Abstract:
BACKGROUND:The oncologic safety of blunt tumor enucleation (TE) of renal cell carcinoma (RCC) depends on the presence of a continuous pseudocapsule (PS) around the tumor and on the possibility of obtaining negative surgical margins (SMs). OBJECTIVE:To investigate the PS and SMs after TE to define the real need to take a rim of healthy parenchyma around the tumor to avoid the risk of positive SMs. The risk of PS invasion related to other clinical and pathologic variables was also evaluated. DESIGN, SETTING, AND PARTICIPANTS:Between September 2006 and December 2007, data were gathered prospectively from 187 consecutive patients who had kidney surgery. Overall, 90 consecutive patients who had TE for RCC were eligible for the study. All specimens were evaluated using an image analyzer by a dedicated uropathologist. INTERVENTION:TE was done by blunt dissection using the natural cleavage plane between the tumor and the normal parenchyma. MEASUREMENTS:PS, SM, and routinely available clinical and pathologic variables were recorded. RESULTS AND LIMITATIONS:In 60 RCC tumors (67%) the PS was intact and free from invasion (PS-) while in 30 (33%) there were signs of penetration within its layers, with or without invasion beyond it. Indeed, 26.6% had PS that had been penetrated on the parenchymal side and 6.6% had penetration on the perirenal fat tissue side. The odds of having PS penetration increased significantly with an increase in clinical tumor size. PS penetration was also significantly associated with pathologic tumor dimensions and grade. In all cases the SMs were negative after TE. The present patients, followed for >2 yr, will enable us to correlate the risk of local recurrence with PS status. CONCLUSIONS:The risk of PS penetration is associated with clinical and pathologic tumor dimensions and grade. If there is PS invasion into normal parenchyma, the presence of a thin layer of tissue allows for negative SM even if a TE is performed.
journal_name
Eur Uroljournal_title
European urologyauthors
Minervini A,di Cristofano C,Lapini A,Marchi M,Lanzi F,Giubilei G,Tosi N,Tuccio A,Mancini M,della Rocca C,Serni S,Bevilacqua G,Carini Mdoi
10.1016/j.eururo.2008.07.038subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1410-8issue
6eissn
0302-2838issn
1873-7560pii
S0302-2838(08)00892-0journal_volume
55pub_type
杂志文章相关文献
EUROPEAN UROLOGY文献大全abstract:OBJECTIVES:To summarize monoinstitutional experience with gastrointestinal (GI) presentations of germ cell malignancy and to review recent medical literature on this issue. METHODS:Retrospective review of 5 cases with advanced germ cell malignancy (testicular 2 and retroperitoneal 3) and involvement of the upper GI tr...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000020368
更新日期:2000-12-01 00:00:00
abstract::We have studied 38 patients with previously untreated, widespread prostatic cancer, who were submitted to therapy with cyproterone acetate and orchiectomy. 70% of patients with symptoms have shown subjective improvement. Moreover, it was possible to observe the regression, stabilization or progression of metastases in...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473314
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The best sequence of targeted therapy in patients with metastatic renal cell carcinoma (mRCC) has not been sufficiently defined. OBJECTIVE:To describe the efficacy and toxicity of sequential everolimus (EV) versus receptor tyrosine kinase inhibitor (rTKI) following failure of first rTKI treatment. DESIGN, ...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2011.07.037
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Studies offer wide variations in inclusion criteria for active surveillance (AS) in prostate cancer (PCa), but the role of the biopsy core number has not been thoroughly assessed. OBJECTIVE:To evaluate the impact of the biopsy core number on the risk of misclassification for AS eligibility. DESIGN, SETTING...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.07.053
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:The association between the severity of LUTS and prostate volume, prostate-related variables and general life-style factors was investigated in a large number of patients with persistent LUTS suggestive of BPH (LUTS/BPH). METHODS:Patients with LUTS/BPH aged between 50 and 80 years, were enrolled in this Ita...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2004.01.011
更新日期:2004-06-01 00:00:00
abstract::In order to present or minimize the frequent occurrence of urinary infection and other complications following indwelling catheterization, we devised a drug-releasing silicon catheter. Attached to its tip is an appliance which has a honeycomb pattern with many spaces into which antibiotic particles are inserted. In ou...
journal_title:European urology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:We retrospectively evaluated the safety, efficacy and patient satisfaction following the male sling procedure for stress urinary incontinence. MATERIALS AND METHODS:Forty-six patients, with a median age of 67 years, underwent the perineal male sling procedure for stress urinary incontinence. Radical retropub...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2004.06.021
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:The effectiveness of a chemotherapy regimen including cisplatin, epirubicin, and estramustine phosphate was evaluated in a series of young patients with prostate cancer. METHODS:28 patients with a histological diagnosis of prostatic carcinoma, age < 70 years, performance status (PS) < 2, hormone-refractory s...
journal_title:European urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000473792
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Energy metabolism is important in cancer proliferation and progression, but its role in prostate cancer (PCa) remains unclear. OBJECTIVE:We explored whether single-nucleotide polymorphisms (SNPs) of genes involved in energy metabolic pathways are associated with PCa risk and prognosis, and whether antidiabe...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2015.03.026
更新日期:2015-12-01 00:00:00
abstract:CONTEXT:The European Association of Urology Guideline Panel for Renal Cell Carcinoma (RCC) has prepared evidence-based guidelines and recommendations for RCC management. OBJECTIVES:To provide an update of the 2010 RCC guideline based on a standardised methodology that is robust, transparent, reproducible, and reliable...
journal_title:European urology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.eururo.2015.01.005
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:While the published short-term oncologic outcomes after laparoscopic radical prostatectomy (LRP) are encouraging, intermediate and long-term data are lacking. OBJECTIVE:We analyzed the oncologic outcome after LRP based on 10 yr of experience. DESIGN, SETTING, AND PARTICIPANTS:This retrospective analysis of...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2008.10.036
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Controversy exists regarding the optimal extent of lymphadenectomy and the number of lymph nodes to be retrieved at radical cystectomy (RC). OBJECTIVE:To compare the disease-free survival of patients with standard lymphadenectomy (endopelvic region composed of the internal, external iliac, and obturator gro...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2011.05.062
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Management of recurrent prostate cancer (CaP) after radiotherapy (RT) is dependent on accurate localization of the site of recurrent disease. OBJECTIVE:To describe the anatomic patterns and clinical features associated with CaP recurrence following RT identified on advanced imaging. DESIGN, SETTING, AND PA...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2016.08.055
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To report the utilization of a modified Endo GIA vascular stapler to obtain the full length of the renal vein during transperitoneal laparoscopic live donor right nephrectomy. METHODS:We used a modified Endo GIA stapler, in which the triple staggered rows of staples were removed from the kidney donor side t...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2006.11.052
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The conventional Fuhrman grading system, which categorizes renal cell carcinoma (RCC) with grades I, II, III, and IV, is the most widely used predictor assessment of RCC cancer-specific mortality (CSM). OBJECTIVES:The aim of this study was to test the prognostic ability of simplified Fuhrman grading schemes...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.06.008
更新日期:2009-11-01 00:00:00
abstract::Duplication of the urethra is a rare congenital anomaly, usually found in children and adolescents. The authors present a rare case of urethral duplication, presenting in a 58-yr-old man, with symptoms of bladder outlet obstruction. ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2007.01.019
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:Knowledge regarding the incidence and prevalence of acute urinary retention and the ultimate outcome is very limited. The purpose of the present analysis was to document the natural history and outcomes of acute urinary retention (AUR) further specified as being either precipitated or spontaneous, and to eva...
journal_title:European urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000020189
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether unilaterally orchiectomised testicular cancer survivors (TCSs) are more likely to display reduced Leydig cell function than healthy males. METHODS:A national multi-centre survey of 1235 TCSs was performed in 1998-2000 (mean age: 44 years) treated between 1980 and 1994 (mean follow-up: ...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/s0302-2838(03)00263-x
更新日期:2003-09-01 00:00:00
abstract::The Lithoring Multi-One is a lithotripter recently developed in Italy. Its main features are (1) spark gap generator with large ellipsoid, with tunable power for treatments with or without analgesia; (2) localization by fluoroscopy and ultrasounds without moving the patient; (3) isocentric variation of shock wave wind...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000463856
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Clinically significant nonmetastatic prostate cancer (PCa) is currently treated using whole-gland therapy. This approach is effective but can have urinary, sexual, and rectal side effects. OBJECTIVE:To report on 5-yr PCa control following focal high-intensity focused ultrasound (HIFU) therapy to treat indiv...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2018.06.006
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Even though transurethral resection of the prostate remains the gold standard treatment for lower urinary tract symptoms (LUTS) refractory to medical therapy, photoselective vaporization of the prostate (PVP) has become a popular alternative. Early PVP studies seem encouraging, but few data exist regarding t...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2010.04.027
更新日期:2010-08-01 00:00:00
abstract::No data are available on the surgical safety of radical cystectomy (RC) and pelvic lymph node dissection (PLND) after the administration of checkpoint inhibitors. We aimed at reporting the first prospective rigorous assessment of perioperative outcomes after RC and extended PLND following neoadjuvant pembrolizumab in ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2019.12.019
更新日期:2020-05-01 00:00:00
abstract::Based on experience with over 2,000 patients, the treatment of ureteric stones today relies on extracorporeal shock wave lithotripsy (ESWL) in situ and ureteroscopy with semirigid, ultrathin ureteroscopes combined with pneumatic or laser lithotripsy. All stones in the upper and larger stones in the distal third of the...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000475300
更新日期:1994-01-01 00:00:00
abstract::Although hormone therapy is widely used in the management of prostate cancer, the optimal timing of its initiation remains a matter of debate. Immediate hormone treatment has been compared with deferred treatment in randomized studies conducted by the Veterans Administration Cooperative Urological Research Group, the ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000052337
更新日期:1999-01-01 00:00:00
abstract:CONTEXT:Radiolabelled choline positron emission tomography has changed the management of prostate cancer patients. However, new emerging radiopharmaceutical agents, like radiolabelled prostate specific membrane antigen, and new promising hybrid imaging will begin new challenges in the diagnostic field. OBJECTIVE:The c...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2016.01.029
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:Perioperative morbidity is an essential indicator for the quality of an operative technique. This fact is especially important in radical prostatectomy since different treatment modalities may provide similar outcome in terms of local tumor control. MATERIALS AND METHODS:The conventional type of radical perine...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000049764
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between neuroendocrine differentiation (NED) status and hormone refractory prostate cancer (HRPC) following hormone therapy based on immunohistochemical study. METHODS:Seventy-two prostate cancer specimens obtained at radical prostatectomy and 21 prostate cancer autopsy specimens...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2003.11.032
更新日期:2004-05-01 00:00:00
abstract::A double-blind trial was conducted in 138 patients with superficial transitional cell carcinoma of the bladder following transurethral resection to evaluate the prophylaxis of recurrence by an oral Lactobacillus casei preparation (BLP). Patients were stratified into the following 3 subgroups: (A) with primary multiple...
journal_title:European urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000475138
更新日期:1995-01-01 00:00:00
abstract::23 medical faculties exist in Turkey at the moment and 2 others are being established. Considering that all these faculties run their own programs independently, different education systems might effect the standard of doctors and health care. All of the new graduates in this country face a centralized examination for...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000464040
更新日期:1990-01-01 00:00:00
abstract::We describe our experience with a new technique of complete repair of severe posterior hypospadias in one stage. The operative technique includes some innovative points: penile straightening is realized by urethral mobilization (without detaching it from the glans) to excise the chordee, and then urethroplasty accordi...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474741
更新日期:1992-01-01 00:00:00