Modified induction course: a solution to side-effects?

Abstract:

:Side-effects are commonly manifested during intravesical Bacillus Calmette-Guérin (BCG) immunotherapy of superficial bladder cancer. This often causes delays or interruptions of the instillations and consequently reduces the efficacy of treatment. Treatment strategies aimed at reducing the side-effects of BCG immunotherapy while maintaining efficacy are currently being considered in the search for an optimal treatment regimen. The following two approaches to BCG immunotherapy were investigated at the Department of Urology of Padova University by specific Phase II and III trials designed to evaluate the possibility of reducing BCG-related side-effects without compromising therapeutic efficacy: (1) by reducing the dose of BCG per instillation 'low-dose' regimen, (2) by delaying the interval of the instillations 'slow-rate' regimen.

journal_name

Eur Urol

journal_title

European urology

authors

Bassi P,Spinadin R,Carando R,Balta G,Pagano F

doi

10.1159/000052380

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

31-2

eissn

0302-2838

issn

1873-7560

pii

52380

journal_volume

37 Suppl 1

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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