当前位置： SCI文献检索 > EUROPEAN UROLOGY期刊下所有文献 > Urodynamic effects of doxazosin in men with lower urinary tract symptoms and benign prostatic obstruction. Results from three double-blind placebo-controlled studies.

Urodynamic effects of doxazosin in men with lower urinary tract symptoms and benign prostatic obstruction. Results from three double-blind placebo-controlled studies.

Abstract：

OBJECTIVES:Urodynamic investigations provide an objective, quantitative evaluation of urinary function in patients with benign prostatic obstruction (BPO). The effects of doxazosin, a selective alpha 1-adrenoceptor antagonist, on urodynamic measurements were investigated in three double-blind, placebo-controlled clinical studies of the treatment of BPO. METHODS:302 normotensive and mildly hypertensive men with BPO were evaluated. Patients were randomized to receive doxazosin (1-4 mg o.d.) or placebo for 4-29 weeks. RESULTS:Doxazosin significantly improved free urinary flow rates compared with placebo. Urodynamic studies confirmed that doxazosin was effective in improving urinary flow, and also showed a reduction in detrusor pressure, resulting in decreased voiding time and increased voided volume. Analysis of pressure-flow data demonstrated a significant reduction in a measure of urethral resistance in doxazosin-treated patients. CONCLUSION:These results indicate that doxazosin is an important treatment option for patients with troublesome lower urinary tract symptoms and BPO.

journal_name

Eur Urol

journal_title

European urology

authors

Abrams P

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

39-46

issue

1

eissn

0302-2838

issn

1873-7560

journal_volume

32

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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