Total androgen blockade: the United States experience.

Abstract:

:Maximal androgen blockade may improve the effectiveness of treatment of prostate cancer. To test this hypothesis we conducted a randomized, double-blind trial in patients with disseminated and previously untreated prostate cancer (stage D2). All patients (n = 603) received leuprolide, 1 mg/day s.c. in combination with either placebo (n = 300) or flutamide 250 mg p.o. t.i.d. (n = 303). The median progression-free survival times were estimated at 14 months for the leuprolide plus placebo group and 17 months for leuprolide plus flutamide patients: median times for overall survival were 29 vs. 35 months, respectively. Patients with minimal disease and good performance status did particularly well on combination therapy. Median progression-free survival for this subgroup was 19 months for leuprolide plus placebo patients vs. 48 months for patients on combined therapy (p = 0.035) Flutamide appeared to reduce the disease flare associated with leuprolide monotherapy. Combined androgen blockade with leuprolide and flutamide is superior to leuprolide treatment alone in patients with disseminated prostate cancer.

journal_name

Eur Urol

journal_title

European urology

authors

Benson RC

doi

10.1159/000474395

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

72-6

eissn

0302-2838

issn

1873-7560

journal_volume

24 Suppl 2

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    更新日期:2018-10-01 00:00:00

  • Multiparametric Magnetic Resonance Imaging for the Detection of Clinically Significant Prostate Cancer: What Urologists Need to Know. Part 1: Acquisition.

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    authors: Engels RRM,Israël B,Padhani AR,Barentsz JO

    更新日期:2020-04-01 00:00:00

  • Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis.

    abstract:CONTEXT:Clinical data supporting the use of targeted agents for the treatment of metastatic renal cell carcinoma (RCC) are based predominantly on patients with clear cell histology. Little is known about the efficacy of these drugs in non-clear cell variants. OBJECTIVE:To evaluate the efficacy of different clear cell ...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2014.05.010

    authors: Vera-Badillo FE,Templeton AJ,Duran I,Ocana A,de Gouveia P,Aneja P,Knox JJ,Tannock IF,Escudier B,Amir E

    更新日期:2015-04-01 00:00:00

  • Racial Variation in Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer: Results from the CEASAR Study.

    abstract:BACKGROUND:Relatively little is known about the relationship between race/ethnicity and patient-reported outcomes after contemporary treatments for localized prostate cancer. OBJECTIVE:To test the hypothesis that treatment-related changes in urinary, bowel, sexual, and hormonal function vary by race/ethnicity. DESIGN...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

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    更新日期:2017-08-01 00:00:00

  • Investigations of urothelial cells seeded on commercially available small intestine submucosa.

    abstract:OBJECTIVES:To examine adherence and viability of human urothelial cells seeded on commercially available small intestine submucosa (SIS) specimens under serum-free conditions. MATERIALS AND METHODS:Before seeding, SIS was either washed with incubation medium or coated with collagen A, fibronectin, or pronectin. A poss...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.05.041

    authors: Feil G,Christ-Adler M,Maurer S,Corvin S,Rennekampff HO,Krug J,Hennenlotter J,Kuehs U,Stenzl A,Sievert KD

    更新日期:2006-12-01 00:00:00

  • Phase 2 trial of neoadjuvant axitinib in patients with locally advanced nonmetastatic clear cell renal cell carcinoma.

    abstract:BACKGROUND:Previous studies have shown a modest impact of tyrosine kinase inhibitors on primary renal tumors. Those studies were mostly retrospective or heterogeneous in their eligibility criteria with regard to histology, disease stage, duration of therapy, and time off therapy prior to surgery. OBJECTIVE:To prospect...

    journal_title:European urology

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    更新日期:2014-11-01 00:00:00

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    abstract::More than 100 million people worldwide are affected by bilharziasis, caused by Schistosoma haematobium. For travellers precaution is most important. For the population in endemic areas, an integrated approach including health education is necessary. Effective pharmacologic treatment is available. ...

    journal_title:European urology

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.eururo.2006.02.022

    authors: Bichler KH,Savatovsky I,Members of the Urinary Tract Infection (UTI) Working Group of the Guidelines Office of the European Association of Urology (EAU):.,Naber KG,Bischop MC,Bjerklund-Johansen TE,Botto H,Cek M,Grabe M,Lobel B,Redort

    更新日期:2006-06-01 00:00:00

  • Heparin binding growth factors and the control of teratoma cell proliferation.

    abstract::The role of basic fibroblast growth factor (bFGF) in the control of teratoma cell proliferation was examined. It was found that bFGF stimulates proliferation at low concentrations but induces cell migration at higher doses. These effects could be efficiently counteracted by addition of protamine sulphate. Moreover the...

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    pub_type: 杂志文章

    doi:10.1159/000474573

    authors: Granérus M,Welin A,Lundh B,Schofield PN,Ekström TJ,Engström W

    更新日期:1993-01-01 00:00:00

  • The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics.

    abstract:CONTEXT:Biomarker-driven cancer therapy, also referred to as precision oncology, has received increasing attention for its promise of improving patient outcomes by defining subsets of patients more likely to respond to various therapies. OBJECTIVE:In this collaborative review article, we examine recent literature rega...

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    pub_type: 杂志文章,评审

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    更新日期:2017-02-01 00:00:00

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00134-3

    authors: Grimm MO,Kamphausen S,Hugenschmidt H,Stephan-Odenthal M,Ackermann R,Vögeli TA

    更新日期:2002-06-01 00:00:00

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    abstract::Renal transplantation is the treatment of choice for patients with end-stage renal disease and it has already been described in the literature in patients with orthotopic neobladders, mostly in the paediatric population. We report the first case of a living-donor renal graft in an adult patient with a orthotopic neobl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.05.020

    authors: Airoldi A,Volpe A,Billia M,Marchioro G,Fenoglio R,Lazzarich E,Sacchetti G,Baiocco C,Inglese E,Menegotto A,Terrone C,Stratta P

    更新日期:2010-11-01 00:00:00

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    journal_title:European urology

    pub_type: 杂志文章,多中心研究

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    更新日期:2015-02-01 00:00:00

  • Long-term outcomes of patients with lymph node metastasis treated with radical prostatectomy without adjuvant androgen-deprivation therapy.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2013.03.053

    authors: Touijer KA,Mazzola CR,Sjoberg DD,Scardino PT,Eastham JA

    更新日期:2014-01-01 00:00:00

  • Enhanced Recovery Pathways Versus Standard Care After Cystectomy: A Meta-analysis of the Effect on Perioperative Outcomes.

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    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2016.05.031

    authors: Tyson MD,Chang SS

    更新日期:2016-12-01 00:00:00

  • Primary non-Hodgkin's lymphoma of the urinary bladder.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474808

    authors: Melekos MD,Matsouka P,Fokaefs E,Pantazakos A,Repanti M

    更新日期:1992-01-01 00:00:00

  • Lateralized lumbar pain during sexual intercourse. Early clinical sign of single ectopic ureter?

    abstract::Although a single ectopic ureter opening into the vagina has frequently been reported in literature, lateralized lumbar pain during sexual intercourse and urinary incontinence after pregnancy due to a single ectopic ureter are uncommon. The etiology and pathogenesis are unknown but some clinical, pathological and embr...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473017

    authors: Cisternino A,Artibani W,Aragona F,Bassi P

    更新日期:1988-01-01 00:00:00

  • Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.

    abstract:OBJECTIVES:A dysregulated mitogen-activated protein kinase (MAPK) pathway plays an important role in various malignancies and is often mediated by mutations in several oncogenes (eg, RAF, RAS). B-RAF mutations, predominantly the specific V600E mutation and additional alterations in exons 11 and 15, were frequently dete...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.11.031

    authors: Burger M,Denzinger S,Hammerschmied C,Tannapfel A,Maderstorfer A,Wieland WF,Hartmann A,Stoehr R

    更新日期:2006-11-01 00:00:00

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    abstract::We compared the history of 100 consecutive women complaining of incontinence with their urodynamic findings. The real urodynamic situation proved unpredictable on the basis of the medical history. A good correlation between history and urodynamics was found in 80% of the women complaining of stress incontinence. The i...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472986

    authors: Maes D,Wyndaele JJ

    更新日期:1988-01-01 00:00:00

  • Impotence due to corporeal veno-occlusive dysfunction: long-term follow-up of venous surgery.

    abstract::Corporeal veno-occlusive dysfunction is an important cause of organic impotence and is characterized by increased flow rates to create and to maintain erection during artificial erection produced by intracavernous saline infusion. Sixty-seven patients with this erectile insufficiency underwent penile ligature-resectio...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474815

    authors: Wespes E,Delcour C,Preserowitz L,Herbaut AG,Struyven J,Schulman C

    更新日期:1992-01-01 00:00:00

  • Preoperative and postoperative evaluation of prostate-specific antigen in localized prostatic cancer treated by radical prostatectomy.

    abstract::Preoperative prostate-specific antigen (PSA) values were determined in 73 patients with clinically localized prostatic cancer and candidates for a radical procedure. Correlation of preoperative PSA with a final pathological stage was attempted. Only in 44.8% of our 22 patients with organ-confined disease was the PSA v...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474902

    authors: Zattoni F,Piazza R,Vianello R,Garbeglio A,Pagano F

    更新日期:1992-01-01 00:00:00

  • Spread of onabotulinumtoxinA after bladder injection. Experimental study using the distribution of cleaved SNAP-25 as the marker of the toxin action.

    abstract:BACKGROUND:OnabotulinumtoxinA (Onabot/A) has been used to treat detrusor overactivity disorders. The treatment is based on several injections of toxin throughout the bladder wall. However, injection protocols are not well established among clinicians, varying in dose and dilution. OBJECTIVE:Study the distribution and ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2012.01.046

    authors: Coelho A,Cruz F,Cruz CD,Avelino A

    更新日期:2012-06-01 00:00:00

  • Urinary symptoms and urodynamic findings in women with pelvic organ prolapse: is there a correlation? Results of an artificial neural network analysis.

    abstract:BACKGROUND:International official guidelines recommend urodynamic (UDS) evaluation in patients with pelvic organ prolapse (POP). However, the real benefit of this examination is still the subject of heated and controversial debate. Therefore, we aimed to assess the correlation between urinary symptoms and UDS findings ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2011.03.010

    authors: Serati M,Salvatore S,Siesto G,Cattoni E,Braga A,Sorice P,Cromi A,Ghezzi F,Bolis P

    更新日期:2011-08-01 00:00:00

  • Treatment of uretero-intestinal and ureterovesical strictures by Acucise balloon catheter.

    abstract:OBJECTIVE:Acucise balloon catheter has been proposed as an alternative to open surgery for the treatment of strictures of the ureteropelvic junction because of its low morbidity and the short hospital stay following the endoscopic procedure. The objective of this study was to evaluate the results of this technique appl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00070-2

    authors: Touiti D,Gelet A,Deligne E,Fassi-Fehri H,Benrais H,Martin X,Dubernard JM

    更新日期:2002-07-01 00:00:00

  • Nocturnal enuresis: basic facts and new horizons.

    abstract::Nocturnal enuresis in children is quite seldom due to psychological factors. Instead, it is caused by a hereditary delay in maturation of the somatic mechanisms (reduction of nocturnal urine production, relaxation of the bladder during sleeping hours, and a normal arousal to a full bladder) which prevent the child fro...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:

    authors: Hjälmås K

    更新日期:1998-01-01 00:00:00

  • The influence of serial sections, immunohistochemistry, and extension of pelvic lymph node dissection on the lymph node status in clinically localized prostate cancer.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00450-5

    authors: Wawroschek F,Wagner T,Hamm M,Weckermann D,Vogt H,Märkl B,Gordijn R,Harzmann R

    更新日期:2003-02-01 00:00:00

  • A progress report on a prospective randomised trial of open and robotic prostatectomy.

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    journal_title:European urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.eururo.2013.10.031

    authors: Gardiner RA,Coughlin GD,Yaxley JW,Dunglison NT,Occhipinti S,Younie SJ,Carter RC,Williams SG,Medcraft RJ,Samaratunga HM,Perry-Keene JL,Payton DJ,Lavin MF,Chambers SK

    更新日期:2014-03-01 00:00:00

  • Androgen receptors in untreated and treated prostatic intraepithelial neoplasia.

    abstract:OBJECTIVES:The effect of androgen deprivation therapy on the expression of androgen receptors (AR) and the proliferation-associated MIB-1 antigen in prostatic intraepithelial neoplasia (PIN) was investigated. METHODS:Immunohistochemistry was performed on tissue sections of prostatectomy specimens of patients with pros...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474179

    authors: van der Kwast TH,Têtu B

    更新日期:1996-01-01 00:00:00

  • Improved Reporting of Randomized Controlled Trials in the Urologic Literature.

    abstract:BACKGROUND:Well-designed randomized controlled trials (RCTs) have the potential to provide high-quality evidence to inform questions of therapy and prevention, but this potential is contingent on the use of appropriate methods and transparent reporting. OBJECTIVE:To systematically assess the quality of urology RCT rep...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2016.07.042

    authors: Narayan VM,Cone EB,Smith D,Scales CD Jr,Dahm P

    更新日期:2016-12-01 00:00:00

  • Handling and pathology reporting of prostate biopsies.

    abstract::Appropriate handling and processing of prostate needle biopsies is critical for an optimal examination by pathologists. Reporting by pathologists should be accurate, unequivocal and concise, giving the information needed for the urologist. Quality parameters need to be developed to survey the performance of pathology ...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2004.04.006

    authors: Boccon-Gibod L,van der Kwast TH,Montironi R,Boccon-Gibod L,Bono A,European Society of Uropathology.,European Society of Pathology Uropathology Working Group.

    更新日期:2004-08-01 00:00:00

  • Needle core length is a quality indicator of systematic transperineal prostate biopsy.

    abstract:OBJECTIVE:To analyse the length of needle cores sampled as a quality indicator in systematic transperineal prostate biopsy. We assessed the correlation of core length with the other clinical and topographic parameters. MATERIAL AND METHODS:We prospectively evaluated data from 509 consecutive patients who underwent a f...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.12.057

    authors: Ficarra V,Martignoni G,Novella G,Cerruto MA,Galfano A,Novara G,Pea M,Artibani W

    更新日期:2006-08-01 00:00:00