Abstract:
OBJECTIVES:Hyaluronic acid is a protective barrier of the urothelium. A damaged glycosaminoglycan layer may increase the possibility of bacterial adherence and infection. This damage is proposed to be a causative factor in the development of interstitial cystitis, common urinary tract infections, and hemorrhagic cystitis due to posthematopoietic stem cell transplantation. The aim of this article was to review the available data regarding the use of hyaluronic acid as an alternative treatment of the above-mentioned conditions. METHODS:Articles relevant to our review that were archived by September 2006 were retrieved from PubMed. RESULTS:Nine relevant studies were identified and evaluated. Hyaluronic acid was administered intravesically at a dose of 40 mg every week for 4-6 wk; patients with noted improvement received two additional monthly doses. Short-term responses of patients with interstitial cystitis, hemorrhagic cystitis, and recurrent urinary tract infections were 30-73% (7 studies), 71% (1 study), and 100% (1 study), respectively. The treatment was well tolerated except for occasional development of bacterial cystitis. The cost of each intravesical installation of hyaluronic acid is 120 UK pounds (excluding the cost of the urinary catheterization). CONCLUSIONS:The available clinical data regarding the effectiveness of hyaluronic acid as a potential treatment of patients with interstitial cystitis, recurrent urinary tract infections, and hemorrhagic cystitis are limited. There is need for randomized controlled trials for further investigation of this important therapeutics question; these clinical trials should be disease-specific, blinded, and controlled, and of a sufficient number of patients. Until such studies are available, intravesical instillation of hyaluronic acid cannot be unquestionably endorsed for use for the aforementioned diseases.
journal_name
Eur Uroljournal_title
European urologyauthors
Iavazzo C,Athanasiou S,Pitsouni E,Falagas MEdoi
10.1016/j.eururo.2007.03.020subject
Has Abstractpub_date
2007-06-01 00:00:00pages
1534-40; discussion 1540-1issue
6eissn
0302-2838issn
1873-7560pii
S0302-2838(07)00377-6journal_volume
51pub_type
杂志文章,评审相关文献
EUROPEAN UROLOGY文献大全abstract::We report on 18 patients, aged 43-77 years, with clinical stage-C adenocarcinoma of the prostate, primarily treated by pelvic lymphadenectomy and 125I-seed implantation. After lymphadenectomy, the staging assessment differed from the preoperative diagnosis as follows: 4 patients were classified as stage C; 6 as D1, an...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472587
更新日期:1986-01-01 00:00:00
abstract::Mucosal biopsies were obtained for histological and electron microscopical studies from 20 patients with ileal urinary conduits. Special interest was focused on problems of urinary tract infections and their possible role in the pathogenesis of these changes. Chronic inflammation with mild to total villous atrophy was...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472616
更新日期:1986-01-01 00:00:00
abstract::Results from the ERA 223 trial of abiraterone combined with radium-223 among men with chemotherapy-naïve castration-resistant prostate cancer and bone metastases show no improvement in survival free from symptomatic skeletal events. We hypothesize that this finding might be attributable to bone loss induced by the con...
journal_title:European urology
pub_type: 评论,社论
doi:10.1016/j.eururo.2019.01.026
更新日期:2019-06-01 00:00:00
abstract:CONTEXT:Controversy remains over whether adrenalectomy and lymph node dissection (LND) should be performed concomitantly with radical nephrectomy (RN) for locally advanced renal cell carcinoma (RCC) cT3-T4N0M0. OBJECTIVE:To systematically review all relevant literature comparing oncologic, perioperative, and quality-o...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2013.04.033
更新日期:2013-11-01 00:00:00
abstract::Antitumor effect of recombinant human tumor necrosis factor alpha (TNF) alone or in combination with various anticancer chemotherapeutic agents was tested using an in vitro antiproliferative assay on four human renal carcinoma cell lines (VMRC-RCW, VMRC-RCZ, Caki-1 and A-498). When the dose-dependent effect of TNF was...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473628
更新日期:1991-01-01 00:00:00
abstract::A randomised trial of robotic and open prostatectomy commenced in October 2010 and is progressing well. Clinical and quality of life outcomes together with economic costs to individuals and the health service are being examined critically to compare outcomes. ...
journal_title:European urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.eururo.2013.10.031
更新日期:2014-03-01 00:00:00
abstract::Casodex (bicalutamide, Zeneca Limited) is a nonsteroidal competitive inhibitor of androgens at the androgen receptor. The drug was developed to fulfil a number of needs for the treatment of prostate cancer. The specific aim was to demonstrate pharmacological activity, which would translate into clinical efficacy, good...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000473847
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Although the initial robot-assisted radical prostatectomy (RARP) series showed 12-mo potency rates ranging from 70% to 80%, the few available comparative studies did not permit any definitive conclusion about the superiority of this technique when compared with retropubic radical prostatectomy (RRP) and lapa...
journal_title:European urology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.eururo.2012.05.046
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To establish guidelines for the diagnosis, treatment, and follow-up of BPH. METHODS:A search of published work was conducted using Medline. In combination with expert opinions recommendations were made on the usefulness of tests for assessment and follow-up: mandatory, recommended, or optional. In addition, ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000049784
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:New methods for identifying bladder cancer (BCa) progression are required. Gene expression microarrays can reveal insights into disease biology and identify novel biomarkers. However, these experiments produce large datasets that are difficult to interpret. OBJECTIVE:To develop a novel method of microarray ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.10.029
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To present the current status of laparoscopic radical prostatectomy (LRP) in Germany, Austria and Switzerland with respect to transferability, learning curve, and outcome. MATERIAL AND METHODS:The data of 5824 patients who underwent LRP in 18 centers by 50 urologists from March 1999 to August 2004 were analyze...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2005.10.003
更新日期:2006-01-01 00:00:00
abstract::Signet ring cell adenocarcinoma of the bladder is rare. Only 16 cases are recorded in the literature, although two meet the requirements for being considered of urachal origin. We present the third case of signet cell adenocarcinoma of urachal origin. ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472516
更新日期:1985-01-01 00:00:00
abstract::With intensified screening and the use of new diagnostic tools for prostate cancer (prostate-specific antigen, rectal ultrasound, magnetic resonance imaging with rectal coils, etc), the number of newly diagnosed cases of prostate cancer is rising rapidly, whereas the frequency of death due to prostate cancer remains a...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474384
更新日期:1993-01-01 00:00:00
abstract::In a randomized study of 200 consecutive patients undergoing transurethral prostatectomy (TURP), the combination of internal urethrotomy and TURP (the trial group) was compared with TURP alone (the control group) with regard to the development of urethral strictures postoperatively. Three months after resection, 14% i...
journal_title:European urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000471587
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:in our study, we wanted to assess changes and values of the renal resistive index (RI) in children with vesicoureteral reflux (VUR) using color Doppler ultrasound (CDUS) techniques. METHODS:We investigated 92 kidney units in 46 children (mean age 6 +/- 4 years) with VUR by means of CDUS. The RI was measured ...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1159/000019931
更新日期:1999-01-01 00:00:00
abstract::We have studied 38 patients with previously untreated, widespread prostatic cancer, who were submitted to therapy with cyproterone acetate and orchiectomy. 70% of patients with symptoms have shown subjective improvement. Moreover, it was possible to observe the regression, stabilization or progression of metastases in...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473314
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Limited data exist to guide the use of androgen deprivation therapy (ADT) for men treated with radiation therapy (RT) after radical prostatectomy (RP). The optimal duration of ADT in this setting is unknown. OBJECTIVE:To determine if the duration of ADT influences clinical outcomes for men receiving post-RP...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2015.05.009
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Eraser, a 1318-nm diode laser, has been used for 15 yr for resection of lung metastases. It was recently introduced in urology for small kidney tumors and for the treatment of benign prostatic obstruction. OBJECTIVE:To demonstrate on video our technique of Eraser laser enucleation of the prostate (ELEP) and...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2012.08.049
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES AND METHODS:The effects of double pigtail ureteric catheters (JJS) and percutaneous nephrostomies (PN) on ureteric motility and artificial stone transit was assessed in 12 dogs. Each animal underwent bilateral nephrostomies and an artificial stone insertion into each upper ureter (n = 20). A 4-Fr JJS was ins...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474413
更新日期:1997-01-01 00:00:00
abstract::The authors present their experience (24 children) with the endoscopic subureteral injection of Teflon paste in the correction of secondary vesicoureteral reflux: reimplantation failure; ureterocele; obstructive bladder; exstrophy; postchemocystitis, and Hutch's diverticulum. Of these 24 cases (31 refluxing ureters), ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000464067
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:To assess the factors effecting PSA bounce and to identify any possible relationship with biochemical control after 3-D conformal radiotherapy (3D-CRT) and total androgen deprivation (TAD) for prostate cancer by evaluating four previously described PSA bounce definitions. METHODS:Between January 1998 and Ja...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2005.04.007
更新日期:2005-07-01 00:00:00
abstract::7 children, 20 months to 11 years old, with cystinuria and renal calculi were studied. Surgical treatment and alpha-mercaptopropionylglycine (MPG) gave satisfactory results in 5 children. The causes of the recurrences in the other 2 children are discussed. MPG therapy is effective but can cause a nephrotic syndrome at...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473204
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Robot-assisted thrombectomy (RAT) for inferior vena cava (IVC) thrombus (RAT-IVCT) is being increasingly reported. However, the techniques and indications for robot-assisted cavectomy (RAC) for IVC thrombus are not well described. OBJECTIVE:To develop a decision-making program and analyze multi-institutiona...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2020.03.020
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:It remains unclear whether men selecting active surveillance (AS) are at increased risk of unfavorable longer term outcomes as compared with men who undergo immediate treatment. OBJECTIVE:To compare adverse pathologic outcomes in men with favorable-risk prostate cancer who underwent delayed prostatectomy af...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2015.09.032
更新日期:2016-04-01 00:00:00
abstract::3 cases of retrocaval ureter (one of them presenting multiple urological anomalies) are discussed. In the presence of hydronephrosis, early operative reposition of the ureter is essential. Provided that the condition is diagnosed before extreme renal deterioration, the surgical repair can salvage remaining renal funct...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473971
更新日期:1978-01-01 00:00:00
abstract::To estimate the growth rate of prostate cancer, the doubling times of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) were determined in 51 patients: 44 were refractory to endocrine therapy, and 7 were in an untreated state. Since an exponential increase in PSA and PAP was observed in all patients...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000475162
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:The retroperitoneal laparoscopic approach is utilized to treat a right renal tumor with vena caval thrombus reaching infrahepatic veins. MATERIALS AND METHODS:The patient is an 87-year-old woman with a tumor measuring 8 x 9 cm and a vena caval thrombus (7 cm), stretching as far as the subhepatic vein. The retr...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2004.11.010
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The objective of this research is to identify and determine the relative importance of dietary and environmental risk and risk reduction factors for prostate cancer mortality. MATERIALS AND METHODS:A multicountry ecologic approach was used in multivariate regression analyses with prostate cancer mortality ra...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2003.08.018
更新日期:2004-03-01 00:00:00
abstract::Early-stage prostate cancer is usually asymptomatic and therefore, in the past, has often gone undetected, unless diagnosed by a digital rectal examination. More recently, new tests have been introduced, namely prostate-specific antigen and transrectal ultrasound, in order to improve the detection of early-stage disea...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474379
更新日期:1993-01-01 00:00:00
abstract::The length changes of the flaccid penis provoked by a maximum manual stretching of the glans have been measured in 905 men in order to study its biomechanical qualities. Our study shows that the flaccid penis is deformable, extensible and elastic in its longitudinal axis. The analysis of the variations of these biomec...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474858
更新日期:1992-01-01 00:00:00