Abstract:
:Eosinophilic cystitis (EC) is a rare condition. Recent studies have shown that activated eosinophils release cytotoxic cationic proteins which can induce tissue damage. Moreover, in vitro studies have shown that interleukin-5 (IL-5) is a cytokine able to attract and activate eosinophils. The goal of this study was to detect a possible activation of eosinophils in EC using electron microscopy, in situ hybridization with an IL-5 RNA probe and immunochemistry with a specific anti-IL-5 antibody. Using these combined methods in a typical case of EC, we found numerous activated eosinophils synthesizing and secreting IL-5 protein. IL-5 could enhance the activation of eosinophils and their cytotoxic potential in bladder tissues. This mechanism might explain the chronicity of the lesions in EC.
journal_name
Eur Uroljournal_title
European urologyauthors
Dubucquoi S,Janin A,Desreumaux P,Rigot JM,Copin MC,François M,Torpier G,Capron M,Gosselin Bdoi
10.1159/000475293subject
Has Abstractpub_date
1994-01-01 00:00:00pages
254-8issue
3eissn
0302-2838issn
1873-7560journal_volume
25pub_type
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