Abstract：
AIMS:It is the aim of these studies to derive a numerically defined progression index for prostatic intraepithelial neoplasia (PIN) lesions. METHODS:Histometric and karyometric features were automatically extracted from images of histopathologic sections by a machine vision system. RESULTS:Both histometric and karyometric measures lend themselves to the defining of a progression index. Karyometric features were found to be more sensitive. They allow the detection of very early change. CONCLUSIONS:It is possible to measure progression of PIN lesions with precision. The methodology would lend itself for measurement of regression due to chemopreventive intervention.
journal_name
Eur Uroljournal_title
European urologyauthors
Bartels PH,Montironi R,Duval da Silva V,Hamilton PW,Thompson D,Vaught L,Bartels HGdoi
10.1159/000019884keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
484-91issue
5-6eissn
0302-2838issn
1873-7560pii
19884journal_volume
35pub_type
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