Preferential preservation of bone mineralisation by LHRH agonists in the treatment of metastatic prostate cancer.

Abstract:

:Histomorphometric measurements of tumour-free bone have been undertaken in a closely matched group of patients with metastatic prostate cancer treated either by subcapsular orchidectomy (SCO) or luteinising hormone-releasing hormone (LHRH) agonists. Age, fasting morning urine hydroxyproline/creatinine ratios, alkaline and acid phosphatase levels and elapsed time after hormonal manipulation were similar in those receiving SCO (n = 8) as compared to LHRH therapy (n = 8). Results indicated that osteoid surface and mineralisation rate were significantly reduced in the SCO group (p less than 0.05); other indices were also lower in the SCO patients but failed to reach statistical significance. These changes, possibly due to increased adrenal cortical stimulation secondary to elevated gonadotrophin levels following orchidectomy suggest that medical castration by gonadotrophin inhibition may avoid unnecessary morbidity due to treatment-induced bone dysfunction.

journal_name

Eur Urol

journal_title

European urology

authors

Clarke NW,McClure J,George NJ

doi

10.1159/000473597

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

114-7

issue

2

eissn

0302-2838

issn

1873-7560

journal_volume

19

pub_type

杂志文章
  • Inhibitors of stone formation in hypercalciuric children with and without stone disease.

    abstract::The extretion of two inhibitors of urinary stone formation (citrate, magnesium) was evaluated in 71 hypercalciuric children and 50 controls. Patients were classified into two groups: 42 nonstone former (NSF), 22 boys and 20 girls, 3-14 years old, and 29 stone formers (SF), 18 boys and 11 girls, 2.5-18 years old. Our s...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474843

    authors: al-Qadreh A,Athanasopoulou H,Voskaki I

    更新日期:1992-01-01 00:00:00

  • Prognostic factors in metastatic non-seminomatous germ cell tumours: an interim analysis of the EORTC GU-Group experience.

    abstract::Univariate and multivariate analyses were performed in 632 patients treated with cisplatin combination chemotherapy for metastatic non-seminomatous testicular germ cell tumours. Multivariately, the most important poor prognosis factors for the prediction of survival were: HCG > or = 10,000 IU/l, lung metastases > or =...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000474594

    authors: Stoter G,Sleijfer D,Kaye SB,Jones WG,ten Bokkel Huinink WW,de Pauw M,Sylvester R

    更新日期:1993-01-01 00:00:00

  • Nocturnal enuresis: basic facts and new horizons.

    abstract::Nocturnal enuresis in children is quite seldom due to psychological factors. Instead, it is caused by a hereditary delay in maturation of the somatic mechanisms (reduction of nocturnal urine production, relaxation of the bladder during sleeping hours, and a normal arousal to a full bladder) which prevent the child fro...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:

    authors: Hjälmås K

    更新日期:1998-01-01 00:00:00

  • The radius surgical system - a new device for complex minimally invasive procedures in urology?

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    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.11.046

    authors: Frede T,Hammady A,Klein J,Teber D,Inaki N,Waseda M,Buess G,Rassweiler J

    更新日期:2007-04-01 00:00:00

  • Systemic bacillus Calmette-Guérin infection, 'BCGitis', in patients treated by intravesical bacillus Calmette-Guérin therapy for bladder cancer.

    abstract::Among 169 patients treated for supeficial bladder tumor with 150 mg Pasteur-strain bacillus Calmette-Guérin (BCG) intravesical instillation, 5 cases of 'BCGitis' were observed, i.e. a severe systemic BCG infection with bronchopulmonary lesions and granulomatous hepatitis. In 4 cases, the complications appeared at the ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471561

    authors: Steg A,Leleu C,Debré B,Boccon-Gibod L,Sicard D

    更新日期:1989-01-01 00:00:00

  • Patient satisfaction and clinical efficacy of the new perineal bone-anchored male sling.

    abstract:OBJECTIVE:We retrospectively evaluated the safety, efficacy and patient satisfaction following the male sling procedure for stress urinary incontinence. MATERIALS AND METHODS:Forty-six patients, with a median age of 67 years, underwent the perineal male sling procedure for stress urinary incontinence. Radical retropub...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.06.021

    authors: Rajpurkar AD,Onur R,Singla A

    更新日期:2005-02-01 00:00:00

  • Prostate-specific antigen and age. Is there a correlation? And why does it seem to vary?

    abstract:OBJECTIVES:To determine whether there is a significant correlation between age and prostate-specific antigen (PSA) and to explain the wide literature variations in its value. METHODS:Two different groups were studied; the first (n = 403) consisted of patients undergoing prostatectomies for symptomatic benign prostatic...

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Kirollos MM

    更新日期:1996-01-01 00:00:00

  • Developing and validating the International Consultation on Incontinence Questionnaire bladder diary.

    abstract:BACKGROUND:Despite the common use of urinary diaries to assess lower urinary tract symptoms (LUTS), a standardised validated diary does not exist. OBJECTIVE:To develop a validated urinary diary, using the psychometric validation protocol used in previous International Consultation on Incontinence Questionnaire (ICIQ) ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2014.02.057

    authors: Bright E,Cotterill N,Drake M,Abrams P

    更新日期:2014-08-01 00:00:00

  • The microbiological and pharmacokinetic profile of an antibacterial agent useful for the single-dose therapy of urinary tract infection.

    abstract::Single-dose therapy of uncomplicated urinary tract infection (UTI) has been shown to be effective in many trials in adult women. The question which will be explored in this presentation is what properties constitute the ideal agent for the therapy of UTI. Important microbiological properties include spectrum of activi...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000472856

    authors: Slack R,Greenwood D

    更新日期:1987-01-01 00:00:00

  • Needle core length is a quality indicator of systematic transperineal prostate biopsy.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.12.057

    authors: Ficarra V,Martignoni G,Novella G,Cerruto MA,Galfano A,Novara G,Pea M,Artibani W

    更新日期:2006-08-01 00:00:00

  • PSA nadir is a significant predictor of treatment failure after high-intensity focussed ultrasound (HIFU) treatment of localised prostate cancer.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.07.010

    authors: Ganzer R,Rogenhofer S,Walter B,Lunz JC,Schostak M,Wieland WF,Blana A

    更新日期:2008-03-01 00:00:00

  • Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.11.017

    authors: Moonen PM,Bakkers JM,Kiemeney LA,Schalken JA,Melchers WJ,Witjes JA

    更新日期:2007-08-01 00:00:00

  • Transurethral resection and sequential chemo-immunoprophylaxis in primary T1G3 bladder cancer.

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    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000020171

    authors: Bono AV,Lovisolo JA,Saredi G

    更新日期:2000-04-01 00:00:00

  • Duloxetine, a serotonin and noradrenaline reuptake inhibitor (SNRI) for the treatment of stress urinary incontinence: a systematic review.

    abstract:OBJECTIVE:Surgery and pelvic floor muscle training are established methods for treating stress urinary incontinence (SUI). A new serotonin and noradrenaline reuptake inhibitor, duloxetine, has been studied in multiple phase 3 trials as a form of medical management of this condition. This systematic review determined th...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2006.08.041

    authors: Mariappan P,Alhasso A,Ballantyne Z,Grant A,N'Dow J

    更新日期:2007-01-01 00:00:00

  • Peyronie's disease: prevalence and association with cigarette smoking. A multicenter population-based study in men aged 50-69 years.

    abstract:OBJECTIVES:We present a multicenter, population-based epidemiological survey aimed at assessing the prevalence of Peyronie's disease (PD) and its potential risk factors in the general population. METHODS:In each of the ten centers throughout Italy, a uroandrologist contacted all the men in the age range 50-69 years re...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000049830

    authors: La Pera G,Pescatori ES,Calabrese M,Boffini A,Colombo F,Andriani E,Natali A,Vaggi L,Catuogno C,Giustini M,Taggi F,SIMONA Study Group.

    更新日期:2001-11-01 00:00:00

  • Intratesticular effects of cisplatin-based chemotherapy.

    abstract::The question is addressed whether cisplatin-based chemotherapy for germ cell cancer has the same efficacy in intratesticular and in extragonadal sites. For this purpose, 7 patients with germ cell cancer, aged 16-35 years were analysed. Four of the patients had palpable testicular tumors, 3 had occult testicular tumors...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475015

    authors: Dieckmann KP,Loy V

    更新日期:1995-01-01 00:00:00

  • The two-stage repair for severe primary hypospadias.

    abstract:OBJECTIVES:The repair of severe primary hypospadias represents a major surgical challenge. After initial enthusiasm for single-stage procedures, many paediatric urologists have turned to the alternative two-stage approach after experiencing disappointing results. A single surgeon's experience of the two-stage procedure...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.01.002

    authors: Johal NS,Nitkunan T,O'Malley K,Cuckow PM

    更新日期:2006-08-01 00:00:00

  • Comparison of transperitoneal and extraperitoneal laparoscopic radical prostatectomy using match-pair analysis.

    abstract:PURPOSE:Based on the experience of 1000 cases of laparoscopic radical prostatectomy, we compared the operative parameters of transperitoneal and extraperitoneal approaches in match-paired patient groups. PATIENTS AND METHODS:We reviewed the charts of 53 consecutive patients who underwent selectively extraperitoneal la...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.05.004

    authors: Erdogru T,Teber D,Frede T,Marrero R,Hammady A,Seemann O,Rassweiler J

    更新日期:2004-09-01 00:00:00

  • Incidence and distribution of renal anomalies in patients with neural tube defects.

    abstract::In 190 patients with neural tube defects the sensory levels to pin prick were compared with the incidence and distribution of congenital renal anomalies. 17 such anomalies comprised 3 examples of renal agenesis, 5 horseshoe kidneys, 8 ureteral duplications and one simple ureterocele. The pattern of anomalies showed th...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472810

    authors: Whitaker RH,Hunt GM

    更新日期:1987-01-01 00:00:00

  • Superficial bladder cancer: survival and prognostic factors.

    abstract::Two hundred and seventeen consecutive patients with superficial bladder cancer stages Ta-T1 were analyzed for survival and prognostic factors. The overall 5-year survival was 88 +/- 5.3%. Factors that impacted significantly on survival were: grade of anaplasia (GI 92 +/- 5.9% vs. GII 87 +/- 7.5% vs. GIII 68 +/- 20.7%;...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471697

    authors: Sánchez de la Muela P,Rosell D,Agüera L,De Castro F,Isa W,Robles JE,Zudaire JJ,Berián JM

    更新日期:1991-01-01 00:00:00

  • E-cigarettes and Urologic Health: A Collaborative Review of Toxicology, Epidemiology, and Potential Risks.

    abstract:CONTEXT:Use of electronic cigarettes (ECs) is on the rise in most high-income countries. Smoking conventional cigarettes is a known risk factor for urologic malignancy incidence, progression, and mortality, as well as for other urologic health indicators. The potential impact of EC use on urologic health is therefore o...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2016.12.022

    authors: Bourke L,Bauld L,Bullen C,Cumberbatch M,Giovannucci E,Islami F,McRobbie H,Silverman DT,Catto JWF

    更新日期:2017-06-01 00:00:00

  • Present status of undergraduate urological education in Turkey: is standardization necessary?

    abstract::23 medical faculties exist in Turkey at the moment and 2 others are being established. Considering that all these faculties run their own programs independently, different education systems might effect the standard of doctors and health care. All of the new graduates in this country face a centralized examination for...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000464040

    authors: Akdaş A,Simşek F,Ilker Y

    更新日期:1990-01-01 00:00:00

  • Case of duplication of the urethra in an adult male, presenting with symptoms of bladder outlet obstruction.

    abstract::Duplication of the urethra is a rare congenital anomaly, usually found in children and adolescents. The authors present a rare case of urethral duplication, presenting in a 58-yr-old man, with symptoms of bladder outlet obstruction. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.01.019

    authors: Slavov C,Donkov I,Popov E

    更新日期:2007-10-01 00:00:00

  • Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy.

    abstract:BACKGROUND:Although the initial robot-assisted radical prostatectomy (RARP) series showed 12-mo potency rates ranging from 70% to 80%, the few available comparative studies did not permit any definitive conclusion about the superiority of this technique when compared with retropubic radical prostatectomy (RRP) and lapa...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2012.05.046

    authors: Ficarra V,Novara G,Ahlering TE,Costello A,Eastham JA,Graefen M,Guazzoni G,Menon M,Mottrie A,Patel VR,Van der Poel H,Rosen RC,Tewari AK,Wilson TG,Zattoni F,Montorsi F

    更新日期:2012-09-01 00:00:00

  • Tumour-associated antibodies against renal cell carcinomas detected by immunofluorescence.

    abstract::Serum from 39 of 288 (13.5%) cancer patients contained antibodies detectable by immunofluorescence which reacted with frozen tumour sections from kidneys, prostate glands and ovaries. The serum did not react against areas of normal kidney taken from the same diseased organ. In comparison, 0.7% of normal persons and 3....

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Ackermann R

    更新日期:1975-01-01 00:00:00

  • ETS gene fusions in prostate cancer: from discovery to daily clinical practice.

    abstract:CONTEXT:In 2005, fusions between the androgen-regulated transmembrane protease serine 2 gene, TMPRSS2, and E twenty-six (ETS) transcription factors were discovered in prostate cancer. OBJECTIVE:To review advances in our understanding of ETS gene fusions, focusing on challenges affecting translation to clinical applica...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2009.04.036

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    更新日期:2009-08-01 00:00:00

  • Surgical treatment of Peyronie's disease by the intracavernosal plaque excision method: a new surgical technique.

    abstract:OBJECTIVE:A new surgical method of treating Peyronie's disease consisting in intracavernosal excision of the plaque is presented. MATERIAL AND METHODS:The operation was performed on 16 men aged from 34 to 65 years (mean 50.2 years). The angle of penile curvature was 30 degrees to 60 degrees. Thirteen (81.25%) had impa...

    journal_title:European urology

    pub_type: 杂志文章

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    更新日期:2004-01-01 00:00:00

  • Sigmoid kidney associated with renal adenocarcinoma.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Vandendris M,Schulman CC,Struyven J,Grégoir W

    更新日期:1975-01-01 00:00:00

  • Pathogenesis and treatment of hypertension in renal tuberculosis.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000463780

    authors: Studer UE,Weidmann P

    更新日期:1984-01-01 00:00:00

  • Mucosal morphology of ileal conduits with particular reference to urinary infections.

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    pub_type: 杂志文章

    doi:10.1159/000472616

    authors: Lindell O,Mäkinen J,Nickels J,Lehtonen T

    更新日期:1986-01-01 00:00:00