Abstract:
BACKGROUND:Relatively little is known about the relationship between race/ethnicity and patient-reported outcomes after contemporary treatments for localized prostate cancer. OBJECTIVE:To test the hypothesis that treatment-related changes in urinary, bowel, sexual, and hormonal function vary by race/ethnicity. DESIGN, SETTING, AND PARTICIPANTS:The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled 3708 men diagnosed with localized prostate cancer in 2011-2012. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:Patient-reported disease-specific function was measured using the 26-item Expanded Prostate Index Composite (EPIC) at baseline and 6 and 12 mo after enrollment. Mean treatment differences in function were compared by race using risk-adjusted generalized estimating equations. RESULTS AND LIMITATIONS:While all race/ethnic groups reported considerable declines in scores for urinary incontinence after radical prostatectomy (RP) when compared to active surveillance, African-American men reported a greater difference than white men did (adjusted difference-in-differences 8.4 points, 95% confidence interval 2.0-14.8; p=0.01). No difference in bother scores was noted and the overall proportion of explained variation attributable to race/ethnicity was relatively small in comparison to primary treatment and baseline function. No clinically significant racial variation was noted for the sexual, bowel, irritative voiding, or hormone domains. Limitations include the lack of well-established thresholds for clinical significance using the EPIC instrument. CONCLUSION:While these data demonstrate that incontinence at 1 yr after RP may be worse for African-American compared to white men, the difference appears to be modest overall. Treatment selection and baseline function explain a much greater proportion of the variation in function after treatment. PATIENT SUMMARY:We observed that the effect of treatment for prostate cancer on patient-reported function did not vary dramatically by race/ethnicity. Compared to white men, African-American men experienced a somewhat more pronounced decline in urinary continence after radical prostatectomy, but the corresponding changes in bother scores were not significantly different between the two groups.
journal_name
Eur Uroljournal_title
European urologyauthors
Tyson MD,Alvarez J,Koyama T,Hoffman KE,Resnick MJ,Wu XC,Cooperberg MR,Goodman M,Greenfield S,Hamilton AS,Hashibe M,Paddock LE,Stroup A,Chen VW,Penson DF,Barocas DAdoi
10.1016/j.eururo.2016.10.036subject
Has Abstractpub_date
2017-08-01 00:00:00pages
307-314issue
2eissn
0302-2838issn
1873-7560pii
S0302-2838(16)30750-3journal_volume
72pub_type
杂志文章,多中心研究相关文献
EUROPEAN UROLOGY文献大全abstract::7 children, 20 months to 11 years old, with cystinuria and renal calculi were studied. Surgical treatment and alpha-mercaptopropionylglycine (MPG) gave satisfactory results in 5 children. The causes of the recurrences in the other 2 children are discussed. MPG therapy is effective but can cause a nephrotic syndrome at...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473204
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:With current treatments, men usually survive many years after being diagnosed with prostate cancer. However, without supportive care, the systemic effects of prostate cancer and therapies such as androgen deprivation therapy (ADT) can undermine skeletal integrity, resulting in skeletal complications that may ...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2004.08.016
更新日期:2004-12-01 00:00:00
abstract::Complete duplication of vagina, cervix and uterus, with imperforate hemivagina and renal agenesis is a rare condition with less than 120 cases published. In those articles, urological complications are uncommon with only a 10% of the total. We report 2 cases of uterus didelphys with unilateral hematocolpos and ipsilat...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000471669
更新日期:1991-01-01 00:00:00
abstract::Fifty-five patients with muscle-invasive transitional cell carcinoma of the bladder were treated with preoperative cisplatin-based chemotherapy followed by radiotherapy (20 Gy within 1 week) and cystectomy. DNA flow cytometry (FCM) was performed in paraffin-embedded tissue obtained by transurethral resection immediate...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474779
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence, typology, and experience of urinary incontinence, as well as the available therapeutic modalities and information sources among people living at home in Belgium. METHODS:A representative population sample of 5,269 adults completed a questionnaire in their own homes. There were ...
journal_title:European urology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::A power spectrum of the electromyographic signals in urethral and anal sphincters has been analyzed in 25 patients. Different spectra are observed in each muscle, with higher frequencies in the urethral sphincter. The high frequencies are manifest at short brisk contractions (e.g. cough) and disappear quicly during a ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472130
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To determine the utility of local thrombolysis in the treatment of acute renal arterial occlusion. METHODS:We used local thrombolytic treatment in a female patient, aged 76, with 72 h of anuria, right lumbar and flank pain. She had a 3-year history of ischemic heart disease and atrial fibrillation controlled...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000020303
更新日期:2000-09-01 00:00:00
abstract::An experimental oedema of the bladder wall was produced by electric coagulation current in 130 rats. The amount of oedema was calculated by determination of the difference between the weight of the freshly excised wet bladder and that after drying to constant weight. Thus, oedema of a fairly constant and reproducible ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472035
更新日期:1976-01-01 00:00:00
abstract::Early-stage prostate cancer is usually asymptomatic and therefore, in the past, has often gone undetected, unless diagnosed by a digital rectal examination. More recently, new tests have been introduced, namely prostate-specific antigen and transrectal ultrasound, in order to improve the detection of early-stage disea...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474379
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic disease without an effective treatment, characterized by pain during bladder filling. Most nociceptive bladder afferents course in the trigone. OBJECTIVE:To evaluate efficacy and tolerability of trigonal injection of botulinum toxin A (BoNTA)...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2010.02.031
更新日期:2010-09-01 00:00:00
abstract::Scrotal ultrasonography was performed in 888 testes of 444 randomly selected men appearing before the medical board prior to military service (Mili group, 287 men, median age 18.8 years), and in employees from an industrial company (Empl group, 157 men, median age 35.6 years). The ultrasonic volume of each testis was ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474300
更新日期:1993-01-01 00:00:00
abstract::Formalin-fixed, paraffin-embedded specimens from 91 primary transitional cell cancers (TCC) of the urinary bladder were stained with a monoclonal antibody to c-erb B-2 oncoprotein. Twelve percent (11/91) of the TCC stained for c-erb b-2 oncoprotein, and in 4% (4/91) of cases, the expression was graded as moderate or h...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000471706
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:One of the most effective and popular current procedures for the surgical treatment of stress urinary incontinence (SUI) is tension-free midurethral slings. OBJECTIVE:To evaluate the outcomes of women with retropubic tension-free vaginal tape (TVT) for urodynamic stress incontinence (USI) after 10-yr follow...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2012.01.038
更新日期:2012-05-01 00:00:00
abstract:CONTEXT:An increasing number of small renal masses (SRMs) with heterogeneous histology and clinical behaviour are being detected with modern radiologic imaging. Although surgical removal is the standard of care for small renal tumours, alternative minimally invasive and conservative treatment options are possible in se...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2011.05.044
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The genomic features underpinning renal cell carcinoma with sarcomatoid dedifferentiation (sRCC) are not well understood, and at present, there are no specific or effective therapies for sRCC. OBJECTIVE:To identify genomic alterations in patients with sRCC. DESIGN, SETTING, AND PARTICIPANTS:We conducted ge...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2016.01.051
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:To determine the anatomic extent of pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients at the time of radical prostatectomy (RP), knowledge about the topography of lymph node (LN) metastases is required. OBJECTIVE:Because small-volume LN metastases may be missed by standard histopathologi...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2013.02.007
更新日期:2014-08-01 00:00:00
abstract::Antimuscarinics are commonly used to treat overactive bladder, but increase anticholinergic burden, which has been associated with multiple adverse outcomes in older patients. We advocate for standardization of anticholinergic risk assessment and reevaluation of anticholinergic prescribing practices for the elderly. ...
journal_title:European urology
pub_type: 社论
doi:10.1016/j.eururo.2019.03.021
更新日期:2019-07-01 00:00:00
abstract::The influence of magnesium chloride on various blood and urine parameters in calcium oxalate stone patients is studied. High dose magnesium therapy was found to increase urinary magnesium concentrations, whereas the oxalic acid concentration is reduced. The experiments support the statements on the role of magnesium i...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473189
更新日期:1981-01-01 00:00:00
abstract::Nocturnal enuresis in children is quite seldom due to psychological factors. Instead, it is caused by a hereditary delay in maturation of the somatic mechanisms (reduction of nocturnal urine production, relaxation of the bladder during sleeping hours, and a normal arousal to a full bladder) which prevent the child fro...
journal_title:European urology
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract:CONTEXT:Uncertainty remains about the extent and indications for inguinal lymphadenectomy in penile cancer, a procedure known for relatively high morbidity. Several attempts have been made to develop strategies which can improve the diagnostic quality and reduce the morbidity of the management of inguinal lymph nodes i...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2009.02.021
更新日期:2009-05-01 00:00:00
abstract::Sentinel lymph node (SLN) detection techniques have the potential to change the standard of surgical care for patients with prostate cancer. We performed a lymphatic mapping study and determined the value of fluorescence SLN detection with indocyanine green (ICG) for the detection of lymph node metastases in intermedi...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2016.01.034
更新日期:2016-11-01 00:00:00
abstract::A case of urinary obstruction caused by vulvar fusion in an adult is reported. Anterograde micturition-urethrocystography revealed reflux of urine in the vagina and cavum uteri. Treatment consisted of sharp separation of the labia. Ointment dressing was applied to prevent reagglutination. After 1 year the patient has ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473956
更新日期:1978-01-01 00:00:00
abstract::Extended ipsilateral lymphadenectomy performed on 102 patients with renal cell carcinoma revealed 21 patients (21%) having regional lymph node metastasis. Of the 21 patients, 6 (6%) had single-node metastasis and 15 (15%) multiple-node metastasis. PT, pV, pM, cell type and grade were all correlated with regional node ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000463880
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Based on a recently introduced mathematical model approach we show that uroliths located in the urinary tract (UT) can substantially deplete the urinary concentrations of lithogenic constituents by continuous growth. METHODS:To illustrate the influence of the urinary depletion effect on urinalysis, a "typic...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(03)00365-8
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:Lymphoma is the most frequent testicular malignancy in men over 60 years of age. Even though patients present initially with localized disease, the high incidence of bilateral involvement, synchronous or not, and early systemic dissemination are characteristic of these neoplasms. Sometimes the interval betwe...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000020378
更新日期:2000-12-01 00:00:00
abstract::Assessment of the pelvic lymph node status is a major concern in prostatic cancer staging. In spite of a normal abdominopelvic CT scan examination in patients with organ-confined disease, 7-30% will have lymph node metastases at pathological examination and will not benefit from radical prostatectomy. Laparoscopy enab...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000475282
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence of loss of heterozygosity (LOH) and microsatellite instability (MI) in human renal cell carcinoma (RCC), and to determine a possible activation of H-ras oncogene in these tumours via implication of its polymorphic regions within the first intron and 3' ends. METHODS:In the presen...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000019541
更新日期:1998-01-01 00:00:00
abstract::Preliminary investigation of cell-mediated immunity (CMI) in 49 patients harboring renal cell carcinoma (RCC) by the migration inhibition factor (MIF) tests as compared to 47 patients with simple renal cysts or normal kidneys established the specificity (85%) and reproducibility of this test. A retrospective analysis ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472989
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:To study the effect of botulinum toxin A (BoNTA) injections into the detrusor muscle on the incidence of symptomatic urinary infections in patients with neurogenic detrusor overactivity. METHODS:Between February 2004 and June 2005, 30 patients (18 men, 12 women), mean age 39.4+/-12.1 yr, with neurogenic det...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.eururo.2007.08.039
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To describe the clinical characteristics and treatment results obtained with the application of a homogeneous treatment protocol in 1490 patients with germ-cell tumours (GCT) registered in the 55 hospitals belonging to the Spanish Germ-Cell Cancer Group (GG) during the period between January 1994 and April 20...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(02)00439-6
更新日期:2002-12-01 00:00:00