Guinea pig maximization test of the bark extract from pawpaw, Asimina triloba (Annonaceae).

Abstract:

:Several acetogenins, characteristic of the Annonaceae, have been found to exhibit pesticidal and feeding-deterrent activities against a variety of pests and are undergoing commercial development as pesticides. The sensitizing potential of one of these plants, pawpaw, Asimina triloba Dunal, was examined in the current study. The potential of Fraction F020 (a pesticidal crude extract of pawpaw stem bark) to sensitize and elicit an allergic contact dermatitis response was determined by using a modified guinea pig maximization test (GPMT). Fraction F020 is a weak sensitizer and the active compound, asimicin, a trihydroxy-bistetrahydrofuran fatty acid gamma-lactone, is a weak irritant.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Avalos J,Rupprecht JK,McLaughlin JL,Rodriguez E

doi

10.1111/j.1600-0536.1993.tb04533.x

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

33-5

issue

1

eissn

0105-1873

issn

1600-0536

journal_volume

29

pub_type

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