A prospective, randomised study to compare goserelin acetate (Zoladex) versus cyproterone acetate (Cyprostat) versus a combination of the two in the treatment of metastatic prostatic carcinoma.

Abstract:

:A prospective randomised study was performed to test the hypothesis that total androgen ablation, achieved by combining an LHRH analogue, goserelin acetate (Zoladex), with an antiandrogen, cyproterone acetate (Cyprostat), is more effective than conventional monotherapy in delaying the time to progression of metastatic prostatic cancer. 525 patients were recruited at 18 UK centres between May 1986 and January 1989, 175 patients being allocated to each arm. Patients were clinically and biochemically assessed at 1, 2, 3, 6, 9 and 12 months after initiation of therapy and then every 6 months until a maximum duration of 48 months. There was no statistically significant difference in terms of median time to progression between the combination treatment arm and either monotherapy arm, although there was a statistically significant difference between goserelin acetate alone and cyproterone acetate alone, in favour of goserelin acetate (p = 0.016). All treatment regimens were well tolerated and cyproterone acetate reduced both tumour flare reactions and hot flushes in patients receiving goserelin acetate. It is concluded that total androgen ablation using cyproterone acetate (300 mg/day) and goserelin acetate (3.6 mg every 28 days) confers no advantage in terms of time to progression, to conventional monotherapy, but can reduce certain side effects caused by LHRH analogue treatment alone.

journal_name

Eur Urol

journal_title

European urology

authors

Thorpe SC,Azmatullah S,Fellows GJ,Gingell JC,O'Boyle PJ

doi

10.1159/000473717

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

47-54

issue

1

eissn

0302-2838

issn

1873-7560

journal_volume

29

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.

    abstract:OBJECTIVES:A dysregulated mitogen-activated protein kinase (MAPK) pathway plays an important role in various malignancies and is often mediated by mutations in several oncogenes (eg, RAF, RAS). B-RAF mutations, predominantly the specific V600E mutation and additional alterations in exons 11 and 15, were frequently dete...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.11.031

    authors: Burger M,Denzinger S,Hammerschmied C,Tannapfel A,Maderstorfer A,Wieland WF,Hartmann A,Stoehr R

    更新日期:2006-11-01 00:00:00

  • Androgen receptors in untreated and treated prostatic intraepithelial neoplasia.

    abstract:OBJECTIVES:The effect of androgen deprivation therapy on the expression of androgen receptors (AR) and the proliferation-associated MIB-1 antigen in prostatic intraepithelial neoplasia (PIN) was investigated. METHODS:Immunohistochemistry was performed on tissue sections of prostatectomy specimens of patients with pros...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474179

    authors: van der Kwast TH,Têtu B

    更新日期:1996-01-01 00:00:00

  • Hypospadias: Duckett pedicle tube urethroplasty.

    abstract::The Duckett transverse tube pedicle urethroplasty was used to repair the primary hypospadias of 190 boys over an 11-year period. The fistula rate was 34.4%. The majority of boys have obtained a satisfactory cosmetic and functional result with a single operation. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471657

    authors: Dewan PA,Dinneen MD,Winkle D,Duffy PG,Ransley PG

    更新日期:1991-01-01 00:00:00

  • Posterior hypospadias repair: a new technical approach. Mobilization of the urethral plate and duplay urethroplasty.

    abstract::We describe our experience with a new technique of complete repair of severe posterior hypospadias in one stage. The operative technique includes some innovative points: penile straightening is realized by urethral mobilization (without detaching it from the glans) to excise the chordee, and then urethroplasty accordi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474741

    authors: Montfort G,Bretheau D,di Benedetto V,Bankole R

    更新日期:1992-01-01 00:00:00

  • Surgical Safety of Radical Cystectomy and Pelvic Lymph Node Dissection Following Neoadjuvant Pembrolizumab in Patients with Bladder Cancer: Prospective Assessment of Perioperative Outcomes from the PURE-01 Trial.

    abstract::No data are available on the surgical safety of radical cystectomy (RC) and pelvic lymph node dissection (PLND) after the administration of checkpoint inhibitors. We aimed at reporting the first prospective rigorous assessment of perioperative outcomes after RC and extended PLND following neoadjuvant pembrolizumab in ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2019.12.019

    authors: Briganti A,Gandaglia G,Scuderi S,Gallina A,Colombo R,Fossati N,Barletta F,Pellegrino A,Nocera L,Montorsi F,Necchi A

    更新日期:2020-05-01 00:00:00

  • Cardiovascular morbidity associated with gonadotropin releasing hormone agonists and an antagonist.

    abstract:BACKGROUND:Androgen deprivation therapy (ADT) is associated with increased cardiovascular morbidity. OBJECTIVE:To determine whether cardiovascular morbidity differs following initiation of gonadotropin-releasing hormone (GnRH) agonists compared with an antagonist. DESIGN, SETTING, AND PARTICIPANTS:Pooled data from si...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2013.10.032

    authors: Albertsen PC,Klotz L,Tombal B,Grady J,Olesen TK,Nilsson J

    更新日期:2014-03-01 00:00:00

  • Positive surgical margins and accessory pudendal artery preservation during laparoscopic radical prostatectomy.

    abstract:PURPOSE:To determine whether preservation of accessory pudendal arteries (APAs) adversely influences the rate of positive surgical margins (PSMs) during laparoscopic radical prostatectomy (LRP). MATERIAL AND METHODS:Between January 2003 and January 2005, 377 men with clinically localized prostate cancer underwent a LR...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.08.006

    authors: Secin FP,Karanikolas N,Kuroiwa K,Vickers A,Touijer K,Guillonneau B

    更新日期:2005-11-01 00:00:00

  • PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone.

    abstract:OBJECTIVES:To assess the factors effecting PSA bounce and to identify any possible relationship with biochemical control after 3-D conformal radiotherapy (3D-CRT) and total androgen deprivation (TAD) for prostate cancer by evaluating four previously described PSA bounce definitions. METHODS:Between January 1998 and Ja...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.04.007

    authors: Akyol F,Ozyigit G,Selek U,Karabulut E

    更新日期:2005-07-01 00:00:00

  • Safety study of umbilical single-port laparoscopic radical prostatectomy with a new DuoRotate system.

    abstract:BACKGROUND:Laparoendoscopic single-site (LESS) radical prostatectomy (RP) has been performed through different approaches. A new DuoRotate manual system developed by Richard Wolf (KeyPort; Richard Wolf GmbH, Knittlingen, Germany) can be applied to RP. OBJECTIVES:Our aim was to describe the surgical technique and repor...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2012.04.043

    authors: Cáceres F,Cabrera PM,García-Tello A,García-Mediero JM,Angulo JC

    更新日期:2012-12-01 00:00:00

  • Intramuscular diclofenac versus intravenous indomethacin in the treatment of acute renal colic.

    abstract:OBJECTIVE:We have conducted a clinical trial to compare the pain-relieving effect and safety of diclofenac administered intramuscularly to indomethacin given intravenously. METHODS:The study was designed as a randomized single-blind trial. It was carried out at Oslo Emergency Hospital (outpatient setting or stay < 24 ...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000474196

    authors: Laerum E,Ommundsen OE,Grønseth JE,Christiansen A,Fagertun HE

    更新日期:1996-01-01 00:00:00

  • Multiorgan failure 17 years after initial stone therapy: forgotten ureteral stent in a horseshoe kidney.

    abstract::We report on the case of a 44-yr-old white man who was referred as an emergency from a local hospital to the medical intensive care unit (ICU) at our institution for progressive multiorgan failure of unknown cause. The CT scan of the abdomen showed a horseshoe kidney with extensive stone formation in both kidneys and ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.01.040

    authors: Pühse G,Piechota H,Scheffold C,Kloska S,Hertle L,Wülfing C

    更新日期:2007-12-01 00:00:00

  • Changing concepts in the surgical management of renal cell carcinoma.

    abstract::The foundations of the generally accepted principles underlying the surgical management of renal cell carcinoma (RCC) were best annunciated in 1969 by Robson in his classic description of the radical nephrectomy [J Urol 1969;101;297]. Since then, much has changed in our understanding of the basic biology and genetics ...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2004.02.002

    authors: Lam JS,Shvarts O,Pantuck AJ

    更新日期:2004-06-01 00:00:00

  • A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia.

    abstract:CONTEXT:Several randomized controlled trials (RCTs) on phosphodiesterase type 5 inhibitors (PDE5-Is) have showed significant improvements in both lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in men affected by one or both conditions, without a significant increase in adverse events. However, the re...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2012.02.033

    authors: Gacci M,Corona G,Salvi M,Vignozzi L,McVary KT,Kaplan SA,Roehrborn CG,Serni S,Mirone V,Carini M,Maggi M

    更新日期:2012-05-01 00:00:00

  • Chemical sympathectomy with phenol for chronic prostatic pain.

    abstract::A case of chronic prostatitis where conventional chemotherapy and repeated transurethral resections failed to relieve pain is described. A cutaneous uretero-entero anastomosis was performed for troublesome pain and incontinence and only a permanent sympathetic block with phenol at the level of L4 achieved complete pai...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471971

    authors: Johansson H

    更新日期:1976-01-01 00:00:00

  • EAU guidelines for the management of urinary and male genital tract infections. Urinary Tract Infection (UTI) Working Group of the Health Care Office (HCO) of the European Association of Urology (EAU).

    abstract::A short version of the UTI Guidelines elaborated by the Urinary Tract Infection Working Group of the Health Care Office of the European Association of Urology is presented. The topics include classification, diagnosis, treatment and follow-up of uncomplicated UTI, UTI in children, UTI in diabetes mellitus, renal insuf...

    journal_title:European urology

    pub_type: 指南,杂志文章,实务指引

    doi:10.1159/000049840

    authors: Naber KG,Bergman B,Bishop MC,Bjerklund-Johansen TE,Botto H,Lobel B,Jinenez Cruz F,Selvaggi FP,Urinary Tract Infection (UTI) Working Group of the Health Care Office (HCO) of the European Association of Urology (EAU).

    更新日期:2001-11-01 00:00:00

  • Inhibitors of stone formation in hypercalciuric children with and without stone disease.

    abstract::The extretion of two inhibitors of urinary stone formation (citrate, magnesium) was evaluated in 71 hypercalciuric children and 50 controls. Patients were classified into two groups: 42 nonstone former (NSF), 22 boys and 20 girls, 3-14 years old, and 29 stone formers (SF), 18 boys and 11 girls, 2.5-18 years old. Our s...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474843

    authors: al-Qadreh A,Athanasopoulou H,Voskaki I

    更新日期:1992-01-01 00:00:00

  • Is the diet of patients with interstitial cystitis related to their disease?

    abstract:OBJECTIVE:The dietary habits of interstitial cystitis (IC) patients compared to the average food and fluid consumption of the general population were evaluated and any spontaneous preference or avoidance of specific foodstuffs and fluids of IC patients was investigated. METHODS:A verbal interview with 16 IC patients p...

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Bade JJ,Peeters JM,Mensink HJ

    更新日期:1997-01-01 00:00:00

  • Aneurysmal hemorrhage of the kidney caused by angioleiomyoma.

    abstract::A small angioleiomyoma consisting of proliferating smooth muscle cells and vessels caused macrohematuria in a 52-year-old female patient. The locally ill-defined tumor in the fatty tissue of the renal pelvis immured small arteries and veins as well as an interlobar artery, and caused damage to the vascular walls accom...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472675

    authors: Vogel J,Harder T,Weissbach L

    更新日期:1986-01-01 00:00:00

  • Radical nephrectomy with and without lymph node dissection: preliminary results of the EORTC randomized phase III protocol 30881. EORTC Genitourinary Group.

    abstract:OBJECTIVE:The authors present demographic and surgical data from a randomized phase III trial, instituted by the EORTC Genitourinary Group in 1988, the aim of which was to assess whether complete lymph node dissection in conjunction with radical nephrectomy for renal cell cancer is more effective than radical nephrecto...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000020050

    authors: Blom JH,van Poppel H,Marechal JM,Jacqmin D,Sylvester R,Schröder FH,de Prijck L

    更新日期:1999-12-01 00:00:00

  • Surgical treatment of rectourethral fistulae.

    abstract::9 male patients with rectourethral fistula were treated. Fistulae were congenital in 1 case, iatrogenic in 6 cases and traumatic in 2 cases. In 8 cases we used an abdominoperineal approach with omentoplasty or peritoneal flap; in 1 case a perineal approach was made. In 2 cases it was also necessary to use a transpubic...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472547

    authors: Trippitelli A,Barbagli G,Lenzi R,Fiorelli C,Masini GC

    更新日期:1985-01-01 00:00:00

  • Assessing the use of p16(INK4a) promoter gene methylation in serum for detection of bladder cancer.

    abstract:OBJECTIVE:This study was undertaken to investigate whether hypermethylation in p16(INK4a) gene promoter could serve as plasma biomarker of bladder cancer. METHODS AND PATIENTS:We examined the p16(INK4a) status using methylation-specific PCR in 86 cancer patients and 49 controls (31 healthy people and 18 patients with ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(02)00468-2

    authors: Valenzuela MT,Galisteo R,Zuluaga A,Villalobos M,Núñez MI,Oliver FJ,Ruiz de Almodóvar JM

    更新日期:2002-12-01 00:00:00

  • Malrotation of midgut in adult polycystic kidney disease.

    abstract::A case of malrotation of the midgut and adult polycystic kidney disease is reported. The patient had a stillborn son who had congenital heart disease and adult type of polycystic kidney disease. These findings support the notion that cystic disease of the kidney, gastrointestinal and cardiovascular anomalies are genet...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472926

    authors: Chan HS,Lai KN,Leung JW,Man DW

    更新日期:1988-01-01 00:00:00

  • Erectile implants in female-to-male transsexuals: our experience in 129 patients.

    abstract:BACKGROUND:The combination of a neourethra and erection prosthesis in a single neophallus in the female-to-male transsexual remains a challenge. No good data are available on this subject. OBJECTIVE:To report the outcome in 129 female-to-male transsexuals with a neophallus after the implantation of an erectile prosthe...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.03.013

    authors: Hoebeke PB,Decaestecker K,Beysens M,Opdenakker Y,Lumen N,Monstrey SM

    更新日期:2010-02-01 00:00:00

  • Cytokeratin-20 reverse-transcriptase polymerase chain reaction as a new tool for the detection of circulating tumor cells in peripheral blood and bone marrow of bladder cancer patients.

    abstract:OBJECTIVES:Systemic progression is the prevalent form of bladder tumor recurrence after radical cystectomy. The ability to detect circulating tumor cells in peripheral blood or bone marrow could be of prognostic value for the disease with the consequence of early adjuvant chemotherapy. We established a sensitive and sp...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000052496

    authors: Retz M,Lehmann J,Röder C,Weichert-Jacobsen K,Loch T,Romahn E,Lühl C,Kalthoff H,Stöckle M

    更新日期:2001-05-01 00:00:00

  • Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis.

    abstract:CONTEXT:Clinical data supporting the use of targeted agents for the treatment of metastatic renal cell carcinoma (RCC) are based predominantly on patients with clear cell histology. Little is known about the efficacy of these drugs in non-clear cell variants. OBJECTIVE:To evaluate the efficacy of different clear cell ...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2014.05.010

    authors: Vera-Badillo FE,Templeton AJ,Duran I,Ocana A,de Gouveia P,Aneja P,Knox JJ,Tannock IF,Escudier B,Amir E

    更新日期:2015-04-01 00:00:00

  • Is renal living-donor transplantation indicated in adult patients with orthotopic ileal neobladder? Lessons learned from a clinical case.

    abstract::Renal transplantation is the treatment of choice for patients with end-stage renal disease and it has already been described in the literature in patients with orthotopic neobladders, mostly in the paediatric population. We report the first case of a living-donor renal graft in an adult patient with a orthotopic neobl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.05.020

    authors: Airoldi A,Volpe A,Billia M,Marchioro G,Fenoglio R,Lazzarich E,Sacchetti G,Baiocco C,Inglese E,Menegotto A,Terrone C,Stratta P

    更新日期:2010-11-01 00:00:00

  • Prevalence of contralateral testicular intraepithelial neoplasia (carcinoma in situ) in patients with testicular germ cell tumour. Results of the German multicentre study.

    abstract::Contralateral biopsies taken from 1,188 patients with testicular germ-cell tumour were examined immunohistologically by staining for placental alkaline phosphatase. Testicular intraepithelial neoplasia (TIN; carcinoma in situ) was detected in 53 patients (4.5%; 95% confidence interval 3.3-5.7%). Testicular atrophy was...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000474579

    authors: Loy V,Dieckmann KP

    更新日期:1993-01-01 00:00:00

  • Urethrogluteal fistula occurring after radical cystectomy for bladder cancer.

    abstract::We report on a patient who developed a urethrogluteal fistula 11 years following cystectomy performed for carcinoma of the bladder. The diagnosis was established by retrograde urethrography and fistulography. To the best of our knowledge, no previous case has been reported in the literature. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472777

    authors: Tasca A,Aragona F,Piazza R,Calabró A,Artibani W

    更新日期:1987-01-01 00:00:00

  • Effect of long-term sitting on serum prostate-specific antigen levels.

    abstract:OBJECTIVE:The aim of this study was to evaluate the effect of long-term sitting on serum prostate-specific antigen (PSA) levels. METHOD:The serum PSA levels of 50 bus drivers under the age of 45 (mean 37.7) years who worked at least 8 h a day for more than 3 weeks were compared with those of 50 healthy surgeons in sim...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000020021

    authors: Gumus E,Miroglu C,Horasanli K,Ekinci M,Saporta L,Kilinc F

    更新日期:1999-11-01 00:00:00

  • CO2 laser for therapeutic circumcision in adults.

    abstract::The use of carbon dioxide laser for 38 posthetomies or therapeutic circumcisions in the treatment of phimosis, paraphimosis, balanitis of Zoon or a genital infection by the human papillomaviurs permits clean and hemostatic incisions. The clean and dry wound produced by the carbon dioxide beam offers several advantages...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475024

    authors: Aynaud O,Casanova JM,Tranbaloc P

    更新日期:1995-01-01 00:00:00