Wegener's granulomatosis associated with vasculitis of the temporal artery: report of five cases.

Abstract:

:Between January 1973 and October 1991 at the Mayo Clinic, 5 of 345 patients with Wegener's granulomatosis initially had features suggestive of giant cell arteritis and subsequently were found to have biopsy-proven vasculitis of the temporal artery. All five patients were older than 60 years of age and had jaw claudication, sudden loss of vision, severe headache with or without diplopia, or polymyalgia rheumatica at the time of initial examination. The erythrocyte sedimentation rate was high at the time of onset of symptoms in four patients (and unavailable in one patient). A temporal artery biopsy specimen revealed giant cell arteritis in one patient and non-giant cell arteritis in four patients. All five patients subsequently had pulmonary and renal lesions characteristic of Wegener's granulomatosis, with typical histopathologic features on biopsy or positive cytoplasmic staining antineutrophil cytoplasmic antibodies. Thus, overlapping features of giant cell arteritis and Wegener's granulomatosis do occur in some patients.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Nishino H,DeRemee RA,Rubino FA,Parisi JE

doi

10.1016/s0025-6196(12)60157-8

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

115-21

issue

2

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(12)60157-8

journal_volume

68

pub_type

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