loss due to the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections (1 mg/kg, i.p., twice daily) separated by 10 days of rest. This regimen, simil...

journal_title：Hearing research

authors： Minami SB,Sha SH,Schacht J

更新日期：2004-12-01 00:00:00

abstract：:This paper will review some of the functional changes that occur in the central auditory pathway after the cochlea is damaged by acoustic overstimulation or by carboplatin, an ototoxic drug that selectively destroys inner hair cells (IHCs) in the chinchilla. Acoustic trauma typically impairs the sensitivity and tuning...

journal_title：Hearing research

authors： Salvi RJ,Wang J,Ding D

更新日期：2000-09-01 00:00:00

abstract：:Tinnitus is highly prevalent in the general population. Tinnitus sufferers often report having difficulties focusing on a task at hand and ignoring the tinnitus percept. Behavioral studies have shown evidence for impairments in attention, interference inhibition, and various other executive functions in tinnitus. Howe...

journal_title：Hearing research

authors： Amaral AA,Langers DR

更新日期：2015-08-01 00:00:00

abstract：:The lipophilic dye, DiI, was placed into the macula lagena of paraformaldehyde-fixed embryonic chicks. Retrogradely labeled cells were found bilaterally in the pontine reticular formation (RF) between the dorsal facial nucleus and the abducens nerve root. This location is similar to that of the dorsomedial group of ef...

journal_title：Hearing research

authors： Code RA

更新日期：1995-01-01 00:00:00

abstract：:Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This stud...

journal_title：Hearing research

authors： Rowe D,Chambers S,Hampson A,Eastwood H,Campbell L,O'Leary S

更新日期：2016-03-01 00:00:00

abstract：:Recent physiological and pharmacological studies have implicated involvement of the Na/H exchanger (NHE) in regulating inner ear ion homeostasis, but the cellular distribution of this membrane transporter remains unknown. Here reverse transcription and the polymerase chain reaction (RT-PCR) were employed to screen adu...

journal_title：Hearing research

authors： Bond BR,Ng LL,Schulte BA

更新日期：1998-09-01 00:00:00

abstract：:To create experimental lesions localized to the low frequency region of the organ of Corti, a cryoprobe was applied to the apical area of 37 cochleas from 26 adult chinchillas. Twenty cochleas were exposed to single applications of a cryoprobe for 2.5, 3.0 and 3.5 min; 17 cochleas were exposed to two applications of 1...

journal_title：Hearing research

authors： Brown JN,Nuttall AL

更新日期：1987-01-01 00:00:00

abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

journal_title：Hearing research

authors： Ruan RS,Leong SK,Yeoh KH

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To objectively measure speech intelligibility of individual subjects from the EEG, based on cortical tracking of different representations of speech: low-level acoustical, higher-level discrete, or a combination. To compare each model's prediction of the speech reception threshold (SRT) for each individual wi...

journal_title：Hearing research

authors： Lesenfants D,Vanthornhout J,Verschueren E,Decruy L,Francart T

更新日期：2019-09-01 00:00:00

abstract：:The role of the endolymphatic sac (ES) in endolymph volume homeostasis is speculative. The present study investigates changes of the ES's epithelia and luminal filling after induction of an acute endolymphatic hydrops. After microinjection of 1.1 mul artificial endolymph into scala media of the cochlea, guinea pigs we...

journal_title：Hearing research

authors： Valk WL,Wit HP,Segenhout JM,Dijk F,van der Want JJ,Albers FW

更新日期：2005-04-01 00:00:00

abstract：:The distribution of calcitonin gene-related peptide immunoreactivity (CGRPi) within efferent vestibular neurons in the chinchilla was investigated using fluorescent retrograde labeling combined with immunohistochemistry. Efferent vestibular neurons were found bilaterally in clusters: dorsolateral (group E1) and medial...

journal_title：Hearing research

authors： Marco RA,Hoffman LF,Wackym PA,Micevych PE,Popper P

更新日期：1996-08-01 00:00:00

abstract：:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in a...

journal_title：Hearing research

authors： Maurer J,Heinrich UR,Mann W

更新日期：1994-01-01 00:00:00

abstract：:The present study examined synaptic potentials of neurons in inferior colliculus (IC) cortex slice and the roles of GABA and glutamate receptors in generating these potentials. Multipolar (82%) and elongated (18%) cells were observed with intracellular biocytin staining. Electrical stimulation of the IC commissure (Co...

journal_title：Hearing research

authors： Li Y,Evans MS,Faingold CL

更新日期：1999-11-01 00:00:00

abstract：:We examined the frequency specificity of amplitude envelope patterns in 4 frequency bands, which universally appeared through factor analyses applied to power fluctuations of critical-band filtered speech sounds in 8 different languages/dialects [Ueda and Nakajima (2017). Sci. Rep., 7 (42468)]. A series of 3 perceptua...

journal_title：Hearing research

authors： Ueda K,Araki T,Nakajima Y

更新日期：2018-09-01 00:00:00

abstract：:Recently it was shown that distortion product otoacoustic emissions (DPOAEs) can be measured as vibration of the human tympanic membrane in vivo, and proposed to use these vibration DPOAEs to support a differential diagnosis of middle-ear and cochlear pathologies. Here, we investigate how the reverse transfer function...

journal_title：Hearing research

authors： Dalhoff E,Turcanu D,Gummer AW

更新日期：2011-10-01 00:00:00

abstract：:The IgG1 mouse monoclonal antibody (MAb) KHRI-3, binds to an antigen of 65-68 kDa expressed on inner ear supporting cells in guinea pigs. We previously showed [Nair et al. (1995) Monoclonal antibody induced hearing loss. Hear. Res. 83, 101-113] that mice carrying the KHRI-3 hybridoma develop high frequency hearing los...

journal_title：Hearing research

authors： Nair TS,Prieskorn DM,Miller JM,Mori A,Gray J,Carey TE

更新日期：1997-05-01 00:00:00

abstract：:Phantom electrode (PE) stimulation can extend the lower limit of pitch perception with cochlear implants (CIs) by using simultaneous out-of-phase stimulation of the most apical primary electrode and the adjacent basal compensating electrode. The total electrical field may push the excitation pattern beyond the most ap...

journal_title：Hearing research

authors： Luo X,Garrett C

更新日期：2020-05-01 00:00:00

abstract：:Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...

journal_title：Hearing research

authors： Bibikov NG,Nizamov SV

更新日期：1996-11-01 00:00:00

abstract：:The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at th...

journal_title：Hearing research

authors： Kaltenbach JA,Schmidt RN,Kaplan CR

更新日期：1992-07-01 00:00:00

abstract：:Doppler vibrometers are used by many research groups to monitor the motion of the tympanic membrane (TM) and of middle ear ossicles for in vivo and in vitro studies. Power densities in these applications reach 80 W/cm(2). To determine the safe limit of exposure, a cw dye laser at a wavelength of 633 nm was used to inv...

journal_title：Hearing research

authors： Foth H,Färber S,Gauer A,Wagner R

更新日期：2000-04-01 00:00:00

abstract：:Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...

journal_title：Hearing research

authors： Okanoya K,Dooling RJ

更新日期：1990-12-01 00:00:00

abstract：:There is increasing evidence to suggest that free radical generation is central to a variety of pathological processes, including drug toxicity. Studies demonstrating the ability of gentamicin to facilitate the generation of radical species suggest that this process plays an important role in aminoglycoside-induced ot...

journal_title：Hearing research

authors： Conlon BJ,Smith DW

更新日期：1998-01-01 00:00:00

abstract：:Admittance at the tympanic membrane was measured in one ear of 73 chicks in 8 age groups between 1 and 150 days post-hatch. Admittance at 7 frequencies (0.66-1.8 kHz) was calculated from measurements of the magnitude and phase angle of sound pressure in front of the tympanic membrane. The results show that admittance ...

journal_title：Hearing research

authors： Saunders JC,Relkin EM,Rosowski JJ,Bahl C

更新日期：1986-01-01 00:00:00

abstract：:Although the tectorial membrane has a key role in the function of the organ of Corti, its structural relationship within the cochlear partition is still not fully characterised. Being an acellular structure, the tectorial membrane is not readily stained with dyes and is thus difficult to visualise. We present here det...

journal_title：Hearing research

authors： Ulfendahl M,Flock A,Scarfone E

更新日期：2001-01-01 00:00:00

abstract：:Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...

journal_title：Hearing research

authors： Takeda-Nakazawa H,Harada N,Shen J,Kubo N,Zenner HP,Yamashita T

更新日期：2007-05-01 00:00:00

abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...

journal_title：Hearing research

authors： Gross J,Rheinländer C,Fuchs J,Mazurek B,Machulik A,Andreeva N,Kietzmann T

更新日期：2003-09-01 00:00:00

abstract：:Recordings were made from 185 neurons in the primary auditory cortex of cats in the age range of 15 to 297 days. A comparison was made between the tuning for click repetition-rate and for amplitude modulation-frequency of a noise burst on the basis of temporal Modulation Transfer Functions (tMTF). 90 of the 185 units ...

journal_title：Hearing research

authors： Eggermont JJ

更新日期：1993-02-01 00:00:00

abstract：:The cytosolic pH (pHi) of transitional cells from the ampulla of the gerbil was measured micro-fluorometrically with the pH-sensitive dye 2',7'-bicarboxyethyl-5(6)-carboxyfluorescein (BCECF) to assess the possible contribution of a Na+/H+ exchanger to the regulation of pHi. All experiments were conducted in virtually ...

journal_title：Hearing research

authors： Wangemann P,Shiga N,Marcus DC

更新日期：1993-09-01 00:00:00

abstract：:Previous studies indicate the presence of adenosine receptors in the cochlear tissues obtained from different animals. This study was initiated to determine the subtypes of adenosine receptor (AR) present in the chinchilla cochlea and to assess their function. Radioligand binding studies demonstrate the presence of bo...

journal_title：Hearing research

authors： Ford MS,Maggirwar SB,Rybak LP,Whitworth C,Ramkumar V

更新日期：1997-03-01 00:00:00

abstract：:The laminar distribution and reciprocity of commissural axon terminals and cells of origin in cat primary auditory cortex (AI) were studied after injections of tritiated proline combined with horseradish peroxidase in the middle ectosylvian gyrus. Terminal fields were found in every cortical layer in the contralateral...

journal_title：Hearing research

authors： Code RA,Winer JA

更新日期：1986-01-01 00:00:00