Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.

abstract：OBJECTIVE:To evaluate the diagnostic utility of free prostate specific antigen (fPSA), alpha-1- antichymotrypsin-bound PSA (PSA-ACT), complexed PSA (cPSA), and including their associated ratios to total PSA (tPSA) in serum for discrimination between prostate cancer (PCa) and benign prostatic hyperplasia (BPH). METHODS...

journal_title：European urology

authors： Lein M,Jung K,Elgeti U,Petras T,Stephan C,Brux B,Sinha P,Winkelmann B,Schnorr D,Loening S

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Information on autonomic neurapraxia in female urogenital surgery is scarce, and a model to study it is not available. OBJECTIVE:To develop a model to study the impact of autonomic neurapraxia on bladder function in female rats, as well as to assess the effects of corticosteroid therapy on the recovery of b...

journal_title：European urology

authors： Castiglione F,Bergamini A,Bettiga A,Bivalacqua TJ,Benigni F,Strittmatter F,Gandaglia G,Rigatti P,Montorsi F,Hedlund P

更新日期：2012-12-01 00:00:00

abstract：AIMS:It is the aim of these studies to derive a numerically defined progression index for prostatic intraepithelial neoplasia (PIN) lesions. METHODS:Histometric and karyometric features were automatically extracted from images of histopathologic sections by a machine vision system. RESULTS:Both histometric and karyom...

journal_title：European urology

authors： Bartels PH,Montironi R,Duval da Silva V,Hamilton PW,Thompson D,Vaught L,Bartels HG

更新日期：1999-01-01 00:00:00

abstract：AIM:In this prospective study our aim was to establish the time it takes cystectomized patients' to adapt to their new health status. MATERIALS AND METHOD:A total of 68 patients, having radical cystectomy for bladder cancer (64 males and 4 females) were enrolled in the study. The mean age of the group was 55.4 +/- 8.0...

journal_title：European urology

authors： Kulaksizoglu H,Toktas G,Kulaksizoglu IB,Aglamis E,Unlüer E

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:Hyaluronic acid is a protective barrier of the urothelium. A damaged glycosaminoglycan layer may increase the possibility of bacterial adherence and infection. This damage is proposed to be a causative factor in the development of interstitial cystitis, common urinary tract infections, and hemorrhagic cystit...

journal_title：European urology

authors： Iavazzo C,Athanasiou S,Pitsouni E,Falagas ME

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Androgen inactivation occurs mainly through the glucuronidation conjugative reaction mediated by UDP-glucuronosyltransferases (UGTs). This metabolic process is involved in the control of systemic and local androgen bioavailability. OBJECTIVE:To examine the relationship among expression of the androgen-inact...

journal_title：European urology

authors： Belledant A,Hovington H,Garcia L,Caron P,Brisson H,Villeneuve L,Simonyan D,Têtu B,Fradet Y,Lacombe L,Guillemette C,Lévesque E

更新日期：2016-04-01 00:00:00

abstract：CONTEXT:Medical expulsive therapy (MET) for urolithiasis has gained increasing attention in the last years. It has been suggested that the administration of alpha-adrenoreceptor antagonists (alpha-blockers) or calcium channel blockers augments stone expulsion rates and reduces colic events. OBJECTIVE:To evaluate the e...

journal_title：European urology

authors： Seitz C,Liatsikos E,Porpiglia F,Tiselius HG,Zwergel U

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Despite the documented survival benefit conferred by neoadjuvant (NAC) and adjuvant chemotherapy (AC), there has been a slow adoption of guideline recommendations for the use of perioperative chemotherapy (POC) in patients with muscle-invasive bladder cancer (MIBC). OBJECTIVE:To evaluate temporal trends in ...

journal_title：European urology

authors： Reardon ZD,Patel SG,Zaid HB,Stimson CJ,Resnick MJ,Keegan KA,Barocas DA,Chang SS,Cookson MS

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Using videourodynamics (VUDS) we prospectively investigated the etiologies of lower urinary tract symptoms (LUTS) and low uroflow in young men and correlated the results with clinical symptoms and noninvasive exams. METHODS:From 1999 to 2001, 90 men 18-50 years old with LUTS and low uroflow were enrolled. P...

journal_title：European urology

authors： Wang CC,Yang SS,Chen YT,Hsieh JH

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To obtain clinical experience of a reservoir using a detubularized ileocecal segment (Mainz pouch) and continent appendiceal stoma connected to the umbilicus. METHODS:The operation was performed in 23 patients. The submucosally placed in situ appendix was connected to the umbilicus acting as the continence m...

journal_title：European urology

authors： Nurmi M,Rajala P,Laato M

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:Multifocality and frequent recurrence of urothelial carcinoma of the urinary bladder indicate a disease of the entire "urothelial field", but little is known about chromosomal alterations in histologically normal urothelium. Histopathologically normal urothelium from patients with and without concurrent urot...

journal_title：European urology

authors： Stoehr R,Zietz S,Burger M,Filbeck T,Denzinger S,Obermann EC,Hammerschmied C,Wieland WF,Knuechel R,Hartmann A

更新日期：2005-01-01 00:00:00

abstract：:An improved technique of tubeless cutaneous ureterostomy through a single stoma was devised by modifing the traditional cutaneous ureterostomy. Using this method, urinary diversions were performed on 12 cases with malignancies: 6 had radical cystectomy and the other 6 had pelvic exenteration. Normal bilateral ureters ...

journal_title：European urology

authors： Hirokawa M,Iwasaki A,Yamazaki A,Asakura S,Nozaki A,Yamagishi T

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:T1G3 superficial bladder cancer is considered to be at high risk for progression, and in some institutions early cystectomy is advocated. Other authors and personal experience suggest that conservative treatment, such as TURBT followed by intravesical prophylaxis, may be adequate in the majority of cases. Th...

journal_title：European urology

authors： Bono AV,Lovisolo JA,Saredi G

更新日期：2000-04-01 00:00:00

abstract：:A double-blind trial was conducted in 138 patients with superficial transitional cell carcinoma of the bladder following transurethral resection to evaluate the prophylaxis of recurrence by an oral Lactobacillus casei preparation (BLP). Patients were stratified into the following 3 subgroups: (A) with primary multiple...

journal_title：European urology

authors： Aso Y,Akaza H,Kotake T,Tsukamoto T,Imai K,Naito S

更新日期：1995-01-01 00:00:00

abstract：:Cytoplasmic and nuclear androgen receptors were measured in benign prostatic hypertrophy, untreated malignant prostates and diethylstilboestrol-treated malignant prostates. The levels of total androgen receptors in benign prostatic hypertrophy were not statistically different from those in the untreated or treated mal...

journal_title：European urology

authors： Ghanadian R,Auf G,Williams G

更新日期：1981-01-01 00:00:00

abstract：:Casodex (bicalutamide, Zeneca Limited) is a nonsteroidal competitive inhibitor of androgens at the androgen receptor. The drug was developed to fulfil a number of needs for the treatment of prostate cancer. The specific aim was to demonstrate pharmacological activity, which would translate into clinical efficacy, good...

journal_title：European urology

authors： Blackledge GR

更新日期：1996-01-01 00:00:00

abstract：CONTEXT:Extracorporeal shock wave lithotripsy (SWL) and ureteroscopy (URS), with or without intracorporeal lithotripsy, are the most common treatments for upper ureteric stones. With advances in technology, it is unclear which treatment is most effective and/or safest. OBJECTIVE:To systematically review literature rep...

journal_title：European urology

authors： Drake T,Grivas N,Dabestani S,Knoll T,Lam T,Maclennan S,Petrik A,Skolarikos A,Straub M,Tuerk C,Yuan CY,Sarica K

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Given the highly variable behavior and clinical course of prostate cancer (PCa) and the multiple available treatment options, a personalized approach to oncologic risk stratification is important. Novel genetic approaches offer additional information to improve clinical decision making. OBJECTIVE:To review the...

journal_title：European urology

authors： Boström PJ,Bjartell AS,Catto JW,Eggener SE,Lilja H,Loeb S,Schalken J,Schlomm T,Cooperberg MR

更新日期：2015-12-01 00:00:00

abstract：:Extended ipsilateral lymphadenectomy performed on 102 patients with renal cell carcinoma revealed 21 patients (21%) having regional lymph node metastasis. Of the 21 patients, 6 (6%) had single-node metastasis and 15 (15%) multiple-node metastasis. PT, pV, pM, cell type and grade were all correlated with regional node ...

journal_title：European urology

authors： Tsukamoto T,Kumamoto Y,Miyao N,Yamazaki K,Takahashi A,Satoh M

更新日期：1990-01-01 00:00:00

abstract：:The kinetics of fosfomycin in serum and in urine was studied in 5 healthy volunteers after intravenous administration of disodium fosfomycin and after oral administration of trometamol fosfomycin at 50 mg/kg. The presence of secondary peaks in serum kinetics, more evident after oral administration, requires the use of...

journal_title：European urology

authors： Segre G,Bianchi E,Cataldi A,Zannini G

更新日期：1987-01-01 00:00:00

abstract：:We present a case of villous adenoma of the prostatic urethra, without malignant transformation. A review of the diagnostic and therapeutic criteria and pathogenic hypotheses on this kind of lesion in the lower urinary tract are made. ...

journal_title：European urology

authors： Algaba F,Matias-Guiu X,Badia F,Solé-Balcells F

更新日期：1988-01-01 00:00:00

abstract：:A new method of quantitative analysis of bone metastasis in prostate cancer is described. By using a variance-dependent filter and a smoothing filter, the increased uptake lesions were distinctly demonstrated on the bone scintigraphy. The images were divided into several areas and analyzed. These procedures resulted i...

journal_title：European urology

authors： Kubota Y,Nakada T,Sasagawa I,Izumiya K

更新日期：1993-01-01 00:00:00

abstract：CONTEXT:The outcome prediction for renal cell cancer (RCC) remains controversial, and although many parameters have been tested for prognostic significance, only a few have achieved widespread acceptance in clinical practice. The TNM staging system defines local extension of the primary tumour (T), involvement of regio...

journal_title：European urology

authors： Moch H,Artibani W,Delahunt B,Ficarra V,Knuechel R,Montorsi F,Patard JJ,Stief CG,Sulser T,Wild PJ

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Prior studies assessing the correlation of Gleason score (GS) at needle biopsy and corresponding radical prostatectomy (RP) predated the use of the modified Gleason scoring system and did not factor in tertiary grade patterns. OBJECTIVE:To assess the relation of biopsy and RP grade in the largest study to d...

journal_title：European urology

authors： Epstein JI,Feng Z,Trock BJ,Pierorazio PM

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Given the high possibility of co-occurrence of benign prostatic hyperplasia (BPH) and cardiovascular disease, we evaluated whether patients using BPH drugs are at an increased risk of acute hospital admission for ischemic heart disease (IHD). METHODS:A nested case control study within a cohort of 4414 men (a...

journal_title：European urology

authors： Souverein PC,Herings RM,Man in 't Veld AJ,de la Rosette JJ,Farmer RD,Leufkens HG

更新日期：2002-09-01 00:00:00

abstract：:The bulbocavernosus reflex can be elicited either by penile or urethral stimulation. The mean signal transit time after electrostimulation of the dorsal penile nerve to evoked response in the anal sphincter (35 msec) was only half the signal transit time after stimulation in the posterior urethra (60 msec). Thus, the ...

journal_title：European urology

authors： Nordling J,Andersen JT,Walter S,Meyhoff HH,Hald T,Gammelgaard PA

更新日期：1979-01-01 00:00:00

abstract：:Bladder cancer has a high worldwide incidence matched by a tendency to recur, necessitating close and regular follow-up. Current methods of investigation of bladder cancer involve cystoscopy, ultrasound scanning and contrast urography, with additional information provided by cytology. These methods, although having a ...

journal_title：European urology

authors： Saad A,Hanbury DC,McNicholas TA,Boustead GB,Woodman AC

更新日期：2001-06-01 00:00:00

abstract：:Nineteen lambs underwent colocystoplasty using a segment of demucosalised sigmoid colon, and were compared to 14 control animals. Nine animals had a procedure which included the addition of the muscle patch to an autoaugmented bladder, and 10 had a clam cystoplasty with the denuded colon. Six months after the procedur...

journal_title：European urology

authors： Dewan PA,Lorenz C,Stefanek W,Byard RW

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Treatment of patients with mucosal prostatic urethral transitional cell carcinoma (TCC) is controversial. In this study, we evaluated the outcome of patients with mucosal prostatic urethral TCC who were managed conservatively. METHODS:The data of 290 consecutive male patients with superficial TCC of the blad...

journal_title：European urology

authors： Canda AE,Tuzel E,Mungan MU,Yorukoglu K,Kirkali Z

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:To examine the association between the complexed-to-total (C:T) prostate-specific antigen (PSA) ratio and prostate cancer pathological stage to assess whether the C:T PSA ratio may predict the final pathological stage in patients with clinically localized prostate cancer. PATIENTS AND METHODS:In a prospecti...

journal_title：European urology

authors： Martínez M,Navarro S,Medina P,Villavicencio H,Rioja L,Solsona E,Estellés A,Aznar J,Jiménez-Cruz JF,España F

更新日期：2003-06-01 00:00:00