当前位置： SCI文献检索 > EUROPEAN UROLOGY期刊下所有文献 > Phosphodiesterase type 5 inhibitors: the day after.

Phosphodiesterase type 5 inhibitors: the day after.

Abstract：

OBJECTIVE:Review the literature on phosphodiesterase type 5 inhibitors (PDE5-Is), addressing critical issues in their current and future use, assessing unanswered questions, and identifying research needs. METHODS:A MEDLINE search was conducted on PDE5-Is, with emphasis on clinical trials and experience, for interpretation and analysis of their present and future role. RESULTS:Although approximately 40 million patients with erectile dysfunction have been treated successfully worldwide with the three available PDE5-Is, inappropriate instructions, lack of follow-up, and lack of patient-centered care models are the main reasons for "non-response," leading to drop-out rates of >50%. Patients with severe neurologic damage, diabetes mellitus, or severe vascular disease may be resistant to PDE5-Is. Preservation of corporal smooth muscle with chronic administration of PDE5-Is has been reported and substantial evidence indicates that these drugs have beneficial effects on endothelium and cardiovascular function; sildenafil has been approved for the treatment of idiopathic pulmonary hypertension. Improvement of lower urinary tract symptoms in men with benign prostatic hyperplasia after PDE5-I administration has been also suggested. CONCLUSIONS:The data indicate the necessity for (1) exploration of the pharmacologic characteristics of the three PDE5-Is; (2) research on their pharmacologic differences because some actions seems to be drug-specific; (3) development of alternative management strategies, such as chronic, low, everyday doses of PDE5-Is, if the monthly cost is affordable; and (4) clinical trials on use of PDE5-Is to treat other chronic conditions. The door for innovative therapeutic approaches will open, specifically for cross-risk factor treatment with PDE5-Is or their use in combination treatments or new multimodal pills that take advantage of drugs that exert pleiotropic vascular actions.

journal_name

Eur Urol

journal_title

European urology

authors

Hatzimouratidis K,Hatzichristou D

doi

10.1016/j.eururo.2006.07.020

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

75-88; discussion 89

issue

1

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(06)00855-4

journal_volume

51

pub_type

杂志文章,评审

相关文献

EUROPEAN UROLOGY文献大全
  • Pulmonary excretion of foreign bodies and necrotic material from the bladder wall.

    abstract：:Following injection of carbon suspension into the bladder wall of white rats, carbon particles were observed in the cytoplasm of cells located as the alveolar macrophages. Following injections of a solution of AgNO3 into the bladder wall of white rats, dark stained spots were observed in the cytoplasm of cells located...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000471955

    authors： Bertheussen KJ,Nissen HM

    更新日期：1976-01-01 00:00:00

  • Two-year follow-up of a prospective randomised trial of electrovaporization versus resection of prostate.

    abstract：OBJECTIVES:Transurethral electrovaporization of the prostate (TUVP) has become a popular, minimally invasive procedure to treat BPH with promising initial results. This study was conducted to compare the efficacy, safety and durability of TUVP with standard TURP. We report the 2-year follow-up. METHODS:104 consecutive...

    journal_title：European urology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1159/000019710

    authors： Hammadeh MY,Madaan S,Singh M,Philp T

    更新日期：1998-09-01 00:00:00

  • Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial.

    abstract：BACKGROUND:The extent of lymph node dissection (LND) in bladder cancer (BCa) patients at the time of radical cystectomy may affect oncologic outcome. OBJECTIVE:To evaluate whether extended versus limited LND prolongs recurrence-free survival (RFS). DESIGN, SETTING, AND PARTICIPANTS:Prospective, multicenter, phase-III...

    journal_title：European urology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.eururo.2018.09.047

    authors： Gschwend JE,Heck MM,Lehmann J,Rübben H,Albers P,Wolff JM,Frohneberg D,de Geeter P,Heidenreich A,Kälble T,Stöckle M,Schnöller T,Stenzl A,Müller M,Truss M,Roth S,Liehr UB,Leißner J,Bregenzer T,Retz M

    更新日期：2019-04-01 00:00:00

  • Robotic-assisted laparoscopic prostatectomy: functional and pathologic outcomes with interfascial nerve preservation.

    abstract：INTRODUCTION:Robotic-assisted laparoscopic radical prostatectomy (RLRP) is increasingly becoming an alternative to open and laparoscopic radical prostatectomy in the treatment of localized prostate cancer. RLRP has been associated with low morbidity, short convalescence and comparable oncologic and functional outcomes....

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2006.10.019

    authors： Zorn KC,Gofrit ON,Orvieto MA,Mikhail AA,Zagaja GP,Shalhav AL

    更新日期：2007-03-01 00:00:00

  • Safety study of umbilical single-port laparoscopic radical prostatectomy with a new DuoRotate system.

    abstract：BACKGROUND:Laparoendoscopic single-site (LESS) radical prostatectomy (RP) has been performed through different approaches. A new DuoRotate manual system developed by Richard Wolf (KeyPort; Richard Wolf GmbH, Knittlingen, Germany) can be applied to RP. OBJECTIVES:Our aim was to describe the surgical technique and repor...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2012.04.043

    authors： Cáceres F,Cabrera PM,García-Tello A,García-Mediero JM,Angulo JC

    更新日期：2012-12-01 00:00:00

  • A prospective, randomised trial comparing plasmakinetic enucleation to standard transurethral resection of the prostate for symptomatic benign prostatic hyperplasia: three-year follow-up results.

    abstract：BACKGROUND:Plasmakinetic enucleation of the prostate (PKEP) has recently been proved a safe and technically feasible procedure for benign prostatic hyperplasia (BPH). However, its long-term safety, efficacy, and durability in comparison with the gold-standard transurethral resection of the prostate (TURP) have not yet ...

    journal_title：European urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eururo.2010.08.026

    authors： Zhao Z,Zeng G,Zhong W,Mai Z,Zeng S,Tao X

    更新日期：2010-11-01 00:00:00

  • Randomized Trial Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: Oncologic Outcomes.

    abstract：BACKGROUND:Open radical cystectomy (ORC) has proven to be an important component in the treatment of high-risk bladder cancer (BCa). ORC surgical morbidity remains high; therefore, minimally invasive surgical techniques have been introduced in an attempt to improve patient outcomes. OBJECTIVE:To compare cancer outcome...

    journal_title：European urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eururo.2018.04.030

    authors： Bochner BH,Dalbagni G,Marzouk KH,Sjoberg DD,Lee J,Donat SM,Coleman JA,Vickers A,Herr HW,Laudone VP

    更新日期：2018-10-01 00:00:00

  • Laparoscopic surgery versus antegrade scrotal sclerotherapy: Retrospective comparison of two different approaches for varicocele treatment.

    abstract：OBJECTIVE:Both laparoscopic surgery and antegrade sclerotherapy are effective treatment options in the management of varicoceles. However, very limited data comparing these two approaches are available in the literature. We present our experience regarding outcome and complications with each treatment modality. PATIEN...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2005.10.023

    authors： May M,Johannsen M,Beutner S,Helke C,Braun KP,Lein M,Roigas J,Hoschke B

    更新日期：2006-02-01 00:00:00

  • Systematic review of adrenalectomy and lymph node dissection in locally advanced renal cell carcinoma.

    abstract：CONTEXT:Controversy remains over whether adrenalectomy and lymph node dissection (LND) should be performed concomitantly with radical nephrectomy (RN) for locally advanced renal cell carcinoma (RCC) cT3-T4N0M0. OBJECTIVE:To systematically review all relevant literature comparing oncologic, perioperative, and quality-o...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2013.04.033

    authors： Bekema HJ,MacLennan S,Imamura M,Lam TB,Stewart F,Scott N,MacLennan G,McClinton S,Griffiths TR,Skolarikos A,MacLennan SJ,Sylvester R,Ljungberg B,N'Dow J

    更新日期：2013-11-01 00:00:00

  • Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors.

    abstract：:Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. It is unclear whether this applies to patients receiving immune checkpoint inhibitors (ICIs). In this case series, 7...

    journal_title：European urology

    pub_type：

    doi：10.1016/j.eururo.2020.05.024

    authors： Szabados B,Abu-Ghanem Y,Grant M,Choy J,Bex A,Powles T

    更新日期：2020-08-01 00:00:00

  • Value of computerized tomography and ultrasonography in the preoperative diagnosis of renal cell carcinoma extending into the inferior vena cava.

    abstract：:During a 15-year period, 34 patients with renal cell carcinoma extending into the inferior vena cava were submitted to radical ablative surgery at our institution. 8 patients had caval tumor thrombus (TT) extension at the level of the renal veins, 17 had infrahepatic, 8 retrohepatic and 1 atrial TT extension. Cavograp...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000472731

    authors： Giuliani L,Giberti C,Martorana G,Isotta A,Neumaier CE

    更新日期：1987-01-01 00:00:00

  • Learning Curve in Robot-assisted Kidney Transplantation: Results from the European Robotic Urological Society Working Group.

    abstract：BACKGROUND:Recently, robot-assisted kidney transplantation (RAKT) was recently introduced as renal replacement mini-invasive surgery. OBJECTIVE:To report surgical technique, including tips and tricks, and the learning curve for RAKT. DESIGN, SETTING, AND PARTICIPANTS:All consecutive RAKTs performed in the five highes...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2019.12.008

    authors： Gallioli A,Territo A,Boissier R,Campi R,Vignolini G,Musquera M,Alcaraz A,Decaestecker K,Tugcu V,Vanacore D,Serni S,Breda A

    更新日期：2020-08-01 00:00:00

  • Trans-obturator vaginal tape (TOT) for female stress incontinence: one year follow-up in 120 patients.

    abstract：OBJECTIVES:The aim of this study was to evaluate the effectiveness of a new minimally invasive surgical procedure, the Trans-obturator Vaginal Tape (TOT) in the treatment of female urodynamic stress incontinence (USI) and to analyse functional results and quality of life after one year of follow up. MATERIAL AND METHO...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2005.08.003

    authors： Roumeguère T,Quackels T,Bollens R,de Groote A,Zlotta A,Bossche MV,Schulman C

    更新日期：2005-11-01 00:00:00

  • Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of Castration-resistant Prostate Cancer.

    abstract：:Bipolar androgen therapy (BAT) is a paradoxical treatment for castrate-resistant prostate cancer whereby testosterone levels are rapidly alternated between supraphysiologic and near-castrate concentrations. Initial studies demonstrated that BAT is safe and produces clinical responses. A trial comparing enzalutamide ag...

    journal_title：European urology

    pub_type： 社论

    doi：10.1016/j.eururo.2017.03.022

    authors： Schweizer MT,Antonarakis ES,Denmeade SR

    更新日期：2017-09-01 00:00:00

  • Guidelines on erectile dysfunction.

    abstract：:The introduction of new oral therapies has completely changed the diagnostic and therapeutic approach to erectile dysfunction. A panel of experts in this field have developed guidelines for clinical evaluation and treatment based on the review of available scientific information. ...

    journal_title：European urology

    pub_type： 指南,杂志文章,实务指引

    doi：10.1016/s0302-2838(01)00008-2

    authors： Wespes E,Amar E,Hatzichristou D,Montorsi F,Pryor J,Vardi Y,European Association of Urology.

    更新日期：2002-01-01 00:00:00

  • Follow-up in prostate cancer patients: which parameters are necessary?

    abstract：AIM:In a retrospective study we examined whether follow-up of prostate cancer (PC) patients can be managed by using prostate-specific antigen (PSA) as a unique tool as postulated recently. PATIENTS AND METHODS:According to strict criteria established in the eighties, at our institution PC patients were monitored by PS...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000019814

    authors： Strohmaier WL,Keller T,Bichler KH

    更新日期：1999-01-01 00:00:00

  • Intravesical ions, osmolality and pH influence the volume pressure response in the normal rat bladder, and this is more pronounced after DMSO exposure.

    abstract：:The influence of intravesical ions, osmolality, pH value, and active transurothelial NaCl-transport inhibition (furosemide) on the rat bladder volume-pressure response was studied according to the concept of a permeable urothelium and according to direct effects of osmolality and K+ on in vitro muscle preparations. It...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000472470

    authors： Hohlbrugger G,Lentsch P

    更新日期：1985-01-01 00:00:00

  • Measurement of the blood supply to the abdominal testis by means of near infrared spectroscopy.

    abstract：:Cryptorchidism is the most common male sexual disorder. In the case of an abdominal testis there is no objective criterion to choose between autotransplantation or orchiopexy after ligation of the spermatic vessels with subsequent development of collateral blood supply. By combining near infrared spectroscopy (NIRS) w...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000475150

    authors： Colier WN,Froeling FM,de Vries JD,Oeseburg B

    更新日期：1995-01-01 00:00:00

  • Localization of NADPH diaphorase and vasoactive intestinal polypeptide-containing neurons in the efferent pathway to the rat corpus cavernosum.

    abstract：OBJECTIVE:We examined the coexistence of nitric oxide synthase (NOS) and vasoactive intestinal peptide (VIP) in the efferent pathway to the rat corpus cavernosum. METHODS:We used NADPH diaphorase (ND) histochemical staining, a specific marker of neuronal NOS, in combination with retrograde axonal transport of True Blu...

    journal_title：European urology

    pub_type： 杂志文章

    doi：

    authors： Tamura M,Kagawa S,Tsuruo Y,Ishimura K,Kimura K,Kawanishi Y

    更新日期：1997-01-01 00:00:00

  • Pathologic Outcomes in Favorable-risk Prostate Cancer: Comparative Analysis of Men Electing Active Surveillance and Immediate Surgery.

    abstract：BACKGROUND:It remains unclear whether men selecting active surveillance (AS) are at increased risk of unfavorable longer term outcomes as compared with men who undergo immediate treatment. OBJECTIVE:To compare adverse pathologic outcomes in men with favorable-risk prostate cancer who underwent delayed prostatectomy af...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2015.09.032

    authors： Tosoian JJ,Sundi D,Trock BJ,Landis P,Epstein JI,Schaeffer EM,Carter HB,Mamawala M

    更新日期：2016-04-01 00:00:00

  • Polyamines and prostatic carcinoma: clinical and therapeutic implications.

    abstract：:The erythrocyte polyamines, spermidine and spermine, are known proliferation markers. The authors present their experience with polyamines and prostatic carcinoma. 229 patients with prostatic carcinoma had polyamine erythrocyte determination at diagnosis. Previous results confirmed a tendency to spermidine increase wi...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000474279

    authors： Cipolla B,Guillé F,Moulinoux JP,Quemener V,Staerman F,Corbel L,Lobel B

    更新日期：1993-01-01 00:00:00

  • Videourodynamics identifies the causes of young men with lower urinary tract symptoms and low uroflow.

    abstract：OBJECTIVES:Using videourodynamics (VUDS) we prospectively investigated the etiologies of lower urinary tract symptoms (LUTS) and low uroflow in young men and correlated the results with clinical symptoms and noninvasive exams. METHODS:From 1999 to 2001, 90 men 18-50 years old with LUTS and low uroflow were enrolled. P...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/s0302-2838(03)00060-5

    authors： Wang CC,Yang SS,Chen YT,Hsieh JH

    更新日期：2003-04-01 00:00:00

  • Long-term outcomes among noncuratively treated men according to prostate cancer risk category in a nationwide, population-based study.

    abstract：BACKGROUND:Limited data exist on long-term outcomes among men with prostate cancer (PCa) from population-based cohorts incorporating information on clinical risk category. OBJECTIVE:To assess 15-yr mortality for men with PCa treated with noncurative intent according to clinical stage, Gleason score (GS), serum levels ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2012.08.001

    authors： Rider JR,Sandin F,Andrén O,Wiklund P,Hugosson J,Stattin P

    更新日期：2013-01-01 00:00:00

  • Clinical experience with the N-shaped ileal neobladder: assessment of complications, voiding patterns, and quality of life in our series of 58 patients.

    abstract：PURPOSE:The purpose of this retrospective study was to assess complications, voiding patterns, and quality of life in patients with an orthotopic bladder substitution, using an N-shaped ileal neobladder. MATERIALS AND METHODS:Between May 1996 and December 2002, 58 patients (52 men and 6 women) underwent an orthotopic ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2004.12.006

    authors： Joniau S,Benijts J,Van Kampen M,De Waele M,Ooms J,Van Cleynenbreugel B,Van Poppel H

    更新日期：2005-05-01 00:00:00

  • Enhanced Recovery Pathways Versus Standard Care After Cystectomy: A Meta-analysis of the Effect on Perioperative Outcomes.

    abstract：CONTEXT:Enhanced recovery after surgery (ERAS) protocols aim to improve surgical outcomes by reducing variation in perioperative best practices. However, among published studies, results show a striking variation in the effect of ERAS pathways on perioperative outcomes after cystectomy. OBJECTIVE:To perform a systemat...

    journal_title：European urology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.eururo.2016.05.031

    authors： Tyson MD,Chang SS

    更新日期：2016-12-01 00:00:00

  • Long-term Impact of Mode of Delivery on Stress Urinary Incontinence and Urgency Urinary Incontinence: A Systematic Review and Meta-analysis.

    abstract：CONTEXT:Stress urinary incontinence (SUI) and urgency urinary incontinence (UUI) are associated with physical and psychological morbidity, and large societal costs. The long-term effects of delivery modes on each kind of incontinence remain uncertain. OBJECTIVE:To investigate the long-term impact of delivery mode on S...

    journal_title：European urology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.eururo.2016.01.037

    authors： Tähtinen RM,Cartwright R,Tsui JF,Aaltonen RL,Aoki Y,Cárdenas JL,El Dib R,Joronen KM,Al Juaid S,Kalantan S,Kochana M,Kopec M,Lopes LC,Mirza E,Oksjoki SM,Pesonen JS,Valpas A,Wang L,Zhang Y,Heels-Ansdell D,Guyatt GH

    更新日期：2016-07-01 00:00:00

  • Renal vein involvement with nephroblastoma: a report of the National Wilms' Tumor Study-3.

    abstract：:The records of children enrolled in the National Wilms' Tumor Study-3 who had Wilms' tumor and thrombosis into the renal vein were reviewed. There were 164 patients with gross involvement of the extrarenal vein and 47 patients with microscopic involvement, an incidence of 11.3% (211 of 1,865 evaluable patients). Two-y...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000464022

    authors： Ritchey ML,Othersen HB Jr,de Lorimier AA,Kramer SA,Benson C,Kelalis PP

    更新日期：1990-01-01 00:00:00

  • Urinary cytokeratin 20 as a marker for transitional cell carcinoma.

    abstract：OBJECTIVES:To determine if detection of cytokeratin 20 (CK20) gene expression, by reverse transcriptase-polymerase chain reaction (RT-PCR) in urine from transitional cell carcinoma (TCC) patients, can provide a new noninvasive tool for the follow-up of patients with urothelial carcinoma of the bladder. METHODS:Urine w...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000020199

    authors： Rotem D,Cassel A,Lindenfeld N,Mecz Y,Sova Y,Resnick M,Stein A

    更新日期：2000-05-01 00:00:00

  • Male complete urethral duplication: report of 3 new cases.

    abstract：:Urethral duplication (UD) is a very rare congenital malformation, either in its complete or incomplete presentation. Its different types of appearance as well as the usually associated malformations (genitourinary, gastrointestinal, musculo-skeletal, and others) make it a complex disorder which requires an individuali...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000463928

    authors： Sarmentero E,Estornell F,Beamud A,Martinez Verduch M,García Ibarra F

    更新日期：1990-01-01 00:00:00

  • A case of nonseminomatous testicular tumor with liver metastases, treated by intrahepatic arterial cisplatinum-diaminedichloride infusion.

    abstract：:We report a case of nonseminomatous testicular tumor with lymph node involvement and multiple lung and liver metastases. The patient was considered to have a poor prognosis. He received systemic chemotherapy and cytoreductive surgery. Postoperatively a residual metastatic tumor in the liver was treated by intrahepatic...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000463917

    authors： Kawai K,Sasaki A,Nishijima Y,Kikuchi K,Ohtani M,Rinshou K,Koiso K,Adachi S,Ishikawa A,Iwasaki Y

    更新日期：1990-01-01 00:00:00