The microbiological and pharmacokinetic profile of an antibacterial agent useful for the single-dose therapy of urinary tract infection.

Abstract:

:Single-dose therapy of uncomplicated urinary tract infection (UTI) has been shown to be effective in many trials in adult women. The question which will be explored in this presentation is what properties constitute the ideal agent for the therapy of UTI. Important microbiological properties include spectrum of activity to include all common urinary pathogens, bactericidal action in urine and low prevalence of resistant bacteria. The vital feature of an antibacterial drug useful in the therapy of UTI is prolonged urinary concentrations. The agent must therefore be well absorbed and have slow renal excretion. Most beta-lactam drugs do not have these combined properties. Aminoglycosides are effective drugs but cannot be administered orally. Quinolones and the calcium salt of fosfomycin are useful but do not have an ideal pharmacokinetic profile. Cotrimoxazole, trimethoprim alone and the trometamol salt of fosfomycin all have good antibacterial activity combined with slow urinary excretion.

journal_name

Eur Urol

journal_title

European urology

authors

Slack R,Greenwood D

doi

10.1159/000472856

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

32-6

eissn

0302-2838

issn

1873-7560

journal_volume

13 Suppl 1

pub_type

临床试验,杂志文章
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    abstract:BACKGROUND:Prior studies assessing the correlation of Gleason score (GS) at needle biopsy and corresponding radical prostatectomy (RP) predated the use of the modified Gleason scoring system and did not factor in tertiary grade patterns. OBJECTIVE:To assess the relation of biopsy and RP grade in the largest study to d...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2012.01.050

    authors: Epstein JI,Feng Z,Trock BJ,Pierorazio PM

    更新日期:2012-05-01 00:00:00

  • Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma.

    abstract:BACKGROUND:Bone metastases (BMs) are frequently present in patients with metastatic renal cell carcinoma (mRCC) and cause significant morbidity. OBJECTIVE:The purpose of this analysis was to assess the impact of BMs and bisphosphonate therapy (BT) on outcomes in mRCC. DESIGN, SETTING, AND PARTICIPANTS:We conducted a ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2014.02.040

    authors: McKay RR,Lin X,Perkins JJ,Heng DY,Simantov R,Choueiri TK

    更新日期:2014-09-01 00:00:00

  • Effect of lectins on 3H-uridine and 3H-thymidine uptake by cultured renal cell carcinoma and normal renal cells.

    abstract::The effect of lectins on cultured renal cell carcinoma and normal renal cells was studied. Ricin II showed effective inhibition of 3H-uridine and 3H-thymidine uptake by renal cell carcinoma and normal renal cells in all cases. Normal renal cells were more resistant to the inhibitory effect of ricin II as compared to r...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472595

    authors: Bazeed MA,Becht E,Schärfe T,Schmidt J,Jacobi GH,Thüroff JW

    更新日期:1986-01-01 00:00:00

  • BCG treatment of existing Ta, T1 tumours or carcinoma in situ of the bladder.

    abstract::There are theoretical limits to the efficacy of intravesical instillation of anticancer agents as a method to prevent recurrence of superficial bladder cancer. Studies on the direct efficacy of intravesical instillation of bacillus Calmette-Guérin (BCG) to treat existing papillary tumours (Ta, T1) have shown a complet...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000475202

    authors: Akaza H

    更新日期:1995-01-01 00:00:00

  • Renal lesions in Von Hippel-Lindau disease: the benign, the malignant, the unknown.

    abstract:OBJECTIVES:To describe the features and treatment of renal lesions in von Hippel-Lindau disease (VHL) from a series of patients, to highlight important issues in the management of these lesions. MATERIALS AND METHODS:We performed a retrospective study in 7 patients with VHL who underwent surgery for renal lesions betw...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019771

    authors: Salomé F,Colombeau P,Fermeaux V,Cazaux P,Dumas JP,Pfeifer P,Moreau JJ,Richard S,Labrousse F

    更新日期:1998-01-01 00:00:00

  • Technical Refinements in Superextended Robot-assisted Radical Prostatectomy for Locally Advanced Prostate Cancer Patients at Multiparametric Magnetic Resonance Imaging.

    abstract:BACKGROUND:The feasibility and efficacy of robot-assisted radical prostatectomy (RARP) in locally advanced prostate cancer (PCa) patients with iT3 lesion at magnetic resonance imaging (MRI) are currently not explored. OBJECTIVE:To describe our revised RARP technique (ie, superextended RARP [SE-RARP]) for PCa patients ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2020.09.009

    authors: Mazzone E,Dell'Oglio P,Rosiello G,Puliatti S,Brook N,Turri F,Larcher A,Beato S,Andras I,Wisz P,Pandey A,De Groote R,Schatteman P,De Naeyer G,D'Hondt F,Mottrie A

    更新日期:2020-09-14 00:00:00

  • Surgical treatment of Peyronie's disease by the intracavernosal plaque excision method: a new surgical technique.

    abstract:OBJECTIVE:A new surgical method of treating Peyronie's disease consisting in intracavernosal excision of the plaque is presented. MATERIAL AND METHODS:The operation was performed on 16 men aged from 34 to 65 years (mean 50.2 years). The angle of penile curvature was 30 degrees to 60 degrees. Thirteen (81.25%) had impa...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2003.05.001

    authors: Darewicz JS,Darewicz BA,Galek LM,Kudelski J,Badri BM

    更新日期:2004-01-01 00:00:00

  • Gleason scores from prostate biopsies obtained with 18-gauge biopsy needles poorly predict Gleason scores of radical prostatectomy specimens.

    abstract:OBJECTIVES:Prostate cancer is the most frequent cancer among men in the US. Histological grading is an important part of the diagnostic evaluation aside from clinical staging and serum PSA. The most commonly used grading system is the one described by Gleason. From a prognostic point of view, it is of considerable inte...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019578

    authors: Djavan B,Kadesky K,Klopukh B,Marberger M,Roehrborn CG

    更新日期:1998-01-01 00:00:00

  • Methotrexate, vinblastine, adriamycin and cisplatin versus methotrexate and cisplatin in advanced urothelial cancer. A randomized study.

    abstract::From September 1984 to December 1988, 28 consecutive patients with metastatic urothelial cancer entered a randomized study to compare 4 courses of modified methotrexate, vinblastine, adriamycin and cisplatin (M-VAC) to 4 courses of methotrexate followed by folinic acid rescue and cisplatin (MP). Non-responders or rela...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000471672

    authors: Pizzocaro G,Milani A,Piva L,Faustini M,Spino E

    更新日期:1991-01-01 00:00:00

  • Performance characteristics of computed tomography in detecting lymph node metastases in contemporary patients with prostate cancer treated with extended pelvic lymph node dissection.

    abstract:BACKGROUND:Computed tomography (CT) is a commonly used noninvasive procedure for prostate cancer (PCa) staging. All previous studies addressing the ability of CT scan to predict lymph node invasion (LNI) were based on historical patients treated with limited pelvic lymph node dissection (PLND). OBJECTIVE:Assess the va...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2011.11.008

    authors: Briganti A,Abdollah F,Nini A,Suardi N,Gallina A,Capitanio U,Bianchi M,Tutolo M,Passoni NM,Salonia A,Colombo R,Freschi M,Rigatti P,Montorsi F

    更新日期:2012-06-01 00:00:00

  • Delay in the surgical treatment of bladder cancer and survival: systematic review of the literature.

    abstract:OBJECTIVES:Eighty per cent of the newly diagnosed invasive bladder tumours are invasive from the outset. Half of these patients already have occult distant metastases reflecting the rapid nature of progression. The aim of the current study was to review the literature to determine if delay in cystectomy leads to worse ...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2006.05.046

    authors: Fahmy NM,Mahmud S,Aprikian AG

    更新日期:2006-12-01 00:00:00

  • Quality of life as an outcome measure in cancer clinical trials.

    abstract::In the past decade, increasing attention has been given to more systematic and quantitative ways of evaluating explicitly the impact of diseases and medical interventions on quality of life. A substantial part of this research pertained to the field of cancer where cure is not always possible and treatments are mostly...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000474532

    authors: Kiebert GM

    更新日期:1997-01-01 00:00:00

  • Prevalence of contralateral testicular intraepithelial neoplasia (carcinoma in situ) in patients with testicular germ cell tumour. Results of the German multicentre study.

    abstract::Contralateral biopsies taken from 1,188 patients with testicular germ-cell tumour were examined immunohistologically by staining for placental alkaline phosphatase. Testicular intraepithelial neoplasia (TIN; carcinoma in situ) was detected in 53 patients (4.5%; 95% confidence interval 3.3-5.7%). Testicular atrophy was...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000474579

    authors: Loy V,Dieckmann KP

    更新日期:1993-01-01 00:00:00

  • Local thrombolytic treatment for renal arterial embolism.

    abstract:OBJECTIVE:To determine the utility of local thrombolysis in the treatment of acute renal arterial occlusion. METHODS:We used local thrombolytic treatment in a female patient, aged 76, with 72 h of anuria, right lumbar and flank pain. She had a 3-year history of ischemic heart disease and atrial fibrillation controlled...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000020303

    authors: Glück G,Croitoru M,Deleanu D,Platon P

    更新日期:2000-09-01 00:00:00

  • T lymphocytes infiltrating the bladder wall of patients with carcinoma of urinary bladder are in vivo activated.

    abstract:OBJECTIVES:This paper studies the phenotypical characteristics of the lymphocytes present in mononuclear cell (MNC) preparations from peripheral blood (PBMNC), lymph nodes (LNMNC), tumor bladder (TBMNC), and tumor-free bladder (TFBMNC) from patients with infiltrated transitional cell carcinoma (TCC) of the bladder and ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474509

    authors: Reyes E,Carballido J,Prieto A,Molto L,Manzano L,Alvarez-Mon M

    更新日期:1997-01-01 00:00:00

  • Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.

    abstract:BACKGROUND:Recent large high-quality trials have questioned the clinical effectiveness of medical expulsive therapy using tamsulosin for ureteral stones. OBJECTIVE:To evaluate the efficacy and safety of tamsulosin for distal ureteral stones compared with placebo. DESIGN, SETTING, AND PARTICIPANTS:We conducted a doubl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2017.10.033

    authors: Ye Z,Zeng G,Yang H,Tang K,Zhang X,Li H,Li W,Wu Z,Chen L,Chen X,Liu X,Deng Y,Pan T,Xing J,Wang S,Cheng Y,Gu X,Gao W,Yang J,Zhang Y,Mi Q,Qi L,Li J,Hu W,Liang P,Sun Z,Xu C,Long Y,Liao Y,Liu S,Liu

    更新日期:2018-03-01 00:00:00

  • Posterior hypospadias repair: a new technical approach. Mobilization of the urethral plate and duplay urethroplasty.

    abstract::We describe our experience with a new technique of complete repair of severe posterior hypospadias in one stage. The operative technique includes some innovative points: penile straightening is realized by urethral mobilization (without detaching it from the glans) to excise the chordee, and then urethroplasty accordi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474741

    authors: Montfort G,Bretheau D,di Benedetto V,Bankole R

    更新日期:1992-01-01 00:00:00

  • Prognostic value of Ki-67 expression in renal cell carcinomas.

    abstract:OBJECTIVE:The aim of the study was to determine the prognostic power of Ki-67 immunostaining in renal cell carcinomas (RCC). METHODS:Clinical follow-up data were reviewed in 111 RCC and the results of Ki-67 immunolabelling were correlated to standard prognostic factors and survival data of the patients. RESULTS:Ki-67...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474482

    authors: Aaltomaa S,Lipponen P,Ala-Opas M,Eskelinen M,Syrjänen K

    更新日期:1997-01-01 00:00:00

  • Cytokeratin-19 fragment (CYFRA 21-1) in bladder cancer.

    abstract::The present study was designed to evaluate the role of the cytokeratin-19 fragment (CYFRA 21-1) as a tumor marker in bladder cancer. The bladder cancer cell line JMSU1 was used in the preclinical study. Subjects comprised 120 healthy volunteers, 20 patients with benign bladder diseases including acute cystitis and bla...

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Morita T,Kikuchi T,Hashimoto S,Kobayashi Y,Tokue A

    更新日期:1997-01-01 00:00:00

  • The potential impact of prostate volume in the planning of optimal number of cores in the systematic transperineal prostate biopsy.

    abstract:OBJECTIVES:We compared the detection rates of different transperineal prostate biopsy protocols with the aim to optimize the number of cores to sample according to prostate volume. MATERIAL AND METHODS:From October 2002 to October 2004 we evaluated 480 consecutive patients with PSA between 2.5 and 20 ng/ml undergoing ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.08.008

    authors: Ficarra V,Novella G,Novara G,Galfano A,Pea M,Martignoni G,Artibani W

    更新日期:2005-12-01 00:00:00

  • Absence of brain parenchymal damage following intravascular injection of polytetrafluoroethylene paste.

    abstract:OBJECTIVE:Polytetrafluoroethylene (PTFE) paste has been used for over 30 years to treat urinary incontinence and for 14 years to treat vesicoureteral reflux with little reported morbidity. Some investigators have been concerned by the use of PTFE as the implanted substance, because migration of PTFE particles from the ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019720

    authors: Miyakita H,O'Briain DS,Puri P

    更新日期:1998-09-01 00:00:00

  • Renal cell carcinoma (RCC) in patients with end-stage renal disease exhibits many favourable clinical, pathologic, and outcome features compared with RCC in the general population.

    abstract:BACKGROUND:Patients with end-stage renal disease (ESRD) are at risk of developing renal tumours. OBJECTIVE:Compare clinical, pathologic, and outcome features of renal cell carcinomas (RCCs) in ESRD patients and in patients from the general population. DESIGN, SETTING, AND PARTICIPANTS:Twenty-four French university de...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2011.02.035

    authors: Neuzillet Y,Tillou X,Mathieu R,Long JA,Gigante M,Paparel P,Poissonnier L,Baumert H,Escudier B,Lang H,Rioux-Leclercq N,Bigot P,Bernhard JC,Albiges L,Bastien L,Petit J,Saint F,Bruyere F,Boutin JM,Brichart N,Karam G

    更新日期:2011-08-01 00:00:00

  • Prostate-specific antigen density: a means to enhance detection of prostate cancer.

    abstract::The ability of serum prostate-specific antigen (PSA) and PSA density (PSAD) to distinguish patients with prostate cancer from those with benign diseases of the prostate was assessed in 495 men. All men were evaluated with PSA determination, digital rectal examination (DRE), transrectal ultrasonography (TRUS) and ultra...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475303

    authors: Ramon J,Boccon-Gibod L,Billebaud T,Astier L,Kobelinsky M,Meulemans A,Dauge MC,Boccon-Gibod L,Villers A

    更新日期:1994-01-01 00:00:00

  • Impotence due to corporeal veno-occlusive dysfunction: long-term follow-up of venous surgery.

    abstract::Corporeal veno-occlusive dysfunction is an important cause of organic impotence and is characterized by increased flow rates to create and to maintain erection during artificial erection produced by intracavernous saline infusion. Sixty-seven patients with this erectile insufficiency underwent penile ligature-resectio...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474815

    authors: Wespes E,Delcour C,Preserowitz L,Herbaut AG,Struyven J,Schulman C

    更新日期:1992-01-01 00:00:00

  • Intratesticular effects of cisplatin-based chemotherapy.

    abstract::The question is addressed whether cisplatin-based chemotherapy for germ cell cancer has the same efficacy in intratesticular and in extragonadal sites. For this purpose, 7 patients with germ cell cancer, aged 16-35 years were analysed. Four of the patients had palpable testicular tumors, 3 had occult testicular tumors...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475015

    authors: Dieckmann KP,Loy V

    更新日期:1995-01-01 00:00:00

  • Immunologic aspect of testicular torsion: detection of antisperm antibodies in contralateral testicle.

    abstract:OBJECTIVE:To evaluate the immunologic etiology in unilateral testicular torsion, an experimental study in rats was carried out. MATERIALS AND METHODS:75 adult Wistar rats included in the study program were divided into six different groups according to a torsion-detorsion procedure. Torsion degree was kept constant fo...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000020060

    authors: Koşar A,Küpeli B,Alçigir G,Ataoglu H,Sarica K,Küpeli S

    更新日期:1999-12-01 00:00:00

  • Normocalcemic hyperparathyroidism.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473257

    authors: Zechner O,Kovarik J,Willvonseder R

    更新日期:1981-01-01 00:00:00

  • Beckwitt-Wiedemann's syndrome with medullary sponge kidneys, agonadism and persistent testosterone production.

    abstract::A patient with Beckwitt-Wiedemann's syndrome is described in which associated malformations were hemihypertrophy of the body, medullary sponge kidneys and absence of testes and internal ducts. On the other hand, we demonstrated biochemically the existence of testosterone secretion, with active response to a 3-day HCG ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472070

    authors: Salgado AL,Macia AL,Freire A,Paramo P,Fernandez-Cruz A

    更新日期:1977-01-01 00:00:00

  • The methodology of corpus cavernosum electromyography revisited.

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    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.04.002

    authors: Jiang XG,Wijkstra H,Meuleman EJ,Wagner G

    更新日期:2004-09-01 00:00:00

  • Increase in the prevalence of symptomatic upper urinary tract stones during the last ten years.

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    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000020094

    authors: Trinchieri A,Coppi F,Montanari E,Del Nero A,Zanetti G,Pisani E

    更新日期:2000-01-01 00:00:00