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Neutron therapy of bladder carcinoma: can a high rate of severe complications be avoided in neutron therapy?

Abstract：

:We reviewed retrospectively a series of 58 patients with deeply invasive bladder cancer treated with fast neutron therapy (p(65) + Be) in order to evaluate its tolerance and side effects. Patients were divided into three groups according to treatment technique. Patients of group A received whole pelvis irradiation up to 50 Gy photon equivalent followed by a boost to the bladder up to 57-66 Gy photon equivalent (40-56 days). Group B patients were treated by a split course regimen of 30 Gy photon equivalent on the whole pelvis at 3-4 weeks interval (66-108 days). Group C patients, not suitable for radical treatment, received only 40-54 Gy photon equivalent (26-70 days). The overall 5-year actuarial survival rate was 30% (SE 8%). As expected, T stage was a statistically significant prognostic factor. The overall local control rate reached 21% at 4 years. Acute and late side effects were minimal to moderate. These results suggest that high-energy neutron beam treatment is at least as effective as photon beam treatment for bladder carcinoma, without a higher incidence of major side effects.

journal_name

Eur Urol

journal_title

European urology

authors

Kirkove C,Richard F,Van Cangh PJ,Ledent G,Octave-Prignot M,Wambersie A

doi

10.1159/000474262

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

52-7

issue

1

eissn

0302-2838

issn

1873-7560

journal_volume

24

pub_type

杂志文章,评审

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