Anticholinergic Burden in the Elderly Population: An Emerging Concern.

Abstract:

:Antimuscarinics are commonly used to treat overactive bladder, but increase anticholinergic burden, which has been associated with multiple adverse outcomes in older patients. We advocate for standardization of anticholinergic risk assessment and reevaluation of anticholinergic prescribing practices for the elderly.

journal_name

Eur Urol

journal_title

European urology

authors

Pierce H,Thomas D,Asfaw T,Chughtai B

doi

10.1016/j.eururo.2019.03.021

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

7-8

issue

1

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(19)30207-6

journal_volume

76

pub_type

社论
  • Interferon-alpha suppresses the antiapoptotic effect of NF-kB and sensitizes renal cell carcinoma cells in vitro to chemotherapeutic drugs.

    abstract:BACKGROUND:Immunochemotherapy (ICT) with interleukin-2 (IL-2) and interferon-alpha (IFNalpha) with a secondary effector (5-fluorouracil, 5 FU) is the only promising treatment for advanced renal cell carcinoma (RCC). With IFNalpha, besides the activation mechanisms of the immunosystem, a direct antitumor effect on tumor...

    journal_title:European urology

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    doi:10.1159/000052489

    authors: Steiner T,Junker U,Henzgen B,Nuske K,Durum SK,Schubert J

    更新日期:2001-04-01 00:00:00

  • Prognostic factors for response to sildenafil in patients with erectile dysfunction.

    abstract:OBJECTIVE:To assess the clinical efficacy of sildenafil as treatment for erectile dysfunction (ED) the factors associated with treatment failure were investigated. METHODS:Open, prospective study including 244 patients suffering from ED who were evaluated by anamnesis, physical exploration, blood test, dynamic penile ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000049850

    authors: Martínez-Jabaloyas JM,Gil-Salom M,Villamón-Fort R,Pastor-Hernández F,Martínez-García R,García-Sisamón F

    更新日期:2001-12-01 00:00:00

  • Current status of cytotoxic chemotherapy in hormone refractory prostate cancer.

    abstract::Adenocarcinoma of the prostate is the most prevalent neoplastic disease in men and continues to be a major cause of morbidity and mortality. Death from prostate cancer is associated with objective and biochemical progression following hormonal manipulations often described as hormone refractory prostate cancer (HRPCA)...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052426

    authors: Heidenreich A,von Knobloch R,Hofmann R

    更新日期:2001-02-01 00:00:00

  • The place of acupuncture in the management of psychogenic impotence.

    abstract::Successful sexual functioning is a complex process involving psychological and social responses as well as neurological, biochemical and vascular processes. Today it is believed that more than 50% of the sexual dysfunction cases have an organic etiology. Reflecting the controversy over the management of psychogenic im...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000475342

    authors: Yaman LS,Kiliç S,Sarica K,Bayar M,Saygin B

    更新日期:1994-01-01 00:00:00

  • Membrano-bulbo-urethral junction stenosis. Posterior urethra obstruction due to extreme caliber disproportion in the male urethra.

    abstract:OBJECTIVE:Based on 4 cases of infravesical obstruction due to extreme caliber disproportion between the posterior urethra and the penile urethra, a pathophysiological mechanism for this dynamic obstruction is given and endoscopic treatment is described. SUBJECTS:Four cases of membrano-bulbo-urethral junction (MBUJ) st...

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Hoebeke PB,Van Laecke E,Raes A,Vande Walle J,Oosterlinck W

    更新日期:1997-01-01 00:00:00

  • Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.

    abstract:OBJECTIVES:A dysregulated mitogen-activated protein kinase (MAPK) pathway plays an important role in various malignancies and is often mediated by mutations in several oncogenes (eg, RAF, RAS). B-RAF mutations, predominantly the specific V600E mutation and additional alterations in exons 11 and 15, were frequently dete...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.11.031

    authors: Burger M,Denzinger S,Hammerschmied C,Tannapfel A,Maderstorfer A,Wieland WF,Hartmann A,Stoehr R

    更新日期:2006-11-01 00:00:00

  • A Specific Mapping Study Using Fluorescence Sentinel Lymph Node Detection in Patients with Intermediate- and High-risk Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection.

    abstract::Sentinel lymph node (SLN) detection techniques have the potential to change the standard of surgical care for patients with prostate cancer. We performed a lymphatic mapping study and determined the value of fluorescence SLN detection with indocyanine green (ICG) for the detection of lymph node metastases in intermedi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2016.01.034

    authors: Nguyen DP,Huber PM,Metzger TA,Genitsch V,Schudel HH,Thalmann GN

    更新日期:2016-11-01 00:00:00

  • The prognostic significance of capsular incision into tumor during radical prostatectomy.

    abstract:BACKGROUND:The prognostic significance of capsular incision (CapI) into tumor during radical prostatectomy (RP) with otherwise organ-confined disease remains uncertain. OBJECTIVE:To evaluate the impact of CapI into tumor on oncologic outcome. DESIGN, SETTING, AND PARTICIPANTS:A retrospective review of 8110 consecutiv...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2010.12.005

    authors: Preston MA,Carrière M,Raju G,Morash C,Doucette S,Gerridzen RG,Bella AJ,Eastham JA,Scardino PT,Cagiannos I

    更新日期:2011-04-01 00:00:00

  • Multiple renal angiomyolipomas associated with renal artery dysplasia and a benign pulmonary tumour.

    abstract::A case of multiple bilateral renal angiomyolipomas, associated with renal artery dysplasia and a solitary benign pulmonary tumour, in a woman with no evidence of tuberous sclerosis, is described. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472637

    authors: Knox AJ,Metcalfe P,Aparicio S,Page RL

    更新日期:1986-01-01 00:00:00

  • How prenatal ultrasound can affect the treatment of ureterocele in neonates and children.

    abstract::Prenatal ultrasound has set the stage for new trends in the diagnosis and treatment of many urinary tract malformations, in particular duplication of the renal collecting system with ureterocele. The authors have reviewed their experience with 41 ureteroceles in 7 years. The 36 patients were divided into two groups: t...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471568

    authors: Caione P,Zaccara A,Capozza N,De Gennaro M

    更新日期:1989-01-01 00:00:00

  • Traumatic injuries of the lower ureter associated with pelvic fractures.

    abstract::Ureteral injuries following blunt pelvic trauma are extremely rare. Experiences with two cases of lacerations of the lower ureter due to pelvic fractures are presented. In patients with acetabular fractures the likelihood of lower ureteral injuries should be suspected and excluded by an intravenous urogram. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000463774

    authors: Bick C,Oesterwitz H,Ziegler PF

    更新日期:1984-01-01 00:00:00

  • Treatment of uretero-intestinal and ureterovesical strictures by Acucise balloon catheter.

    abstract:OBJECTIVE:Acucise balloon catheter has been proposed as an alternative to open surgery for the treatment of strictures of the ureteropelvic junction because of its low morbidity and the short hospital stay following the endoscopic procedure. The objective of this study was to evaluate the results of this technique appl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00070-2

    authors: Touiti D,Gelet A,Deligne E,Fassi-Fehri H,Benrais H,Martin X,Dubernard JM

    更新日期:2002-07-01 00:00:00

  • Prognostic relevance of tumour size in T3a renal cell carcinoma: a multicentre experience.

    abstract:OBJECTIVE:To evaluate the prognostic role of tumour size in pathological stage T3a renal cell carcinoma (RCC) with fat invasion only and to assess whether this subgroup maintains its relevance over the other pathological stages. METHODS:We retrospectively studied 2113 patients from eight international institutions who...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2007.01.106

    authors: Lam JS,Klatte T,Patard JJ,Goel RH,Guillè F,Lobel B,Abbou CC,De La Taille A,Tostain J,Cindolo L,Altieri V,Ficarra V,Artibani W,Prayer-Galetti T,Schips L,Zigeuner R,Pantuck AJ,Figlin RA,Belldegrun AS

    更新日期:2007-07-01 00:00:00

  • Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti-PD-1 Immune Checkpoint Inhibitors.

    abstract::Preclinical models and early clinical data suggest an interplay between the gut microbiome and response to immunotherapy in solid tumors including metastatic renal cell carcinoma (mRCC). We sought to characterize the stool microbiome of mRCC patients receiving a checkpoint inhibitor (CPI) and to assess treatment-relat...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2020.07.011

    authors: Salgia NJ,Bergerot PG,Maia MC,Dizman N,Hsu J,Gillece JD,Folkerts M,Reining L,Trent J,Highlander SK,Pal SK

    更新日期:2020-10-01 00:00:00

  • Prospective Implementation of Enhanced Recovery After Surgery Protocols to Radical Cystectomy.

    abstract:BACKGROUND:Multimodal enhanced recovery after surgery (ERAS) regimens have improved outcomes from colorectal surgery. OBJECTIVE:We report the application of ERAS to patients undergoing radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS:Prospective collection of outcomes from consecutive patients undergoing RC...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2017.07.031

    authors: Pang KH,Groves R,Venugopal S,Noon AP,Catto JWF

    更新日期:2018-03-01 00:00:00

  • Treatment of localized prostatic carcinoma using the transrectal ultrasound guided transperineal implantation technique.

    abstract::Treatment of localized prostate cancer by ultrasonically guided transperineal 125I implantation, in contrast to open 125I implantation, may allow for ideal distribution of the seeds and may therefore lead to better treatment results. 46 patients with localized prostatic carcinoma (T1-T2, G1-G3, N0, M0) have been treat...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474797

    authors: Vijverberg PL,Kurth KH,Blank LE,Dabhoiwala NF,de Reijke TH,Koedooder K

    更新日期:1992-01-01 00:00:00

  • Serum anti-p53 antibodies and p53 protein status in the sera and tumors from bladder cancer patients.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the association between the serum anti-p53 antibodies (Abs) status and the p53 protein status in the sera and tumors as well as clinical or pathological parameters in bladder cancer patients retrospectively. METHODS:Serum samples from 100 patients with bladder cance...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000020104

    authors: Morita T,Tachikawa N,Kumamaru T,Nukui A,Ikeda H,Suzuki K,Tokue A

    更新日期:2000-01-01 00:00:00

  • The natural history and predictors of outcome following biochemical relapse in the dose escalation era for prostate cancer patients undergoing definitive external beam radiotherapy.

    abstract:BACKGROUND:The management of biochemical failure (BF) following external beam radiotherapy (EBRT) for prostate cancer is controversial, due to both the heterogeneous disease course following a BF and a lack of clinical trials in this setting. OBJECTIVE:We sought to characterize the natural history and predictors of ou...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2014.09.028

    authors: Zumsteg ZS,Spratt DE,Romesser PB,Pei X,Zhang Z,Polkinghorn W,McBride S,Kollmeier M,Yamada Y,Zelefsky MJ

    更新日期:2015-06-01 00:00:00

  • Urological complications associated to uterus didelphys with unilateral hematocolpos. A case report and review of the literature.

    abstract::Complete duplication of vagina, cervix and uterus, with imperforate hemivagina and renal agenesis is a rare condition with less than 120 cases published. In those articles, urological complications are uncommon with only a 10% of the total. We report 2 cases of uterus didelphys with unilateral hematocolpos and ipsilat...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000471669

    authors: Broseta E,Boronat F,Ruiz JL,Alonso M,Osca JM,Jiménez-Cruz JF

    更新日期:1991-01-01 00:00:00

  • Multidrug chemotherapy in the treatment of non-elderly patients with hormone-refractory prostatic carcinoma. A phase II study. North-Eastern Italian Oncology Group (GOCCNE).

    abstract:OBJECTIVE:The effectiveness of a chemotherapy regimen including cisplatin, epirubicin, and estramustine phosphate was evaluated in a series of young patients with prostate cancer. METHODS:28 patients with a histological diagnosis of prostatic carcinoma, age < 70 years, performance status (PS) < 2, hormone-refractory s...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000473792

    authors: Veronesi A,Re GL,Foladore S,Merlo A,Giuliotto N,Talamini R,Monfardini S

    更新日期:1996-01-01 00:00:00

  • Pharmacological management of incontinence.

    abstract::Many patients with incontinence do not need surgery - for these patients symptoms can often be considerably improved by conservative measures, including drugs. Several different pharmacological actions are potentially useful depending on the underlying cause of the incontinence: a) Detrusor instability (DI) responds t...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052327

    authors: Sullivan J,Abrams P

    更新日期:1999-01-01 00:00:00

  • Tumour-associated antibodies against renal cell carcinomas detected by immunofluorescence.

    abstract::Serum from 39 of 288 (13.5%) cancer patients contained antibodies detectable by immunofluorescence which reacted with frozen tumour sections from kidneys, prostate glands and ovaries. The serum did not react against areas of normal kidney taken from the same diseased organ. In comparison, 0.7% of normal persons and 3....

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Ackermann R

    更新日期:1975-01-01 00:00:00

  • Congenital bladder diverticula in infants.

    abstract:OBJECTIVE:Congenital bladder diverticula (CBD) usually occur in areas where the muscle is inadequately formed, typically at the ureterovesical junction, or between bundles of hypertrophied muscle. CBD are mostly asymptomatic and the cases are found incidentally. Occasionally, some cases of CBD may produce urinary obstr...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019520

    authors: Sarihan H,Abes M

    更新日期:1998-01-01 00:00:00

  • Two-year follow-up of a prospective randomised trial of electrovaporization versus resection of prostate.

    abstract:OBJECTIVES:Transurethral electrovaporization of the prostate (TUVP) has become a popular, minimally invasive procedure to treat BPH with promising initial results. This study was conducted to compare the efficacy, safety and durability of TUVP with standard TURP. We report the 2-year follow-up. METHODS:104 consecutive...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000019710

    authors: Hammadeh MY,Madaan S,Singh M,Philp T

    更新日期:1998-09-01 00:00:00

  • The outcome of patients treated with sunitinib prior to planned nephrectomy in metastatic clear cell renal cancer.

    abstract:BACKGROUND:The role of cytoreductive nephrectomy in metastatic clear cell renal cell carcinoma (ccRCC) is controversial. OBJECTIVE:To determine the outcome of patients with metastatic ccRCC who receive sunitinib prior to planned nephrectomy. DESIGN, SETTING, AND PARTICIPANTS:The study combined the data from two prosp...

    journal_title:European urology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.eururo.2011.05.028

    authors: Powles T,Blank C,Chowdhury S,Horenblas S,Peters J,Shamash J,Sarwar N,Boleti E,Sahdev A,O'Brien T,Berney D,Beltran L,Nathan P,Haanen J,Bex A

    更新日期:2011-09-01 00:00:00

  • Transurethral prostatectomy: a long-term follow-up study of 166 patients over 80 years of age.

    abstract:OBJECTIVES AND METHODS:In a retrospective analysis, the medical records of 166 patients over 80 years of age (80-99 years, mean age 82 years) who underwent transurethral prostatectomy (TURP) for clinically benign prostatic hyperplasia (BPH) were reviewed in order to evaluate the morbidity and mortality rates in this sp...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474208

    authors: Matani Y,Mottrie AM,Stöckle M,Voges GE,Fichtner J,Hohenfellner R

    更新日期:1996-01-01 00:00:00

  • Blind-ending bifid ureter with an intravesical ectopic orifice.

    abstract::Blind-ending bifid ureters, as one type of duplications, are a rare congenital anomaly of the urinary tract. Occasionally they present with unspecific symptoms and require surgical intervention. This case of a blind-ending bifid ureter was associated with an intravesical ectopic orifice. Recurrent urinary tract infect...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000463849

    authors: Müller SC,Riedmiller H,Walz PH,Hohenfellner R

    更新日期:1984-01-01 00:00:00

  • Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data Advanced Bladder Cancer (ABC) Meta-analysis Collaboration.

    abstract:OBJECTIVES:To evaluate the effect of adjuvant chemotherapy in invasive bladder cancer. METHODS:: We conducted a systematic review and meta-analysis of updated individual patient data from all available randomised controlled trials comparing local treatment plus adjuvant chemotherapy versus the same local treatment alo...

    journal_title:European urology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.eururo.2005.04.005

    authors: Advanced Bladder Cancer (ABC) Meta-analysis Collaboration.

    更新日期:2005-08-01 00:00:00

  • Treatment of anterior vaginal wall prolapse with porcine skin collagen implant by the transobturator route: preliminary results.

    abstract:OBJECTIVE:To assess the feasibility and efficacy of porcine skin collagen (Pelvicol) implant by the transobturator route for the treatment of anterior vaginal wall prolapse. PATIENTS AND METHODS:Twenty-seven women with stage III or IV prolapse underwent anterior vaginal wall repair with porcine skin collagen implantat...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2003.09.005

    authors: Salomon LJ,Detchev R,Barranger E,Cortez A,Callard P,Darai E

    更新日期:2004-02-01 00:00:00

  • Prostate Cancer Registries: Current Status and Future Directions.

    abstract:CONTEXT:Disease-specific registries that enroll a considerable number of patients play a major role in prostate cancer (PCa) research. OBJECTIVE:To evaluate available registries, describe their strengths and limitations, and discuss the potential future role of PCa registries in outcomes research. EVIDENCE ACQUISITIO...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2015.05.046

    authors: Gandaglia G,Bray F,Cooperberg MR,Karnes RJ,Leveridge MJ,Moretti K,Murphy DG,Penson DF,Miller DC

    更新日期:2016-06-01 00:00:00