Abstract：
OBJECTIVE:To analyze a large cohort of patients who underwent exercise testing and also report sex differences in other exercise heart rate (HR) parameters to determine whether separate sex-based equations to predict peak HR are indicated. PATIENTS AND METHODS:Patients aged 40 to 89 years who performed treadmill exercise tests (Bruce protocol) from September 21, 1993, to December 20, 2010, were included. Patients with cardiovascular disease or taking HR-attenuating drugs were excluded. After analyses on preliminary cohort, peak HR-modifying factors were eliminated to obtain a pure data set. Analysis of variance was used to test difference in HR responses by sex with age adjustment. RESULTS:A total of 37,010 patients (67.3% men) were included in the preliminary cohort. Men had higher peak HR (166±17 vs 163±16 beats/min [bpm]; P<.001), HR reserve (90±19 vs 84±17 bpm; P<.001), and HR recovery (19±8 vs 18±9 bpm; P<.03). Poor exercise capacity, current smoking, diabetes, and obesity had significant peak HR-lowering effects (all P<.001). In a pure cohort of 19,013 patients (51.3% of full cohort) without these factors, regression lines approximated more closely the traditional line of 220 - age. For men, the regression line in our final cohort was peak HR = 220 - 0.95 × age. For women, both slope (0.79 bpm/y) and intercept (210 bpm) were still substantially different from those obtained with the traditional formula. CONCLUSION:The HR responses to exercise are different in men and women. The HR response of men was close to that obtained with the traditional formula, but peak HR in women had a lower intercept and decreased more slowly with age. A separate formula for peak HR in women appears to be appropriate.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Sydó N,Abdelmoneim SS,Mulvagh SL,Merkely B,Gulati M,Allison TGdoi
10.1016/j.mayocp.2014.08.018subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1664-72issue
12eissn
0025-6196issn
1942-5546pii
S0025-6196(14)00796-4journal_volume
89pub_type
杂志文章abstract：OBJECTIVE:To investigate whether patients with traumatic brain injury (TBI) have an increased risk of stroke or poststroke mortality. PARTICIPANTS AND METHODS:Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study of 30,165 patients with new TBI and 120,660 persons withou...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.09.019
更新日期：2014-02-01 00:00:00
abstract：:We describe a patient who had severe myalgias, bronchial asthma, pulmonary infiltrates, and eosinophilia. The findings on physical examination and the erythrocyte sedimentation rate were normal; there was no elevation of the serum creatine kinase. Muscle biopsy demonstrated an inflammatory exudate that contained eosin...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62663-9
更新日期：1988-01-01 00:00:00
abstract：:The surgical treatment of Crohn's disease is necessitated by complications of the disease or by failure of medical therapy. Despite the fact that the patients with Crohn's disease who undergo operation have the most severe spectrum of problems, about half these patients may never need a further procedure, and the mort...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61933-8
更新日期：1986-04-01 00:00:00
abstract：:Effective antimicrobial therapy for most urinary tract infections has been available since the sulfonamide era. Innovations in chemotherapy now include single-dose treatment of acute bacterial cystitis and acute urethral syndrome and effective suppression of recurrent bacteriuria with low-dose antimicrobial agents. ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:In this article, we report a case of Leuconostoc bacteremia in a 7-month-old infant who had short-gut syndrome after a gastroschisis repair and who was dependent on total parenteral nutrition through a central venous catheter. The organism was initially misidentified as viridans group streptococcus. Detection of vanco...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/71.12.1171
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVE:To assess the impact of direct-to-consumer (DTC) predictive genomic risk information on perceived risk and worry in the context of routine clinical care. PATIENTS AND METHODS:Patients attending a preventive medicine clinic between June 1 and December 18, 2009, were randomly assigned to receive either genomic...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,随机对照试验
doi：10.4065/mcp.2011.0190
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To review our institution's experience with patients who failed to benefit from septal artery ablation, which necessitated subsequent septal myectomy, and to examine reasons for ablation failure and outcome of myectomy after ablation. PARTICIPANTS AND METHODS:Of 550 patients who underwent septal myectomy at ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/S0025-6196(11)61096-3
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:To measure carotid artery intima-media thickness (CIMT), a marker of subclinical atherosclerosis, in postmenopausal women with and without histories of preeclampsia and to synthesize these results with those from prior studies of CIMT performed 10 or more years after preeclamptic pregnancies. PATIENTS AND ME...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2017.05.030
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:To explore the influence of referral bias on complication rates after vaginal hysterectomy. PATIENTS AND METHODS:Community-based (local) and referral patients had benign indications and underwent vaginal hysterectomy from January 1, 2004, through December 31, 2005. We retrospectively evaluated patient charac...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2009.0299
更新日期：2010-02-01 00:00:00
abstract：:To our knowledge, we describe the first reported case of paradoxical embolization via a patent foramen ovale (PFO) in an adult with moderately severe cystic fibrosis (CF) and advanced lung disease. Fluctuating neurologic symptoms and signs suggestive of cerebrovascular disease in an adult patient with advanced CF may ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/75.10.1100
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:To define mortality associated with isolated tricuspid regurgitation (TR) and identify risk factors associated with decreased survival. PATIENTS AND METHODS:We conducted a retrospective cohort study of residents of southeastern Minnesota with moderate-severe or more severe isolated TR diagnosed between Janua...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2019.04.036
更新日期：2019-10-01 00:00:00
abstract：:Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especi...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2017.09.007
更新日期：2017-11-01 00:00:00
abstract：:Type I anti-neuronal nuclear autoantibodies (ANNA-I, also known as "Hu") are a distinctive serologic marker of small cell lung carcinoma (SCLC) in patients who have peripheral neuropathies or encephalomyeloradiculopathies. A tumor antigen reactive with these antibodies has been identified by other investigators by Wes...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62471-9
更新日期：1991-12-01 00:00:00
abstract：:Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is a common disorder, occurring at least twice a week and causing at least moderate distress in 1.5% to 2.7% of the population. It is important for primary care physicians to be familiar with this disorder and its management. Much has changed in its management si...
journal_title：Mayo Clinic proceedings
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.mayocp.2013.06.016
更新日期：2013-09-01 00:00:00
abstract：:A 27-year-old man with a history of acne presented to his primary care physician because of fatigue and dyspnea on exertion of 4 weeks' duration. He was remarkably pale, orthostatic pulse changes were noted, and a systolic ejection murmur was heard. The patient had profound anemia (hemoglobin concentration, 5.0 g/dL) ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/77.7.713
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To compare health care usage between suicide decedents and living controls in the year before suicide in a large representative US population. PATIENTS AND METHODS:Cases (n=1221) and controls (n=3663) belonged to an integrated health care system from January 1, 2009, through December 31, 2014. Cases and cont...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2019.04.037
更新日期：2019-10-01 00:00:00
abstract：:Pergolide is a potent dopamine agonist and is known to have anti-Parkinson properties. We administered pergolide to patients with suboptimal control of Parkinson's disease who had a short-duration response to carbidopa-levodopa in a 6-month, double-blind study. Pergolide added to the carbidopa-levodopa regimen resulte...
journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0025-6196(12)64911-8
更新日期：1988-10-01 00:00:00
abstract：OBJECTIVE:To investigate the pharmacodynamic properties of inclisiran, a small interfering RNA targeting proprotein convertase subtilisin-kexin type 9 (PCSK9), in individuals with normal renal function and renal impairment (RI). PATIENTS AND METHODS:The analysis included participants with normal renal function and mil...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mayocp.2019.08.021
更新日期：2020-01-01 00:00:00
abstract：:Total joint replacement in the upper extremity has developed in step with that of the lower extremity. The indications for treatment, the place of total joint arthroplasty in contrast to other forms of arthroplasty, and the criteria for patient selection have recently been classified. A number of problem areas are und...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：OBJECTIVE:To determine whether blood type affects the risk of thromboembolic complications in patients with atrial fibrillation (AF). PATIENTS AND METHODS:The Mayo Clinic electronic medical record was searched (between January 1, 2004, and December 31, 2010) to identify all patients with AF with blood group assessment...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2014.11.013
更新日期：2015-02-01 00:00:00
abstract：:Prospective data and follow-up information were collected on the initial 200 patients who underwent laparoscopic cholecystectomy at the Mayo Clinic. The operation was completed laparoscopically in all but five patients, who required conversion to laparotomy because of dense scarring or stones in the common bile duct. ...
journal_title：Mayo Clinic proceedings
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doi：10.1016/s0025-6196(12)60390-5
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/82.5.556
更新日期：2007-05-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)60670-8
更新日期：2009-11-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60023-8
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abstract：:A need exists for a self-report questionnaire that reliably and accurately measures symptoms and that distinguishes patients with functional gastrointestinal disease from those with other conditions. We have developed such an instrument, the bowel disease questionnaire, and herein describe details of its discriminator...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62169-7
更新日期：1990-11-01 00:00:00
abstract：:Hypochondriasis (HC), which involves preoccupation with the fear of having a serious illness despite appropriate medical examination, is often encountered in medical settings. The most conspicuous feature of this disorder is seeking excessive reassurance from physicians, medical references, or self-inspection; however...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/77.12.1323
更新日期：2002-12-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2014.07.017
更新日期：2014-12-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)60585-5
更新日期：2009-06-01 00:00:00
abstract：:There is an ongoing debate in the medical community regarding the effects of testosterone on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding the association of endogenous testosterone levels and CV disease (CVD) events that has resulted in much debate and confusion among health c...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2017.11.006
更新日期：2018-01-01 00:00:00
abstract：:Restless legs syndrome (RLS) is a common disorder with a prevalence of 5% to 15%. Primary care physicians must become familiar with management of this disorder. This algorithm for the management of RLS was written by members of the Medical Advisory Board of the Restless Legs Syndrome Foundation and is based on scienti...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/79.7.916
更新日期：2004-07-01 00:00:00
