The biochemical basis of cobalamin deficiency.

abstract：:A 37-year-old man was referred to our institution for assessment of possible sarcoidosis with involvement of the central nervous system. Before referral, he experienced a systemic illness that persisted for several months, during which time ocular and pulmonary noncaseating granulomas were identified. Sarcoidosis with...

journal_title：Mayo Clinic proceedings

authors： Edmonds LC,Stubbs SE,Ryu JH

更新日期：1992-01-01 00:00:00

abstract：:Between January 1973 and October 1991 at the Mayo Clinic, 5 of 345 patients with Wegener's granulomatosis initially had features suggestive of giant cell arteritis and subsequently were found to have biopsy-proven vasculitis of the temporal artery. All five patients were older than 60 years of age and had jaw claudica...

journal_title：Mayo Clinic proceedings

authors： Nishino H,DeRemee RA,Rubino FA,Parisi JE

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:To investigate the incidence and risk of adverse clinical outcomes in a "real-world" cohort of patients with atrial fibrillation (AF) anticoagulated with vitamin K antagonists (VKAs) from the Murcia AF Project in comparison with the warfarin arm of the randomized clinical trial (RCT) AMADEUS (Evaluating the U...

journal_title：Mayo Clinic proceedings

authors： Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Valdés M,Vicente V,Roldán V,Lip GYH

更新日期：2018-08-01 00:00:00

abstract：:Pulmonary hypertension (PH) in patients with interstitial lung diseases (ILDs) is not well recognized and can occur in the absence of advanced pulmonary dysfunction or hypoxemia. To address this topic, we identified relevant studies in the English language by searching the MEDLINE database (1966 to November 2006) and ...

journal_title：Mayo Clinic proceedings

authors： Ryu JH,Krowka MJ,Pellikka PA,Swanson KL,McGoon MD

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To study differences in treatment outcomes between patients with chronic noncancer pain taking vs those not taking maintenance opioids at admission to a pain rehabilitation program. PATIENTS AND METHODS:A nonrandomized 2-group prepost design was used to compare 356 patients admitted to the Mayo Comprehensive...

journal_title：Mayo Clinic proceedings

authors： Rome JD,Townsend CO,Bruce BK,Sletten CD,Luedtke CA,Hodgson JE

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:To analyze a large cohort of patients who underwent exercise testing and also report sex differences in other exercise heart rate (HR) parameters to determine whether separate sex-based equations to predict peak HR are indicated. PATIENTS AND METHODS:Patients aged 40 to 89 years who performed treadmill exerc...

journal_title：Mayo Clinic proceedings

authors： Sydó N,Abdelmoneim SS,Mulvagh SL,Merkely B,Gulati M,Allison TG

更新日期：2014-12-01 00:00:00

abstract：:Effective antimicrobial therapy for most urinary tract infections has been available since the sulfonamide era. Innovations in chemotherapy now include single-dose treatment of acute bacterial cystitis and acute urethral syndrome and effective suppression of recurrent bacteriuria with low-dose antimicrobial agents. ...

journal_title：Mayo Clinic proceedings

authors： Keys TF,Edson RS

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:To determine the effect of adding a trained intensivist on patient care and educational outcomes in a community teaching hospital. MATERIAL AND METHODS:We retrospectively reviewed outcomes for patients admitted to the medical intensive-care unit (MICU) of a 270-bed community teaching hospital between July 19...

journal_title：Mayo Clinic proceedings

authors： Manthous CA,Amoateng-Adjepong Y,al-Kharrat T,Jacob B,Alnuaimat HM,Chatila W,Hall JB

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To assess the impact of direct-to-consumer (DTC) predictive genomic risk information on perceived risk and worry in the context of routine clinical care. PATIENTS AND METHODS:Patients attending a preventive medicine clinic between June 1 and December 18, 2009, were randomly assigned to receive either genomic...

journal_title：Mayo Clinic proceedings

authors： James KM,Cowl CT,Tilburt JC,Sinicrope PS,Robinson ME,Frimannsdottir KR,Tiedje K,Koenig BA

更新日期：2011-10-01 00:00:00

abstract：:Increased intracranial pressure can result in irreversible injury to the central nervous system. Among the many functions of the cerebrospinal fluid, it provides protection against acute changes in venous and arterial blood pressure or impact pressure. Nevertheless, trauma, tumors, infections, neurosurgical procedures...

journal_title：Mayo Clinic proceedings

authors： Lyons MK,Meyer FB

更新日期：1990-05-01 00:00:00

abstract：:A series of 58 operations on 56 patients, in whom a branch of the superficial temporal artery was anastomosed to a branch of the middle cerebral artery (STA-MCA bypass or Yasargil procedure), is reviewed. These operations were performed chiefly for occlussions or for inaccessible stenotic lesions of the internal carot...

journal_title：Mayo Clinic proceedings

authors： Sundt TM Jr,Siekert RG,Piepgras DG,Sharbrough FW,Houser OW

更新日期：1976-11-01 00:00:00

abstract：:The Human Genome Project has resulted in a new era in the field of pharmacogenetics in which researchers are rapidly discovering new genetic variation, which may help to explain interindividual variability in drug efficacy and toxicity. Pharmacogenetics is the study of the role of genetic inheritance in individual var...

journal_title：Mayo Clinic proceedings

authors： Goetz MP,Ames MM,Weinshilboum RM

更新日期：2004-03-01 00:00:00

abstract：:Emerging preclinical and clinic evidence described herein suggests that the mechanism of action of rifaximin is not restricted to direct antibacterial effects within the gastrointestinal tract. Data from this study were derived from general and clinical trial-specific PubMed searches of English-language articles on ri...

journal_title：Mayo Clinic proceedings

authors： DuPont HL

更新日期：2015-08-01 00:00:00

abstract：:We have observed the effects of concussion on nonanesthetized rats and humans. We believe the phenomenon in both to be identical. There are four obvious stages to concussion and the recovery therefrom: fourth stage--visceral (respiratory) and somatic immobility; third stage--return of irregular visceral (respiratory) ...

journal_title：Mayo Clinic proceedings

authors： Parkinson D

更新日期：1977-08-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common articular disease, and it continues to be a major public health problem related to pain, disability, loss of time from work, and economics. Most patients with OA seek medical attention because of pain. In the past few years, changes in the treatment of OA have been substantial. M...

journal_title：Mayo Clinic proceedings

authors： Manek NJ

更新日期：2001-05-01 00:00:00

abstract：:To our knowledge, edema of the lower extremities has not previously been reported as a sign of a pancreatic pseudocyst. In this case report, we describe a 66-year-old man in whom such a lesion compressed the inferior vena cava and caused pronounced leg swelling. After drainage of the pseudocyst, the edema did not recu...

journal_title：Mayo Clinic proceedings

authors： Browman MW,Litin SC,Binkovitz LA,Mohr DN

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To examine the effect of objectively measured exercise capacity (EC) on early mortality (EM) after a first myocardial infarction (MI). PATIENTS AND METHODS:This retrospective cohort study included 2061 patients without a history of MI (mean age, 62±12 years; 38% [n=790] women; 56% [n=1153] white) who underwe...

journal_title：Mayo Clinic proceedings

authors： Shaya GE,Al-Mallah MH,Hung RK,Nasir K,Blumenthal RS,Ehrman JK,Keteyian SJ,Brawner CA,Qureshi WT,Blaha MJ

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of cardiac troponin T (cTnT) in predicting death, recurrent ischemic events, and heart failure among community-dwelling persons with first myocardial infarction (MI). PATIENTS AND METHODS:Consecutive Olmsted County, Minnesota, residents with an incident MI between November 6, 2002, and D...

journal_title：Mayo Clinic proceedings

authors： Gerber Y,Jaffe AS,Weston SA,Jiang R,Roger VL

更新日期：2012-03-01 00:00:00

abstract：:The evaluation of the patient with diarrhea can be complex and the treatment challenging. In this article, the definition of diarrhea and the pathophysiologic mechanisms that lead to diarrhea are reviewed. A simplified 5-step approach to the patient with diarrhea is provided and applied in a case-oriented manner appli...

journal_title：Mayo Clinic proceedings

authors： Sweetser S

更新日期：2012-06-01 00:00:00

abstract：:Staphylococcus lugdunensis, a coagulase-negative staphylococcus, is being increasingly recognized as the cause of serious infections. We report 2 cases of total knee arthroplasty infection caused by S lugdunensis. S lugdunensis frequently produces a clumping factor that can result in a positive slide (short) coagulase...

journal_title：Mayo Clinic proceedings

authors： Sampathkumar P,Osmon DR,Cockerill FR 3rd

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether patients with traumatic brain injury (TBI) have an increased risk of stroke or poststroke mortality. PARTICIPANTS AND METHODS:Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study of 30,165 patients with new TBI and 120,660 persons withou...

journal_title：Mayo Clinic proceedings

authors： Liao CC,Chou YC,Yeh CC,Hu CJ,Chiu WT,Chen TL

更新日期：2014-02-01 00:00:00

abstract：:Hip arthroplasty using the Thompson femoral prosthesis with methyl methacrylate fixation was performed on 109 hips in 106 patients. During an average follow-up period of 36 months, 26 patients died. Fifty-one procedures were performed for fresh fractures of the femoral neck and results were satisfactory in this group ...

journal_title：Mayo Clinic proceedings

authors： Beckenbaugh RD,Tressler HA,Johnson EW Jr

更新日期：1977-06-01 00:00:00

abstract：:Two entities of special interest in sleep disorders medicine are restless legs syndrome and periodic movements of sleep. Most patients with restless legs syndrome have periodic movements of sleep, but most patients with the nocturnal disorder do not have restless legs when awake. In both conditions, the underlying cau...

journal_title：Mayo Clinic proceedings

authors： Krueger BR

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of intra- and extra-articular sacroiliac joint (SIJ) pain, which injection is more beneficial, and whether fluoroscopy improves outcomes. PATIENTS AND METHODS:This patient- and evaluator-blinded comparative effectiveness study randomized 125 participants with SIJ pain from April ...

journal_title：Mayo Clinic proceedings

authors： Cohen SP,Bicket MC,Kurihara C,Griffith SR,Fowler IM,Jacobs MB,Liu R,Anderson White M,Verdun AJ,Hari SB,Fisher RL,Pasquina PF,Vorobeychik Y

更新日期：2019-04-01 00:00:00

abstract：:Ever since ancient times, man has been searching for the proper artificial substitute for living tissue. This has been a most frustrating and challenging task for the scientific community involved. Prosthetic restoration is the only alternative to reconstructive surgery for the facially deformed. This paper reviews th...

journal_title：Mayo Clinic proceedings

authors： Gonzalez JB

更新日期：1978-07-01 00:00:00

abstract：:The feasibility and accuracy of continuous-wave Doppler echocardiography in measuring pressure gradients across the pulmonary artery band were assessed. Simultaneous continuous-wave Doppler and catheter pressure measurements were prospectively performed in 20 patients with complex congenital heart disease and prior pu...

journal_title：Mayo Clinic proceedings

authors： Fyfe DA,Currie PJ,Seward JB,Tajik AJ,Reeder GS,Mair DD,Hagler DJ

更新日期：1984-11-01 00:00:00

abstract：:In 51 patients with type 1 and 9 patients with type 2 membranoproliferative glomerulonephritis, we found a male predominance in both types, a wide age range but with younger patients having predominantly type 2 disease, and clinical presentations that varied and included the nephrotic syndrome, an abnormal urinalysis ...

journal_title：Mayo Clinic proceedings

authors： Donadio JV Jr,Slack TK,Holley KE,Ilstrup DM

更新日期：1979-03-01 00:00:00

abstract：:Epilepsy is one of the most common and challenging neurologic disorders affecting children. Although various modalities exist to treat pediatric-onset seizures, seizures in 25% of children who are diagnosed as having epilepsy remain refractory to available therapies. Of the 8 new antiepileptic drugs (AEDs) (felbamate,...

journal_title：Mayo Clinic proceedings

authors： Jarrar RG,Buchhalter JR

更新日期：2003-03-01 00:00:00

abstract：:Emergency teams asked to provide cardiopulmonary resuscitation for pediatric patients often consist of nurses and physicians from various pediatric and nonpediatric specialties. Team members should agree on the timing of termination of unsuccessful resuscitative efforts; however, no firm guidelines about such timing h...

journal_title：Mayo Clinic proceedings

authors： O'Marcaigh AS,Koenig WJ,Rosekrans JA,Berseth CL

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:To present a multiyear clinical experience with intravenous bevacizumab for the management of severe gastrointestinal bleeding and/or epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT). PATIENTS AND METHODS:All patients treated with intravenous bevacizumab for severe hereditary hemorrhagi...

journal_title：Mayo Clinic proceedings

authors： Iyer VN,Apala DR,Pannu BS,Kotecha A,Brinjikji W,Leise MD,Kamath PS,Misra S,Begna KH,Cartin-Ceba R,DuBrock HM,Krowka MJ,O'Brien EK,Pruthi RK,Schroeder DR,Swanson KL

更新日期：2018-02-01 00:00:00