Abstract：
OBJECTIVE:To investigate whether patients with traumatic brain injury (TBI) have an increased risk of stroke or poststroke mortality. PARTICIPANTS AND METHODS:Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study of 30,165 patients with new TBI and 120,660 persons without TBI between January 1, 2000, and December 31, 2004. The risk of stroke was compared between 2 cohorts through December 31, 2008. To investigate the association between in-hospital mortality after stroke and history of TBI, we conducted a case-control study of 7751 patients with newly diagnosed stroke between January 1, 2005, and December 31, 2008. RESULTS:The TBI cohort had an increased stroke risk (hazard ratio [HR], 1.98; 95% CI, 1.86-2.11). Among patients with stroke, those with a history of TBI had a higher risk of poststroke mortality compared with those without TBI (odds ratio, 1.57; 95% CI, 1.13-2.19). In the TBI cohort, factors associated with stroke were history of TBI hospitalization (HR, 3.14; 95% CI, 2.77-3.56), emergency care for TBI (HR, 3.37; 95% CI, 2.88-3.95), brain hemorrhage (HR, 2.69; 95% CI, 2.43-2.99), skull fracture (HR, 3.00; 95% CI, 2.42-3.71), low income (HR, 2.65; 95% CI, 2.16-3.25), and high medical expenditure for TBI care (HR, 2.26; 95% CI, 2.09-2.43). The severity of TBI was also correlated with poststroke mortality. CONCLUSIONS:Traumatic brain injury was associated with risk of stroke and poststroke mortality. The relationship between TBI and poststroke mortality does not seem to transcend all age groups. This research shows the importance of prevention, early recognition, and treatment of stroke in this vulnerable population.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Liao CC,Chou YC,Yeh CC,Hu CJ,Chiu WT,Chen TLdoi
10.1016/j.mayocp.2013.09.019subject
Has Abstractpub_date
2014-02-01 00:00:00pages
163-72issue
2eissn
0025-6196issn
1942-5546pii
S0025-6196(13)00979-8journal_volume
89pub_type
杂志文章abstract：:The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed r...
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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journal_title：Mayo Clinic proceedings
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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doi：
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